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| 1 | A Rare Allele of GS2 Enhances Grain Size anc Grain Yield in Rice显示文摘谷物尺寸决定谷物重量并且影响谷物质量。调整谷物尺寸的几主要量的特点 loci (QTL ) 被克隆;然而,我们调整米饭谷物的尺寸的内在的机制的理解仍然保持碎片。这里,我们报导克隆和主导的 QTL 的描述,染色体 2 上的谷物尺寸(GS2 ) 编码调整生长的因素 4,一个 transcriptional 管理者。GS2 本地化到原子核并且可以充当抄写使活跃之物。影响 microRNA 的有约束力的地点的 GS2 的一个稀罕变化, OsmiR396c,原因提高了 GS2/OsGRF4 的表示。GS2 表示的增加导致更大的房间和房间的增加的数字,它因此提高谷物重量和产量。进米饭栽培变种的 GS2/OsGRF4 的这稀罕等位基因的介绍能显著地提高谷物重量和增加谷物产量,用在引起产量很高的米饭变化的可能的应用。 | Jiang Hu Yuexing Wang Yunxia Fang Longjun Zeng Jie Xu Haiping Yu Zhenyuan Shi Jiangjie Pan Dong Zhang Shujing Kang Li Zhu Guojun Dong Longbiao Guo Dali Zeng Guangheng Zhang Lihong Xie Guosheng Xiong Jiayang Li Qian Qian | 2015 | Molecular Plant2015，8，10： | 57 |
| 2 | Review on biological degradation of mycotoxins显示文摘The worldwide contamination of feeds and foods with mycotoxins is a significant problem. Mycotoxins pose huge health threat to animals and humans. As well, mycotoxins bring enormous economic losses in food industry and animal husbandry annually. Thus, strategies to eliminate or inactivate mycotoxins in food and feed are urgently needed. Traditional physical and chemical methods have some limitations such as limited efficacy, safety issues, losses in the nutritional value and the palatability of feeds, as well as the expensive equipment required to implement these techniques. Biological degradation of mycotoxins has shown promise because it works under mild, environmentally friendly conditions. Aflatoxin(AF), zearalenone(ZEA) and deoxynivalenol(DON) are considered the most economically important mycotoxins in terms of their high prevalence and significant negative effects on animal performance.Therefore, this review will comprehensively describe the biological degradation of AF, ZEA and DON by microorganisms(including fungi and bacteria) and specific enzymes isolated from microbial systems that can convert mycotoxins with varied efficiency to non-or less toxic products. Finally, some strategies and advices on existing difficulties of biodegradation research are also briefly proposed in this paper. | Cheng Ji Yu Fan Lihong Zhao | 2016 | Animal Nutrition2016，，3： | 24 |
| 3 | Numerical study of regional environmental carrying capacity for livestock and poultry farming based on planting-breeding balance显示文摘In consideration of the need to maintain planting-breeding balance, this article examines the capacity of the soil in Putian City, Fujian Province to absorb livestock and poultry excreta, and computes the environmental carrying capacity for livestock and poultry farming (ECCLPF) in each district of the city in terms of the fertility characteristics of the soil in the city, as well as its mix of crops cultivated and farming methods. On the basis of the computations, this work proceeds to classify the alarm grades of the city's environmental carrying capacity for livestock and poultry framing, and assess the environmental impact of the livestock and poultry farming industry. The results of our study indicate that, the city's ECCLPF ranges from 8.27 to 23.23 heads per ha when computed on the basis of nitrogen, and from 5.79 to 24.53 heads per ha when computed on the basis of phosphorus. A comparison between our research findings and the existing farming scale in Putian reveals that, in certain parts of the city, ECCLPF is overburdened to varying degrees. Specifically, Chengxiang District is severely overburdened, Hanjiang District and Meizhou Island have a level of overburdening between virtual overburdening and significant overburdening, Licheng District is virtually overburdened, and Xiuyu, Xianyou, and Bei'an Districts have not exceeded their environmental carrying capacity and therefore have varying levels of potential for growth. | Lihong Peng Yu Bai | 2013 | Journal of Environmental Sciences2013，25，9： | 20 |
