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| 1 | Inhibition of the B7-H3 immune checkpoint limits tumor growth by enhancing cytotoxic lymphocyte function显示文摘在肿瘤和免疫系统之间的相互作用仍然糟糕被理解。重要临床的回答在对 CTLA4 和 PD-1/PD-L1 检查点与抗体对待的癌症病人被完成了;然而,仅仅病人的小部分对治疗作出回应,显示需要探索为癌症治疗的另外的 co 禁止的分子。B7-H3, B7 总科的一个成员,被我们以前显示出禁止 T 房间激活和 autoimmunity。在这研究,我们在肿瘤免疫分析了 B7-H3 的功能。B7-H3 的表示在多重肿瘤线,渗入肿瘤的树枝状的房间,和巨噬细胞被发现。与对抗抗体对待到 B7-H3 的 B7-H3-deficient 老鼠或老鼠显示出多重肿瘤的减少的生长,它取决于 NK 和 CD8 + T 房间。与细胞毒素的淋巴细胞表示的通常认为的受体, B7-H3 禁止了他们的激活,并且它的缺乏在忍受肿瘤的鼠标导致了增加的细胞毒素的淋巴细胞功能。B7-H3 和 PD-1 的联合封锁导致了迟了阶段的肿瘤的进一步提高的治疗学的控制。一起拿,我们的结果显示 B7-H3 检查点可以对癌症为免疫疗法用作一个新奇目标。 | Young-hee Lee Natalia Martin-Orozco Peilin Zheng Jing Li Peng Zhang Haidong Tan Hyun Jung Park Mira Jeong Seon Hee Chang Byung-Seok Kim Wei Xiong Wenjuan Zang Li Guo Yang Liu Zhong-jun Dong Willem W Overwijk Patrick Hwu Qing Yi Larry Kwak Zhiying Yang Tak W Mak Wei-Li Laszlo G Radvanyi Ling Ni Dongfang Liu Chen Dong | 2017 | Cell Research2017，27，8： | 29 |
| 2 | Carbon and nitrogen storage in an age-sequence of Pinus densiflora stands in Korea显示文摘The carbon(C) and nitrogen(N) storage capabilities of Pinus densiflora in six different stand ages(10,27,30,32,44,and 71 years old) were investigated in Korea.Thirty sample trees were destructively harvested and 12 were excavated.Samples from the above and belowground tree components,coarse woody debris(CWD),forest floor,and mineral soil(0-30 cm) were collected.Tree biomass was highest in the 71-year-old stand(202.8 t ha-1) and lowest in the 10-year-old stand(18.4 t ha-1).C and N storage in the mineral soil was higher in the 71-year-old stand than in the other stands,mainly due to higher soil C and N concentrations.Consequently,the total ecosystem C and N storage(tree+forest floor+CWD+soil) was positively correlated with stand age:increasing from a minimum in the 10 year old stand(18.8 t C ha-1 and 1.3 t N ha-1) to a maximum in the 71-year-old stand(201.4 t C ha-1 and 8.5 t N ha-1).The total ecosystem C storage showed a similar sigmoidal pattern to that of tree C storage as a function of the age-sequence,while N storage in the CWD,forest floor and mineral soil showed no significant temporal trends.Our results provide important insights that will increase our understanding of C and N storage in P.densiflora stands and our ability to predict changes according to stand age in the region. | NOH Nam-Jin SON Yowhan LEE Sue-Kyoung SEO Kyung-Won HEO Su-Jin1 YI Myong-Jong PARK Pil-Sun KIM Rae-Hyun SON Yeong-Mo LEE Kyeong-Hak | 2010 | Science China(Life Sciences)2010，53，7： | 24 |
| 3 | A one-step method for producing microencapsulated phase change materials显示文摘This short communication reports our recent work on the synthesis and characterisation of microcapsules of phase change materials using silica as the shell material through a one-step method.The method uses no surfactants or dispersants for stabilising the capsules.The results show that the one-step method allows the tuning of the size and polydispersity of the capsules,and the use of different core materials.Analyses of the capsules show that they contain about 65%phase change materials.The results also suggest no need for a stabilising agent due to self-stabilisation by the amine groups.Further work is underway to investigate the mechanical and thermal properties of the microcapsules and the scale-up of the method. | Yi Jin Waipeng Lee Zenfira Musina Yulong Ding | 2010 | Particuology2010，8，6： | 14 |
