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| 1 | Chinese deserts and sand fields in Last Glacial Maximum and Holocene Optimum显示文摘The Last Glacial Maximum (LGM, c. 26-16 ka) and the Holocene Optimum (HO, c. 9-5 ka) were characterized by cold-dry and warm-wet climates respectively in the recently geological Earth. How Chinese deserts and sand fields responded to these distinctive climatic changes is still not clear, however. To reconstruct environments of the deserts and sand fields during the LGM and HO is helpful to understand the forcing mechanisms of environment change in this arid region, and to test paleoclimatic modeling results. Through our long-term field and laboratory investigations, 400 optically stimulated luminescence (OSL) ages and more than 100 depositional records in the Chinese deserts and sand fields were obtained; on the basis of these data, we reconstruct spatial distributions of the deserts and sand fields during the LGM and HO. Our results show that the sand fields of Mu Us, Hunshandake, Horqin and Hulun Buir in northern and northeastern China had expanded 25%, 37%, 38% and 270%, respectively, during the LGM; the sand fields of Gonghe in the northeastern Qinghai-Tibetan Plateau had expanded 20%, and the deserts of Badain Jaran, Tengger in central northern China had expanded 39% and 29% separately during the LGM; the deserts of Taklimakan, Gurbantünggüt and Kumtag in northwestern China had expanded 10%-20% respectively, compared to their modern areas. On the other hand, all of the sand fields were nearly completely covered by vegetation during the HO; the deserts in northwestern and central northern China were reduced by around 5%-20% in area during this time. Lakes in this arid region were probably expanded during the HO but this conclusion needs more investigation. Compared with the geological distributions of deserts and sand fields, human activity has clearly changed (expanded) the area of active sand dunes at the present time. Our observations show that environmental conditions of Chinese deserts and sand fields are controlled by regional climate together with human activity. | LU HuaYu YI ShuangWen XU ZhiWei ZHOU YaLi ZENG Lin ZHU FangYing FENG Han DONG LiNa ZHUO HaiXin YU KaiFeng MASON Joseph WANG XiaoYong CHEN YingYong LU Qi WU Bo DONG ZhiBao QU JianJun WANG XunMing GUO ZhengTang | 2013 | Chinese Science Bulletin2013，58，23： | 40 |
| 2 | Screening and breeding of high taxol producing fungi by genome shuffling显示文摘To apply the fundamental principles of genome shuffling in breeding of taxol-producing fungi, Nodulisporium sylviform was used as starting strain in this work. The procedures of protoplast fusion and genome shuffling were studied. Three hereditarily stable strains with high taxol production were obtained by four cycles of genome shuffling. The qualitative and quantitative analysis of taxol produced was confirmed using thin-layer chromatography (TLC), high performance liquid chromatography (HPLC) and LC-MS. A high taxol producing fungus, Nodulisporium sylviform F4-26, was obtained, which produced 516.37 μg/L taxol. This value is 64.41% higher than that of the starting strain NCEU-1 and 31.52%―44.72% higher than that of the parent strains. | ZHAO Kai, PING WenXiang, ZHANG LiNa, LIU Jun, LIN Yan, JIN Tao & ZHOU DongPo Laboratory of Microbiology, College of Life Science, Heilongjiang University, Harbin 150080, China | 2008 | Science China(Life Sciences)2008，51，3： | 25 |
