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| 1 | Paeoniflorin suppresses TGF-β mediated epithelial- mesenchymal transition in pulmonary fibrosis through a Smad-dependent pathway显示文摘 | Yu JI Yan-nong DOU Qian-wen ZHAO Ji-zhou ZHANG Yan YANG Ting WANG Yu-feng XIA Yue DAI Zhi-feng WEI | 2016 | Acta Pharmacologica Sinica2016，37，6： | 48 |
| 2 | H2A.Z Represses Gene Expression by Modulating Promoter Nucleosome Structure and Enhancer Histone Modifications in Arabidopsis显示文摘 | Xiaozhuan Dai Youhuang Bai Lihua Zhao Xianying DOU Yanhui Liu Lulu Wang Yi Li Weimin Li Yanan Hui Xinyu Huang Zonghua Wang Yuan Qin | 2017 | Molecular Plant2017，10，10： | 14 |
| 3 | ON SOME KEY SEDIMENTATION PROBLEMS OF THREE GORGES PROJECT (TGP)显示文摘This article addresses the problems of maintaining a useful life for the reservoir. flood stages to be anticipated at Chongqing, sedimentation in its region of fluctuating backwater. deposition of sediment in the vicinity of the dam and assessment of any possible impacts of the project on the estuary of the Yangtze River. | Lin Bingnan Dou Guoren Xie Jianheng Dai Dingzhong Chen Jisheng Tang Richang and Zhang Ren (Members of the Sedimentation Specialist Group. for the feasibility study of TGP.) | 1989 | International Journal of Sediment Research1989，4，1： | 12 |
| 4 | Two-year clinical outcome after successful implantation of drug-eluting and bare metal stents in diabetic patients: results from a real-world single center registry显示文摘背景 Drug-eluting stents (DES ) 由戏剧性地改善革命化了 interventional 心病学的地临床并且 angiographic 结果。有糖尿病 mellitus (DM ) 的病人在经皮的冠的干预(一种总线标准) 以后与不利临床的结果的增加的风险被联系。在糖尿病的病人的 DES 和赤裸的金属 stent (BMS ) 的功效和安全的可得到的信息从 2004 年 4 月仍然是 scarce.Methods 到 2006 年 10 月,有糖尿病的 1565 个病人,成功地在中国北京在 Fu Wai 医院经历了选任的 stenting,在这研究被注册。所有注册病人被分到一个药 eluting stent 组和一个赤裸的金属 stent 组。我们获得了后续数据:死亡,心肌的梗塞(MI ) ,血栓,目标损害 revascularization (TLR ) ,和在 30 天和 12 和 24 个月的目标容器 revascularization (TVR ) 由学术研究协会定义弧) 。我们计算了并且比较所有 unadjusted 在二个组的各种各样的不利事件的累积频率。考克斯与倾向分数调整的比例危险的模型被用来在 24 个月在 24 months.Results 估计所有结果措施的相对风险,在二的定义 stent 血栓组织的所有弧是类似的;在 30 天,更明确的血栓在 BES 组被发现(0.08% 对 0.81% , P=0.016 ) 。与 DES 对待的病人显示出 TLR 的重要更低的风险(3.88% 对 10.89% ;危险比率(HR ) 0.159 (95% CI:0.151-0.444 ) , P < 0.001 ) , TVR (5.48% 对 11.69% ;HR 0.383 (95% CI:0.232-0.633 ) , P < 0.001 ) ,并且任何 revascularization (12.47% 对 18.55% ;HR 0.555 (95% CI:0.370-0.831 ) , P=0.0004 ) 在 24 个月。没有重要差别以在当代的社会的大、糖尿病的人口的所有原因死亡, MI,和所有原因 mortality/MI.Conclusions 是明显的, DES 的使用在 TLR, TVR,和任何 revascularization 的风险与长期的重要减小被联系。在在在有在 24 月的后续的糖尿病的病人的 DES 和 BMS 之间的所有原因死亡, MI,和血栓没有重要差别。 | DOU Ke-fei XU Bo YANG Yue-jin CHEN Ji-lin QIAO Shu-bin LI Jian-jun QIN Xue-wen LIU Hai-bo WU Yong-jian CHEN Jue YAO Min YOU Shi-jie YUAN Jin-qing DAI Jun GAO Run-lin | 2009 | Chinese Medical Journal2009，，6： | 7 |