| 4 | Influence of Ren and Du meridian electro-acupuncture on neural stem cell proliferation and extracellular signal-regulated kinase pathway in a rat model of focal cerebral ischemia injury显示文摘BACKGROUND:Studies have shown that electro-acupuncture at the Ren meridian could improve proliferation of subventricular zone neural stem cells in cerebral-ischemic rats. However,there are few reports on the influence of electro-acupuncture at the Du meridian on neural stem cell proliferation. OBJECTIVE:To observe the influence of electro-acupuncture at Ren and Du meridians on neural stem cell proliferation in the subventricular zone and altered signal transduction in cerebral ischemia rats. DESIGN,TIME AND SETTING:A randomized,controlled,animal experiment was performed at the Laboratory of Human Anatomy,Medical College of Sun Yat-sen University from May 2006 to February 2008. MATERIALS:Mouse anti-rat bromodeoxyuridine (BrdU) monoclonal antibody was provided by Sigma,USA; mouse anti-rat nestin monoclonal antibody and extracellular signal-regulated protein kinase (ERK) specific inhibitor PD98059 were provided by Calbiochem,Germany; acupuncture needle was provided by Suzhou Acupuncture Supplies,China. METHODS:A total of 126 rats were randomly assigned to four groups:model (n = 36),Du meridian (n = 36),Ren/Du meridian (n = 36),and Ren/Du meridian + PD98059 (n = 18). Rats in the Ren /Du meridian + PD98059 group were observed on days 7 (n = 6) and 14 (n = 12) after cerebral ischemia injury. Rats in the model,Du meridian,and Ren/Du meridian groups were observed on days 7,14,and 28 after cerebral ischemia injury,with 12 rats per group at each time point. Thread occlusion was used to establish middle cerebral artery occlusion models. Electro-acupuncture was performed at Renzhong (DU 26) and Baihui (DU 20) acupoints in the Du meridian group,as well as Chengjiang (RN 24),Guanyuan (RN 4),Renzhong,and Baihui acupoints in the Ren/Du meridian and Ren/Du meridian + PD98059 groups 2 days after model establishment. In addition,electro-acupuncture stimulation with disperse-dense waves was performed,with 30 Hz disperse wave,100 Hz dense wave,and 5 V intensity for 20 minutes. Rats in the Ren/Du meridian + PD98059 group were treated with 0.2 μg PD98059 injection into the subventricular zone,2 μL per rat. Rats in the model group were not treated with electro-acupuncture. MAIN OUTCOME MEASURES:BrdU/nestin immunofluorescent staining was used to detect proliferating neural stem cells in the subventricular zone of cerebral ischemia rats; Western blot was used to determine phosphorylated ERK1 and 2 (pERK1/2) expression in the subventricular zone. RESULTS:On days 14 and 28 after cerebral ischemia,there were significantly more BrdU-positive and BrdU/nestin-positive cells in the Ren /Du meridian group compared with the Du meridian group (P < 0.05). PD98059 decreased the number of BrdU-positive and BrdU/nestin-positive cells induced by electro-acupuncture at the Ren and Du meridians (P < 0.05). On days 7,14,and 28 after treatment,pERK1/2 expression was significantly greater in the Du meridian and Ren/Du meridian groups compared with the model group (P < 0.05). The promoting effect of electro-acupuncture at Ren and Du meridians on ERK1/2 phosphorylation was superior to electro-acupuncture at the Du meridian alone on day 14 after model induction (P < 0.05). However,PD98059 completely abolished the promoting effect of electro-acupuncture at Ren/Du meridians on pERK1/2 expression (P < 0.05). CONCLUSION:Electro-acupuncture at Ren and Du meridians increased proliferation of subventricular zone neural stem cells,which was related to activation of the ERK pathway in a rat model of cerebral ischemia injury. | Wenshu Luo Haibo Yu Zhuoxin Yang Min Pi Lihong Diao Xiaodan Rao | 2010 | Neural Regeneration Research2010，5，6： | 14 |