| 3 | Interaction between Rice stripe virus Disease- Specific Protein and Host PsbP Enhances Virus Symptoms显示文摘瑞斯条纹病毒(RSV ) 在许多东方亚洲国家在 Oryza sativa (米饭) 引起严重疾病。RSV 的疾病特定的蛋白质(SP ) 是非结构的蛋白质,它在米饭植物的 accumulationlevel 被显示决定 RSV 症状的严厉。这里,我们在米饭或 Nicotiana benthamiana 独自一个的 RSVSP 的那表情没生产可见症状的现在的证据。然而,在这二植物的 SP 的表示提高了 RSV- 或土豆病毒 X (PVX ) 导致了症状。通过酵母二混血儿的屏蔽, GST 下拉,和双分子的荧光互补试金,我们证明 RSV SP 与 PsbP 交往了, 23-kDa 演变氧的复杂蛋白质,在米饭和 N。benthamiana。而且,我们的调查证明在两植物的 PsbP 表示的 silencing 增加了疾病症状 severityand 病毒累积。共焦的显微镜学使用 N。benthamiana 原物证明 PsbP 在野类型的 N 在叶绿体主要积累了。benthamiana 房间。面对 RSV SP,大多数 PsbP 被招募进 assayed 房间的细胞质。另外, accumulationof SP 在 RSV 感染期间导致了叶绿体结构和功能的改变。我们的调查结果使位于 RSV 疾病症状 development.Key 词下面的 molecularmechanism 清楚些: | Lingfang Kong Jianxiang Wu Lina Lu Yi Xu Xueping Zhou | 2014 | Molecular Plant2014，7，4： | 13 |
| 4 | The calcium-dependent kinase OsCPK24 functions in cold stress responses in rice显示文摘Calcium-dependent protein kinases(CPKs)are serine/threonine protein kinases that function in plant stress responses. Although CPKs are recognized as key messengers in signal transduction, the specific roles of CPKs and the molecular mechanisms underlying their activity remain largely unknown. Here, we characterized the function of Os CPK_(24), a cytosol-localized calciumdependent protein kinase in rice. Os CPK_(24) was universally and highly expressed in rice plants and was induced by cold treatment. Whereas Os CPK_(24) knockdown plants exhibited increased sensitivity to cold compared to wild type(WT), Os CPK_(24)-overexpressing plants exhibited increased cold tolerance. Plants overexpressing Os CPK_(24) exhibited increased accumulation of proline(an osmoprotectant) and glutathione(an antioxidant) and maintained a higher GSH/GSSG(reduced glutathione to oxidized glutathione) ratio during cold stress compared to WT. In addition to these effects in response to cold stress, we observed the kinase activity of Os CPK_(24) varied under different calcium concentrations. Further,Os CPK_(24) phosphorylated Os Grx_(10), a glutathionedependent thioltransferase, at rates modulated by changes in calcium concentration. Together, our results support the hypothesis that Os CPK_(24) functions as a positive regulator of cold stress tolerance in rice, a process mediated by calcium signaling and involving phosphorylation and the inhibition of Os Grx_(10) to sustain higher glutathione levels. | Yu Liu Chunjue Xu Yanfen Zhu Lina Zhang Taiyu Chen Fei Zhou Hao Chen Yongjun Lin | 2018 | Journal of Integrative Plant Biology2018，60，2： | 12 |
| 5 | Protein microarrays for systems biology显示文摘系统生物学为在系统水平上理解生物系统拿钥匙。它最后为象癌症,糖尿病,肥胖,心理混乱,和许多其它那样的复杂疾病的治疗和痊愈拿钥匙。-omics' 技术例如 genomics, transcriptomics, proteomics,和 metabonomics,在系统生物学的主要驱动力之中。是展示了高产量,使小型化,并且能够平行分析,蛋白质 microarrays 已经为系统成为了一个重要技术平台生物学。在这评论,我们将用蛋白质 microarrays 集中于系统水平或生物系统的全球分析。蛋白质 microarrays 的四种主要类型将被讨论:proteome microarrays,抗体 microarrays,反向阶段的蛋白质数组,和 lectin microarrays。我们将也为系统生物学讨论挑战和蛋白质 microarray 技术和他们的应用的未来方向。我们强烈相信蛋白质 microarrays 将很快为系统生物学成为一个不可缺少、无价的工具。 | Lina Yang | 2011 | Acta Biochimica et Biophysica Sinica2011，43，3： | 9 |
| 6 | XBP-1u suppresses autophagy by promoting the degradation of FoxO1 in cancer cells显示文摘Autophagy 被激活响应滋养的饥饿维持细胞的精力动态平衡。然而, autophagy 固执地没被激活,它糟糕在机械学的水平被理解。这里,我们报导 FoxO1 的那周转涉及夫酸安饥饿引起的动态 autophagic 过程。X-box-binding protein-1u (XBP-1u ) 由招募在 FoxO1 降级有一个关键角色 FoxO1 到 20S proteasome。另外,由 Ser61 和 Ser176 上的细胞外的调整蛋白质 kinases1/2 (ERK1/2 ) 的 XBP-1u 的 phosphorylation 被发现在夫酸安饥饿之上为在 XBP-1u 和 FoxO1 之间的增加的相互作用批评。而且,引起 FoxO1 的持续水平和 autophagy 的坚持的激活的 XBP-1u 击倒,在房间生存能力导致重要减少。最后,在 XBP-1u 之间的反的关联和 FoxO1 表示同意很好,表示侧面在许多人的癌症纸巾观察了。因此,我们的调查结果连接到 XBP-1u-induced FoxO1 的 autophagy 的动态过程降级。 | Ying Zhao Xue Li Mu-Yan Cai Ke Ma Jing Yang Jingyi Zhou Wan Fu Fu-Zheng Wei Lina Wang Dan Xie Wei-Guo Zhu | 2013 | Cell Research2013，23，4： | 8 |