| 4 | Producing Designer Oils in Industrial Microalgae by Rational Modulation of Co-evolving Type-2 Diacylglycerol Acyltransferases显示文摘Microalgal 上油,取决于他们 unsaturation 的度,能作为也营养的补充被利用或造成;因此,一件化工物品与遗传上设计了并且 unsaturation 的悦耳的度是合乎需要的最大化过程效率和产品通用性。前的系统的介绍? vivo (在酵母),在里面? vitro ,并且在里面?经由反向的遗传,在 Nannochloropsis 大洋洲( NoDGAT2s 或 NoDGTTs )的 type-2 diacylglycerol acyltransferases 的 vivo 活动表明 NoDGAT2A 比较喜欢浸透的丰满的酸( SFA ), NoDGAT2D 比较喜欢 monounsaturated 丰满的酸( MUFA ),和 NoDGAT2C 展览向多元不堡和的最强壮的活动丰满的酸( PUFA )。作为 NoDGAT2A , 2C ,和 2D 从绿水藻,红水藻,和真核细胞的主人发源第二等的 endosymbiosis 的祖先的参加者分别地,产油的一个机械学的模型被揭开,在哪个土生土长、采用的 NoDGAT2s 提出了功能的补充和位于僵硬 SFA 下面的特定的抄本丰富比率: MUFA :在 triacylglycerol (标签)的 PUFA 层次。由讲道理地 modulating NoDGAT2A:2C:2D 抄本的比率, N 的一个银行。与 unsaturation 的大量度为营养的补充或燃料生产优化的大洋洲紧张被创造,在哪个在 1.3- , 3.7- ,和 11.2 褶层分别地改变的标签的 SFA, MUFA,和 PUFA 的比例。这建立了新奇策略同时从工业 microalgae 改进油的生产率和质量。 | Yi Xin Yandu Lu Yi-Ying Lee Li Wei Jing Jia Qintao Wang Dongmei Wang Fali Bai Hanhua Hu Qiang Hu Jin Liu Yantao Li Jian Xu | 2017 | Molecular Plant2017，10，12： | 14 |
| 5 | Effects of biochar-based fertilizers on nutrient leaching in a tobacco-planting soil显示文摘Biochar is a soil amendment for increasing soil quality and decreasing nutrient leaching. However, there is little information on the impact of biochar-based fertilizer(BF) on soil nutrient leaching in agricultural soils. We conducted a soil column leaching experiment to study the effects of BF on the leaching of total nitrogen(TN), total phosphorus, and total potassium(TK) in tobacco soils. The distribution characteristics of NH_4^+-N, available P, and available K in soil profiles were analyzed after the application of BF. Biochar was prepared by pyrolysis of fluecured tobacco stems. It was applied at four levels, 0%, 3%,9%, and 15%(w/w), respectively, to the compound fertilizer. Compared with the control, the leaching loss of soil TN decreased by 8.36%, 6.72%, and 6.45%, and the loss of soil TK decreased by 9.18%, 9.31% and 11.82% in the 3%,9%, and 15% BF treatments, respectively. However, BF had no significant effect on the P leaching due to the low movement of P in the soil profile. In addition, the BF addition increased the immobilization of NH_4^+-N, available P, and available K in the soil profile. These results indicate that addition of BF to a tobacco-planting soil reduced nutrient leaching, and suggest that BF could be an effective method of applying biochar to agriculture fields. | Yunlong Li Jianzhong Cheng Xinqing Lee Yi Chen Weichang Gao Wenjie Pan Yuan Tang | 2019 | Acta Geochimica2019，38，1： | 13 |