| 5 | Tracing the first hematopoietic stem cell generation in human embryo by single-cell RNA sequencing显示文摘Tracing the emergence of the first hematopoietic stem cells(HSCs)in human embryos,particularly the scarce and transient precursors thereof,is so far challenging,largely due to the technical limitations and the material rarity.Here,using single-cell RNA sequencing,we constructed the first genome-scale gene expression landscape covering the entire course of endothelial-to-HSC transition during human embryogenesis.The transcriptomically defined HSC-primed hemogenic endothelial cells(HECs)were captured at Carnegie stage(CS)12-14 in an unbiased way,showing an unambiguous feature of arterial endothelial cells(ECs)with the up-regulation of RUNX1,MYB and ANGPTL Importantly,subcategorizing CD34+CD45-ECs into a CD44+population strikingly enriched HECs by over 10-fold.We further mapped the developmental path from arterial ECs via HSC-primed HECs to hematopoietic stem progenitor cells,and revealed a distinct expression pattern of genes that were transiently over-represented upon the hemogenic fate choice of arterial ECs#including EMCN,PROCR and RUNX1T1.We also uncovered another temporally and molecularly distinct intra-embryonic HEC population,which was detected mainly at earlier CS 10 and lacked the arterial feature.Finally,we revealed the cellular components of the putative aortic niche and potential cellular interactions acting on the HSCprimed HECs.The cellular and molecular programs that underlie the generation of the first HSCs from HECs in human embryos,together with the ability to distinguish the HSC-primed HECs from others,will shed light on the strategies for the production of clinically useful HSCs from pluripotent stem cells. | Yang Zeng Jian He Zhijie Bai Zongcheng Li Yandong Gong Chen Liu Yanli Ni Junjie Du Chunyu Ma Lihong Bian Yu Lan Bing Liu | 2019 | Cell Research2019，29，11： | 14 |
| 6 | Acupuncture treatment of lung-spleen Qi deficiency in stable chronic obstructive pulmonary disease: a randomized, open-label, controlled trial显示文摘OBJECTIVE:To evaluate the effectiveness and safety of acupuncture that reinforces the spleen to strengthen the lung in patients with stable chronic obstructive pulmonary disease(COPD).METHODS:This was a randomized,open-controlled trial in which the acupuncturist and the participants were not blinded,but the outcome evalu-ators and data analysts were blinded.One-hundred-and-two patients with stable COPD were randomly divided into two groups in a 1∶1 ratio.The acupuncture group received 30-minute sessions of acupuncture therapy at the same acupoints three times weekly for 6 weeks in addition to routine conventional Western Medicine treatment;the control group received routine conventional Western Medicine treatment alone.The primary outcome was the Borg scale score,which was assessed immediately after the 6-minute walk test.The secondary outcomes were the 6-minute walk distance,lung function,and oxygen saturation.Measurements were obtained at baseline and after 6 weeks of treatment.RESULTS:After 6 weeks of treatment,the Borg scale score in the acupuncture group was significantly better than that in the control group(2.02±0.71 versus 5.01±0.34,P<0.05).Furthermore,the post-treatment improvements in the 6-minute walk distance,lung function,and oxygen saturation were significantly greater in the acupuncture group than in the control group,showing that the acupuncture group had better exercise tolerance.CONCLUSION:The findings suggest that acupuncture that aims to reinforce the spleen to strengthen the lung is a safe and effective adjuvant therapy that effectively improves the exercise capacity of patients with stable COPD. | Li Yu Xiong Chan Zeng Yan Wei Hua Zhuang Guangtong Zhao Lihong Li Chenyi Li Lin Qin Erqi Chen Xiaoqin Fu Juanjuan | 2019 | Journal of Traditional Chinese Medicine2019，39，6： | 13 |
