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| 1 | Bevacizumab biosimilar LY01008 compared with bevacizumab(Avastin)as first-line treatment for Chinese patients with unresectable,metastatic,or recurrent non-squamous non-small-cell lung cancer:A multicenter,randomized,double-blinded,phase Ⅲ trial显示文摘Background:Previous studies have demonstrated the preclinical pharmacological and toxicological consistency,and clinical pharmacokinetic equivalence of bevacizumab biosimilar LY01008 with reference bevacizumab(Avastin).This randomized controlled trial aimed to compare the efficacy and safety of LY01008 with Avastin in first-line treatment of Chinese patients with advanced or recurrent non-squamous non-small cell lung cancer(NSCLC).Methods:StageⅢB-ⅣNSCLC patients with evaluable lesions,good physical status,and adequate organ functions from 67 centers across China were randomized in a ratio of 1:1 to receive LY01008 or Avastin 15 mg/kg intravenously in combination with paclitaxel/carboplatin(combined treatment)for 4-6 cycles,followed by maintenance monotherapy with LY01008 until disease progression,intolerable toxicity,or death.The primary endpoint was objective response rate(ORR)in accordance with Response Evaluation Criteria in Solid Tumors(RECIST)version 1.1 confirmed by independent radiological review committees(IRRC).Secondary endpoints included disease control rate(DCR),duration of response(DoR),progression-free survival(PFS),overall survival(OS),and safety.This study was registered in Clinical Trials.gov(NCT03533127).Results:Between December 15^(th),2017,and May 15^(th),2019,a total of 649 patients were randomized to the LY01008(n=324)or Avastin(n=325)group.As of September 25th,2019 for primary endpoint analysis,589 patients received ORR evaluation,with a median number of combined treatment cycles of 5(range 1-6)andmedian duration of treatment of 3.0(range 0.0-5.1)months.ORRof responseevaluable patients in the LY01008 and Avastin groups were 48.5% and 53.0%,respectively.The stratified ORR ratio was 0.91(90%CI 0.80-1.04,within the prespecified equivalence margin of 0.75-1.33).Up to May 15^(th),2020,with a median follow-up of 13.6(range 0.8-28.4)months,no notable differences in DCR,median DoR,median PFS,median OS,and 1-year OS rate were observed between the LY01008 and Avastin groups.There were no clinically meaningful differences in safety and immunogenicity across treatment groups.Conclusions:LY01008 demonstrated similarity to Avastin in terms of efficacy and safety in Chinese patients with advanced or recurrent non-squamous NSCLC.LY01008 combined with paclitaxel/carboplatin is expected to become a new treatment option for unresectable,metastatic,LY01008 and Avastin groups.There were no clinically meaningful differences in safety and immunogenicity across treatment groups.Conclusions:LY01008 demonstrated similarity to Avastin in terms of efficacy and safety in Chinese patients with advanced or recurrent non-squamous NSCLC.LY01008 combined with paclitaxel/carboplatin is expected to become a new treatment option for unresectable,metastatic,or recurrent non-squamous NSCLC patients in the first-line setting. | Yuankai Shi Kaijian Lei Yuming Jia Bingqiang Ni Zhiyong He Minghong Bi Xicheng Wang Jianhua Shi Ming Zhou Qian Sun Guolei Wang Dongji Chen Yongqian Shu Lianke Liu Zhongliang Guo Yong Liu Junquan Yang Ke Wang Ke Xiao LinWu Tienan Yi Debin Sun Mafei Kang Tianjiang Ma Yimin Mao Jinsheng Shi Tiegang Tang Yan Wang Puyuan Xing Dongqing Lv Wangjun Liao Zhiguo Luo Bin Wang Xiaohong Wu Xiaoli Zhu Shuhua Han Qisen Guo Rongyu Liu Zhiwei Lu Jianyong Zhang Jian Fang Changlu Hu Yinghua Ji Guolong Liu Hong Lu Dedong Wu Junhong Zhang Shuyang Zhu Zheng Liu Wensheng Qiu Feng Ye Yan Yu Yanqiu Zhao Qinhong Zheng Jun Chen Zhanyu Pan Yiping Zhang Wenjuan Lian Bo Jiang Bo Qiu Guojun Zhang Hua Zhang Yanju Chen Yuan Chen Hongbing Duan Manxiang Li Shengming Liu Lijun Ma Hongming Pan Xia Yuan Xueli Yuan Yulong Zheng Emei Gao Li Zhao Shumin Wang Can Wu | 2021 | Cancer Communications2021，41，9： | 5 |