| 7 | Platelet-rich plasma accelerates skin wound healing by promoting re-epithelialization显示文摘Background:Autologous platelet-rich plasma(PRP)has been suggested to be effective for wound healing.However,evidence for its use in patients with acute and chronic wounds remains insufficient.The aims of this study were to comprehensively examine the effectiveness,synergy and possible mechanism of PRP-mediated improvement of acute skin wound repair.Methods:Full-thickness wounds were made on the back of C57/BL6 mice.PRP or saline solution as a control was administered to the wound area.Wound healing rate,local inflammation,angiogenesis,re-epithelialization and collagen deposition were measured at days 3,5,7 and 14 after skin injury.The biological character of epidermal stem cells(ESCs),which reflect the potential for re-epithelialization,was further evaluated in vitro and in vivo.Results:PRP strongly improved skin wound healing,which was associated with regulation of local inflammation,enhancement of angiogenesis and re-epithelialization.PRP treatment significantly reduced the production of inflammatory cytokines interleukin-17A and interleukin-1β.An increase in the local vessel intensity and enhancement of re-epithelialization were also observed in animals with PRP administration and were associated with enhanced secretion of growth factors such as vascular endothelial growth factor and insulin-like growth factor-1.Moreover,PRP treatment ameliorated the survival and activated the migration and proliferation of primary cultured ESCs,and these effects were accompanied by the differentiation of ESCs into adult cells following the changes of CD49f and keratin 10 and keratin 14.Conclusion:PRP improved skin wound healing by modulating inflammation and increasing angiogenesis and re-epithelialization.However,the underlying regulatory mechanism needs to be investigated in the future.Our data provide a preliminary theoretical foundation for the clinical administration of PRP in wound healing and skin regeneration. | Pengcheng Xu Yaguang Wu Lina Zhou Zengjun Yang Xiaorong Zhang Xiaohong Hu Jiacai Yang Mingying Wang Binjie Wang Gaoxing Luo Weifeng He Biao Cheng | 2020 | Burns & Trauma2020，8，1： | 8 |
| 8 | Mett13-Mettl14 methyltransferase complex regulates the quiescence of adult hematopoietic stem cells显示文摘 | QiJason Yao Lina Sang Minghui Lin Xiujuan Yin Wenjie Dong Yuping Gong Bo O. Zhou | 2018 | Cell Research2018，28，9： | 8 |
| 9 | Facile construction of carbon dots via acid catalytic hydrothermal method and their application for target imaging of cancer cells显示文摘为了解决高温度或长反应的问题,在碳点(CD ) 的热水的合成预定,一个新奇方法基于支持的碳化由盐酸催化作用在现在的工作被开发的酸。催化的碳点的酸(ACD ) 在 200 虪箳椰嬑郢 G | Zhenggang Wang Boshi Fu Siwei Zou Bo Duan Chunyu Chang Bai Yang Xiang Zhou Lina Zhang | 2016 | Nano Research2016，9，1： | 8 |
| 10 | FXYD6: a novel therapeutic target toward hepatocellular carcinoma显示文摘FXYD6, FXYD 领域包含离子运输管理者 6,被报导了影响 Na 的活动 < 啜 class= “ a-plus-plus ” >+/K+-ATPase 并且与心理疾病被联系。这里,我们证明 FXYD6 在 hepatocellular 癌(HCC ) 是起来调整的并且提高 HCC 房间的迁居和增长。FXYD6 的起来规定不仅断然随 Na 的增加相关 < 啜 class= “ a-plus-plus ” >+/K 有它发信号的下游的 Src 英皇家空军之阶级最低之兵的激活的 +-ATPase 而且坐标小径。更重要地,显著地由它的功能的抗体堵住 FXYD6 在老鼠禁止 xenografted HCC 肿瘤的生长潜力,显示 FXYD6 代表向 HCC 的一个潜在的治疗学的目标。总的来说,我们的结果在 HCC 前进建立 FXYD6 的一个关键角色并且建议指向 FXYD6 的治疗能向 HCC 病人有益于临床的治疗。 | Qian Gao Xiongfei Chen Hongxia Duan Zhaoqing Wang Jing Feng Dongling Yang Lina Song Ningxin Zhou Xiyun Yan | 2014 | Protein & Cell2014，5，7： | 7 |
| 11 | Identification of microRNA-like RNAs in Ophiocordyceps sinensis显示文摘Ophiocordyceps sinensis is well known as a traditional Chinese medicine and has widely been used for over 2,000 years to stimulate immune system, decrease blood pressure and to inhibit tumor growth. While miRNAs are increasingly recognized for their roles in post-transcriptional regulation of gene expression in animals and plants, miRNAs in fungi were less studied until the discovery of microRNA-like RNA(milRNA). High-throughput sequencing and bioinformatics approaches were used to identify conserved and novel milRNAs in O. sinensis. 