| 6 | Calcium signaling and T-type calcium channels in cancer cell cycling显示文摘Regulation of intracellular calcium is an important signaling mechanism for cell proliferation in both normal and cancerous cells. In normal epithelial cells, free calcium concentration is essential for cells to enter and accomplish the S phase and the M phase of the cell cycle. In contrast, cancerous cells can pass these phases of the cell cycle with much lower cytoplasmic free calcium concentrations, indicating an alternative mechanism has developed for fulfilling the intracellular calcium requirement for an increased rate of DNA synthesis and mitosis of fast replicating cancerous cells. The detailed mechanism underlying the altered calcium loading pathway remains unclear; however, there is a growing body of evidence that suggests the T-type Ca2+ channel is abnormally expressed in cancerous cells and that blockade of these channels may reduce cell proliferation in addition to inducing apoptosis. Recent studies also show that the expression of T-type Ca2+ channels in breast cancer cells is proliferation state dependent, i.e. the channels are expressed at higher levels during the fast-replication period, and once the cells are in a non-proliferation state, expression of this channel isminimal. Therefore, selectively blocking calcium entry into cancerous cells may be a valuable approach for preventing tumor growth. Since T-type Ca2+ channels are not expressed in epithelial cells, selective T-type Ca2+ channel blockers may be useful in the treatment of certain types of cancers. | James T Taylor Xiang-Bin Zeng Jonathan E Pottle Kevin Lee Alun R Wang Stephenie G Yi lennifer A S Scruggs Suresh S Sikka Ming Li | 2008 | World Journal of Gastroenterology2008，14，32： | 12 |
| 7 | Improved corrosion resistance and thermal stability of sintered Nd-Fe-B magnets with holmium substitution显示文摘The effects of Ho substitution for Nd on the microstructure, corrosion resistance and thermal stability of the Nd-Fe-B magnets were investigated. The(Nd,Ho)-O phase was formed with increasing Ho substitution. The results of potentiodynamic polarization and highly accelerated stress test show improved corrosion resistance with increasing Ho substitution. The optimum mass loss 0.29 mg/cm^2 is achieved.Moreover, the average temperature coefficients for remanence and coercivity in the range of 25-150℃are both closer to zero, indicating improved thermal stability. The mechanisms for the improved corrosion resistance and thermal stability are discussed in relation to the microstructure featuring the(Nd,Ho)-O phase. | Jinghui Di Shuai Guo Ling Chen Pengpeng Yi Guangfei Ding Kan Chen Ming Li Don Lee Aru Yan | 2018 | Journal of Rare Earths2018，36，8： | 11 |
| 8 | Transcriptomic landscape regulated by the 14 types of bone morphogenetic proteins(BMPs)in lineage commitment and differentiation of mesenchymal stem cells(MSCs)显示文摘Mesenchymal stem cells(MSCs)are ubiquitously-existing multipotent progenitors that can self-renew and differentiate into multiple lineages including osteocytes,chondrocytes,adipocytes,tenocytes and myocytes.MSCs represent one of the most commonly-used adult progenitors and serve as excellent progenitor cell models for investigating lineagespecific differentiation regulated by various cellular signaling pathways,such as bone morphogenetic proteins(BMPs).As members of TGFb superfamily,BMPs play diverse and important roles in development and adult tissues.At least 14 BMPs have been identified in mammals.Different BMPs