| 7 | Changing Forestry Policy by Integrating Water Aspects into Forest/Vegetation Restoration in Dryland Areas in China显示文摘Restoration forestry (forest rehabilitation) or re-vegetation is one effective measure to solve environmental problems, notably soil erosion. It may be further stimulated by the Clean Development Mechanism for carbon sequestration. However, there is an intensive and on-going debate about the adverse effects arising from afforestation in dryland areas, such as soil drying up which may cause further damage to the success of forest restoration, and the water yield reduction from watershed which may harm the regional development. On other hand, some preliminary studies showed a possibility that these adverse effects may be diminished more or less by properly designing the system structure and spatial distribution of forest/vegetation in a watershed. However, it is urgent to develop an evidence-based and sustainable new forestry policy for harmonizing forest-water interrelation. As a leading country in afforestation, China is beginning to develop a more trans-disciplinary and cross-sectoral forestry policy for harmonizing forestry development with water management. The main points of the changing new forestry policy should include: (1) Establishing a regional development strategy focusing on harmonized forest-water relations; (2) Taking forest-water interactions as an important part of evaluation; (3) Reducing the 'eco-water' quota of forests through technical advancement; (4) Developing and extending water-adaptive forest management practices; (5) Strengthening forest ecohydrological research and decision support ability. | WANG Yanhui Mike Bonell Karl-Heinz Feger YU Pengtao XIONG Wei XU Lihong | 2012 | Bulletin of the Chinese Academy of Sciences2012，26，1： | 9 |
| 8 | Water yield reduction due to forestation in arid mountainous regions, northwest China显示文摘Forestation has been encouraged worldwide due to increasing demand for forest products, and for its ecological benefits such as soil erosion control and sediment reduction. However, forestation reduces runoff, thus potentially aggravating water shortages in arid regions. In order to quantitatively estimate the possible water yield reductions caused by forestation in an arid region, a small watershed (the Pailugou watershed) in the Qilian Mountains of northwest China was chosen as a study area. The responses of hydrological dynamics to different forestation scenarios in the study area were simulated using the TOPOG model. The results showed that forestation could lead to a complete loss of runoff at the site scale. At the watershed scale, a 10% increase in forest coverage led to a runoff reduction of 25.6 mm, equivalent to 13% of the runoffin the un-forested watershed. However, due to climatological and topographical constraints, the potential forest distribution occupied only 46.3% of the watershed area, and runoff reduction was estimated to reach a maximum of 60% when the forest cover ratio increased from 0.41% to 46.1%. Actual forest coverage is 36% in the study area, thus the water yield will be reduced with any further increase in forest area. Our study suggested that a trade-off between the numerous benefits of forest coverage increase and its negative impact on water yield should be carefully addressed in arid regions with inherently severe water-shortage. | Pengtao YU Yanhui WANG Xudong WU Xiaohong DONG Wei XIONG Gaowa BU Shunli WANG Jinye WANG Xiande LIU Lihong XU | 2010 | International Journal of Sediment Research2010，25，4： | 7 |
| 9 | Occurrence of mycotoxins in feed ingredients and complete feeds obtained from the Beijing region of China显示文摘Background:The current study was carried out to provide a reference for the control of mycotoxin contamination in feed ingredients and complete feeds for swine.Methods:A total of 55 feed ingredients,including 14 corn,13 wheat bran,11 soybean meal and 17 dried distillers grains with solubles(DDGS) as well as 76 complete swine feeds including 7 creep feeds,14 starter feeds,14 grower feeds,18 grower-finisher feeds,10 gestating sow feeds,and 13 lactating sow feeds were randomly collected from15 swine farms located in the Beijing region of China from July to August 2011.Immunoaffinity clean-up,using High-Performance Liquid Chromatography(HPLC) in combination with UV or Fluorescence Detection,was used for