40 conserved milRNAs were identified, while 23 pre-miRNA candidates encoding 31 novel milRNAs were predicted. Furthermore, the potential target genes of milRNAs in human were predicted and gene ontology analysis was applied to these genes. Enrichment analysis of GO-represented biological process showed that target genes of both conserved and novel milRNAs are involved in development, metabolic and immune processes, indicating the potential roles of milRNAs of O. sinensis in pharmacological effects as health food and traditional Chinese medicine. This study is the first report on genome-wide analysis of milRNAs in O. sinensis and it provides a useful resource to further study the potential roles of milRNAs as active components of O. sinensis in health food or traditional Chinese medicine. | Wen Zhang Xiaona Li Lina Ma Uzair Urrehman Xilinqiqige Bao Yujing Zhang Chen-Yu Zhang Dongxia Hou Zhen Zhou | 2019 | Science China(Life Sciences)2019，62，3： | 6 |
| 12 | Distinct regulatory mechanism of immunoglobulin gene transcription in epithelial cancer cells显示文摘The restriction of immunoglobulin(Ig)expression to B lymphocytes is well established.However,several reports have confirmed that the Ig gene can be expressed in many non-B cancer cells and/or some normal cells.Our aim is to determine whether the Ig gene promoter can be activated in non-B cancer cells and to identify the regulatory mechanism for Ig gene expression.Our results show that the Ig promoter of VH4-59 was activated in several non-B cancer cell lines.Moreover,two novel positive regulatory elements,an enhancer-like element at 2800 to 2610 bp and a copromoter-like element at 2610 to 2300 bp,were identified in two epithelial cancer cell lines,HeLa S3 and HT-29.The octamer element(59-ATGCAAAT-39)located in the Ig promoter,a crucial element for B-cell-derived Ig gene transcription,was also very important for non-B-cell-derived Ig gene transcription.More importantly,we confirmed that octamer-related protein-1(Oct-1),but not Oct-2,was a crucial transcriptional factor for Ig gene transcription due to its ability to bind to the octamer element of the Ig promoter in epithelial cancer cells.These results suggested the presence of a distinct regulatory mechanism for Ig gene expression in non-B cancer cells. | Xiaohui Zhu Lina Wu Li Zhang Peng Hao Shuai Zhang Jing Huang Jie Zheng Yinan Liu Wenjun Li Yingmei Zhang Chunyan Zhou Youhui Zhang C Cameron Yin Xiaoyan Qiu | 2010 | Cellular & Molecular Immunology2010，7，4： | 5 |
| 13 | 3D printing of calcium phosphate bioceramic with tailored biodegradation rate for skull bone tissue reconstruction显示文摘The bone regenerative scaffold with the tailored degradation rate matching with the growth rate of the new bone is essential for adolescent bone repair.To satisfy these requirement,we proposed bone tissue scaffolds with controlled degradation rate using osteoinductive materials(Ca-P bioceramics),which is expected to present a controllable biodegradation rate for patients who need bone regeneration.Physicochemical properties,porosity,compressive strength and degradation properties of the scaffolds were studied.3D printed Ca-P scaffold(3DS),gas foaming Ca-P scaffold(FS)and autogenous bone(AB)were used in vivo for personalized beagle skull defect repair.Histological results indicated that the 3DS was highly vascularized and well combined with surrounding tissues.FS showed obvious newly formed bone tissues.AB showed the best repair effect,but it was found that AB scaffolds were partially absorbed and degraded.This study indicated that the 3D printed Ca-P bioceramics with tailored biodegradation rate is a promising candidate for personalized skull bone tissue reconstruction. | Boqing Zhang Huan Sun Lina Wu Liang Ma Fei Xing Qingquan Kong Yujiang Fan Changchun Zhou Xingdong Zhang | 2019 | Bio-Design and Manufacturing2019，2，3： | 5 |