exert distinct but overlapping biological functions.Through a comprehensive analysis of 14 BMPs in MSCs,we demonstrated that BMP9 is one of the most potent BMPs in inducing osteogenic differentiation of MSCs.Nonetheless,a global mechanistic view of BMP signaling in regulating the proliferation and differentiation of MSCs remains to be fully elucidated.Here,we conducted a comprehensive transcriptomic profiling in the MSCs stimulated by 14 types of BMPs.Hierarchical clustering analysis classifies 14 BMPs into three subclusters:an osteo/chondrogenic/adipogenic cluster,a tenogenic cluster,and BMP3 cluster.We also demonstrate that six BMPs(e.g.,BMP2,BMP3,BMP4,BMP7,BMP8,and BMP9)can induce ISmads effectively,while BMP2,BMP3,BMP4,BMP7,and BMP11 up-regulate Smad-independent MAP kinase pathway.Furthermore,we show that many BMPs can upregulate the expression of the signal mediators of Wnt,Notch and PI3K/AKT/mTOR pathways.While the reported transcriptomic changes need to be further validated,our expression profiling represents the first-of-its-kind to interrogate a comprehensive transcriptomic landscape regulated by the 14 types of BMPs in MSCs. | Linghuan Zhang Qing Luo Yi Shu Zongyue Zeng Bo Huang Yixiao Feng Bo Zhang Xi Wang Yan Lei Zhenyu Ye Ling Zhao Daigui Cao Lijuan Yang Xian Chen Bin Liu William Wagstaff Russell R*Reid Hue H*Luu Rex C*Haydon Michael J*Lee Jennifer Moriatis Wolf Zhou Fu Tong-Chuan He Quan Kang | 2019 | Genes & Diseases2019，6，3： | 11 |
| 9 | Scalable synthesis of nanoporous silicon microparticles for highly cyclable lithium-ion batteries显示文摘Nanoporous silicon is a promising anode material for high energy density batteries due to its high cycling stability and high tap density compared to other nanostructured anode materials.However,the high cost of synthesis and low yield of nanoporous silicon limit its practical application.Here,we develop a scalable,low-cost top-down process of controlled oxidation of Mg2Si in the air,followed by HCl removal of MgO to generate nanoporous silicon without the use of HF.By controlling the synthesis conditions,the oxygen content,grain size and yield of the porous silicon are simultaneously optimized from commercial standpoints.In situ environmental transmission electron microscopy reveals the reaction mechanism;the Mg2Si microparticle reacts with O2 to form MgO and Si,while preventing SiO2 formation.Owing to the low oxygen content and microscale secondary structure,the nanoporous silicon delivers a higher initial reversible capacity and initial Coulombic efficiency compared to commercial Si nanoparticles(3,033 mAh/g vs.2,418 mAh/g,84.3%vs.73.1%).Synthesis is highly scalable,and a yield of 90.4%is achieved for the porous Si nanostructure with the capability to make an excess of 10 g per batch.Our synthetic nanoporous silicon is promising for practical applications in next generation lithium-ion batteries. | Jiangyan Wang William Huang Yong Seok Kim You Kyeong Jeong Sang Cheol Kim Jeffrey Heo Hiang Kwee Lee Bofei Liu Jaehou Nah Yi Cui | 2020 | Nano Research2020，13，6： | 9 |
