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| 1 | Dextran sulfate sodium-induced colitis-associated neoplasia:a promising model for the development of chemopreventive interventions显示文摘与 ulcerative 大肠炎诊断的个人面对开发颜色的显著地增加的风险表面的发育异常和癌症在他们的一生期间。迄今为止,注意为葡聚糖硫酸盐钠(决策支持系统)的这个 high-riskpopulation.The 鼠标模型被给了 chemopreventive 干预的开发的很少导致了大肠炎代表两个都描绘面对发炎为肿瘤形成要求的分子的事件并且估计精选代理人的能力到的一个优秀现出症状之前的潜的系统在在长期的大肠炎的建立和颜色的开发喝水结果禁止决策支持系统的 thisprocess.Cyclic 管理有人的联系大肠炎的瘤形成类似于那些的病理学的特征的表面的发育异常和癌症。观察的损害的发生和复合变化取决于使用的鼠标紧张(即,瑞士韦伯斯特, C57BL/6J , CBA , ICR )并且剂量(0.7%-5.0%)和瘤形成的 DSS.Theincidence 的时间表( 1-15 周期与或没有一个随后的恢复时期)能被增加,它到侵略癌症的前进由与已知的冒号致癌物在联合管理决策支持系统显著地加速了( azoxymethane ( AOM ), 2-ammo-3-methylimidazo [ 4,5-f ]喹啉( IQ ), 2-amino-l-methyl-6-phenylimidazo [ 4,5-b ] pyridine ( PhTP ))在遗传上定义的老鼠的联系大肠炎的瘤形成的最近的正式就职拉紧的 oriron.More 提供了新卓见进特定的基因的角色(即, adenomatous polyposiscoli ( Apc ), p53 ,可诱导的氮的氧化物 synthase ( i NOS ), Msh2 )在从 chemopreventive 干预的 colitis-associatedneoplasias.Emerging 数据的开发,研究在禁止导致决策支持系统的瘤形成记录几个代理人的功效并且提供 colitis-associatedcolorectal 瘤形成是可防止的疾病的大诺言。 | Margie Lee CLAPPER Harry Stanley COOPER Wen-Chi Lee CHANG | 2007 | Acta Pharmacologica Sinica2007，28，9： | 17 |
| 2 | 肌萎缩性侧索硬化蛋白激活小胶质细胞NLRP3炎性小体显示文摘小胶质细胞NLRP3炎性小体激活正在成为神经退行性变过程中神经炎症的关键因素。诸如β-淀粉样蛋白和α-突触核蛋白之类的致病性蛋白质聚集体触发小胶质NLRP3激活,从而导致半胱天冬酶-1激活和IL-1β的分泌。在小鼠肌萎缩性侧索硬化症(ALS)的SOD1G93A模型中,半胱天冬酶-1和IL-1β均促进疾病进展,提示小胶质NLRP3在该进程中发挥作用。然而先前的研究表明,SOD1G93A小鼠小胶质细胞不表达NLRP3,SOD1G93A蛋白在小胶质细胞中产生独立于NLRP3的IL-1β。本研究论证了使用Nlrp3-GFP基因敲入小鼠,在SOD1G93A小鼠中小胶质细胞表达NLRP3。本研究显示聚集和可溶性SOD1G93A均可激活小鼠原代小胶质细胞中的炎性小体,导致半胱天冬酶-1和IL-1β裂解,ASC斑点形成以及呈剂量和时间依赖性的IL-1β分泌。重要的是,SOD1G93A无法从缺乏Nlrp3的小胶质细胞或者用特异性NLRP3抑制剂MCC950预处理的小胶质细胞中诱导IL-1β分泌,从而证实NLRP3是介导SOD1诱导的小胶质细胞IL-1β分泌的关键炎症小体复合物。在TDP-43Q331K ALS小鼠模型中也观察到小胶质NLRP3上调,TDP-43野生型和突变蛋白亦可以NLRP3依赖性的方式激活小胶质炎性小体。从机制上讲,本研究确定了活性氧簇和ATP的生成是SOD1G93A介导的NLRP3激活所需的关键事件。总之,本研究的数据表明ALS小胶质细胞表达NLRP3,而病理ALS蛋白激活小胶质NLRP3炎性小体。因此,NLRP3抑制可能是阻止小胶质细胞神经炎症和ALS疾病进展的潜在治疗方法。 | Vandana Deora John D Lee Eduardo AAlbornoz Luke McAlary Cyril J Jagaraj Avril A B Robertson Julie D Atkin Matthew A Cooper Kate Schroder Justin J Yerbury Richard Gordon Trent MWoodruff 杜一星(编译) | 2020 | 神经损伤与功能重建2020，15，9： | 13 |
| 3 | 利用北冰洋多光谱数据计算光合有效辐射的研究显示文摘光合有效辐射(PAR)是重要的生物光学量,与海洋浮游植物的初级生产过程有密切联系。PAR通常由宽波段的PAR传感器直接测量,也可以由多光谱数据计算得出。在极区用多光谱数据计算PAR不仅面对不同谱宽度的问题,而且还受海冰的影响。本文研究了四种可能导致PAR计算误差的主要因素。多光谱仪器避开了大气对太阳辐射的主要吸收带,用多光谱数据计算会对PAR高估。实测数据分析表明多光谱计算的PAR与高光谱数据的计算结果非常接近,误差在1%以内。用本文建立的拟合函数进行校正,校正后的结果与高光谱数据计算的结果达到同样的精度。计算PAR的衰减率要用到进入海水表面的PAR(PAR0),本文提出先确定表层衰减系数,再通过最小二乘拟合确定PAR0值,与水下观测数据有很好的衔接。根据海上同一站位不同时间的观测数据计算的PAR衰减系数相差很小,这表明PAR的衰减系数是海水的光学性质,与辐射强度无关。在海冰覆盖的条件下,PAR的观测结果与无冰海水的PAR有明显差别。由于海冰选择性的吸收,穿透海冰进入海洋的PAR组分已经发生变化,海水对PAR的衰减系数也会相应变化。由此可以推断,不同海冰中成分的差别将导致进入海水中PAR的差别,影响PAR的衰减特性。通过本文的研究,解决了在极区用多光谱计算PAR的各种问题,使多光谱数据成为PAR的重要数据源。 | 赵进平 王维波 Cooper Lee | 2010 | 极地研究2010，22，2： | 6 |