| 14 | Oxidative Desulfurization of Fuel Oil at Room Temperature Catalyzed by Ordered Meso-macroporous HPW/SiO2显示文摘A serial of ordered meso-macroporous phosphotungstic acid(HPW) supported on SiO2 nanocomposites were successfully prepared by a homogeneous precipitation method, using monodispersed polystyrene(PS) microspheres and cationic surfactant as structure directing agent. These nanocomposites were used as catalysts for oxidative desulfurization(ODS) of model fuel. The materials were characterized by scanning electron microscopy(SEM), transmission electron microscopy(TEM), N2 adsorption-desorption isothrem, X-ray diffraction(XRD), and Fourier transform infrared spectra(FTIR). The characterization results suggested that the as-prepared material possessed ordered meso-macroporous architectures with Keggin type phosphotungstic acid dispersed homogeneously in SiO2 matrix. Under the selected reaction conditions, dibenzothiophene(DBT) in model fuel can be removed within 2 h at room temperature(30 ℃). In addition, only 1.2% of efficiency lose than the fresh catalyst even after 5 cycles. | 郭振冉 杜岳 雷家珩 ZHOU Lina DU Xiaodi | 2019 | Journal of Wuhan University of Technology(Materials Science)2019，34，5： | 5 |
| 15 | Effect of newly identified hTERT-interacting proteins on telomerase activity显示文摘在 telomerestelomerase 和年龄相关的疾病之间有一种靠近的关系。人的 telomerase 颠倒 transcriptase (hTERT ) 两个都是人的 telomerase 和 telomerase 活动的限制率的决定因素的催化部件。Itstranscriptional 规定是 telomerase 活动的控制的主要模式。为探索 hTERT 表示和 telomerase 活动的规章的机制发现蛋白质 interactingwith hTERT 是批评的。在这研究, theyeast 二混血儿的系统被用来屏蔽 hTERT 的潜在的交互蛋白质。六蛋白质被获得, amongwhich T 星, LOXL3, HKR3,和 Par-4 被 co-immunoprecipitation.Then 进一步作为 hTERT 的交往的蛋白质证实感觉和 antisense 基因包含这四基因的真核细胞的表示向量被构造, transfectedinto 肿瘤房间排队。在这四蛋白质, hTERT 的表示水平,和 telomerase 活动的表示层次之中的关联被分析。结果证明 T 星表示和 down-regulationof HKR3 表示的起来规定导致了 hTERT 表示和 telomerase 活动的增加,当 LOXL3and Par-4 表情的起来规定和下面规定没有明显的效果时。当 HKR3 可以是一个否定管理者时,我们的结果建议 T 星与 telomeraseactivity 有积极关联。这个结论是重要的进一步探索人的 telomerase 活动的影响因素 orregulation 小径,它可能为潜在的临床的申请是很重要的。 | Lina Zhou Bing Chen Xing Hua Ping Zhou Lian Guo Yong Peng Kunhua Qiu | 2013 | Acta Biochimica et Biophysica Sinica2013，45，8： | 4 |
| 16 | Sedimentology and Sequence Stratigraphy of Marine to Lacustrine Deltaic Deposits in a Craton Basin and Their Controlling Factors: Shan 2 Member–He 8 Member(Guadalupian–Lopingian, Permian), Southeast Ordos Basin, North China显示文摘The Shan 2 Member, Shan 1 Member and He 8 Member of the Mid–Late Permian Shanxi and lower Xiashihezi formations, in the southeastern Ordos Basin, together comprise ~150 m of deltaic deposits. This sequence records an overall evolution from deep marine environment to shallow lake associated with braided river, braided river delta and meandering river delta. Core description, well log interpretation, and stable isotope analysis, including carbon, oxygen and strontium, were conducted to understand the sedimentary evolution of Shan 2 to He 8 Member. The Shanxi Formation, which consists of the Shan 2 and Shan 1 members, is characterized by a tidal-influenced meandering river delta environment and a higher δ^(13)C value and ^(87)Sr?(^(86)Sr) ratio and a lower δ^(18)O value. The He 8 Member, the basal part of the Xiashihezi Formation, is featured by a braided river to braided river delta system and a lower δ^(13)C value, ^(87)Sr?(^(86)Sr) ratio, and a higher δ^(18)O value. Four third-order depositional sequences separated by five sequence boundaries are determined. Coarsening upward sequences of the Shan 2 Member–He 8 Member indicate a general regression trend, which can be correlated to global sea-level fall occurring during the Roadian–Wuchiapingian, as also evidenced by previous published zircon U–Pb results. The coal-bearing sequence(Shanxi Formation) to non-coal-bearing sequence(He 8 Member), as well as a decrease of ^(87)Sr?(^(86)Sr), suggest a trend from humid to arid climates. A combined effect of sea-level drop and a small uplift at the end of Shanxi Formation are proposed. | SHAN Xin YU Xinghe Peter CLIFT LI Yalong JIN Lina SU Dongxu DU Yonghui ZHOU Jinsong HAN Xiaoqin | 2018 | Acta Geologica Sinica(English Edition)2018，92，1： | 4 |
