|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Epidemiology of gastroesophageal reflux disease:A general population-based study in Xi'an of Northwest China显示文摘AIM: Gastroesophageal reflux disease (GERD) is a common disorder in the Western population, but detailed population-based data in China are limited. The aim of this study was to understand the epidemiology of symptomatic gastroesophageal reflux (SGER) in adults of Xi'an, a northwestern city of China, and to explore the potential risk factors of GERD. METHODS: Symptoms suggestive of GERD, functional dyspepsia (FD), irritable bowel syndrome (IBS), upper respiratory diseases and some potential risk factors were investigated in a face-to-face manner in a region-stratified random samples of 2 789 residents aged 18-70 years in Xi'an by using a standardized questionnaire. METHODS: With a response rate of 91.8%, the prevalence of SGER was 16.98% (95% CI, 14.2-18.92) in Xi'an adults, and no gender-related difference was observed (P<0.05). SGER was more common among subjects aged 30-70 years than in those aged 18-29 years (P<0.01). The prevalence of SGER in rural, urban and suburban subjects was 21.07%, 17.44% and 12.12%, respectively, and there was a significant difference between rural, urban and suburban regions (P<0.05). Compared with subjects without SGER, the prevalence of symptoms suggestive of FD and IBS, pneumonia, asthma, bronchitis, laryngitis, pharyngitis, chronic cough, wheeze, globus sensation, oral ulcer and snore was significantly increased in subjects with SGER (P<0.01). Heavy smoking (OR=5.76; CI, 3.70-6.67), heavy alcohol use (OR=2.85; CI, 1.67-4.49), peplJc ulcer (OR=5.76; CI, 3.99-8.32), cerebral palsy (OR=3.97; CI, 1.97-8.00), abdominal operation (OR=2.69; CI, 1.75-4.13), obesity(OR=2.16; CI, 1.47-3.16), excessive food intake (OR= 1.43;CI, 1.17-1.15), sweet food (OR=1.23; CI, 0.89-1.54), and consumption of coffee (OR= 1.23; CI, 0.17-2.00) were independently associated with SGER. The episodes of GERD were commonly precipitated by dietary factors (66.05%), followed by body posture (26.54%), ill temper (23.72%), fatigue (22.32%) and stress (10.93%). CONCLUSION: GERD is common in Xi'an's adult population with a mild or moderate degree. The etiology and pathogenesis of GERD are probably associated with FD, IBS, and some respiratory, laryngopharyngeal and odontostological diseases or symptoms. Some lifestyles, diseases and dietary factors are the risk factors of GERD. | Jin-HaiWang Jin-YanLuo LeiDong JunGong MingTong | 2004 | World Journal of Gastroenterology2004，10，11： | 48 |
| 2 | Effects of neurotrophins on gastrointestinal myoelectric activities of rats显示文摘AIM: To observe the effects of mouse nerve growth factor (NGF), rat recombinant brain derived neurotrophic factor (rm-BDNF) and recombinant human neurotrophin-3 (rh-NT3) on the gastrointestinal motility and the migrating myoelectric complex (MMC) in rat.METHODS: A randomized, double-blinded, placebo-controlled experiment was performed. 5-7 days after we chronically implanted four or five bipolar silver electrodes on the stomach, duodenum, jejunum and colon, 21 experimental rats were coded and divided into 3 groups and injected NGF, rm-BDNF, rh-NT-3 or placebo respectively via tail vein activity was recorded 2 hours before and after the test substance infusions in these consciously fasting rats.RESULTS: The neurotrophins-induced pattern of activity was characterized by enhanced spiking activity of different amplitudes at all recording sites, especially in the colon. In the gastric antrum and intestine, only rh-NT-3 had increased effects on the demographic characteristics of electrical activities (P<0.05), but did not affect the intervals of MMCs.In the colon, all the three kinds of neurotrophins could significantly increase the frequency, amplitude and duration levels of spike bursts, and also rh-NT-3 could prolong the intervals of MMC in the transverse colon (25±11 min vs 19±6 min, P<0.05). In the distal colon rh-NT-3 could evoke phase Ⅲ-like activity and disrupt the MMC pattern, which was replaced by a continuously long spike bursts (LSB) and irregular spike activity (ISA) for 48±6 min.CONCLUSION: Exogenous neurotrophic factors can stimulate gut myoelectric activities in rats. | Ning-LiChai, LeiDong Zong-FangLi Ke-XinDu 3ian-HuaWang Li-KunYan Xi-LinDong | 2003 | World Journal of Gastroenterology2003，9，8： | 14 |
