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| 1 | Evaluation of protective effect of cactus pear seed oil(Opuntia ficusincida L. MILL.) against alloxan-induced diabetes in mice显示文摘Objective: To evaluate the in vitro antioxidant power of cactus pear seed oil [Opuntia ficusincida L. MILL.(CPSO)] and its protective effect against chemically induced diabetes mellitus in mice. Methods: The in vitro antioxidant effect of CPSO was evaluated using 2,2-diphenyl-1-picrylhydrazyl(DPPH) scavenging assay. The preventive effect was conducted on Swiss albino mice treated with CPSO(2 m L/kg, per os), before and after a single intraperitoneal alloxan administration(100 mg/kg). Survival rate, body weight and fasting blood glucose were measured and histopathological analysis of pancreas was performed to evaluate alloxaninduced tissue injuries. Results: CPSO exhibited an antioxidant effect in DPPH scavenging assay. Moreover, the administration of CPSO(2 m L/kg) significantly attenuated alloxaninduced death and hyperglycemia(P<0.001) in treated mice. Morphometric study of pancreas revealed that CPSO significantly protected islets of langerhans against alloxan induced-tissue alterations. Conclusions: Based on theses results, CPSO can prevent alloxan-induced-diabetes by quenching free radicals produced by alloxan and inhibiting tissue injuries in pancreatic β-cells. | Berraaouan Ali Ziyyat Abderrahim Mekhfi Hassane Legssyer Abdelkhaleq Aziz Mohammed Bnouham Mohamed | 2015 | Asian Pacific Journal of Tropical Medicine2015，8，7： | 6 |
| 2 | Antihyperglycemic activity of the aqueous extract of Urtica dioica显示文摘 | Bnouham M Merhfour FZ Ziyyat A | 2003 | Fitoterapia2003，74，78： | 1 |
| 3 | Hepatoprotective effect of Opuntia dillenii seed oil on CCl_4 induced acute liver damage in rat显示文摘Objective:To investigate the hepatoprotective effect of Opuntia dillenii seed oil(ODSO)on CCl_4 provoked liver injury in rat.Methods:Animals were treated orally with ODSO at a concentration of 2 mL/kg,once daily for one week before the first intraperitoneal injection of CCl_4,and thereafter the administration of the oil was continued for 7 days until the introduction of the second injection of CCl_4.Fourteen hours after the last dose of CCl_4,rats were sacrificed,and the relative liver weight,weight gain,alkaline phosphatase,aspartate amino transferase,alanine aminotransferase,direct bilirubin,total bilirubin,triglycerides,total cholesterol,very low density lipoprotein,low density lipoprotein,high density lipoprotein,plasmatic glucose,urea,creatinine,acid uric and malondialdehyde were determined.Results:The significant increase was found in relative liver weight and plasma levels of alanine aminotransferase,aspartate amino transferase,alkaline phosphatase,total bilirubin,direct bilirubin,triglycerides,very low-density lipoprotein,urea,uric acid and malondialdehyde.Likewise,the significant decrease was indicated in the weight gain and the level of glucose plasmatic,and high-density lipoprotein levels in CCl_4 produced liver injury in rats were re-established to normal levels when treated with ODSO.While,no change was observed in the total cholesterol,low-density lipoprotein and creatinine in all animals.Conclusions:We conclude that the ODSO has a protective effect on CCl_4-mediated liver injury.Hence,we suggest its inclusion as a preventive control of liver disorders. | Mohamed Bouhrim Hayat Ouassou Mohamed Choukri Hassane Mekhfi Abderrahim Ziyyat Abdelkhaleq Legssyer Mohammed Aziz Mohamed Bnouham | 2018 | Asian Pacific Journal of Tropical Biomedicine2018，8，5： | 1 |
| 4 | Phytotherapy of hypertension and diabetes in oriental Morocco 显示文摘 | Ziyyat A Legssyer A Mekhfi H | 1997 | J Ethnopharmaco1997，58，： | 1 |
| 5 | Antihyperglycemic activity of the aqueous extract of Urtica dioica显示文摘 | Bnouham M Merhfour FZ Ziyyat A | 2003 | Fitoterapia2003，74，78： | 1 |
| 6 | Effect of induced peritoneal endometriosis on oocyte and embryo quality in a mouse model 显示文摘 | Cohen J Ziyyat A Naoura I | 2015 | J Assist Reprod Genet2015，32，2： | 1 |
| 7 | Antihyperglycemic activity of the aqueous extract of Urtica dioica显示文摘 | BNOUHAM M MERHFOUR FZ ZIYYAT A | 2003 | Fitoterapia2003，74，78： | 1 |
| 8 | Short gamete co-incubation during in vitro fertilization decreases the fertilization rate and does not improve embryo quality: a prospective auto controlled study显示文摘 | V. Barraud-Lange C. Sifer K. Pocaté A. Ziyyat B. Martin-Pont R. Porcher J. N. Hugues J. P. Wolf | 2008 | Journal of Assisted Reproduction and Genetics2008，，7： | 1 |
