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| 1 | Evaluation of protective effect of cactus pear seed oil(Opuntia ficusincida L. MILL.) against alloxan-induced diabetes in mice显示文摘Objective: To evaluate the in vitro antioxidant power of cactus pear seed oil [Opuntia ficusincida L. MILL.(CPSO)] and its protective effect against chemically induced diabetes mellitus in mice. Methods: The in vitro antioxidant effect of CPSO was evaluated using 2,2-diphenyl-1-picrylhydrazyl(DPPH) scavenging assay. The preventive effect was conducted on Swiss albino mice treated with CPSO(2 m L/kg, per os), before and after a single intraperitoneal alloxan administration(100 mg/kg). Survival rate, body weight and fasting blood glucose were measured and histopathological analysis of pancreas was performed to evaluate alloxaninduced tissue injuries. Results: CPSO exhibited an antioxidant effect in DPPH scavenging assay. Moreover, the administration of CPSO(2 m L/kg) significantly attenuated alloxaninduced death and hyperglycemia(P<0.001) in treated mice. Morphometric study of pancreas revealed that CPSO significantly protected islets of langerhans against alloxan induced-tissue alterations. Conclusions: Based on theses results, CPSO can prevent alloxan-induced-diabetes by quenching free radicals produced by alloxan and inhibiting tissue injuries in pancreatic β-cells. | Berraaouan Ali Ziyyat Abderrahim Mekhfi Hassane Legssyer Abdelkhaleq Aziz Mohammed Bnouham Mohamed | 2015 | Asian Pacific Journal of Tropical Medicine2015，8，7： | 6 |
| 2 | Acute diuretic,natrriuretic and hypotensive effects of a continuous perfusion of aqueous extract of urtica dioica in the rat 显示文摘 | Tahri A Yamani S Legssyer A | 2000 | Ethnopharmacol2000，73，12： | 1 |
| 3 | Hepatoprotective effect of Opuntia dillenii seed oil on CCl_4 induced acute liver damage in rat显示文摘Objective:To investigate the hepatoprotective effect of Opuntia dillenii seed oil(ODSO)on CCl_4 provoked liver injury in rat.Methods:Animals were treated orally with ODSO at a concentration of 2 mL/kg,once daily for one week before the first intraperitoneal injection of CCl_4,and thereafter the administration of the oil was continued for 7 days until the introduction of the second injection of CCl_4.Fourteen hours after the last dose of CCl_4,rats were sacrificed,and the relative liver weight,weight gain,alkaline phosphatase,aspartate amino transferase,alanine aminotransferase,direct bilirubin,total bilirubin,triglycerides,total cholesterol,very low density lipoprotein,low density lipoprotein,high density lipoprotein,plasmatic glucose,urea,creatinine,acid uric and malondialdehyde were determined.Results:The significant increase was found in relative liver weight and plasma levels of alanine aminotransferase,aspartate amino transferase,alkaline phosphatase,total bilirubin,direct bilirubin,triglycerides,very low-density lipoprotein,urea,uric acid and malondialdehyde.Likewise,the significant decrease was indicated in the weight gain and the level of glucose plasmatic,and high-density lipoprotein levels in CCl_4 produced liver injury in rats were re-established to normal levels when treated with ODSO.While,no change was observed in the total cholesterol,low-density lipoprotein and creatinine in all animals.Conclusions:We conclude that the ODSO has a protective effect on CCl_4-mediated liver injury.Hence,we suggest its inclusion as a preventive control of liver disorders. | Mohamed Bouhrim Hayat Ouassou Mohamed Choukri Hassane Mekhfi Abderrahim Ziyyat Abdelkhaleq Legssyer Mohammed Aziz Mohamed Bnouham | 2018 | Asian Pacific Journal of Tropical Biomedicine2018，8，5： | 1 |