quantitative analysis of aflatoxin B,(AFB,),deoxynivalenol(DON),zearalenone(ZEA) and ochratoxin A(OTA) in the ingredients and complete feeds.Results:DON and ZEA were the most prevalent mycotoxins found.DON was detected at percentages of 93,92,54,100 and 97%with a mean level of 1.01,0.44,0.05,1.36 and 0.65 ppm in the samples of corn,wheat bran,soybean meal,DDGS and complete feeds,respectively.The detected percentages of ZEA were 100,100,54,100 and 100 with mean levels of 109.1,14.9,9.2,882.7 and 58.9 ppb in the same samples.In the wheat bran and soybean meal samples,the content of all four mycotoxins were below the maximum limits set by Chinese regulations while the percentage of samples that exceeded regulatory limits were 7,57 and 7%for corn,and 7,14 and 3%for the complete feeds for AFB,,DON and OTA respectively.DDGS showed the most serious mycotoxin contamination and the percentage of samples that exceeded regulatory limits were 6,88 and 41%,for AFB,,DON and ZEA,respectively.Conclusions:This paper is the first to present data on the natural occurrence of AFB,,DON,ZEA and OTA in ingredients and complete feeds obtained from swine farms in China's Beijing region.The data shows that feed ingredients and complete swine feeds obtained from these farms are most often contaminated with DON followed by contamination with AFB,and ZEA. | Xiaoying Li Lihong Zhao Yu Fan Yaxiong Jia Lei Sun Shanshan Ma Cheng Ji Qiugang Ma Jianyun Zhang | 2014 | Journal of Animal Science and Biotechnology2014，5，4： | 7 |
| 10 | Alleviation of mycotoxin biodegradation agent on zearalenone and deoxynivalenol toxicosis in immature gilts显示文摘Background: The current study was carried out to evaluate the effects of mycotoxin biodegradation agent(MBA, composed of Bacillus subtilis ANSB01 G and Devosia sp. ANSB714) on relieving zearalenone(ZEA) and deoxynivalenol(DON) toxicosis in immature gilts.Methods: A total of forty pre-pubertal female gilts(61.42 ± 1.18 kg) were randomly allocated to four diet treatments: CO(positive control); MO(negative control, ZEA 596.86 μg/kg feed and DON 796 μg/kg feed);COA(CO + 2 g MBA/kg feed); MOA(MO + 2 g MBA/kg feed). Each treatment contained 10 replicates with 1 gilt per replicate. Gilts were housed in an environmentally controlled room with the partially slatted floor.Results: During the entire experimental period of 28 d, average daily gain(ADG) and average daily feed intake(ADFI)of gilts in MO group was significantly reduced compared with those in CO group. The vulva size of gilts was significantly higher in MO group than CO group. In addition, significant increases in the plasma levels of Ig A,Ig G, IL-8, IL-10 and PRL were determined in MO group compared with that in CO group. ZEA and DON in the diet upregulated apoptotic caspase-3 in ovaries and uteri, along with down-regulated the anti-apoptotic protein Bcl-2 in ovaries. The supplementation of MBA into diets co-contaminated with ZEA and DON significantly increased ADG, decreased the vulva sizes, reduced the levels of Ig G, IL-8 and PRL in plasma, and regulated apoptosis in ovaries and uteri of gilts.Conclusions: The present results indicated that feeding diet contaminated with ZEA and DON simultaneously(596.86 μg/kg + 796 μg/kg) had detrimental effects on growth performance, plasma immune function and reproductive status of gilts. And MBA could reduce the negative impacts of these two toxins, believed as a promising feed additive for mitigating toxicosis of ZEA and DON at low levels in gilts. | Donghui Shi Jianchuan Zhou Lihong Zhao Xiaoping Rong Yu Fan Humera Hamid Wenqiang Li Cheng Ji Qiugang Ma | 2018 | Journal of Animal Science and Biotechnology2018，9，3： | 7 |
