| 1 | Endogenous adult neurogenesis and cognitive function recovery following traumatic brain injury in the rat hippocampus显示文摘BACKGROUND:Endogenous neural progenitor cells play a beneficial role for cognitive recovery following traumatic brain injury.However,there are few classification-control studies aimed at varying graded brain trauma.OBJECTIVE:To observe the effects of adult endogenous neurogenesis on cognitive function repair and regeneration of neural progenitor cells following varying graded traumatic hippocampal injury to determine the significance of endogenous neurogenesis in the repair of brain injury.DESIGN,TIME AND SETTING:A randomized,controlled,animal experiment was performed at the Key Laboratory of Injuries,Variations and Regeneration of Nervous System,Tianjin Medical University General Hospital,from February to October 2009.MATERIALS:Mouse anti-rat 5-bromodeoxyuridine (BrdU) and neuronal nuclei (NeuN) monoclonal antibodies were purchased from Millipore Corporation,USA.METHODS:A total of 45 Wistar rats were randomly assigned to three groups.Mild and severe injury groups were respectively subjected to (182 ± 2) kPa and (284 ± 4) kPa lateral fluid percussion to establish models of brain injury,and the control group was subjected to surgery with no lateral fluid percussion.MAIN OUTCOME MEASURES:Cognitive function was estimated using the Morris water maze.Proliferation,survival,and differentiation of newly generated cells in the injured hippocampus were observed through the use of immunofluorescent staining.RESULTS:At 7 days post-injury,the number of BrdU+ cells in the hippocampal dentate gyrus significantly increased in the mild and severe injury groups compared with the control group (P < 0.01).At 61 days post-injury,the number of BrdU+/NeuN+ cells in the hippocampal dentate gyrus was significantly greater in the mild injury group compared with the severe injury and control groups (P < 0.01).In addition,the control group exhibited the greatest proportion of surviving cells that differentiated into mature neurons compared with the injury groups (P < 0.01).Moreover,at 61 days post-injury,cognitive function in rats with mild injury recovered to normal levels,whereas the severe injury group exhibited cognitive deficits (P < 0.01).CONCLUSION:Traumatic brain injury may be a stimulation factor for proliferation of neural progenitor cells in the adult hippocampus but severe brain trauma does not lead to an increased number of newly generated cells.Endogenous adult neurogenesis repairs neurological functions to an extent.However,recovery of neurological function remains limited following severe traumatic brain injury. | Wangmiao Zhao Linchun Huan Yan Zhao Jie Zhao Qi Zhang Lin Zhang Rong Yan Shuyuan Yang Xinyu Yang | 2010 | Neural Regeneration Research2010，5，9： | 2 |
| 4 | High sensitivity ratiometric fluorescence temperature sensing using the microencapsulation of CsPbBr3 and K2SiF6:Mn4+phosphor显示文摘A dual emission sensing film has been prepared for colorimetric temperature sensing using CsPbBr_(3)perovskite nanocrystals(CsPbBr_(3)NCs)and manganese doped potassium fluorosilicate(K_(2)SiF_(6):Mn^(4+),KSF)encapsulated in polystyrene by a microencapsulation strategy.The CsPbBr_(3)-KSF-PS film shows good temperature sensing response from 30℃to 70℃,with a relative temperature sensitivity(Sr)up to 10.31%℃^(−1) at 45℃.Meanwhile,the film maintains more than 95%intensity after 6 heating-cooling cycles and keeps its fluorescence characteristics after 3 months.The film can be used to monitor temperature change by naked eye under a UV lamp.In particular,the temperature discoloration point of the sensing film can be controlled by the ratio change of CsPbBr_(3):KSF to expand its applications.The study of the CsPbBr_(3)-KSF-PS sensing mechanism in this work is helpful to provide effective strategies for the design of reliable,high sensitivity and stable temperature sensing system using CsPbBr_(3)NCs. | Jingwen Jin Jie Lin Yipeng Huang Linchun Zhang Yaqi Jiang Dongjie Tian Fangyuan Lin Yiru Wang Xi Chen | 2022 | Chinese Chemical Letters2022，33，11： | 1 |
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