| 4 | P53 protein expression in benign and malignant skin turnouts显示文摘 | RO YS COOPER PN LEE JL | 1993 | Br J Dermatol1993，128，： | 1 |
| 5 | Histologic characterization of coblation nucleoplasty performed on sheep intervertebral discs 显示文摘 | Lee Ms Cooper G Lutz GE | 2003 | Pain Physician2003，6，4： | 1 |
| 6 | Modem management of spinaltubercu!osis显示文摘 | Rezai AR Lee M Cooper PR ef al | 1995 | Neurosurgery1995，36，1： | 1 |
| 7 | Improved direct PCR screen for bacterial colonies-wooden toothpicks inhibit PCR amplifi-cation 显示文摘 | LEE A B COOPER T A | 1995 | Biotechniques1995，18，： | 1 |
| 8 | Doppler ultrasound of the uterine arteries:the importance of bilat-eral notching in the prediction of preclampsia,placental abruption or delivery of a small for gestationgal age baby显示文摘 | Harrington K Cooper D Lees C | 1996 | Ultrasound Obstet Gynecol1996，，3： | 1 |
| 9 | Enhancing Hematopoietic Stem Cell Transplantation Efficacy by Mitigating Oxygen Shock显示文摘 | Charlie R. Mantel Heather A. O’Leary Brahmananda R. Chitteti XinXin Huang Scott Cooper Giao Hangoc Nickolay Brustovetsky Edward F. Srour Man Ryul Lee Steven Messina-Graham David M. Haas Nadia Falah Reuben Kapur Louis M. Pelus Nabeel Bardeesy Julien Fitama | 2015 | Cell2015，，7： | 1 |
| 10 | Delayed leaf senescence in ethylene-deficient ACC-oxidase antisense tomato plants: molecular and physiological analysis显示文摘 | JOHN I DRAKE R FARRELL1 A COOPER W LEE P HORTON P GRIERSON D | 1995 | The Plant Journal1995，7，3： | 1 |
| 11 | The major genetic determinants of HIV-1control affect HLA class I peptide presentation显示文摘 | International HIV Controllers Study Pereyra F Jia X McLaren P J Telenti A de Bakker P I Walker B D Ripke S Brumme C J Pulit S L Carrington M Kadie C M Carlson J M Heckerman D Graham R R Plenge R M Deeks S G Gianniny L Crawford G Sullivan J Gonzalez E Davies L Camargo A Moore JM Beattie N Gupta S Crenshaw A Burtt N P Guiducci C Gupta N Gao X Qi Y Yuki Y Piechocka-Trocha A Cutrell E Rosenberg R Moss K L Lemay P O'Leary J Schaefer T Verma P Toth I Block B Baker B Rothchild A Lian J Proudfoot J Alvino D M Vine S Addo M M Allen T M Altfeld M Henn M R Le Gall S Streeck H Haas D W Kuritzkes D R Robbins G K Shafer R W Gulick R M Shikuma C M Haubrich R Riddler S Sax P E Daar E S Ribaudo H J Agan B Agarwal S Ahern R L Allen B L Altidor S Altschuler E L Ambardar S Anastos K Anderson B Anderson V Andrady U Antoniskis D Bangsberg D Barbaro D Barrie W Bartczak J Barton S Basden P Basgoz N Bazner S Bellos N C Benson A M