| 3 | Effects of motilin and ursodeoxycholic acid on gastrointestinal myoelectric activity of different origins in fasted rats显示文摘AIM: To investigate gastrointestinal migrating myoelectric complex (MMC) and the effects of porcine motilin and ursodeoxycholic acid (UDCA) on MMC of gastrointestinal tract of different origins in fasted rats.METHODS: Three bipolar silver electrodes were chronically implanted on the antrum, duodenum and jejunum. Seven days later 24 experimental rats were divided into 2 groups.One group was injected with porcine motilin via sublingual vein at a dose of 20 lig/kg, the other group was perfused into stomach with UDCA. The gastrointestinal myoelectric activity was recorded 1 h before and 2 h after the test substance infusions into the rats.RESULTS: In all fasted rats a typical pattern of MMC was observed. Among the totally 68 activity fronts recorded in fasted rats under control, 67% started in duodenum, and 33% in antrum. MMC cycle duration and duration of phase III of antral origin were longer than those of duodenal origin. Administration of 20 lig/kg porcine motilin induced a premature antral phase III of antral origin. But perfusion into stomach with UDCA resulted in shorter MMC cycle duration, longer duration of phase III of duodenal origin,which were followed with shorter cycle duration and duration of antral phase III.CONCLUSION: In fasted rats, MMC could originate from antrum and duodenum respectively. The characteristics of MMC of different origins may contribute to the large variations within subjects. The mechanisms of different origins of phase III may be different. Porcine motilin and UDCA could affect MMC of different origins of the gastrointestinal tract in fasted state, respectively. | PingFang LeiDong Jin-YanLuo Xiao-LongWan Ke-XinDu Ning-LiChai | 2004 | World Journal of Gastroenterology2004，10，17： | 12 |
| 4 | Effects of estradiol on liver estrogen receptor-α and its mRNA expression in hepatic fibrosis in rats显示文摘AIM:Estradiol treatment regulates estrogen receptor (ER) level in normal rat liver.However,little information is available concerning the role of estrogen in regulating liver ER in hepatic fibrosis in rats.The present study was conducted to determine whether estradiol treatment in CCl4-induced liver fibrosis of female and ovariectomized rats altered liver ERα and its mRNA expression,and to investigate the possible mechanisms.METHODS:Seventy female rats were divided into seven groups with ten rats in each. The ovariectomy groups were initiated with ovariectomies and the sham operation groups were initiated with just sham operations.The CCl4 toxic fibrosis groups received 400mL/L CCI4 subcutaneously at a dose of 2 mL/kg twice weekly.Estrogen groups were treated subcutaneously with estradiol 1mg/kg, the normal control group and an ovariectomy group received injection of peanut oil vehicle twice weekly.At the end of 8 weeks,all the rats were killed to detect their serum and hepatic indicators,their hepatic collagen content, and liver ER and ER mRNA expression.RESULTS: Estradiol treatment in both ovariectomy and sham ovariectomy groups reduced liver levels of ALT (from 658±220nkat/L to 311±146nkat/L and 540±252nkat/L to 314±163nkat/L,P<0.05) and AST (from 697±240nkat/L to 321±121nkat/L and 631±268nkat/L to 302±153nkat/L,P<0.05),increased serum nitric oxide (NO) level (from 53.7±17.1μmol/L to 93.3±4.2μmol/L