| 17 | Mutant p53 increases exosome-mediated transfer of mi R-21-3p and mi R-769-3p to promote pulmonary metastasis显示文摘Objective: Tumor metastasis is a complex, multistep process that depends on tumor cells and their communication with the tumor microenvironment. A p53 gain-of-function mutant has been shown to enhance the tumorigenesis, invasion, and metastasis abilities of tumor cells. This study aimed to investigate the roles of p53 R273 H mutation in the tumor microenvironment.Methods: The in vitro and in vivo effects of the p53 R273 H mutant on the invasion and metastasis of HCT116 cells were investigated. Exosomes from wild-type and HCT116-TP53(R273 H) cells were cocultured with mouse embryonic fibroblasts(MEFs). The roles of differentially expressed exosomal micro RNAs identified by microarray analysis were investigated. The functions of the p53 R273 H mutant in tumor cells were also investigated via gene expression microarray and quantitative polymerase chain reaction(q PCR) analyses.Results: Introducing p53 R273 H mutant into HCT116 cells significantly potentiated pulmonary metastasis in vivo. In the presence of exosomes derived from HCT116-TP53(R273 H) cells, the exosomes were taken up by MEFs and became activated. Microarray analysis showed that the p53 R273 H mutation increased the exosomal levels of mi R-21-3 p and mi R-769-3 p. Intriguingly, in clinical samples, mi R-21-3 p and mi R-769-3 p levels were significantly higher in patients with a p53 mutation than in those without this mutation. Furthermore, both mi R-21-3 p and mi R-769-3 p activated fibroblasts and exerted a synergistic effect via their target genes on the transforming growth factor-β(TGF-β)/Smad signaling pathway. The activated fibroblasts excreted cytokine TGF-β and may have reciprocally induced cancer cells to undergo epithelial-mesenchymal transition(EMT). Indeed, HCT116-TP53(R273 H) cells showed increased expression of ZEB1 and SNAI2 and decreased transcription of several cell adhesion molecules.Conclusions: The mutant p53-exosomal mi R-21-3 p/mi R-769-3 p-fibroblast-cytokine circuit appears to be responsible for communication between tumor and stromal cells, with exosomal mi RNAs acting as a bridge. mi R-21-3 p and mi R-769-3 p are potential predictive markers of pulmonary metastasis and candidate targets for therapeutic interventions. | Qiang Ju Lina Zhao Jiajia Gao Lanping Zhou Yang Xu Yulin Sun Xiaohang Zhao | 2019 | Chinese Journal of Cancer Research2019，31，3： | 4 |
| 18 | A complete genome assembly of Glaciecola mesophila sp. nov. sequenced by using BIGIS-4 sequencer system显示文摘Using a pyrosequencing-based custom-made sequencer BIGIS-4, we sequenced a Gram-negative bacterium Glaciecola mesophila sp. nov. (Gmn) isolated from marine invertebrate specimens. We generated 152043 sequencing reads with a mean high-quality length of 406 bp, and assembled them using the BIGIS-4 post-processing module. No systematic low-quality data was detected beyond expected homopolymer-derived errors. The assembled Gmn genome is 5144318 bp in length and harbors 4303 annotated genes. A large number of metabolic genes correspond to various nutrients from surface marine invertebrates. Its abundant cold-tolerant and cellular signaling and related genes reveal a fundamental adaptation to low-temperature marine environment. | YUAN LiNa REN LuFeng LI YunTao HAN WeiJing YU Yong CHU YaNan LIU GuiMing YU Dan TENG MingJing WANG Liang WANG XuMin ZHOU XiaoGuang YU YuDe YU Jun | 2011 | Science China(Life Sciences)2011，54，9： | 4 |