| 5 | Xuebijing Injection(血必净注射液)Increases Early Survival Rate by Alleviating Pulmonary Vasopermeability in Rats Subjected to Severe Burns显示文摘Objective: To investigate the effects of Xuebijing Injection(血必净注射液, XBJ) on survival rate and pulmonary vasopermeability in a rat model of severe scald injury. Methods: Rats were divided into two experiments: experiment 1 was monitored for 12 h post-injury for survival analysis after severe burns; in experiment 2, rats were killed for determination of pulmonary vascular permeability and pro-inflammatory mediators. In both experiments, rats were subject to third-degree 50% total body surface area(TBSA) burns or sham injury followed by XBJ or normal saline(NS) treatment. In addition, rat pulmonary microvascular endothelium cells(PMECs) were pretreated with either XBJ or phosphate buffer saline(PBS), and then subjected to sham serum or scald serum stimulation for 2 or 6 h, followed by transwell examination for the permeability of PMECs. Meanwhile, pro-inflammatory mediators in PMECs culture supernatant were also investigated. Results: The average survival time in the scald+XBJ group was 582.1±21.2 min, which was significantly longer than that in the scald + NS group(345.8±25.4 min, P<0.01). Plasma levels of tumor necrosis factor-alpha(TNF-α), E-selectin, interleukin-6(IL-6), vascular permeability and water content of lung tissues were significantly increased in animals after severe burns(P<0.01). However, administration of XBJ significantly decreased these levels in plasma and lung tissue. In in vitro cell experiments, XBJ markedly attenuated permeability in PMECs monolayer and reduced the levels of TNF-α, IL-6 and soluble E-selectin after stimulation with scald serum(P<0.01). Conclusions: XBJ increases early survival rate by alleviating pulmonary vasopermeability and inhibiting pro-inflammatory mediators in rats subjected to lethal scald injury. XBJ may be a potent drug in treatment of severe burns. | DAI Yue-long LI Jing-yuan BAI Hui-ying LIU Si DOU Yong-qi HU Sen | 2017 | Chinese Journal of Integrative Medicine2017，23，9： | 6 |
| 6 | All-optical manipulation of micrometer-sized metallic particles显示文摘Optical traps use focused laser beams to generate forces on targeted objects ranging in size from nanometers to micrometers. However, for their high coefficients of scattering and absorption, micrometer-sized metallic particles were deemed non-trappable in three dimensions using a single beam. This barrier is now removed. We demonstrate, both in theory and experiment, three-dimensional(3D) dynamic all-optical manipulations of micrometersized gold particles under high focusing conditions. The force of gravity is found to balance the positive axial optical force exerted on particles in an inverted optical tweezers system to form two trapping positions along the vertical direction. Both theoretical and experimental results confirm that stable 3D manipulations are achievable for these particles regardless of beam polarization and wavelength. The present work opens up new opportunities for a variety of in-depth research requiring metallic particles. | YUQUAN ZHANG XIUJIE Dou YANMENG DAI XIANYOU WANG CHANGJUN MIN AND XIAOCONG YUAN | 2018 | Photonics Research2018，6，2： | 6 |
| 7 | Clinical and angiographic characteristics of premenopausal women with coronary artery disease显示文摘当中年的 men.It 的疾病广泛地被接受,背景冠的动脉疾病( CAD )通常被考虑因为荷尔蒙 protection.Based ,为绝经前的女人的 CAD 的风险是低的,没有足够的 concern.Even nowthere ,更绝经前的女人受不了咽峡炎和心肌的梗塞,这仍然是有限的详细数据为了描述绝经前的 CAD patients.This 的 characteristicsmechanism 和预后,文章瞄准了到分析临床所有 P < 0.05 )我们在绝经前的 CAD 发现了单个容器的更多的经常的参与的 .Although (43.2%对 26.9%P=0 ),并且三倍的容器在绝经后( 56-60 岁) CAD 病人(33.8%对 20.4%P=0 )更严重的损害(90%)在留给主要(2.9%对1.1%, P=0.048 )并且近似左前面的下降动脉(男孩)(28.2%对 16.6%P=0 )在绝经前的 CAD ,组是有胸不快的绝经前的女人总是被发现把明显的 atherosclerosismore 使倾向了被定位的 found. | DOU Ke-fei XU Bo YANG Yue-jin Lü Rong QIU Hong YANG Wei-xian MU Zhao-wei GAO Run-lin GAO Zhan CHEN Ji-lin QIAO Shu-bin LI Jian-jun QIN Xue-wen LIU Hai-bo WU Yong-jian CHEN Jue YAO Min YOU Shi-jie YUAN Jin-qing DAI Jun | 2008 | Chinese Medical Journal2008，，23： | 5 |