| 10 | Methylprednisolone Inhibits the Expression of Glial Fibrillary Acidic Protein and Chondroitin Sulfate Proteoglycans in Reactivated Astrocytes显示文摘创伤后的神经胶质增生导致硫酸软骨素蛋白聚糖(CSPG)的显著表达,从而抑制轴突生长和再生。甲基强地松龙(MP),一种合成的糖皮质激素,在急性脊髓损伤(SCI)的治疗中有神经保护作用和抗炎效应。但是,MP对于CSPG在活性胶质细胞中的表达的作用尚不清楚。本文用a-氨基-3-羟基-5-甲基-4-异恶唑丙酸酯(AM-PA)诱导星形胶质细胞再活化,用环噻嗪模拟SCI的兴奋性中毒刺激。AMPA治疗后,星形胶质细胞再活化的标志物-胶质纤维酸性蛋白(GFAP)、CSPG神经聚糖和磷酸盐的表达都显著上调。AMPA治疗星形胶质细胞的条件培养液强烈抑制大鼠背根神经节中神经元的轴突生长,但这种作用能被MP的预处理所逆转。此外,MP下调成年SCI大鼠中GFAP和CSPG的表达,对抗RU486的糖皮质激素受体(GR)和GR si RNA能逆转MP对GFAP和神经聚糖表达的抑制作用。这些结果提示,MP能在兴奋性中毒损伤后通过GR介导的星形胶质细胞再活化下调和GSPG表达抑制来改善神经修复,促进轴突生长。 | WEI-LIN LIU YI-HSUAN LEE SHIH-YING TSAI CHUNG YI HSU YU-YO SUN LIANG-YO YANG SHING-HAN TSAI AND WEI-CHUNG VIVIAN YANG | 2008 | 神经损伤与功能重建2008，3，5： | 9 |
| 11 | Retrospective analysis of extra-gastrointestinal stromal tumors显示文摘AIM:To investigate the clinicopathologic features of patients with extra-gastrointestinal stromal tumors(EGISTs)in South Korea.METHODS:A total of 51 patients with an EGIST were identified.The clinicopathologic features,including sex,age,location,tumor size,histology,mitotic rate,immunohistochemical features,genetic status and survival data,were analyzed.RESULTS:The median age was 55 years(range:29-80years),and male:female ratio was 1:1.04.The most common site was in the mesentery(n=15)followed by the retroperitoneum(n=13)and omentum(n=8).The median tumor size was 9.0 cm(range:2.6-30.0cm)and the median mitotic rate was 5.0/50HPF.(1/50-185/50).KIT was analyzed in 16,which revealed 10cases with wild-type KIT and 6 cases with an exon 11mutation.Among 51 patients,31 patients had undergone surgery,and 10 had unresectable disease and had taken palliative imatinib,which resulted in 22.7 mo of progression-free survival.Of the patients who had undergone surgery,18 did not take adjuvant imatinib,and 8 of these were categorized as'high risk'according to the risk criteria.However,the relapse-free survival was not different(P=0.157)between two groups.CONCLUSION:Because the biologic behaviors of GISTs differ according to the location of the tumor,a more stratified strategy is required for managing EGISTs including incorporation of molecular features. | Jun Ho Yi Byeong-Bae Park Jung Hun Kang In Gyu Hwang Dong Bok Shin Sun Jin Sym Hee Kyung Ahn Soon Il Lee Do Hyoung Lim Keon Woo Park Young-Woong Won Sung Hee Lim Se Hoon Park | 2015 | World Journal of Gastroenterology2015，21，6： | 9 |
| 12 | Gα_s Relays Sphingosine-1-Phosphate Receptor 1 Signaling to Stabilize Vascular Endothelial-Cadherin at Endothelial Junctions to Control Mouse Embryonic Vascular Integrity显示文摘Sphingosine-1-phosphate receptor 1(S1PR1),a G protein-coupled receptor(GPCR),controls vascular stability by stabilizing vascular endothelial(VE)-cadherin junctional localization and inhibiting vascular endothelial growth factor receptor 2(VEGFR2) signaling.However,the molecular mechanisms that link S 1PR1 signaling to intracellular effectors remain unknown,In this study,we demonstrate that the heterotrimeric G protein subfamily member Gα_s,encoded by GNAS,acts as a relay mediator of S1PR1 signaling to control vascular integrity by stabilizing VE-cadherin at endothelial junctions.The endothelial cell-specific deletion of Gαs in mice causes early embryonic lethality with massive hemorrhage and a