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| 1 | Evaluation of protective effect of cactus pear seed oil(Opuntia ficusincida L. MILL.) against alloxan-induced diabetes in mice显示文摘Objective: To evaluate the in vitro antioxidant power of cactus pear seed oil [Opuntia ficusincida L. MILL.(CPSO)] and its protective effect against chemically induced diabetes mellitus in mice. Methods: The in vitro antioxidant effect of CPSO was evaluated using 2,2-diphenyl-1-picrylhydrazyl(DPPH) scavenging assay. The preventive effect was conducted on Swiss albino mice treated with CPSO(2 m L/kg, per os), before and after a single intraperitoneal alloxan administration(100 mg/kg). Survival rate, body weight and fasting blood glucose were measured and histopathological analysis of pancreas was performed to evaluate alloxaninduced tissue injuries. Results: CPSO exhibited an antioxidant effect in DPPH scavenging assay. Moreover, the administration of CPSO(2 m L/kg) significantly attenuated alloxaninduced death and hyperglycemia(P<0.001) in treated mice. Morphometric study of pancreas revealed that CPSO significantly protected islets of langerhans against alloxan induced-tissue alterations. Conclusions: Based on theses results, CPSO can prevent alloxan-induced-diabetes by quenching free radicals produced by alloxan and inhibiting tissue injuries in pancreatic β-cells. | Berraaouan Ali Ziyyat Abderrahim Mekhfi Hassane Legssyer Abdelkhaleq Aziz Mohammed Bnouham Mohamed | 2015 | Asian Pacific Journal of Tropical Medicine2015，8，7： | 6 |
| 2 | Hepatoprotective effect of Opuntia dillenii seed oil on CCl_4 induced acute liver damage in rat显示文摘Objective:To investigate the hepatoprotective effect of Opuntia dillenii seed oil(ODSO)on CCl_4 provoked liver injury in rat.Methods:Animals were treated orally with ODSO at a concentration of 2 mL/kg,once daily for one week before the first intraperitoneal injection of CCl_4,and thereafter the administration of the oil was continued for 7 days until the introduction of the second injection of CCl_4.Fourteen hours after the last dose of CCl_4,rats were sacrificed,and the relative liver weight,weight gain,alkaline phosphatase,aspartate amino transferase,alanine aminotransferase,direct bilirubin,total bilirubin,triglycerides,total cholesterol,very low density lipoprotein,low density lipoprotein,high density lipoprotein,plasmatic glucose,urea,creatinine,acid uric and malondialdehyde were determined.Results:The significant increase was found in relative liver weight and plasma levels of alanine aminotransferase,aspartate amino transferase,alkaline phosphatase,total bilirubin,direct bilirubin,triglycerides,very low-density lipoprotein,urea,uric acid and malondialdehyde.Likewise,the significant decrease was indicated in the weight gain and the level of glucose plasmatic,and high-density lipoprotein levels in CCl_4 produced liver injury in rats were re-established to normal levels when treated with ODSO.While,no change was observed in the total cholesterol,low-density lipoprotein and creatinine in all animals.Conclusions:We conclude that the ODSO has a protective effect on CCl_4-mediated liver injury.Hence,we suggest its inclusion as a preventive control of liver disorders. | Mohamed Bouhrim Hayat Ouassou Mohamed Choukri Hassane Mekhfi Abderrahim Ziyyat Abdelkhaleq Legssyer Mohammed Aziz Mohamed Bnouham | 2018 | Asian Pacific Journal of Tropical Biomedicine2018，8，5： | 1 |
| 3 | Creatine kinase is the main target of reactive oxygen species in cardiac myofibrils 显示文摘 | Hassane Mekhfi Vladimir Veksler Philippe Mateo | 1996 | Circulation Research1996，78，6： | 1 |
| 4 | Phytotherapy of hypertension and diabetes in oriental Morocco 显示文摘 | Ziyyat A Legssyer A Mekhfi H | 1997 | J Ethnopharmaco1997，58，： | 1 |
| 5 | Platelet anti-aggregant property of some Moroccan medicinal plants显示文摘 | Mekhfi H Haouari ME Legssyer A | 2004 | Ethnopharmacol2004，94，23： | 1 |
| 6 | Antihypertensive and endothelium-dependent vasodilator effects of aqueous extract of Cistus ladaniferus显示文摘 | Mounia Belmokhtar Nour Elhouda Bouanani Abderrahim Ziyyat Hassane Mekhfi Mohamed Bnouham Mohamed Aziz Philippe Matéo Rodolphe Fischmeister Abdelkhaleq Legssyer | 2009 | Biochemical and Biophysical Research Communications2009，，1： | 1 |
| 7 | Platelet Anti-aggregant Property of Some Moroccan Medicinal Plants显示文摘 | Mekhfi H Haouari M E Legssyer A | 2004 | Ethnopharmacology2004，94，23： | 1 |
| 8 | Platelet anti-aggregant property of some Moroccan medicinal plants显示文摘 | Mekhfi H Haouari M E Legssyer A | 2004 | Jour-nal of ethnopharmacology2004，94，2： | 1 |