| 8 | Pharmacokinetics of sifuvirtide, a novel anti-HIV-1 peptide, in monkeys and its inhibitory concentration in vitro显示文摘瞄准:学习 sifuvirtide 的 pharmacokinetics,新奇反人的免疫不全病毒(HIV ) 肽,在猴子并且到在 HIV-1-infected-cell 上比较 sifuvirtide 和 enfuvirtide 的禁止的集中熔化。方法:猴子收到了 1.2 mg/kg iv 或 sifuvirtide 的 sc。与液相色谱法双人脚踏车团分光术(SPE-LC/MS/MS ) 相结合的一个联机稳固阶段的抽取过程被建立并且适用在猴子血浆决定 sifuvirtide 的集中。一四 --(127 ) 我 iodinated 肽被用作一个内部标准。房间熔化上的 sifuvirtide 的百分之五十禁止的集中(IC (50 )) 被合作耕作试金决定。结果:试金与好精确和精确性被验证。刻度弯因为在血浆的 sifuvirtide 在 4.88-5000 microg/L 的一个范围上是线性的,与超过 0.9923 的相关系数。在 iv 或 sc 管理以后, sifuvirtide 的观察山峰集中是 10 626+/-2886 microg/L 和 528+/-191 microg/L,和终端消除一半生活(T (1/2 )) 分别地是 6.3+/-0.9 h 和 5.5+/-1.0 h。在 sc 以后, T (最大) 是 0.25-2 h,并且绝对简历可获得性是 49%+/-13% 。Sifuvirtide 长期地禁止了在 HIV-1 之间的合胞体形成有 0.33 microg/L 的 IC (50 ) 的感染的房间和 uninfected 房间。结论:一条联机 SPE-LC/MS/MS 途径为肽 pharmacokinetic 研究被建立。Sifuvirtide 很快皮下地被吸收进血发行量。sifuvirtide 的 T (1/2 ) 比它的类似物的显著地长, enfuvirtide,在健康猴子报导了,它授与集中铺平比它的 IC (50 ) 在试管内高的长期的血浆。 | Shu-jia DAI Gui-fang DOU Xiao-hong QIAN Hai-feng SONG Zhong-ming TANG De-sheng LIU Xiu-wen LIU Liu-meng YANG Yong-tang ZHENG Qing LIANG | 2005 | Acta Pharmacologica Sinica2005，26，10： | 5 |
| 9 | Optimizing interfacial electronic coupling with metal oxide to activate inert polyaniline for superior electrocatalytic hydrogen generation显示文摘Tuning and optimization of electronic structures and related reaction energetics are critical toward the rational design of efficient electrocatalysts.Herein,experimental and theoretical calculation demonstrate the originally inert N site within polyaniline(PANI)can be activated for hydrogen evolution by proper d-πinterfacial electronic coupling with metal oxide.As a result,the assynthesized WO3 assemblies@PANI via a facile redox-induced assembly and in situ polymerization,exhibits the electrocatalytic production of hydrogen better than other control samples including W18O49@PANI and most of the reported nobel-metal-free electrocatalysts,with low overpotential of 74 mV at 10 mA·cm−2 and small Tafel slope of 46 mV·dec−1 in 0.5M H2SO4(comparable to commercial Pt/C).The general efficacy of this methodology is also validated by extension to other metal oxides such as MoO3 with similar improvements. | Zhen-Feng Huang Jiajia Song Yonghua Du Shuo Dou Libo Sun Wei Chen Kaidi Yuan Zhengfei Dai Xin Wang | 2019 | Carbon Energy2019，1，1： | 5 |
| 10 | CRISPR/Cas9-introduced single and multiple mutagenesis in strawberry显示文摘CRISPR/Cas9-mediated genome editing is a powerful tool for life science research.Recently,strawberry (Fragaria × ananassa),an important horticultural crop,has emerged as a model organism for investigating the regulatory mechanisms of fruit development and ripening (Shulaev et al.,2011;Jia et al.,2013,2017;Kang et al.,2013;Han et al.,2015).While most cultivated strawberries (e.g.,F.× ananassa)are octoploid,most wild strawberries (e.g.,F.vesca)are diploid.Although CRISPR/Cas9 methods have been established in many plants,the use of this tool in strawberry needs to be further explored (Zhou et al.,2018). | Sinian Xing Meiru Jia Lingzhi Wei Wenwen Mao Usman Ali Abbasi Yaoyao Zhao Yating Chen Minglin Cao Kai Zhang Zhengrong Dai Zhechao Dou Wensuo Jia Bingbing Li | 2018 | Journal of Genetics and Genomics2018，45，12： | 4 |