| 2 | Silver nanocrystals sensitize magnetic-nanoparticle-mediated thermo-induced killing of cancer cells显示文摘磁性的 nanoparticles (MNP ) 能加热肿瘤纸巾起来并且导致在外部交流磁场下面癌症房间杀死。然而,磁性的 nanoparticles 过高热(MNPH ) 要求被注入肿瘤以便因为复杂的热转移,在 vivo 和 MNP 的有限的热质量获得临床上需要的热剂量的 MNP 的高集中。为了切,击倒 MNP 的剂量并且提高这 Nanotherapy 的效果,我们与不同尺寸准备了银 nanoparticles (AgNPs ) 并且在 MNPH 治疗在癌症房间上调查了这些 AgNPs 的效果。AgNPs 能提高 glioma 房间的 thermo 敏感,这效果是尺寸依赖者,这被发现。AgNPs 能导致在 G2/M 阶段逮捕并且在过高热以后提高了癌症房间的 apoptosis 率的房间周期。在适用的老鼠建模的 glioma,与 AgNPs 相结合的 MNPH 能在癌症房间提高 Bax 表示。我们的结果建议 AgNPs 能是潜在的 thermo 敏化并且能进一步为 MNPH 治疗为 Ag 基于 nanostructure 的热种子的设计被开发。 | Lianke Liu Fang Ni Jianchao Zhang Xiaoli Jiang Xiang Lu Zhirui Guo Ruizhi Xu | 2011 | Acta Biochimica et Biophysica Sinica2011，43，4： | 4 |
| 3 | ia-PNCC: Noise Processing Method for Underwater Target Recognition Convolutional Neural Network显示文摘Underwater target recognition is a key technology for underwater acoustic countermeasure.How to classify and recognize underwater targets according to the noise information of underwater targets has been a hot topic in the field of underwater acoustic signals.In this paper,the deep learning model is applied to underwater target recognition.Improved anti-noise Power-Normalized Cepstral Coefficients(ia-PNCC)is proposed,based on PNCC applied to underwater noises.Multitaper and normalized Gammatone filter banks are applied to improve the anti-noise capacity.The method is combined with a convolutional neural network in order to recognize the underwater target.Experiment results show that the acoustic feature presented by ia-PNCC has lower noise and are wellsuited to underwater target recognition using a convolutional neural network.Compared with the combination of convolutional neural network with single acoustic feature,such as MFCC(Mel-scale Frequency Cepstral Coefficients)or LPCC(Linear Prediction Cepstral Coefficients),the combination of the ia-PNCC with a convolutional neural network offers better accuracy for underwater target recognition. | Nianbin Wang Ming He Jianguo Sun Hongbin Wang Lianke Zhou Ci Chu Lei Chen | 2019 | Computers, Materials & Continua2019，，1： | 3 |
| 4 | FRACTAL ANALYSES OF DIRECTIONAL SOLIDIFICATION BEHAVIOR OF A Ni-BASE SUPERALLOY显示文摘The morphology of solid/liquid interface of a directionally solidification process is describedby means of fractal analysis,and the relations among the fractal dimension of the solid/liq-uid interface,solidification rate,dendrite arm space and the phosphorus content of the test al-loys have been given.It was found that the increase of the solidification rate and the phos-phorus content of the test alloy will lead to a increase,following the regularity of exponentialfunction,in the fractal dimension of solid/liquid interface.Furthermore,by combining thefractal theory and the thermodynamic principle with the measured results,it has been provedthat the fractal dimension is not only a kind of simple geometrical parameter used in des-cribing irregular geometry,but also a state function depending the change of solidificationparameters and chemical compositions. | SUN Liling DONG Lianke ZHANG Jishan TANG Yajun ZHANG Jinghua HU Zhuangqi Institute of Metal Research,Academia Sinica,Shenyang,China SUN Liling,Institute of Metal Research,Academia Sinica,Shenyang 110015,China | 1993 | Acta Metallurgica Sinica(English Letters)1993，6，5： | 2 |