| 9 | Antihypertensive and endothelium-dependent vasodilator effects of aqueous extract of Cistus ladaniferus显示文摘 | Mounia Belmokhtar Nour Elhouda Bouanani Abderrahim Ziyyat Hassane Mekhfi Mohamed Bnouham Mohamed Aziz Philippe Matéo Rodolphe Fischmeister Abdelkhaleq Legssyer | 2009 | Biochemical and Biophysical Research Communications2009，，1： | 1 |
| 10 | Antidiabetic effect of Opuntia dillenii seed oil on streptozotocin-induced diabetic rats显示文摘Objective: To assess the antidiabetic effect of Opuntia dillenii seed oil on rats with diabetes mellitus. Methods: A rat diabetes model was established by intraperitoneal injection of rats with 50 mg/kg streptozotocin. Thirty albino Wistar rats were divided into five groups: the diabetic control group and normal control group were treated only with distilled water, two diabetic groups received 1 and 2 m L/kg of oil per day, respectively, for 30 days and one diabetic group received 2 mg/kg of glibenclamide. In addition, blood glucose was determined weekly. Body weight, average daily food, water intake and urinary volume of each animal were determined before and after the treatment period. After the treatment period, hepatic glycogen was determined using the anthrone reagent, and glycosuria, total cholesterol, triglycerides, alanine aminotransferase, aspartate aminotransferase, urea, creatinine and uric acid were estimated using common clinical diagnostic kits. Results: Oral intake of the oil at 1 and 2 m L/kg for the diabetic animals significantly diminished blood glucose, glycosuria, total cholesterol, triglycerides, alanine aminotransferase, aspartate aminotransferase, urea, creatinine and uric acid, accompanied by a noticeable elevation in the amount of hepatic glycogen in comparison with the diabetic control group. Similarly, Opuntia dillenii seed oil significantly increased the food intake and decreased the urinary volume per day in treated rats of the same groups in comparison with the period before the treatment intervention and attenuated body weight loss in the diabetic rats. Moreover, this effect of the oil was dose dependent. On the other hand, the oil did not affect their need for water. Conclusions: The results show that Opuntia dillenii seed oil has a very important antidiabetic effect on streptozotocin-induced diabetic rats. Hence, we suggest it as a preventive control of diabetes mellitus. | Mohamed Bouhrim Hayat Ouassou El Hassania Loukili Mohammed Ramdani Hassane Mekhfi Abderrahim Ziyyat Abdelkhaleq Legssyer Mohammed Aziz Mohamed Bnouham | 2019 | Asian Pacific Journal of Tropical Biomedicine2019，9，9： | 1 |
| 11 | Chenopodium ambrosioides induces an endothelium-dependent relaxation of rat isolated aorta显示文摘Objective: This study aims to evaluate the vasodilatory effect of Chenopodium ambrosioides on the isolated rat aorta, and to explore its mechanism of action.Methods: The vasorelaxant effect and the mode of action of various extracts from the leaves of C. ambrosioides were evaluated on thoracic aortic rings isolated from Wistar rats. In addition, ethyl acetate and methanol fractions were analyzed, using thin-layer chromatography and high-performance liquid chromatography techniques, for their polyphenolic content.Results: The various active extracts of C. ambrosioides at four concentrations(10^(-3), 10^(-2), 10^(-1) and 1 mg/mL) relaxed the contraction elicited by phenylephrine, in a concentration-dependent manner.This effect seems to be endothelium-dependent, since the vasodilatory effect was entirely absent in denuded aortic rings. The vasorelaxant effect of the methanol fraction(MF) of C. ambrosioides at 1 mg/mL was also inhibited by atropine and tetraethylammonium. This effect remained unchanged by Nx-nitro-L-arginine methyl ester hydrochloride and glibenclamide. The preliminary phytochemical analysis showed that the leaves of C. ambrosioides are rich in phenolic and flavonoid derivatives.Conclusion: These results suggest that the MF of C. ambrosioides produces an endothelium-dependent relaxation of the isolated rat aorta, which is thought to be mediated mainly through stimulation of the muscarinic receptors, and probably involving the opening of Ca^(2+)-activated potassium channels. | Asmae Assaidi Ikram Dib Monique Tits Luc Angenot Said Bellahcen Nourelhouda Bouanani Abdelkhaleq Legssyer Mohammed Aziz Hassane Mekhfi Mohammed Bnouham Michel Frederich Abderrahim Ziyyat | 2019 | Journal of Integrative Medicine2019，17，2： | 0 |
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