| 11 | Treating chronic hepatitis B virus:Chinese physicians' awareness of the 2010 guidelines显示文摘AIM: To investigate Chinese physicians' awareness of the 2010 guidelines on the treatment of chronic hepatitis B virus(HBV) infection.METHODS: This was a quantitative survey that investigated the characteristics and practices of physicians who were treating patients with hepatitis B, the profile of their patients and physician practices regarding the diagnosis and treatment of HBV at the time of the survey. Participants were randomly selected from available databases of Chinese physicians and requested to complete either an online or paper-based survey. Data from the survey responses were analysed. For data validation and interpretation, qualitative in-depth interviews were conducted with 39 of the respondents.RESULTS: Five-hundred completed surveys, from 663 physicians were available for analysis. A mean of 175 chronic hepatitis B(CHB) patients was seen by each physician every month, of whom 85(49%) were treated in line with therapeutic indications stated in the 2010 guidelines. A total of 444(89%) physicians often(> 60% of the time) adhered to the guidelines. Most physicians used antiviral medications as recommended. For patients with compensated and decompensated cirrhosis, 342(68%) and 336(67%) of physicians, respectively, often followed the recommendation to use potent nucleos(t)ide analogues with a high genetic barrier to resistance, using the appropriate treatment more than 60% of the time. Physicians from infectious disease or liver disease departments were better informed than those from gastrointestinal or other departments.CONCLUSION: The majority of Chinese physicians often adhere to Chinese 2010 CHB guidelines and are well-informed about the use of antiviral medications for hepatitis B. | Lai Wei Ji-Dong Jia Xin-Hua Weng Xiao-Guang Dou Jia-Ji Jiang Hong Tang Qin Ning Qing-Qing Dai Run-Qin Li Jie Liu | 2016 | World Journal of Hepatology2016，8，18： | 4 |
| 12 | Two-year clinical outcomes following elective drug-eluting versus bare-metal stent implantation: results from a large single-center database显示文摘响应有 drug-eluting stent (DES ) 的安全的增加的 concem 的背景,试图评估 DES 的长期的安全和功效的现在的学习为一张中国耐心的人口使用了。方法经历了一个索引的所有病人有在到 2006 年 12 月的从 2004 年 4 月的一个单个机构的 DES 或赤裸金属的 stent (BMS ) 的培植的选任的经皮的冠的干预,在分析被包括。匹配技术的一个倾向分数被使用调整并且最小化使因素惊讶的影响。结果外套,有 1465 个病人(20.2%) ,经历了仅仅仅仅 DES 的 BMS,和 5769 个病人(79.8%) 的培植。匹配技术的倾向分数为分析建立了 1321 个病人。stent 血栓的率之间没有重要差别(明确、可能) 二个组(1.06% 对 1.21% , P=-0.8580 ) 。尽管死亡和心肌的梗塞( MI )的率没显著地在2年的后续时期期间不同, death/MI 的率(3.0%对4.5%, P=0.0263 ),目标损害 revascularization ( TLR ,3.2%对 8.5 , P=0.0001 ),目标容器 revascularization ( TVR ,5.8%对9.5%, P < 0.0001 )并且任何 revascularization (10.0%对13.3%, P=0.0066 )比为 BMS 组为 DES 组是显著地更低的。在设备为离开标签指示在被植入的病人之中,倾向分数匹配 stent 血栓,死亡, MI ,和 death/MI 的率不是显著地不同的,当时 TLR 的率, TVR 和任何 revascularization 在后续柱子 stenting 的 2 年期间比为 BMS group.Conclusions 为 DES 组是显著地更低的, DES 使用与 death/MI , TLR , TVR 和任何 revascularization 的更低的率被联系与 BMS 相比,在倾向分数匹配的脊骨在离开标签用法的背景, DES 使用也与类似的优点被联系。 | GAO Run-lin XU Bo CHEN Ji-lin YANG Yue-jin QIAO Shu-bin WANG Yang DOU Ke-fei QIN Xue-wen YAO Min LIU Hai-bo WU Yong-jian YUAN Jin-qing CHEN Jue YOU Shi-jie DAI Jun MA Wei-hua LI Wei | 2009 | Chinese Medical Journal2009，，19： | 4 |