disorganized vasculature.The immunostalning results revealed that Gα_s deletion remarkably reduces the junctional localization of VE-cadherin,whereas the mural cell coverage of the vessels is not impaired.In addition,we found that Gαs depletion blocks the S1PRl-activation induced VE-cadherin stabilization at junctions,supporting that Gα_s acts downstream of S1PR1 signaling,Thus,our results demonstrate that Gα_s is an essential mediator to relay S1PR1 signaling and maintain vascular integrity. | Ximing Shao Ke Liu Yi Fan Zhihao Ding Min Chen Minyan Zhu Lee S.Weinstein Hongchang Li Huashun Li | 2015 | Journal of Genetics and Genomics2015，42，11： | 8 |
| 13 | Optimal culture conditions for the generation of natural killer cell-induced dendritic cells for cancer immunotherapy显示文摘Dendritic cell(DC)-based vaccines continue to be considered an attractive tool for cancer immunotherapy.DCs require an additional signal from the environment or other immune cells to polarize the development of immune responses toward T helper 1(Th1)or Th2 responses.DCs play a role in natural killer(NK)cell activation,and NK cells are also able to activate and induce the maturation of DCs.We investigated the types of NK cells that can induce the maturation and enhanced function of DCs and the conditions under which these interactions occur.DCs that were activated by resting NK cells in the presence of inflammatory cytokines exhibited increased expression of several costimulatory molecules and an enhanced ability to produce IL-12p70.NK cell-stimulated DCs potently induced Th1 polarization and exhibited the ability to generate tumor antigen-specific cytotoxic T lymphocyte responses.Our data demonstrate that functional DCs can be generated by coculturing immature DCs with freshly isolated resting NK cells in the presence of Toll-like receptor agonists and proinflammatory cytokines and that the resulting DCs effectively present antigens to induce tumor-specific T-cell responses,which suggests that these cells may be useful for cancer immunotherapy. | Thanh-Nhan Nguyen-Pham Deok-Hwan Yang Truc-Anh Thi Nguyen Mi-Seon Lim Cheol Yi Hong Mi-Hyun Kim Hyun Ju Lee Youn-Kyung Lee Duck Cho Soo-Young Bae Jae-Sook Ahn Yeo-Kyeoung Kim Ik-Joo Chung Hyeoung-Joon Kim Je-Jung Lee | 2012 | Cellular & Molecular Immunology2012，9，1： | 8 |
| 14 | Phylogenetic inferences in Prunus (Rosaceae) using chloroplast ndhF and nuclear ribosomal ITS sequences显示文摘Sequences of the chloroplast ndhF gene and the nuclear ribosomal ITS regions are employed to recon-struct the phylogeny of Prunus (Rosaceae), and evaluate the classification schemes of this genus. The two data sets are congruent in that the genera Prunus s.l. and Maddenia form a monophyletic group, with Maddenia nested within Prunus. However, the ndhF data set is incongruent with the ITS data supporting two major groups within Prunus: one consisting of subgenera Laurocerasus (including Pygeum) and Padus as well as the genus Maddenia and another of subgenera Amygdalus, Cerasus, and Prunus. The ITS data, on the other hand, support a clade composed of subgenera Amygdalus and Prunus and Prunus sect. Microcerasus in addition to a paraphyletic