| 11 | Precipitation behaviors of X70 acicular ferrite pipeline steel显示文摘The morphology, structure, and chemical composition of precipitates in the final microstructure of Nb-V-Ti microalloyed X70 acicular ferrite pipeline steel were investigated using transmission electron microscopy (TEM) and energy dispersive X-ray spectroscopy (EDS). Precipitates observed by TEM can be classified into two groups. The large precipitates are complex compounds that comprise square-shaped TiN precipitate as core with fine Nb-containing precipitate nucleated on pre-existing TiN precipitate as caps on one or more faces at high temperature. In contrast, the fine and spherical Nb carbides and/or carbonitrides precipitate heterogene-ously on dislocations and sub-boundaries at low temperature. From the analysis in terms of thermodynamics, EDS and chemical composition of the steel, NbC precipitation is considered to be the predominant precipitation behavior in the tested steel under the processing conditions of this research. | Hao Yu Yi Sun Qixiang Chen Haitao Jiang Lihong Zhang | 2006 | Journal of University of Science and Technology Beijing2006，13，6： | 6 |
| 12 | Alteration of the microRNA expression profile and identification of miRNA/mRNA negative regulation pairs in neural tube defects显示文摘MicroRNAs (miRNAs) are small, noncoding transcripts, and ~22 nucleotides long, which belong to a class of endogenous small regulatory RNA molecules that target mRNAs and trigger either translational suppression or mRNA degradation [1–3]. Several studies have shown that miRNAs play crucial roles in neurogenesis and development of nervous system [4,5] and have distinct expression patterns within the developing brain and central nervous system (CNS)[6]. Abnormal expression of miRNAs has also been reported in dysregulated neural tube (NT) development including NT defects (NTDs)[7,8]. To date, however, all NTD-related miRNA profiles were obtained from different microarray platforms, which always contain limited probes, and the data obtained are less precise in quantitative analysis. No quantitatively profiled global miRNA expression in mouse NTD fetuses has been characterized so far. To gain further insight of the possible roles of miRNAs in NTDs, we used deep sequencing to carry out a comprehensive survey of miRNA expression in all-trans retinoic acid (RA)-induced NTD mouse fetuses collected from three different embryonic time points (E8.5, E9.5, and E10.5). This study is the first, to our knowledge, to report the deep sequencing miRNA profile, which defined unique gene expression signatures of a range of miRNAs and their potential regulatory networks in response to RA stress and the development of NTDs in mouse model. | Juan Zhang Lihong Yang Juan Yu Qiaoyan Yang Jianbing Mu Jun Xie | 2019 | Acta Biochimica et Biophysica Sinica2019，51，7： | 6 |
| 13 | Notch signaling in the differentiation of MEE cells from the developing mouse palate显示文摘 | Yanping Zhang Jixia Chai Yi Qiu Meihua Zhang Lihong Zhang Jianchun Yu | 2014 | Acta Biochimica et Biophysica Sinica2014，46，4： | 5 |
| 14 | Estimation of bioaccessibility and potential human health risk of mercury in Chinese patent medicines显示文摘Mercury(Hg), mainly in cinnabar species, has been used in medicine for thousands of years in China, and worldwide concern has been raised on its toxicity. In this work, the amount of bioaccessible mercury in 16 Chinese patent medicines(CPMs) was measured by using an in vitro simulated digestion system, consisting of simulated gastric and intestinal fluid, to investigate the bioavailability of mercury in CPMs and evaluate its potential risk to human health. Total mercury and mercury in the gastrointestinal extracts were measured by inductively coupled plasma mass spectrometry(ICP-MS). The levels of total Hg in 16 CPMs ranged from not detected to 11.89 mg/g, with a mean value of 1.13 mg/g, while the extractable Hg ranged from not detected to 4.37 μg/g, with a mean value of 0.42 μg/g.Mercury bioaccessibility varied significantly in the investigated CPMs, depending on the ingredient. Compared to the CPMs without cinnabar(2.5%–30.9%), the percentage of mercury in the gastrointestinal supernatants for CPMs with cinnabar was quite a bit lower(0.037%). By comparing with the Food and Agricultural Organization/World Health Organization Joint Expert Committee on Food Additives(FAO/WHO) safety guideline, the average daily intake dose(ADD) of Hg in the medicines was then calculated to access the risk of mercury to human health from taking CPMs. | Lihong Liu Yu Zhang Zhaojun Yun Bin He Guibin Jiang | 2016 | Journal of Environmental Sciences2016，28，1： | 5 |