| 13 | 日粮中添加牛磺酸对不同饲养方式蛋鸡输卵管功能的影响(英文)显示文摘目的:本研究旨在调查饲喂牛磺酸和降低饲养密度对蛋鸡输卵管功能的影响。创新点:着眼于动物健康的动物福利,探讨在现代社会高密度饲养的笼养鸡伴随的许多健康问题。方法:在本研究中,绿壳蛋鸡被随机分为散养组、低密度组和高密度组,每组又被分为对照组和饲喂牛磺酸实验组。每个组别的蛋鸡日常饮食是一样的,除了实验组中添加0.1%的牛磺酸。15天后,无菌采集输卵管组织,并分析了组织病理学学上的变化、炎症介质水平、氧化和抗氧化水平等指标的变化。结论:这些数据表明牛磺酸可以保护输卵管组织,降低炎症介质水平、氧化水平以及增强抗氧化水平等。另外,散养和低密度饲养同样能降低氧化应激和输卵管炎症因子水平等。 | Bin DAI Yuan-shu ZHANG Zi-li MA Liu-hai ZHENG Shuang-jie LI Xin-hong DOU Jian-sen GONG Jin-feng MIAO | 2015 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2015，16，6： | 4 |
| 14 | Bone-targeted pH-responsive cerium nanoparticles for anabolic therapy in osteoporosis显示文摘Antiresorptive drugs are widely used for treatment of osteoporosis and cancer bone metastasis,which function mainly through an overall inhibition of osteoclast.However,not all osteoclasts are“bone eaters”;preosteoclasts(pOCs)play anabolic roles in bone formation and angiogenesis through coupling with osteoblasts and secreting platelet derived growth factor-BB(PDGF-BB).In this study,a bone-targeted pH-responsive nanomaterial was designed for selectively eliminating mature osteoclasts(mOCs)without affecting pOCs.Biocompatible cerium nano-system(CNS)was guided to the acidic extracellular microenvironment created by mOCs and gained oxidative enzymatic activity.Oxidative CNS decreased the viability of mOCs through accumulating intracellular reactive oxygen species and enhancing calcium oscillation.Non-acid secreting anabolic pOCs were thus preserved and kept producing PDGF-BB,which lead to mesenchymal stem cell osteogenesis and endothelial progenitor cell angiogenesis via PI3K-Akt activated focal adhesion kinase.In treating osteoporotic ovariectomized mice,CNS showed better protective effects compare with the current first line antiresorptive drug due to the better anabolic effects marked by higher level of bone formation and vascularization.We provided a novel anabolic therapeutic strategy in treating bone disorders with excessive bone resorption. | Ce Dou Jianmei Li Jian He Fei Luo Tao Yu Qijie Dai Yueqi Chen Jianzhong Xu Xiaochao Yang Shiwu Dong | 2021 | Bioactive Materials2021，6，12： | 3 |
| 15 | Epidemiological and clinical characteristics of COVID-19 patients in Hengyang,Hunan Province,China显示文摘BACKGROUND In December 2019,an ongoing outbreak of coronavirus disease 2019(COVID-19)was first identified in Wuhan,China.The characteristics of COVID-19 patients treated in local hospitals in Wuhan are not fully representative of patients outside Wuhan.Therefore,it is highly essential to analyze the epidemiological and clinical characteristics of COVID-19 in areas outside Wuhan or Hubei Province.To date,a limited number of studies have concentrated on the epidemiological and clinical characteristics of COVID-19 patients