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| 1 | Leptin signaling and leptin resistance显示文摘Leptin is secreted into the bloodstream by adipocytes and is required for the maintenance of energy homeostasis and body weight.Leptin deficiency or genetic defects in the components of the leptin signaling pathways cause obesity.Leptin controls energy balance and body weight mainly through leptin receptor b(LEPRb)-expressing neurons in the brain,particularly in the hypothalamus.These LEPRb-expressing neurons function as the first-order neurons that project to the second-order neurons located within and outside the hypothalamus,forming a neural network that controls the energy homeostasis and body weight.Multiple factors,including inflammation and endoplasmic reticulum(ER)stress,contribute to leptin resistance.Leptin resistance is the key risk factor for obesity.This review is focused on recent advance about leptin action,leptin signaling,and leptin resistance. | Yingjiang Zhou Liangyou Rui | 2013 | Frontiers of Medicine2013，7，2： | 8 |
| 2 | SH2B1 regulation of energy balance, body weight, and glucose metabolism显示文摘The Src homology 2B(SH2B)family members(SH2B1,SH2B2 and SH2B3)are adaptor signaling proteins containing characteristic SH2 and PH domains.SH2B1(also called SH2-B and PSM)and SH2B2(also called APS)are able to form homo-or hetero-dimers via their N-terminal dimerization domains.Their C-terminal SH2 domains bind to tyrosyl phosphorylated proteins,including Janus kinase 2(JAK2),TrkA,insulin receptors,insulin-like growth factor-1 receptors,insulin receptor substrate-1(IRS1),and IRS2.SH2B1 enhances leptin signaling by both stimulating JAK2 activity and assembling a JAK2/IRS1/2 signaling complex.SH2B1 promotes insulin signaling by both enhancing insulin receptor catalytic activity and protecting against dephosphorylation of IRS proteins.Accordingly,genetic deletion of SH2B1 results in severe leptin resistance,insulin resistance,hyperphagia,obesity,and type 2 diabetes in mice.Neuronspecific overexpression of SH2B1βtransgenes protects against diet-induced obesity and insulin resistance.SH2B1 in pancreaticβcells promotesβcell expansion and insulin secretion to counteract insulin resistance in obesity.Moreover,numerous SH2B1 mutations are genetically linked to leptin resistance,insulin resistance,obesity,and type 2 diabetes in humans.Unlike SH2B1,SH2B2 and SH2B3 are not required for the maintenance of normal energy and glucose homeostasis.The metabolic function of the SH2B family is conserved from insects to humans. | Liangyou Rui | 2014 | World Journal of Diabetes2014，5，4： | 5 |
| 3 | Application of wavelet neural networks on vibration fault diagnosis for wind turbine gearbox显示文摘 | HUANG Qian JIANG Dongxiang HONG Liangyou | 2008 | Lecture Notes in Computer Science2008，5264，： | 1 |
| 4 | SH2B Regulation of Growth, Metabolism, and Longevity in Both Insects and Mammals显示文摘 | Wei Song Decheng Ren Wenjun Li Lin Jiang Kae Won Cho Ping Huang Chen Fan Yiyun Song Yong Liu Liangyou Rui | 2010 | Cell Metabolism2010，，5： | 1 |
| 5 | Insight into the Reaction Mechanism of Graphene Oxide with Oxidative Free Radical显示文摘 | ZHOU Xuejiao XU Liangyou | 2017 | Chemical Research in Chinese Universities2017，33，5： | 1 |
| 6 | The MNS16A polymorphism in the TERT gene in peri-centenarians from the Han Chinese population显示文摘MNS16A,a variable number of tandem repeats polymorphism in the TERT gene,has been suggested to regulate telomerase activity.As telomerase activity has been reported to be related to life-span,we hypothesized that this polymorphism might affect human longevity by controlling the length of the telomere.To test this hypothesis,we collected 446 unrelated pericentenarian individuals(age≥90,mean 94.45±3.45 years)and 332 normal controls(age 22-53,mean 35.0±12.0 years)from Dujiangyan,Sichuan,China.We typed the MNS16A polymorphism in both groups,and compared the allele and genotype frequencies between the peri-centenarian and control groups using the chi-squared test.There was no significant difference between the peri-centenarian and control groups.Thus,the MNS16A polymorphism in TERT might not influence human life-span,at least in the Han Chinese population studied here. | LIU LiNa WANG ChengYe LU Xiang XIAO FuHui WANG HuaWei YANG LiQin XU LiangYou KONG QingPeng | 2014 | Science China(Life Sciences)2014，57，10： | 1 |
| 7 | Progress in the study on the plants that hyperaccumulate heavy metal 显示文摘 | Shen Zhenguo Liu Liangyou | 1998 | Plant Physiology communications1998，34，2： | 1 |
| 8 | Brain regulation of energy balance and body weight显示文摘 | Liangyou Rui | 2013 | Reviews in Endocrine and Metabolic Disorders2013，，4： | 1 |
| 9 | Development of selective inhibitors for anti-apoptotic Bcl-2proteins from BHI-1显示文摘 | Xing Chengguo Wang Liangyou Tang XiaoHu | | 0，，05： | 1 |
| 10 | WL-276,an antagonist against Bcl-2 proteins,overcomes drug resistance and suppresses prostate tumor growth显示文摘 | Wang Liangyou Sloper TD Addo NS | | 0，，11： | 1 |
| 11 | Human SH2B1 mutations are associated with maladaptive behaviors and obesity显示文摘 | Doche Michael E Bochukova Elena G Su Hsiao-Wen Pearce Laura R Keogh Julia M Henning Elana Cline Joel M Dale Anne Cheetham Tim Barroso Inês Argetsinger Lawrence S O’Rahilly Stephen Rui Liangyou Carter-Su Christin Farooqi I Sadaf | 2012 | Journal of Clinical Investigation2012，，12： | 1 |
| 12 | The expression of CXCR4, CXCL12 and CXCR7 in malignant pleural mesothelioma显示文摘 | TongLi HuiLi YuchengWang ChansonetteHarvard Jia‐LiTan AlfredAu ZhidongXu David MJablons LiangYou | 2011 | J Pathol2011，，4： | 1 |
| 13 | Application of wavelet neural networks on vibration fault diagnosis for wind turbine gearbox 显示文摘 | HUANG Qian JIANG Dongxiang HONG Liangyou | 2008 | Lecture Notes in Computer Science2008，5264，： | 1 |
| 14 | 锌指蛋白snail1通过抑制脂肪酶ATGL的表达调控脂肪分解显示文摘脂肪分解为新陈代谢提供能量。然而,脂肪分解功能异常会导致脂质异常积累和脂毒性。甘油三酯脂肪酶(ATGL)是体内脂肪催化分解的第一步限速酶,但其调控机制尚不明确。 | Chengxin Sun Lin Jiang Yan Liu Hong Shen Stephen J.Weiss 周义发 Liangyou Rui | 2017 | 科学新闻2017，0，4： | 0 |
| 15 | Preparation of Monodispersed Carbon Spheres via Hydrothermal Carbonization of Ascorbic Acid and Their Application in Lithium Ion Batteries显示文摘 | ZHOU Xuejiao XU Liangyou LIU Xiyao ZHANG Junjun DIAO Hongchao MA Xiaohua | 2018 | Chemical Research in Chinese Universities2018，34，4： | 0 |
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