| 4 | Captopril inhibits the oxidative modification of apolipoprotein B-100 caused by myeloperoxydase in a comparative in vitro assay of angiotensin converting enzyme inhibitors显示文摘 | Van Antwerpen P Legssyer I Zouaoui Boudjeltia K | 2006 | Eur J Pharmacol2006，537，13： | 1 |
| 5 | Molecular and cellular mechanisms of iron homeostasis and toxicity in mammalian cells 显示文摘 | Crichton RR Wilmet S Legssyer R | 2002 | J Inorg Biochem2002，91，1： | 1 |
| 6 | Phytotherapy of hypertension and diabetes in oriental Morocco 显示文摘 | Ziyyat A Legssyer A Mekhfi H | 1997 | J Ethnopharmaco1997，58，： | 1 |
| 7 | Changes in function of iron-loaded alveolar macrophages after in vivo administration of desferrioxamine and/or chloroquine显示文摘 | Legssyer K Josse C Piette J | 2003 | J Inorg Biochem2003，94，1： | 1 |
| 8 | Acute diuretic,natrriuretic and hypotensive effects of a continuous perfusion of aqueous extract of urtica dioica in the rat显示文摘 | Tahri A Yamani S Legssyer A | 2000 | Ethnopharmacol2000，73，12： | 1 |
| 9 | Molecular and cellularmechanisms of iron homeostasis and toxicity in mammalian cells显示文摘 | Crichton RR Wilmet S Legssyer R | 2002 | J Inorg Biochem2002，91，1： | 1 |
| 10 | Molecular and cellular mechanisms of iron homeostasis and toxicity in mammalian cells 显示文摘 | Criehton R R Wilmet S Legssyer R | 2002 | Journal of Inorganic Biochemistry2002，91，： | 1 |
| 11 | Acute diuretic,natriuretic and hypotensive effects of a continuous perfusion of aqueous extract of Urtica dioica in the rat显示文摘 | Tahri A Yamani s Legssyer A | 2000 | Ethnopharmacol2000，73，12： | 1 |
| 12 | Platelet anti-aggregant property of some Moroccan medicinal plants显示文摘 | Mekhfi H Haouari ME Legssyer A | 2004 | Ethnopharmacol2004，94，23： | 1 |
| 13 | Iron supplementa- tion during pregnancy-a necessary or toxic supplement 显示文摘 | Ward R J Wilmet S Legssyer R | 2003 | Bioinorg Chem Appl2003，1，： | 1 |
| 14 | Acute diuretic,natriuretic and hypotensive effects of a continuous perfusion of aqueous extract of Urtica dioica in the rat显示文摘 | TAHR A YAMANI S LEGSSYER A | 2000 | J Ethnopharmacol2000，73，12： | 1 |
| 15 | Antihypertensive and endothelium-dependent vasodilator effects of aqueous extract of Cistus ladaniferus显示文摘 | Mounia Belmokhtar Nour Elhouda Bouanani Abderrahim Ziyyat Hassane Mekhfi Mohamed Bnouham Mohamed Aziz Philippe Matéo Rodolphe Fischmeister Abdelkhaleq Legssyer | 2009 | Biochemical and Biophysical Research Communications2009，，1： | 1 |
| 16 | Platelet Anti-aggregant Property of Some Moroccan Medicinal Plants显示文摘 | Mekhfi H Haouari M E Legssyer A | 2004 | Ethnopharmacology2004，94，23： | 1 |
| 17 | Oxidation of low density lipoproteins by myeloperoxidase at the surface of endothelial cells:an additional mechanism to sub endothelium oxidation显示文摘 | MOGUILEVSKY N LEGSSYER I | 2004 | Biochem Biophys Res Commun2004，325，： | 1 |
| 18 | Platelet anti-aggregant property of some Moroccan medicinal plants显示文摘 | Mekhfi H Haouari M E Legssyer A | 2004 | Jour-nal of ethnopharmacology2004，94，2： | 1 |
| 19 | Molecular and cellular mechanisms of iron homeostasis and toxicity in mammalian cells显示文摘 | Crichton RR Wilmet S Legssyer R | 2002 | J Inorganic Biochem2002，91，1： | 1 |
| 20 | Antihypertensive and endothelium-dependent vasodilator effects of aqueous extract of Cistus ladaniferus显示文摘 | Mounia Belmokhtar Nour Elhouda Bouanani Abderrahim Ziyyat Hassane Mekhfi Mohamed Bnouham Mohamed Aziz Philippe Matéo Rodolphe Fischmeister Abdelkhaleq Legssyer | 2009 | Biochemical and Biophysical Research Communications2009，，1： | 1 |
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