with different genders,clinical classification,and with or without basic diseases.AIM To study the epidemiological and clinical characteristics of COVID-19 patients in Hengyang(China)and provide a reliable reference for the prevention and control of COVID-19.METHODS From January 16 to March 2,2020,a total of 48 confirmed cases of COVID-19 were reported in Hengyang,and those cases were included in this study.The diagnostic criteria,clinical classification,and discharge standard related to COVID-19 were in line with the Diagnosis and Treatment Protocol for Novel Coronavirus Pneumonia(Trial Version 7)released by National Health Commission and National Administration of Traditional Chinese Medicine.The presence of SARS-CoV-2 in pharyngeal swab specimens was detected by quantitative reverse transcription polymerase chain reaction.All the data were imported into the excel worksheet and statistically analyzed by using SPSS 25.0 software.RESULTS A total of 48 cases of COVID-19 were collected,of which 1 was mild,38 were moderate,and 9 were severe.It was unveiled that there were 31(64.6%)male patients and 17(35.4%)female patients,with a female-to-male ratio of 1.82:1.The range of age of patients with COVID-19 was dominantly 30-49 years old[25(52.1%)of 48],followed by those aged over 60 years old[11(22.9%)].Besides,29.2%(14 of 48)of patients had basic diseases,and 57.2%(8 of 14)of patients with basic diseases were aged over 60 years old.The occupations of 48 COVID-19 patients were mainly farmers working in agricultural production[15(31.5%)of 48],rural migrant workers from Hengyang to Wuhan[15(31.5%)],and service workers operating in the service sector[8(16.7%)].The mean latent period was 6.86±3.57 d,and the median was 7[interquartile range(IQR):4-9]d.The mean time from onset of symptoms to the first physician visit was 3.38±2.98(95%CI:2.58-9.18)d,with a median of 2(IQR:1-5)d,and the mean time from hospital admission to confirmed diagnosis was 2.29±2.11(95%CI:1.18-6.42)d,with a median of 2(IQR:1-3)d.The main symptoms were fever[43(89.6%)of 48],cough and expectoration[41(85.4%)],fatigue[22(45.8%)],and chills[22(45.8%)].Other symptoms included poor appetite[13(27.1%)],sore throat[9(18.8%)],dyspnea[9(18.8%)],diarrhea[7(14.6%)],dizziness[5(10.4%)],headache[5(10.4%)],muscle pain[5(10.4%)],nausea and vomiting[4(8.3%)],hemoptysis[4(8.3%)],and runny nose[1(2.1%)].The numbers of peripheral blood leukocytes,lymphocytes,and eosinophils were significantly reduced in the majority of the patients.The levels of C-reactive protein,fibrinogen,blood glucose,lactate dehydrogenase,Ddimer,alanine aminotransferase(ALT),aspartate aminotransferase(AST),gamma-glutamyl transferase(γ-GT),myoglobin(MB),and creatine kinase(CK)were increased in 64.6%,44.7%,43.2%,37.0%,29.5%,22.9%,20.8%,21.6%,13.6%,and 12.8%of patients,respectively.The incidence of ALT elevation in male patients was remarkably higher than that in females(P<0.01),while the incidences of AST,CK,and blood glucose elevations in severe patients were remarkably higher than those in moderate patients(P<0.05,respectively).Except for the mild patients,chest computed tomography showed characteristic pulmonary lesions.All the patients received antiviral