| 19 | Extraction and back-extraction behaviors of 14 rare earth elements from sulfuric acid medium by TODGA显示文摘The unique physical and chemical properties of rare earth elements lay the foundation for their extensive application. N,N,N',N' Tetra-octyl-3-oxopentanediamide(TODGA) is excellent in its ability of extracting rare earth elements and it is favored for green initiative. In this paper, the extraction and back-extraction of14 rare earth elements by TODGA were studied. Experiments show that in conditions of 6 mol/L sulfuric acid, the extraction temperature of 25 ℃,the phase ratio of 1:1 and 0.04 mol/LTODGA(aviation kerosene as the diluent), the extraction rates of 14 rare earth elements including lanthanum, cerium, praseodymium,neodymium, europium, gadolinium, terbium, dysprosium, holmium, erbium, thulium, ytterbium, lutetium, and yttrium were 99.00%-99.73%. Mixed with hydrochloric acid and nitric acid(HCl 3.5 mol/L, HNO_30.5 mol/L), the recoveries of the 14 rare earth elements are 91.52%-99.91% when the extraction temperature is 25 ℃ and the ratio is 1:1. The following application is based on the optimum conditions above with practical samples(from the roasting production line of China North Rare Earth High-tech Company Limited) for extraction and back-extraction experiments. Experiments show that TODGA has excellent enrichment effect on 14 rare earth elements, the extraction rates are 91.36%-99.80%, the back-extraction rates are 87.29%-99.64% and the total recoveries are 81.19%-99.44%. | Huiting Yuan Weixiang Hong Yushan Zhou Baisong Pu Aijun Gong Tao Xu Qishan Yang Fukai Li Lina Qiu Weiwei Zhang Yuning Liu | 2018 | Journal of Rare Earths2018，36，6： | 4 |
| 20 | Serum macrophage migration inhibitory factor as a potential biomarker to evaluate therapeutic response in patients with allergic asthma:an exploratory study显示文摘Background:Previous studies have shown that macrophage migration inhibitory factor(MIF)is involved in the pathogenesis of asthma.This study aimed to investigate whether serum MIF reflects a therapeutic response in allergic asthma.Methods:We enrolled 30 asthmatic patients with mild-to-moderate exacerbations and 20 healthy controls,analyzing the parameter levels of serum MIF,serum total immunoglobulin E(tIgE),peripheral blood eosinophil percentage(EOS%),and fractional exhaled nitric oxide(FeNO).Lung function indices were used to identify disease severity and therapeutic response.Results:Our study showed that all measured parameters in patients were at higher levels than those of controls.After one week of treatment,most parameter levels decreased significantly except for serum tIgE.Furthermore,we found that serum MIF positively correlated with EOS%as well as FeNO,but negatively correlated with lung function indices.Receiver operator characteristic(ROC)curve analysis indicated that among the parameters,serum MIF exhibited a higher capacity to evaluate therapeutic response.The area under the curve(AUC)of MIF was 0.931,with a sensitivity of 0.967 and a specificity of 0.800.Conclusions:Our results suggested that serum MIF may serve as a potential biomarker for evaluating therapeutic response in allergic asthma with mild-to-moderate exacerbations. | Huiyuan ZHU Shaochun YAN Jingshuo WU Zhong ZHANG Xiaolin LI Zheng LIU Xing MA Lina ZHOU Lin ZHANG Mingming FENG Yiwei GENG Aixin ZHANG Sabina JANCIAUSKIENE Aiguo XU | 2021 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2021，22，6： | 3 |
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