| 15 | Dissecting human embryonic skeletal stem cell ontogeny by single-cell transcriptomic and functional analyses显示文摘Human skeletal stem cells(SSCs)have been discovered in fetal and adult long bones.However,the spatiotemporal ontogeny of human embryonic SSCs during early skeletogenesis remains elusive.Here we map the transcriptional landscape of human limb buds and embryonic long bones at single-cell resolution to address this fundamental question.We found remarkable heterogeneity within human limb bud mesenchyme and epithelium,and aligned them along the proximal-distal and anterior-posterior axes using known marker genes.Osteo-chondrogenic progenitors first appeared in the core limb bud mesenchyme,which give rise to multiple populations of stem/progenitor cells in embryonic long bones undergoing endochondral ossification.Importantly,a perichondrial embryonic skeletal stem/progenitor cell(eSSPC)subset was identified,which could self-renew and generate the osteochondral lineage cells,but not adipocytes or hematopoietic stroma.eSSPCs are marked by the adhesion molecule CADM1 and highly enriched with FOXP1/2 transcriptional network.Interestingly,neural crest-derived cells with similar phenotypic markers and transcriptional networks were also found in the sagittal suture of human embryonic calvaria.Taken together,this study revealed the cellular heterogeneity and lineage hierarchy during human embryonic skeletogenesis,and identified distinct skeletal stem/progenitor cells that orchestrate endochondral and intramembranous ossification. | Jian He Jing Yan Jianfang Wang Liangyu Zhao Qian Xin Yang Zeng Yuxi Sun Han Zhang Zhijie Bai Zongcheng Li Yanli Ni Yandong Gong Yunqiao Li Han He Zhilei Bian Yu Lan Chunyu Ma Lihong Bian Heng Zhu Bing Liu Rui Yue | 2021 | Cell Research2021，31，7： | 5 |
| 16 | Acupoint combinations used for treatment of Alzheimer's disease: A data mining analysis显示文摘OBJECTIVE: To identify the acupoint combinations used in the treatment of Alzheimer's disease(AD).METHODS: The clinical literature regarding acupuncture and moxibustion for AD was searched and collected from databases including Chinese Biomedical Medicine, China National Knowledge Infrastructure, Wanfang Database and PubMed. The database of acupuncture and moxibustion prescriptions for AD was established by using Excel software so as to conduct the descriptive analysis, association analysis on the data.RESULTS: Baihui(GV 20), Sishencong(EX-HN 1),Shenmen(HT 7), Zusanli(ST 36), Neiguan(PC 6),Fengchi(GB 20), Taixi(KI 3), Dazhui(GV 14), Shenshu(BL 23), Sanyinjiao(SP 6), Shenting(GV 24), Fenglong(ST 40), Xuanzhong(GB 39), Shuigou(GV 26)and Taichong(LR 3) were of higher frequency in the treatment of AD with acupnucture and moxibustion. Most acupoints were selected from the Governor Vessel. The commonly used acupoints were located on the head, face, neck and lower limbs. The combination of the local acupoints with the distal ones was predominated. The crossing points among the specific points presented the advantage in the treatment. The association analysis indicated that the correlation among Fengchi(GB 20)-Baihui(GV 20) was the strongest, followed by combinations of Dazhui(GV 14)-Baihui(GV 20), Shenshu(BL 23)-Baihui(GV 20) and Neiguan(PC 6)-Baihui(GV 20) and indicated the common rules of the clinical acupoint selection and combination for AD.CONCLUSION: Our findings provide a reference for acupoints selection and combination for AD in clinical acupuncture practice. | Yu Chaochao Wang Li Kong Lihong Shen Feng Ma Chaoyang Du Yanjun Zhou Hua | 2018 | Journal of Traditional Chinese Medicine2018，38，6： | 4 |