| 9 | Antihypertensive and endothelium-dependent vasodilator effects of aqueous extract of Cistus ladaniferus显示文摘 | Mounia Belmokhtar Nour Elhouda Bouanani Abderrahim Ziyyat Hassane Mekhfi Mohamed Bnouham Mohamed Aziz Philippe Matéo Rodolphe Fischmeister Abdelkhaleq Legssyer | 2009 | Biochemical and Biophysical Research Communications2009，，1： | 1 |
| 10 | CD9 tetraspanin gen- erates fusion competent sites on the egg membrane for mammalian fertiliza- tion显示文摘 | JAGOU A ZIYYAT A BARRAUD-LANGE V | 2011 | Proc Natl Acad Sci USA2011，108，10： | 1 |
| 11 | Reduced fertility of female mice lacking CD81 显示文摘 | Rubinstein E Ziyyat A Prenant M | 2006 | Dev Biol2006，290，2： | 1 |
| 12 | Seminal leukocytes areGood Samaritans for spermatozoa显示文摘 | Barraud-Lange V Pont J C Ziyyat A | 2011 | Fertil Steril2011，96，6： | 1 |
| 13 | Paradoxical increase ofsperm motility and seminal carnitine asscociated with moderate leu-kocytospermia in infertility patients显示文摘 | Ziyyat A Barraud-Lange V Sifer C | 2008 | Fertil Steril2008，90，6： | 1 |
| 14 | Flow cytometric method to isolate round spermatids from mouse testis显示文摘 | Lassalle B Ziyyat A Testart J | 1999 | Hum Reprod1999，14，2： | 1 |
| 15 | Antihypertensive and endothelium-dependent vasodilator effects of aqueous extract of Cistus ladaniferus显示文摘 | Mounia Belmokhtar Nour Elhouda Bouanani Abderrahim Ziyyat Hassane Mekhfi Mohamed Bnouham Mohamed Aziz Philippe Matéo Rodolphe Fischmeister Abdelkhaleq Legssyer | 2009 | Biochemical and Biophysical Research Communications2009，，1： | 1 |
| 16 | Reduced fer- tility of female mice lacking CD81显示文摘 | Rubinstein E Ziyyat A Prenant M | 2006 | Developmental Biology2006，290，35： | 1 |
| 17 | Antidiabetic effect of Opuntia dillenii seed oil on streptozotocin-induced diabetic rats显示文摘Objective: To assess the antidiabetic effect of Opuntia dillenii seed oil on rats with diabetes mellitus. Methods: A rat diabetes model was established by intraperitoneal injection of rats with 50 mg/kg streptozotocin. Thirty albino Wistar rats were divided into five groups: the diabetic control group and normal control group were treated only with distilled water, two diabetic groups received 1 and 2 m L/kg of oil per day, respectively, for 30 days and one diabetic group received 2 mg/kg of glibenclamide. In addition, blood glucose was determined weekly. Body weight, average daily food, water intake and urinary volume of each animal were determined before and after the treatment period. After the treatment period, hepatic glycogen was determined using the anthrone reagent, and glycosuria, total cholesterol, triglycerides, alanine aminotransferase, aspartate aminotransferase, urea, creatinine and uric acid were estimated using common clinical diagnostic kits. Results: Oral intake of the oil at 1 and 2 m L/kg for the diabetic animals significantly diminished blood glucose, glycosuria, total cholesterol, triglycerides, alanine aminotransferase, aspartate aminotransferase, urea, creatinine and uric acid, accompanied by a noticeable elevation in the amount of hepatic glycogen in comparison with the diabetic control group. Similarly, Opuntia dillenii seed oil significantly increased the food intake and decreased the urinary volume per day in treated rats of the same groups in comparison with the period before the treatment intervention and attenuated body weight loss in the diabetic rats. Moreover, this effect of the oil was dose dependent. On the other hand, the oil did not affect their need for water. Conclusions: The results show that Opuntia dillenii seed oil has a very important antidiabetic effect on streptozotocin-induced diabetic rats. Hence, we suggest it as a preventive control of diabetes mellitus. | Mohamed Bouhrim Hayat Ouassou El Hassania Loukili Mohammed Ramdani Hassane Mekhfi Abderrahim Ziyyat Abdelkhaleq Legssyer Mohammed Aziz Mohamed Bnouham | 2019 | Asian Pacific Journal of Tropical Biomedicine2019，9，9： | 1 |
| 18 | Seminal leukocytes are good samaritans for spermatozoa 显示文摘 | Barraud-Lange V Pont JC Ziyyat A | 2011 | Fertil-Steril2011，96，6： | 1 |
| 19 | Antihyperglycemic activity of the aqueous extract of Urtica dioica显示文摘 | Bnouham M Merhfour FZ Ziyyat A | 2003 | Fitoterapia2003，74，78： | 1 |
| 20 | Antihyperglycemic activity of the aqueous extract of Urtica di- oiea 显示文摘 | Bnouham M Merhfour F Z Ziyyat A | 2003 | Fitoterapia2003，74，78： | 1 |
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