grade of subgenera Laurocerasus and Padus (and the genus Maddenia) taxa. In general, the subgeneric classifications of Prunus s.l. are not supported. The ITS and ndhF phylogenies differ mainly in interspecific relationships and the relative position of the Padus/Laurocerasus group. Both ITS and ndhF data sets suggest that the formerly recog-nized genus Pygeum is polyphyletic and that the distinction of the subgenera Padus and Laurocerasus is not supported. The biogeographic interactions of the temperate and tropical members in the Padus/Laurocera- sus/Maddenia alliance including Pygeum are shown to be highly dynamic and complex. | Jun WEN Scott T. BERGGREN Chung-Hee LEE Stefanie ICKERT-BOND Ting-Shuang YI Ki-Oug YOO Lei XIE Joey SHAW Dan POTTER | 2008 | 植物分类学报2008，46，3： | 7 |
| 15 | Redefining Budd-Chiari syndrome:A systematic review显示文摘AIM:To re-examine whether hepatic vein thrombosis(HVT)(classical Budd-Chiari syndrome)and hepatic vena cava-Budd Chiari syndrome(HVC-BCS)are the same disorder.METHODS:A systematic review of observational studies conducted in adult subjects with primary BCS,hepatic vein outflow tract obstruction,membranous obstruction of the inferior vena cava(IVC),obliterative hepatocavopathy,or HVT during the period of January2000 until February 2015 was conducted using the following databases:Cochrane Library,CINAHL,MEDLINE,Pub Med and Scopus.RESULTS:Of 1299 articles identified,26 were included in this study.Classical BCS is more common in women with a pure hepatic vein obstruction(49%-74%).HVCBCS is more common in men with the obstruction often located in both the inferior vena cava and hepatic veins(14%-84%).Classical BCS presents with acute abdominal pain,ascites,and hepatomegaly.HVC-BCS presents with chronic abdominal pain and abdominalwall varices.Myeloproliferative neoplasms(MPN)are the most common etiology of classical BCS(16%-62%)with the JAK2V617-F mutation found in 26%-52%.In HVCBCS,MPN are found in 4%-5%,and the JAK2V617-F mutation in 2%-5%.Classical BCS responds well to medical management alone and 1st line management of HVC-BCS involves percutaneous recanalization,with few managed with medical management alone.CONCLUSION:Systematic review of recent data suggests that classical BCS and HVC-BCS may be two clinically different disorders that involve the disruption of hepatic venous outflow. | Naomi Shin Young H Kim Hao Xu Hai-Bin Shi Qing-Qiao Zhang Jean Paul Colon Pons Ducksoo Kim Yi Xu Fei-Yun Wu Samuel Han Byung-Boong Lee Lin-Sun Li | 2016 | World Journal of Hepatology2016，8，16： | 6 |
| 16 | Genetic variability of CYP2B6 polymorphisms in four southern Chinese populations显示文摘瞄准:在四张南部的中国人口调查遗传型和细胞色素 P450 2B6 多型性的突变而产生之遗传的频率。方法:DNA 从香港和三个少数从汉汉语从血样品被获得从在南部的中国的云南的组, Wa, Bulang 和拉枯族。Genotyping 用即时 PCR 被执行并且由直接定序证实了。结果:从南部的中国的 507 个题目的一个总数被学习。结果证明用与另外的亚洲人口和白种人上的文学报告相比的种族汉语有 516G >
T (34.5%) 的高流行。516TT 遗传型的频率比在三个另外的种族少数组在汉多数(23.1%) 是更高的(即, 7.4% , 9.1% 和 15.8%) 在南部的中国。结论:这是第一研究在一张南部的中国人口记录 CYP2B6 突变而产生之遗传的变体和遗传型的光谱。516G >
T 等位基因与 efavirenz (EFV ) 的有缺点的新陈代谢被联系,它可以因此预先安排到药毒性。因为关键使人的免疫不全病毒(HIV ) 和海洛因嗜好产生代射变化酶的显著可变性,为的处理政体可以需要在不同人口被优化。 | Bing-Ying Xu Li-Ping Guo Shui-Shan Lee Qing-Ming Dong Yi Tan Hong Yao Li-Hua Li Che-Kit Lin Hsiang-Fu Kung Ming-Liang He | 2007 | World Journal of Gastroenterology2007，13，14： | 6 |