and 55.3±3.1μmol/Lto 87.5±23.6μmol/L, P<0.05) and hepatic nitric oxide synthase (NOS) activity (from 1.73±0.71KU/g to 2.49±1.20KU/g and 1.65±0.46KU/g to 2.68±1.17KU/g, P<0.05),diminished the accumulation of hepatic collagen,decreased centrolobular necrotic areas as well as the inflammatory reaction in rats subjected to CCl4. The positive signal of ER and ER mRNA distributed in parenchymal and non-parenchymal hepatic cells,especially near the hepatic centrolobular and periportal areas.Ovariectomy decreased ER level (from 10.2±3.2 to 4.3±1.3) and ER mRNA expression (from 12.8±2.1 to 10.9±1.3) significantly (P<0.05). Hepatic ER and ER mRNA concentrations were elevated after treatment with estradiol in both ovariectomy (15.8±2.4, 20.8±3.1) and sham ovariectomy(18.7±3.8, 23.1±3.7) fibrotic groups (P | Jun-WangXu JunGong Xin-MingChang Jin-YanLuo LeiDong AiJia Gui-PingXu | 2004 | World Journal of Gastroenterology2004，10，2： | 8 |
| 5 | Expression of gamma-aminobutyric acid A receptor subunits aα_1,β_1,γ_2 mRNA in rats with hepatic encephalopathy显示文摘AIM To investigate the mRNA expression of gammaaminobutyric acid A (GABAA) receptor subunits α1,β1, γ2in different parts of the brain of rats with hepaticencephalopathy.METHODS: Twelve adult male Sprague-Dawley rats were randomly divided into two groups: (1) hepatic encephalopathy model group (n = 6), which was induced by intraperitoneal injection of thioacetamide (TAA, 350 mg/kg) for threeconsecutive days; (2) control group (n = 6), in which the rats were treated with same dose of normal saline solution. After the freeze slice of cerebrum was made,in situ hybridization was used to detect the mRNA of GABAA receptor subunits α1, β1, and γ2 in rat cerebral cortex, basal nuclei, substantia nigra and hippocampi. Image data were collected and analyzed quantitatively by QWin550CWmodel image signal gather and analysis system. RESULTS: In rats with hepatic encephalopathy, mRNA expression levels of GABAA receptor subunits α1, β1 increased significantly in basal nuclei, substantia nigra pars compacta, substantia nigra pars reticularis and hippocampi (144.7±15.67/184.14±4.41, 60.61±33.66/113.07±32.44,87.71± 21.25/128.40±18.85, 122.34±5.56/161.60±4.56,123.29±5.21/140.65±4.15, 123.40±4.42/140.09±4.52,124.76±4.18/140.09±4.12, 141.62±15.09/182.80 ±5.20,69.13±30.74/134.21±43.76, 87.87±25.16/151.01±19.49,122.14±6.30/162.33±3.92, 122.81±5.09/137.19±7.12,123.00±4.63/138.11±5.92, 125.75 ±2.43/138.81±6.10,P<0.01), but did not change in the cerebral cortex compared to the control group. Similar changes were found in the mRNA expression levels of GABAA receptor subunit γ2,which increased significantly in basal nuclei, substantia nigra pars compacta, substantia nigra pars reticularis (136.81±26.41/167.97±16.23, 51.00±36.14/113.18±36.52, 86.35±20.30/126.90±19.74, P<0.01), CA1 of hippocampal (162.15±9.05/178.62±6.45, P<0.05), and no changes were found in the cerebral cortex and CA2, CA3, CA4 of hippocampi.CONCLUSION: In rats with hepatic encephalopathy, mRNA expression levels of GABAA receptor subunits α1,β1, γ2 increase significantly in basal nuclei, substantia nigra and hippocampi, suggesting that the changes of mRNA expression levels in GABAA receptor subunits may contribute to the pathogenesis of hepatic encephalopathy. | Xiao-QingLi LeiDong Zhong-HuaLiu Jin-YanLuo | 2005 | World Journal of Gastroenterology2005，11，21： | 3 |
