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| 1 | Positive impact of adding No.14v lymph node to D2 dissection on survival for distal gastric cancer patients after surgery with curative intent显示文摘Background:D2 lymphadenectomy has been increasingly regarded as standard surgical procedure for advanced gastric cancer(GC),while the necessity of No.14 v lymph node(14v) dissection for distal GC is still controversial.Methods:A total of 920 distal GC patients receiving at least a D2 lymph node dissection in Department of Gastric Cancer,Tianjin Medical University Cancer Institute and Hospital were enrolled in this study,of whom,243 patients also had the 14 v dissected.Other 677 patients without 14 v dissection were used for comparison.Results:Forty-five(18.5%) patients had 14 v metastasis.There was no significant difference in 3-year overall survival(OS) rate between patients with and without 14 v dissection.Following stratified analysis,in TNM stages I,II,IIIa and IV,14 v dissection did not affect 3-year OS;in contrast,patients with 14 v dissection had a significant higher 3-year OS than those without in TNM stages IIIb and IIIc.In multivariate analysis,14 v dissection was found to be an independent prognostic factor for GC patients with TNM stage IIIb/IIIc disease [hazard ratio(HR),1.568;95% confidence interval(CI):1.186-2.072;P=0.002].GC patients with 14 v dissection had a significant lower locoregional,especially lymph node,recurrence rate than those without 14 v dissection(11.7 % vs.21.1%,P=0.035).Conclusions:Adding 14 v to D2 lymphadenectomy may be associated with improved 3-year OS for distal GC staged TNM Ⅲb/Ⅲc. | Yuexiang Liang Liangliang Wu Xiaona Wang Xuewei Ding Hongmin Liu Bin Li Baogui Wang Yuan Pan Rupeng Zhang Ning Liu Han Liang | 2015 | Chinese Journal of Cancer Research2015，27，6： | 22 |
| 2 | An App knock-in rat model for Alzheimer’s disease exhibiting Aβand tau pathologies,neuronal death and cognitive impairments显示文摘A major obstacle in Alzheimer’s disease(AD)research is the lack of predictive and translatable animal models that reflect disease progression and drug efficacy.Transgenic mice overexpressing amyloid precursor protein(App)gene manifest non-physiological and ectopic expression of APP and its fragments in the brain,which is not observed in AD patients.The App knock-in mice circumvented some of these problems,but they do not exhibit tau pathology and neuronal death.We have generated a rat model,with three familiar App mutations and humanized Aβsequence knocked into the rat App gene.Without altering the levels of full-length APP and other APP fragments,this model exhibits pathologies and disease progression resembling those in human patients:deposit of Aβplaques in relevant brain regions,microglia activation and gliosis,progressive synaptic degeneration and AD-relevant cognitive deficits.Interestingly,we have observed tau pathology,neuronal apoptosis and necroptosis and brain atrophy,phenotypes rarely seen in other APP models.This App knock-in rat model may serve as a useful tool for AD research,identifying new drug targets and biomarkers,and testing therapeutics. | Keliang Pang Richeng Jiang Wei Zhang Zhengyi Yang Lin-Lin Li Makoto Shimozawa Simone Tambaro Johanna Mayer Baogui Zhang Man Li Jiesi Wang Hang Liu Ailing Yang Xi Chen Jiazheng Liu Bengt Winblad Hua Han Tianzi Jiang Weiwen Wang Per Nilsson Wei Guo Bai Lu | 2022 | Cell Research2022，32，2： | 6 |
| 3 | Regional gravity field modeling based on rectangular harmonic analysis显示文摘Regional gravity field modeling with high-precision and high-resolution is one of the most important scientific objectives in geodesy,and can provide fundamental information for geophysics,geodynamics,seismology,and mineral exploration.Rectangular harmonic analysis(RHA)is proposed for regional gravity field modeling in this paper.By solving the Laplace’s equation of gravitational potential in local Cartesian coordinate system,the rectangular harmonic expansions of disturbing potential,gravity anomaly,gravity disturbance,geoid undulation and deflection of the vertical are derived,and so are the formula for signal degree variance and error degree variance of the rectangular harmonic coefficients(RHC).We also present the mathematical model and detailed algorithm for the solution of RHC using RHA from gravity observations.In order to reduce the edge effects caused by periodic continuation in RHA,we propose the strategy of extending the size of computation domain.The RHA-based modeling method is validated by conducting numerical experiments based on simulated ground and airborne gravity data that are generated from geopotential model EGM2008 and contaminated by Gauss white noise with standard deviation of 2 mGal.The accuracy of the 2.5′×2.5′geoid undulations computed from ground and airborne gravity data is 1 and 1.4cm,respectively.The standard error of the gravity disturbances that downward continued from the flight height of 4 km to the geoid is only 3.1 mGal.Numerical results confirm that RHA is able to provide a reliable and accurate regional gravity field model,which may be a new option for the representation of the fine structure of regional gravity field. | JIANG Tao LI JianCheng DANG YaMin ZHANG ChuanYin WANG ZhengTao KE BaoGui | 2014 | Science China Earth Sciences2014，57，7： | 4 |