| 5 | A Correlation Visual Analytics System for Air Quality显示文摘A visual analytics system is proposed to reveal the lead/lag correlation when air pollution is detected. In this system, an Overview + Detail approach is utilized for analyzing the correlation of air quality under both the spatial and temporal dimensions and different spatial-temporal scales. An annular container is proposed to preserve the context spatial information while the zoom level of the map changes. Based on the annular container, several analysis techniques such as STL decomposition view and correlation algorithm are integrated. | DU Yi Abish Malik ZHOU Lianke ZHOU Yuanchun | 2018 | Chinese Journal of Electronics2018，27，5： | 1 |
| 6 | Hydro- gen Permeability of Slags Containing Calcium Fluoride显示文摘 | Dong Yanwu Jiang Zhouhua Liang Lianke | 2011 | J Cent South Univ Technol2011，18，4： | 1 |
| 7 | Hydro gen Pick-Up During Electroslag Remelting Process显示文摘 | Zhouhua Jiang Yanwu Dong Lianke Liang | 2011 | Jour hal of Iron and Steel Research International2011，18，4： | 1 |
| 8 | Investigation of volatile methyl siloxanes in biogas and the ambient environment in a landfill显示文摘Landfill biogas is a potential alternative for fossil fuel,but the containing impurities,volatile methyl siloxanes(simplified as siloxanes),often cause serious problems in gas turbines when applied to generate electricity.In this research,a collecting and analyzing method based on solvent adsorption and purge and trap-gas chromatography-mass spectrometry was established to determine the siloxanes in biogas from a landfill in Jinan,China,and adjacent ambient samples,such as soil,air,and leachate of the landfill.The results showed that,octamethylcyclotetrasiloxane(D4)and decamethylcyclopentasiloxane(D5)accounted for 63%of total siloxanes;and without considering D4 and D5,the order of detected siloxanes in concentration was found relating to Gibbs free energies of molecules,namely that higher abundant siloxane(except for D4 and D5)usually had lower Gibbs free energy.Additionally,the mass ratio between D4 and octamethyltrisiloxane(L3)in the bio gas varied with different garbage age in landfills,possibly revealing the breaking-down of larger siloxane molecules with time.The samples,which were collected from environmental samples adjacent to the landfill,such as soil,water,and air,presented much higher siloxane level than urban or rural area away from landfills.The current H2 S scrubber of the landfill biogas could decrease the total siloxanes from 10.7 to 5.75 mg/m^3 due to Fe2 O3 and a refrigerant drier in a purification system and cyclic siloxanes were more easily removed than linear ones. | Ning Wang Li Tan Lianke Xie Yu Wang Timothy Ellis | 2020 | Journal of Environmental Sciences2020，32，5： | 1 |
| 9 | Investigation of LD end-pumped Nd:YVO4 crystals with various doping levels and lengths显示文摘 | Sun Lianke Zhang Shaojun | 2001 | Optics & Laser Technology2001，33，： | 1 |
| 10 | Scattering Window Material:Transparent A1_(2)O_(3)Ceramics and Its Fabrication显示文摘A kind of highly transparent A1_(2)O_(3)ceramics is fabricated in a way of reducing the scattering origins such as the boundary scattering and the facies-difference scattering.The ceramics is a hopeful substitute of the optoelectronic detector windows made of crystalline A1_(2)O_(3)with several advantages such as lower cost,improvement of detecting accuracy and increase of the damage threshold etc. | LI Yi SU Xiyu SONG Lianke ZHANG Binglin MENG Xiangsheng | 1995 | Chinese Physics Letters1995，12，7： | 1 |