| 17 | A Joint Learning Framework for the CCKS-2020 Financial Event Extraction Task显示文摘This paper presents a winning solution for the CCKS-2020 financial event extraction task, where the goal is to identify event types, triggers and arguments in sentences across multiple event types. In this task, we focus on resolving two challenging problems(i.e., low resources and element overlapping) by proposing a joint learning framework, named SaltyFishes. We first formulate the event extraction task as a joint probability model. By sharing parameters in the model across different types, we can learn to adapt to low-resource events based on high-resource events. We further address the element overlapping problems by a mechanism of Conditional Layer Normalization, achieving even better extraction accuracy. The overall approach achieves an F1-score of 87.8% which ranks the first place in the competition. | Jiawei Sheng Qian Li Yiming Hei Shu Guo Bowen Yu Lihong Wang Min He Tingwen Liu Hongbo Xu | 2021 | Data Intelligence2021，3，3： | 4 |
| 18 | Effects of different nuclear transfer and activation methods on the development of mouse somatic cell cloned embryos显示文摘A group of adult somatic cell cloned mice were obtained by using cumulus cells as nuclei donor cells. To study the effect of different nuclear transfer (NT) and activation methods on the development of mouse cloned embryos, embryos were reconstructed using two traditional NT methods (electrofusion and direct injection) and four activation treatments (electric pulse, ethanol, SrCl2 and electric pulse combined with SrCl2). The data showed that the efficiency of reconstruction using the direct injection method is significantly higher (90.7%) than that of the electrofusion method (49.7%). Parthenogenetic embryos can develop to blastocyst stage with three activation conditions, including ethanol, electric pulse and SrCl2; however, the rates of development to blastocyst after ethanol and electric pulse acti-vation (52.4%, 54.2%) are significantly lower than after SrCl2 activation (76.9%). Treatment of embryos for 6 h with 10 mmol/L SrCl2 was found to be the best condition for activation of parthenogenetic as well as reconstructed embryos. By contrast, reconstructed embryos failed to develop to blastocyst stage after being activated by ethanol. The use of either injection or electrofusion for embryo reconstruction affected the pre-implantation development. However, after transfer in pseudopregnant mice, cloned mice were obtained from both methods. | Wang ErYao YU Yang Li XueMei JIAO LiHong Wang Liu | 2007 | Chinese Science Bulletin2007，52，2： | 4 |
| 19 | Impact effects on fused quartz glass by ground simulating hypervelocity space debris显示文摘The optical attenuation of fused silica glass impacted by high-speed micro-particle was studied.The high-speed impact test was carried out using a laser-driven flyer system which accelerated 16 ?m-thick flyer to high speed of 3.7 km s?1.Scanning electron microscopy and optical microscopy were used to characterize the damage morphology of the impacted surface.The transmittance of the impacted glass samples was measured by means of UV/VIS double beam spectrophotometer.It was found that the transmittance of the impact region decreased due to the formation of structural defects such as crater,ejecta and micro-crack on the surface.A mathematic formula was established to explain the relationship between glass optical properties and the damaged modes,which aids to describe optical degradation and design long life optical equipments used in spacecrafts under space particles environment. | SONG LiHong WEI Qiang BAI Yu GAO Cheng | 2013 | Chinese Science Bulletin2013，58，7： | 4 |
| 20 | Asymptotic Behavior of Solutions for a Class of Retarded Difference Equations | Huang Lihong Yu Jianshe Dai Binxiang Department of Applied Mathematics, Hunan University, Changsha 410082, China | 1998 | Acta Mathematica Sinica,English Series1998，14，3： | 4 |
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