| 4 | Floristic composition and biogeography of tropical montane rain forest in southern Yunnan of China显示文摘 | Zhu Hua Wang Hong Li Baogui | 2006 | Gardens′ Bulletin Singapore2006，58，： | 1 |
| 5 | Biogeography and floristic affinity of the Limestone flora in southern Yunnan, China显示文摘 | Zhu Hua Wang Hong Li Baogui | 2003 | Annals of the Missouri Botanical Garden2003，90，3： | 1 |
| 6 | A rotating coilmeasurement system based on CMM for high-gradient small-aperture quadrupole in HEPS-TF显示文摘Purpose A new rotating coil measurement system based on the coordinate measurement machine(CMM)is developed for measuring high-gradient small-aperture quadrupole magnet in the Test Facility of High Energy Photon Source(HEPS-TF).Methods The CMMand two groups of Newport translate stages are combined to align the rotating coil relative to the magnet mechanical center.A high precision ceramic skeleton with bucked coil is made as a measurement sensor.The integrated field gradient,harmonics,magnetic center offset and excitation curve of a high-gradient small-aperture quadrupole prototype magnet are measured.Results The rotating coil is aligned to the magnet mechanical center within 10μm.The reproducibility of higher harmonics is within 0.2×10–4.The repeatability of the magnet center in horizontal direction is under 1.5μm,while that in vertical direction is less than 2.5μm in different days.The architecture of the measurement system,the measuring procedure and some primary results of the quadrupole prototype magnet are illustrated in this paper.Conclusion A rotating coil measurement system based on CMM has been well developed,and the collimation efficiency and precision are improved.The harmonic changes caused by iron fingers are measured by the measurement system.The difference between the measurement result and the OPERA-3D simulation result is less than 0.5×10–4.The performance of this measurement system can meet the magnet measurement requirements of HEPS-TF. | Mei Yang Fusan Chen Baogui Yin Ran Liang Shuai Li Yingshun Zhu | 2021 | Radiation Detection Technology and Methods2021，5，1： | 1 |
| 7 | Epidemiological and Clinical Features of Patients with Scrub Typhus—Guangzhou City,Guangdong Province,China,2012–2018显示文摘Summary What is already known about this topic?Scrub typhus(ST)causes public health challenges in the“tsutsugamushi triangle”in the Asia-Pacific area greater than 13 million square kilometers,affecting an estimated one million people each year.What is added by this report?A retrospective study based on 4,501 hospitalized patients with ST in Guangzhou City,China,described the epidemiological and clinical characteristics,laboratory findings of ST. | Yuehong Wei Xiugang Guan Shixia Zhou Anran Zhang Qingbin Lu Ziwei Zhou Jinjin Chen Haiyang Zhang Yang Ji Baogui Jiang Yang Yang Zhicong Yang Hao Li Liqun Fang Wei Liu | 2021 | China CDC weekly2021，3，51： | 1 |
| 8 | IL-13/IL-13RA2 signaling promotes colorectal cancer stem cell tumorigenesis by inducing ubiquitinated degradation of p53显示文摘Cancer stem cells(CSCs)are considered tumor-initiating cells and the main drivers of disease progression.Targeting these rare cancer cells,however,remains challenging with respect to therapeutic benefit.Here,we report the up-regulation of IL-13RA2 expression in colorectal cancer(CRC)tissues and spheroid cells.The expression of IL-13RA2 was positively correlated with canonical stemness markers in CRC.We further demonstrated that the level of IL-13 was up-regulated in the serum of CRC patients.Biologically,recombinant IL-13(rIL13)stimulation promoted the sphere formation,proliferation,and migration of CRC cells in vitro and enhanced tumorigenesis in vivo.This phenotype could be reversed by knocking down IL-13RA2.Mechanistically,IL-13 activated autophagy by inducing LC3I/LC3II transformation in CRC-CSCs,which was crucial for the biological functions of IL-13.We further demonstrated that IL-13RA2 acted as a modular link of the E3 ligase UBE3C and the substrate p53 protein,enhancing the interaction of UBE3C and p53,thereby inducing the K48-linked ubiquitination of p53.In conclusion,the IL-13/IL-13RA2 signaling cascade promotes CRC-CSC self-renewal and tumorigenesis by inducing p53 ubiquitination,adding an important layer to the connection between IL-13 and p53,which can be translated into novel targeted therapies. | Baoyu He Jing Liang Qianqian Qin Yuqin Zhang Shuo Shi Jinghe Cao Zhixin Zhang Qingli Bie Rou Zhao Li Wei Baogui Zhang Bin Zhang | 2024 | Genes & Diseases2024，11，1： | 0 |
| 9 | Visible light and base promoted O-H insertion/cyclization of para-quinone methides with aryl diazoacetates: An approach to 2,3-dihydrobenzofuran derivatives显示文摘A visible light and base promoted O-H insertion/cyclization of para-quinone methides with aryl diazoacetates is developed. This one-pot two step reaction offers a mild and efficient approach for the synthesis of biologically important 2,3-dihydrobenzofuran derivatives in good yields and moderate diastereoselectivities. | Shuangjing Zhou Baogui Cai Chuxia Hu Xu Cheng Lei Li Jun Xuan | 2021 | Chinese Chemical Letters2021，32，8： | 0 |