| 11 | Application of fractal theory on the study of solid-liquid interface morphology显示文摘 | LILING SUN LIANKE DONG JIHUA ZHANG ZHUANGQI HU | 1997 | Journal of Materials Science Letters1997，，6： | 1 |
| 12 | NASCETpercentstenosissemiautomatedversusmanualmeasurementonCTA显示文摘 | LianK WhiteJH BartlettES etal | 2012 | CanJNeurolSci2012，39，3： | 1 |
| 13 | Achieving high-purity colloidal gold nanoprisms and their application as biosensing platforms显示文摘 | Zhirui Guo Xu Fan Lianke Liu Zhiping Bian Chunrong Gu Yu Zhang Ning Gu Di Yang Jinan Zhang | 2010 | Journal of Colloid And Interface Science2010，，1： | 1 |
| 14 | PMS-Sorting:A New Sorting Algorithm Based on Similarity显示文摘Borda sorting algorithm is a kind of improvement algorithm based on weighted position sorting algorithm,it is mainly suitable for the high duplication of search results,for the independent search results,the effect is not very good and the computing method of relative score in Borda sorting algorithm is according to the rule of the linear regressive,but position relationship cannot fully represent the correlation changes.aimed at this drawback,the new sorting algorithm is proposed in this paper,named PMS-Sorting algorithm,firstly the position score of the returned results is standardized processing,and the similarity retrieval word string with the query results is combined into the algorithm,the similarity calculation method is also improved,through the experiment,the improved algorithm is superior to traditional sorting algorithm. | Hongbin Wang Lianke Zhou Guodong Zhao Nianbin Wang Jianguo Sun Yue Zheng Lei Chen | 2019 | Computers, Materials & Continua2019，，4： | 0 |
| 15 | Research of Toxic Mechanism on Anaerobic Digestion by Lead显示文摘The paper analyzes the influence of lead toxicity by anaerobic granule sludge inhibition and recovering experiments. The result shows that there are different inhibition types at differ-ent lead contents. Higher lead content leads to more inhibition granular sludge, and at the same time, the time of gas recovery is different. Lower lead content per microorganism results in sooner sludge recovery. Microorganisms have a good ability to resist lead toxicity. | Han Jianhong Wang Zhe Zhang Lianke Han Jintao | 2008 | Chinese Journal of Population,Resources and Environment2008，6，1： | 0 |
| 16 | Fractal Description of the Solid/Liquid Interface of a Directionally Solidified Superalloy with Different Phosphorus Content显示文摘The solid/liquid interface of a directionally solidified Ni-base superalloy with different phosphoruscontents was quantitatively described by means of fractat method.When the solidification rate wasfixed,the relationship between the fractal dimensionality of the solid/liquid interface and the phos-phorus content of the test alloy was given.Combined the thermodynamics and fractal theory,the ef-fect mechanism of phosphorus content on fractal dimensionality of the solid/liquid interface wasdiscussed. | Liling SUN Lianke DONG Jinghua ZHANG Zhuangqi HU Institute of Metal Research,Academia Sinica,Shenyang,110015,China | 1993 | Journal of Materials Science & Technology1993，9，6： | 0 |