| 17 | Eosinophil-derived CCL-6 impairs hematopoietic stem cell homeostasis显示文摘嗜曙红血球(曙光女神) 长在层次造血的系统被看作了结束阶段受动器房间。证据的众多的线建议了那个曙光女神是关于各种各样的煽动性或有免疫力的反应的开始,繁殖和规定的多功能的白血球,特别在过敏疾病。最近的研究证明了那个曙光女神也为骨头髓血浆房间的维护和 B 房间的区别被要求。然而,曙光女神是否贡献造血的干细胞(HSC ) 的规定,仍然保持不清楚动态平衡。这里,我们证明曙光女神由在野类型的老鼠损害 HSC 静止和体质能力破坏 HSC 动态平衡后面的 ovalbumin (卵) 挑战并且甚至由引起骨头髓 HSC 在 Cd3-Il-5 转基因的老鼠的失败和疲劳。HSC 的损害维护和功能与导致曙光女神的氧化还原作用不平衡(增加的氧化 phosphorylation 和减少的抗氧化剂层次) 被联系。用集体 spectrometry,更重要地,我们决定 CCL-6 在嗜曙红血球过多下面在高水平被表示。我们证明 CCL-6 为损害 HSC 动态平衡导出曙光女神、负责。有趣地,有特定的抵销抗体的 CCL-6 的阻塞,当在质问卵的老鼠加重嗜曙红血球过多航线发炎时,恢复了 HSC 的体质能力。因此,我们的学习在 HSC 动态平衡揭示 Eos/CCL-6 的意外功能。 | Chao Zhang, Fei Li, Xufei Du, Man Luo, Wen Hua, Wen Li, Zhihua Chen, Songmin Ying, Huahao Shen Weiwei Yi, Hu Wang, Zhenyu Ju Hu Wang, Zhenyu Ju Ping Wu, Chao Peng, Catherine CL Wong James J Lee Songmin Ying Songmin Ying Huahao Shen | 2018 | Cell Research2018，28，3： | 6 |
| 18 | Transcription factor IRF8 controls Thl-like regulatory T-cell function显示文摘 | Wonyong Lee Hyeong Su Kim Song Yi Baek Gap Ryol Lee | 2016 | Cellular & Molecular Immunology2016，13，6： | 5 |
| 19 | Experimental investigation of friction coefficient in tube hydroforming显示文摘The friction coefficient between tube and die in guide zone of tube hydroforming was obtained. In hydroforming, the tube is expanded by an internal pressure against the tool wall. By pushing the tube through tool, a friction force at the contact surface between the tube and the tool occurs. In guiding zone, the friction coefficients between tube and die can be estimated from the measured axial feeding forces. In expansion zone, the friction coefficients between tube and die can be evaluated from the measured geometries of expanded tubes and FE analysis. | Hyae Kyung YI Hong Sup YIM Gun Yeop LEE Sung Mun LEE Gi Suk CHUNG Young-Hoon MOON | 2011 | Transactions of Nonferrous Metals Society of China2011，21，A01： | 5 |
| 20 | Risk of complications and urinary incontinence following cytoreductive prostatectomy: a multi-institutional study显示文摘当时,新兴的证据建议了 cytoreductive 前列腺切除术(CRP ) 允许优异 oncologic 控制与照顾雄激素剥夺标准的电流相比治疗独自一个。然而,在变形前列腺癌症(mPCa ) 的 cytoreduction 的安全和利益没被证明。因此,我们评估了在最新与 mPCa 诊断的人跟随 CRP 的复杂并发症的发生。在四个第三级的外科的中心从 2006 ~ 2014 经历了 CRP 的 68 个病人的一个总数与为临床上局部性的前列腺癌症(PCa ) 经历了激进的前列腺切除术的 598 个人相比。尿不能自制被定义为任何垫的使用。CRP 有更长起作用的时间(200 min 对 140 min, P < 0.0001 ) 并且更高估计的血损失(250 ml 对 125 ml, P < 0.0001 ) 与控制组相比。然而,外套(8.82% 对 5.85%) 和主要复杂并发症率(4.41% 对 2.17%) 在二个组之间是可比较的。重要地,尿不能自制率在在外科以后 1 年在 CRP 组是显著地更高的(57.4% 对 90.8% , P < 0.0001 ) 。Univariate 逻辑分析证明估计的血损失在 unadjusted 模型两个都是 perioperative 复杂并发症的唯一的独立预言者(或:1.18;95% CI:1.02-1.37;P = 0.025 ) 并且外科调整类型的模型(或:1.17;95% CI:1.01-1.36;P = 0.034 ) 。在结论, CRP 比激进的前列腺切除术更挑战性、与尿不能自制的尤其是更高的发生联系。不过, CRP 是为选择谁的 PCa 病人的一个技术上可行、安全的手术与节点积极或多骨的转移在场当由富有经验的外科医生表现了时。未来的、多机构的临床的试用当前是在进行之中的验证这个概念。 | Dae Keun Kim Jaspreet Singh Parihar Young Suk Kwon Sinae Kim Brian Shinder Nara Lee Nicholas Farber Thomas Ahlering Douglas Skarecky Bertram Yuh Nora Ruel Wun-lae Kim Koon Ho Rha Isaac Yi Kim | 2018 | Asian Journal of Andrology2018，20，1： | 5 |
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