drugs,38(79.2%)accepted traditional Chinese medicine,and 2(4.2%)received treatment of human umbilical-cord mesenchymal stem cells.On March 2,2020,48 patients with COVID-19 were all cured and discharged.CONCLUSION Based on our results,patients with COVID-19 often have multiple organ dysfunction or damage.The incidences of ALT elevation in males,and AST,CK,and blood glucose elevations in severe patients are remarkably higher. | Zhe-Feng Zhong Jia Huang Xia Yang Jin-Ling Peng Xiao-Yan Zhang Yang Hu Nian Fu Hai-Lian Lin Bo Jiang Ya-Ying Tian Hong-Yi Yao Li-Pu Deng Xiao-Qing Tang Jie-Can Zhou Jian Tang Xia Xie Qiong Liu Jing Liu Cheng-Yun Dou Rong-Juan Dai Bo Yan Xue-Feng Yang | 2020 | World Journal of Clinical Cases2020，8，12： | 3 |
| 16 | Detection of an anti-angina therapeutic module in the effective population treated by a multi-target drug Danhong injection:a randomized trial显示文摘It's a challenge for detecting the therapeutic targets of a polypharmacological drug from variations in the responsed networks in thedfferentiated populations with complex diseases,as stable coronary heart disease.Here,in an adaptive,31-center,randomized,double-blind trial invoving 920 patients with moderate symptomatic stable angina treated by 14-day Danhong injection(DHI),a kind of polyphamacological drug with high quality control,or placebo(0.9%saline),with 76-day following-up,we firstly confrmed that DHl couldincrease the proportion of patients with clinically significant changes on angina-frequency assessed by Seattle Angina Questionnaire(ASAQ-AF220)(12.78%at Day 30,95%confidence interval[C]5.86-19.71%,P=0.0003,13.82%at Day 6C0,95%CI 6.82-20.82%,P=0.0001and 8.95%at Day 90,95%CI 2.06-15.85%,P=0.01).We also found that there were no significant differences in new-onset major vascularevents(P=0.8502)and serious adverse events(P=0.9105)between DHl and placebo.After performing the RNA sequencing in 62 selectedpatients,we developed a systemic modular approach tp identfy differentilly expressed modules(DEMs)of DHI with the Z_(summay)valueless than 0 compared with the control group,calculated by weighted gene co-expression network analysis(WGCNA),and sketched out thebasic framework on a modular map with 25 functional modules targeted by DII.Furthermore,the effective therapeutic module(ETM),defined as the highest corelation value with the phenotype alteration(SAQ-AF,the change in SAQ-AF at Day 30 from baseline)calculatedby WGCNA,was identifed in the population with the best effect(ASAQ-AF240),which is related to anticoagulation and regulation ofcholesterol metabolism.We assessed the modular flexbility of this ETM using the global topological D value based on Euclidean distance,which is corelated with phenotype alteration(r^(2):0.8204,P=0.019)by linear regression.Our study identified the ant-angina therapeuticmodule in the effective population treated by the multi-target drug.Modular methods facilitate the discovery of network pharmacologicalmechanisms and the advancement of precision medicine.