| 17 | A RELIABILITY ENHANCED DENSITY ADAPTIVE DATA DISSEMINATION SCHEME FOR VANETS显示文摘In this paper,a reliability enhanced and density adaptive data disseminating scheme is proposed for Vehicular Ad hoc NETworks(VANETs).The distributed on demand inquiring and responding mechanism is employed to get nodes' connectivity information.The announcing-listening process is also designed to find the nodes with bigger additional degree to rebroadcast,by which the relaying node is selected freely from density's influence.Simultaneously,a reliability parameter is designed to choose redundant relays for each hop.According to the importance of the broadcast,the parameter is set by the source node properly.Simulation results show that the scheme has achieved good performances such as low forwarding ratio,short latency and low load.The broadcast coverage ratio is ensured against the influence of key link errors and relaying nodes failure by paying suitable additional communication. | Zhou Lianke Cui Gang Luo Danyan Liu Hongwei | 2011 | Journal of Electronics(China)2011，28，1： | 0 |
| 18 | Identification of TP53 mutation-associated prognostic genes and investigation of the immune cell infiltration in patients with hepatocellular carcinoma显示文摘Primary liver cancer,which is mainly composed of hepatocellular carcinoma(HcC),is the sixth most common type of cancer worldwide and the thirdmost common cause of cancer mortality.1 The total number of mutations present in tumor specimens is called tumor mutation burden(TMB)and it is an emerging biomarker of immunotherapy response.2 TMB can predict clinical responses to immunotherapy such as ICl(immune checkpoint inhibitor)treatments and higher TMB is related to better survival.3 TP53,a gene encoding a tumor suppressor protein that triggers apoptosis and cell cycle arrest,is one of the most prevalent mutations in 25%-30%of HCC patients.4 Research shows that TP53 mutations in HCC patients are associated with advanced tumor grade and poor prognosis.5 To identify the TP53 mutation-related genes which can predict HCC patients'prognosis and explore the immune cell infiltration,we constructed a risk model based on six TP53 mutation-related genes which can accurately predict patients'prognosis.Besides,six immune cells with a similar expression pattern were identified in The Cancer Genome Atlas(TCGA)and International Cancer Genome Consortium(ICGC)databases. | Qijun Yang Lianke Gao Yuhan Xu Gaoquan Cao Yingcheng He Wenyige Zhang Xue Zhang Chengfeng Wu Kaili Liao Xiaozhong Wang | 2024 | Genes & Diseases2024，11，2： | 0 |
| 19 | FRACTAL DIMENSIONALITY AND CRITICAL EXTENSION FORCE显示文摘Using gauge field theory of defects,the effective critical extension force in elastic-plasticfracture mechanics was given.The rationality of logarithm of effective extension force as alinear function of the fractal dimensionality of the fracture surface was analyzed in theory.The explanation in approach to studying material toughness using fractal has been clarified. | DONG Lianke WANG Xiaowei Institute of Metal Research International Centre for Material Physics,Academia Sinica,Shenyang,China Associate Professor,Institute of Metal Research,Academia Sinica,Shenyang 110015,China | 1990 | Acta Metallurgica Sinica(English Letters)1990，3，5： | 0 |
| 20 | Low Threshold and High Efficiency Nd:S-VAP Laser显示文摘The absorption spectrum of a new sort of crystal Nd:S-VAP was measured,which showed that Nd:S-VAP can be appropriately pumped at 583.0 and 809.0nm.By using tunable dye-laser(570.0-600.0nm)as pumping light,the performance of low threshold and high efficiency Nd:S-VAP laser has been realized.The characteristics of the output laser,such as 1.5nm linewidth,5 ns pulse width,almost total polarity,up to 50% conversion efficiency,down to 2mJ threshold energy and so on,were presented.Meanwhile,the prospect of Nd:S-VAP crystal for low threshold,high efficiency miniature laser was discussed. | ZHAO Shengzhi WANG Qingpu ZHANG Xingyu WANG Xiaojie WANG Xiangtai SUN Lianke ZHANG Shaojun | 1995 | Chinese Physics Letters1995，12，6： | 0 |
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