| 6 | TGSIFT: Robust SIFT Descriptor Based on Tensor Gradient for Hyperspectral Images显示文摘This paper proposes a robust sparse descriptor based on tensor theory by using the spatial and spectral information synthetically,namely the Tensor gradient SIFT(TGSIFT),for Hyperspectral image(HSI).TGSIFT integrates both spatial and spectral information and considers the natural vector feature of HSIs.Based on the HSI Gaussian scale space,a new tensor model for HSI is proposed which takes the vectorial nature of HSI into consideration and preserves all the necessary structural information distributed over all the bands.The TGSIFT descriptor is formed based on the model proposed.Experimentai results of HSI matching show tha t the TGSIFT descrip tor achieves better mat ching performance than other SIFT descriptors under different t ransfbrma tio ns,including illumination change,sensor noise,image rotation,viewpoint change,and scale change. | LI Yanshan FAN Leidong XIE Weixin | 2020 | Chinese Journal of Electronics2020，29，5： | 3 |
| 7 | ESR signals from silk fabrics irradiated by UV-rays显示文摘ESR studies were done on UV-ray irradiated silk fabric samples at room temperature. Different types of UV lamps were used and similar ESR signals were observed. The results indicate that UV-rays can produce free radicals for graft-copolymerization of monomer onto silk fibers without external additives or co additives, Also, radicals in silk fabrics irradiated by UV-rays are purer than that irradiated by γ-rays. The study suggests that UV-lights may be a better tool to improve properties of silk fabrics by grafting monomers onto the polymer chains. | LIU Ruiqin XIE Leidong SHENG Kanglong | 2007 | Nuclear Science and Techniques2007，18，5： | 2 |
| 8 | Composite score of reflux symptoms in diagnosis of gastroesophageal reflux disease显示文摘AIM: To evaluate the significance of the composite score of reflux symptoms in the diagnosis of gastroesophageal reflux disease (GERD), and to determine the relationship of the composite score with reflux esophagitis (RE) and pathological gastroesophageal reflux (PGER). METHODS: Upper digestive endoscopy and/or 24-h esophageal pH monitoring were performed in 244 subjects. Of these, 54 were consecutive patients attending our clinic with symptoms suggestive of GERD, and 190 were randomly selected from 2532 respondents who participated in our previous general population-based study on GERD. A standardized questionnaire was used to classify both the frequency and severity of typical symptoms of GERD (heartburn, acid and food regurgitation) using a 4-score scale, and the composite score of main reflux symptoms (score index: SI, range from 0 to 18) were calculated for every subject. RE was diagnosed according to the Savary-Miller criteria. Subjects with abnormal pH-metry (DeMeester score more than 14.7) were considered to have PGER. GERD patients were defined as the subjects with RE and/or PGER. RESULTS: The sensitivity of SI in the diagnosis of GERD was inversely associated with SI, but the specificity tended to increase with increased SI. With the cut-off of 8, the SI achieved the highest accuracy of 70.0%, with a sensitivity of 78.6% and a specificity of 69.2% in diagnosing GERD, followed by the cut-off of 3, which had an accuracy of 62.1%, a sensitivity of 96.4% and a specificity of 34.6%. The prevalence of RE, PGER and GERD was strongly associated with increased SI (P<0.01), but there was no significant association between the severity of RE and SI (P>0.05). Among patients with RE, 69.2% had PGER, and 30.8% were confirmed to have negative findings of pH monitoring. Among patients with PGER, 52.9% were identified to have RE and 47.1% had negative endscopic findings in esophagus. CONCLUSION: According to the composite score of main reflux symptoms, the diagnosis of GERD can be made without further tests in most cases. However, 24-h esophageal pH monitoring and upper digestive endoscopy are still indicated in patients with mild and atypical symptoms. | Jin-HaiWang Jin-YanLuo LeiDong JunGong Ai-LiZuo | 2004 | World Journal of Gastroenterology2004，10，22： | 2 |
| 9 | Oscillatory of unstable typesecond-order neutral difference equations显示文摘 | Zhen Guo Zhang Biping Wen Leidong | 2002 | Korean J Compute Math2002，9，1： | 1 |
| 10 | 显示文摘 | Haiying Fu Leidong Xie | 2007 | Construction and Building Materials2007，21，7： | 1 |