Berger J Bernard N F Bernard A M Birch C Bodner S J Bolan R K Boudreaux E T Bradley M Braun J F Brndjar J E Brown S J Brown K Brown S T Burack J Bush LM Cafaro V Campbell O Campbell J Carlson R H Carmichael J K Casey K K Cavacuiti C Celestin G Chambers S T Chez N Chirch L M Cimoch P J Cohen D Cohn LE Conway B Cooper D A Cornelson B Cox D T Cristofano M V Cuchural G Jr Czartoski J L Dahman J M Daly J S Davis B T Davis K Davod S M DeJesus E Dietz C A Dunham E Dunn M E Ellerin T B Eron J J Fangman J J Farel C E Ferlazzo H Fidler S Fleenor-Ford A Frankel R Freedberg K A French N K Fuchs JD Fuller J D Gaberman J Gallant J E Gandhi R T Garcia E Garmon D Gathe J C Jr Gaultier C R Gebre W Gilman F D Gilson I Goepfert P A Gottlieb M S Goulston C Groger R K Gurley T D Haber S Hardwicke R Hardy W D Harrigan P R Hawkins T N Heath S Hecht F M Henry W K Hladek M Hoffman R P Horton J M Hsu R K Huhn G D Hunt P Hupert M J Illeman M L Jaeger H Jellinger R M John M Johnson J A Johnson K L Johnson H Johnson K Joly J Jordan W C Kauffman C A Khanlou H Killian R K Kim A Y Kim D D Kinder C A Kirchner J T Kogelman L Kojic E M Korthuis P T Kurisu W Kwon D S LaMar M Lampiris H Lanzafame M Lederman M M Lee D M Lee J M Lee M J Lee E T Lemoine J Levy J A Llibre J M Liguori M A Little S J Liu A Y Lopez A J Loutfy M R Loy D Mohammed D Y Man A Mansour M K Marconi V C Markowitz M Marques R Martin J N Martin H L Jr Mayer K H McElrath M J McGhee T A McGovern B H McGowan K McIntyre D Mcleod GX Menezes P Mesa G Metroka CE Meyer-Olson D Miller A O Montgomery K Mounzer K C Nagami E H Nagin I Nahass R G Nelson M O Nielsen C Norene D L O'Connor D H Ojikutu B O Okulicz J Oladehin O O Oldfield E C Olender S A Ostrowski M Owen WF Jr Pae E Parsonnet J Pavlatos A M Perlmutter A M Pierce M N Pincus J M Pisani L Price L J Proia L Prokesch R C Pujet H C Ramgopal M Rathod A Rausch M Ravishankar J Rhame F S Richards C S Richman D D Rodes B Rodriguez M Rose R C 3rd Rosenberg E S Rosenthal D Ross P E Rubin D S Rumbaugh E Saenz L Salvaggio M R Sanchez WC Sanjana V M Santiago S Schmidt W Schuitemaker H Sestak P M Shalit P Shay W Shirvani V N Silebi V I Sizemore J M Jr Skolnik P R Sokol-Anderson M Sosman J M Stabile P Stapleton J T Starrett S Stein F Stellbrink H J Sterman FL Stone V E Stone D R Tambussi G Taplitz R A Tedaldi E M Telenti A Theisen W Torres R Tosiello L Tremblay C Tribble M A Trinh P D Tsao A Ueda P Vaccaro A Valadas E Vanig T J Vecino I Vega V M Veikley W Wade B H Walworth C Wanidworanun C Ward D J Warner D A Weber R D Webster D Weis S Wheeler D A White D J Wilkins E Winston A Wlodaver C G van't Wout A Wright D P Yang O O Yurdin D L Zabukovic B W Zachary K C Zeeman B Zhao M | 2010 | Science2010，330，6010： | 1 |