(ClinicalTrials.gov identifier:NCTO1681316). | Jun Liu Dan-Dan Li Wei Dong Yu-Qi Liu Yang Wu Da-Xuan Tang Fu-Chun Zhang Meng Qiu Qi Hua Jing-Yu He Jun Li Bai Du Ting-Hai Du Lin-Lin Niu Xue-Jun Jiang Bo Cui Jiang-Bin Chen Yang-Gan Wang Hai-Rong Wang Qin Yu Jing He Yi-Lin Mao Xiao-Fang Bin Yue Deng Yu-Dan Tian Qing-Hua Han Da-Jin Liu Li-Qin Duan Ming-Jun Zhao Cui-Ying Zhang Hai-Ying Dai Ze-Hua Li Ying Xiao You-Zhi Hu Xiao-Yu Huang Kun Xing Xin Jiang Chao-Feng Liu Jing An Feng-Chun Li Tao Tao Jin-Fa Jiang Ying Yang Yao-Rong Dong Lei Zhang Guang Fu Ying Li Shu-Wei Huang Li-Ping Dou Lan-Jun Sun Ying-Qiang Zhao Jie Li Yun Xia Jun Liu Fan Liu Wen-Jin He Ying Li Jian-Cong Tan Yang Lin Ya-Bin Zhou Jian-Fei Yang Guo-Qing Ma Hui-Jun Chen He-Ping Liu Zong-Wu Liu Jian-Xiong Liu Xiao-Jia Luo Xiao-Hong Bin Ya-Nan Yu Hai-Xia Dang Bing Li Fei Teng Wang-Min Qiao Xiao-Long Zhu Bing-Wei Chen Qi-Guang Chen Chun-Ti Shen Yong-Yan Wang Yun-Dai Chen Zhong Wang | 2021 | Signal Transduction and Targeted Therapy2021，6，10： | 2 |
| 17 | Understanding of the capacity Contribution of carbon in phosphorus-carbon composites for high-performance anodes in lithium ion batteries显示文摘Phosphorus has recently received extensive attention as a promising anode for lithium ion batteries (LIB ) due to its high theoretical capacity of 2,596 | Jiantie Xu In-Yup Jeon Jianmin Ma Yuhai Dou Seok-Jin Kim Jeong-Min Seo Huakun Liu Shixue Dou Jong-Beom Baek Liming Dai | 2017 | Nano Research2017，10，4： | 2 |
| 18 | Hybrid Dextran-gadolinium Nano-suitcases as High-relaxivity MRI Contrast Agents显示文摘Dextran-poly(glycidyl methacrylate)(Dex-PGMA) nano-suitcases were synthesized efficiently via a graft copolymerization induced self-assembly(GISA) approach. On this basis, the Dex-PGMA nano-suitcases were modified with hydrazide, and the attachment of multiple chelated Gd(Ⅲ) ions to the interior of the nano-suitcases affords nanoscale MRI contrast agents with high relaxivity values. The highly fenestrated dextran shell of the nano-suitcases assures water exchange which readily occurs between the surrounding environment and the Gd(Ⅲ) ions encapsulated within the hybrid nano-suitcases. The complexation between the hydrophilic hydrazide interior of the nano-suitcases and Gd(Ⅲ) ions results in an impressive Gd payload at 22.6 wt% in the hybrid nano-suitcases. The longitudinal relaxivity(r1) of the hybrid nano-suitcases is reported as 44.4 L/(mmol·s), which is 9-14 folds of that of commercial Gd-DTPA agents. In vivo MRI studies demonstrate that the hybrid nano-suitcases accumulated in the lymph node of the rat due to their nanoscale dimensions and displayed strong signals in vivo. The results indicated that the hybrid nano-suitcases provide a promising platform for the diagnosis of lymph node related diseases. | Hao Wang Ting-Ting Dai Bo-Lun Lu Sheng-Li Li Qing Lu Vincent Mukwaya Hong-Jing Dou | 2018 | Chinese Journal of Polymer Science2018，36，3： | 2 |
| 19 | Carbon Materials for Chemical Capacitive Energy Storage显示文摘 | Yunpu Zhai Yuqian Dou Dongyuan Zhao Pasquale F. Fulvio Richard T. Mayes Sheng Dai | 2011 | Adv. Mater2011，，42： | 2 |
| 20 | Quantification of sifuvirtide in monkey plasma by an on-line solid-phase extraction procedure combined with liquid chromatography/electrospray ionization tandem mass spectrometry 显示文摘 | Dai SJ Song HF Dou GF | 2005 | Rapid Commun Mass Spectrom2005，19，10： | 1 |
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