| 10 | Packet Scheduling in Rechargeable Wireless Sensor Networks under SINR Model显示文摘Two packet scheduling algorithms for rechargeable sensor networks are proposed based on the signal to interference plus noise ratio model.They allocate different transmission slots to conflicting packets and overcome the challenges caused by the fact that the channel state changes quickly and is uncontrollable.The first algorithm proposes a prioritybased framework for packet scheduling in rechargeable sensor networks.Every packet is assigned a priority related to the transmission delay and the remaining energy of rechargeable batteries,and the packets with higher priority are scheduled first.The second algorithm mainly focuses on the energy efficiency of batteries.The priorities are related to the transmission distance of packets,and the packets with short transmission distance are scheduled first.The sensors are equipped with low-capacity rechargeable batteries,and the harvest-store-use model is used.We consider imperfect batteries.That is,the battery capacity is limited,and battery energy leaks over time.The energy harvesting rate,energy retention rate and transmission power are known.Extensive simulation results indicate that the battery capacity has little effect on the packet scheduling delay.Therefore,the algorithms proposed in this paper are very suitable for wireless sensor networks with low-capacity batteries. | Baogui Huang Jiguo Yu Chunmei Ma Guangshun Li Anming Dong | 2023 | China Communications2023，20，3： | 0 |
| 11 | THE SYNTHESIS OF A NEW TYPE OF DISINFECTANT RESIN AND ITS ANTIBACTERIAL ACTIVITY显示文摘Polymer supported alkyl dimethyl benzyl ammonium chloride resin disinfectant used for the disinfection of drinking water has been synthesized, and itsantibacterial activities have been determined, compared with the commerciallyused triiodine disinfectant resin. The basin disinfectant was generated successfully when use the combination of surface active agents and ultrosonic. | Li Wenlan Zhang Zhengpu He Binglin(The State Key Lab. For Separation and Absorption of Functional Polymer,Institute of Polymer Chemistry, Nankai Univ. Tianjin 300071)Hen Changxiu Zhang Baogui(Department of Environmental Science, Nankai Univ. Tianjin 30 | 1998 | Chinese Journal of Reactive Polymers1998，7，1： | 0 |
| 12 | Multisphere Tectonics of the Earth System显示文摘The fundamental theoretical framework of the Multisphere Tectonics of the Earth System is as follows:(1)It intends to extend the geotectonic studies from the crustal and lithospheric tectonics to the multisphere tectonics of the Ear th system as a whole.(2)The global dynamics driven by both the Earth system and the cosmic celestial system:solar energy,multispheric interactions of the Earth system and the combined effects of the motions of celestial bodies in the cosmos syste m are the driving forces of various geological processes.(3)The Continent-Ocean transformation theory:the continent and ocean are two opposite yet unified geological units,which can be transformed into each other;neither continent nor ocean wi ll survive forever;there is no one-way development of continental accretion or ocean extinction;the simple theory of one-way continental accretion is regarded as invalid.(4)The continental crust and mantle are characterized by multiple layers,with different layers liable to slide along the interfaces between them,but corroboration is needed that continents move as a who le or even drift freely.(5)The cyclic evolution theory:the development of Earth’s tectonics is not a uniform change,but a spiral forward evolution,characterized by a combination of non-uniform,non-linear,gradual and catastrophic changes;different evolutionary stages(tectonic cycles)of Earth have distinctive global tectonic patterns and characteristics,one tectonic mo del should not be applied to different tectonic cycles or evolutionary stages.(6)The structure and evolution of Earth are asymmetric and heterogeneous,thus one tectonic model cannot be applied to different areas of the world.(7)The polycyclic evolution of the continental crust:the continental crust is formed by polycyclic tectonics and magmatism,rather than simply lateral or vertical accretion.(8)The role of deep faults:the deep fault zones cutting through different layers of the crus t a nd mantle usually play important roles in tectonic evolution.For example,the present-day mid-ocean ridge fault zones,transform fault zones and Benioff zones outline the global tectonic framework.Different tectonic cycles and stages of Earth’s evolutio n must have their own distinctive deep fault systems which control the global tectonic framework and evolutionary processes during different tectonic cycles and stages.Starting from the two mantle superplumes Jason(Pacific)and Tuzo(Africa),the study of the evolutionary process of the composition and structure of the crust and mantle during the great transformation an d reorganization of the Meso-Cenozoic tectonic framework in China and the other regions of Asia is a good demonstration of theory of Multisphere Tectonics of the Earth System. | REN Jishun NIU Baogui XU Qinqin ZHAO Lei LIU Jianhui LI Shan ZHU Junbin LIU Renyan | 2022 | Acta Geologica Sinica(English Edition)2022，96，3： | 0 |
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