| 12 | Angiotensin converting enzyme inhibition reduces retinal overexpression of vascular endothelial growth factor and hyperpermeability in experimental diabetes显示文摘 | R. E. Gilbert D. J. Kelly A. J. Cox J. L. Wilkinson-Berka J. R. Rumble T. Osicka S. Panagiotopoulos V. Lee E. C. Hendrich G. Jerums M. E. Cooper | 2000 | Diabetologia2000，，11： | 1 |
| 13 | Pathogenic mecha- nisms of myotonic dystrophy 显示文摘 | Lee JE Cooper TA | 2009 | Biochem Soc Trans2009，37，6： | 1 |
| 14 | Improved outcome secondary to concurrent chemoradiotherapy for advanced carcinoma of the nasopharynx: preliminary corroboration of the intergroup experience显示文摘 | Cooper JS Lee H Torrey M | 2000 | Int J Radiat Oncol Biol Phys2000，47，4： | 1 |
| 15 | p53 protein expression in benign and malignant skin tumours显示文摘 | RO Y S COOPER P N LEE J L | 1993 | Br J Dermatol1993，128，： | 1 |
| 16 | Special Project,self-Help:Extrajudicial Rights,Privileges and Remedies in Contemporary American Society显示文摘 | COOPER Melinde Lee GRESHIN Jeremy H | 1984 | Vanderbilt Law Review1984，，37： | 1 |
| 17 | Non-rigid Registration for Large Sets of Microscopic Images onGraphics Processors显示文摘 | Antonio Ruiz Manuel Ujaldon Lee Cooper etc | 2009 | Sign Process Syst2009，55，： | 1 |
| 18 | Histologic characterization of coblation nucleoplasty performed on sheep intervertebral discs显示文摘 | Michael S Lee SH Grant Cooper | 2003 | Pain Physician2003，6，4： | 1 |
| 19 | Total synthesis of a functional designer eukaryotic chromosome 显示文摘 | Annaluru N Muller H Mitchell L A Ramalingam S Stracquadanio G Richardson S M Dymond J S Kuang Z Scheifele L Z Cooper E M Cai Y Z Zeller K Agmon N Han J S Hadjithomas M Tullman J Caravelli K Cirelli K Guo Z Y London V Yeluru A Murugan S Kandavelou K Agier N Fischer G Yang K Martin J A Bilgel M Bohutski P Boulier K M Capaldo B J Chang J Charoen K Choi W J Deng P Dicarlo J E Doong J Dunn J Feinberg J I Fernandez C Floria C E Gladowski D Hadidi P Ishizuka I Jabbari J Lau C Y L Lee P A Li S Lin D Linder M E Ling J Liu J Liu J London M Ma H Mao J Mcdade J E Mcmillan A Moore A M Oh W C Ouyang Y Patel R Paul M Paulsen L C Qiu J Rhee A Rubashkin M G Soh I Y Sotuyo N E Srinivas V Suarez A Wong A Wong R Xie W R Xu Y J Yu A T Koszul R Bader J S Boeke J D Chandrasegaran S | 2014 | Science2014，344，6179： | 1 |
| 20 | A life cycle assessment of end-of-life computer monitor management in the Seattle Metropolitan Region 显示文摘 | Noon M S Lee S J Cooper J S | 2011 | Resources Conservation and Recycling2011，57，： | 1 |
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