| 11 | Storage stability and compatibility of asphalt binder modified by SBS graft copolymer显示文摘 | Haiying Fu Leidong Xie | 2007 | Construction and Building Materials2007，21，7： | 1 |
| 12 | Storage stability and compatibility of asphalt binder modified by SBS graft copolymer显示文摘 | Fu Haiying Xie Leidong Dou Daying | 2007 | Construction and Building Materials2007，21，7： | 1 |
| 13 | Storage stability and compatibility of asphalt binder modified by SBS graft copolymer显示文摘 | Fu Haiying Xie Leidong Dou Daying | 2007 | Construction and Building Materials2007，21，7： | 1 |
| 14 | Changes of gastrointestinal myoelectric activity and bile acid pool size after cholecystectomy in guinea pigs显示文摘AIM: To investigate the bile acid pool size after cholecystectomy whether or not correlated to the gastrointestinal migrating myoelectric complex (MMC) in guinea pigs.METHODS: Gallbladder motilities were assessed before cholecystectomy. Furthermore, we continuously monitored interdigestive gastrointestinal motilities using bipolar electrodes in conscious guinea pigs before and after surgery at 4 wk in standard diet group and high cholesterol diet (cholesterol gallstone) group. Total bile acid pool sizes were measured by isotope dilution method at meantime.RESULTS: After cholecystectomy, there were parallel falls in duration of phase Ⅰ, Ⅱ, Ⅲ and MMC cycle duration but increase in amplitude in the guinea pigs with normal gallbladder function, and in the guinea pigs with cholesterol stones. However, There were not significantly differences. On the other hand, the bile acid pool was definitely small in the GS guinea pigs compared to normal guinea pigs and became slightly smaller after cholecystectomy. Similarly, bile acid in gallbladder bile, fecal bile acid was slightly increased in GS guinea pigs after cholecystectomy, to the same degree as normal. These differences, however, were not significant.CONCLUSION: It is concluded that in the guinea pigs with normal gallbladder function, and in the guinea pigs with cholesterol stones: (1) Cholecystectomy produce a similar but less marked trend in bile acid pool; and (2) MMC are linked to enterohepatic circulation of bile acids, rather than surgery, which is consistent with changes of the bile acid pool size. As a result, gastrointestinal dyskinesia is not involved in occurrence of postcholecystectomy syndrome. | Xue-MeiZhang LeiDong Li-NaLiu Bi-XiaChang QianHe QianLi | 2005 | World Journal of Gastroenterology2005，11，24： | 1 |
| 15 | Storage stability and compatibility of asphalt binder modified by SBS graft copolymer显示文摘 | Haiying Fu Leidong Xie Daying Dou | 2007 | Construction and Building Materials2007，21，： | 1 |
| 16 | Storage Stability and Compatibility of Asphalt Binder Modified by SBS Graft Copolymer 显示文摘 | FU Haiying XIE Leidong DOU Daying et ai | 2007 | Construction and Building Materials2007，21，7： | 1 |
| 17 | Antifouling microfiltration membranes prepared from acrylic acid or methacrylic acid grafted poly(vinylidene fluoride) powder synthesized via pre-irradiation induced graft polymerization显示文摘 | Bo Deng Ming Yu Xuanxuan Yang Bowu Zhang Linfan Li Leidong Xie Jingye Li Xiaofeng Lu | 2010 | Journal of Membrane Science2010，，1： | 1 |
| 18 | Storage stability and compatibility of asphalt binder modified by SBS graft copolymer显示文摘 | Fu Haiying Xie Leidong Dou Daying | 2007 | Construction and Building Materials2007，21，7： | 1 |
| 19 | Gene Expression During Development of Fetal and Adult Leydig Cells显示文摘 | LEIDONG SCOTT A.JELINSKY JOSHUA N.FINGER DANIEL S.JOHNSTON GREGORY S.KOPF CHANTAL M.SOTTAS MATTHEW P.HARDY REN‐SHANGE | 2008 | Annals of the New York Academy of Sciences2008，，1： | 1 |
| 20 | Microfiltration membranes with pH dependent property prepared from poly(methacrylic acid) grafted polyethersulfone powder显示文摘 | Deng Bo Yang Xuanxuan Xie Leidong | 2009 | Journal of Membrane Science2009，330，12： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员