|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Apoptosis and its relationship with cell proliferation,p53,Waf1p21,bcl-2 and c-mycin esophageal carcinogenesis studied with a high-risk population in northern China显示文摘Apoptosisanditsrelationshipwithcelproliferation,p53,Waf1p21,bcl2andcmycinesophagealcarcinogenesisstudiedwithahighriskpopul... | WANG LiDong1, ZHOU Qi1, WEI JunPing1, YANG WanCai1, ZHAO Xin1, WANG LiXia1, ZOU Jian Xiang1, GAO ShanShan1, LI YongXin1 and YANG C.S.2Keywords esophageal neoplasms apoptosis precancerous lesions Waf1 p21 gene p53 | 1998 | World Journal of Gastroenterology1998，4，4： | 295 |
| 2 | Prevalence of Autism Spectrum Disorder in China:A Nationwide Multi-center Population-based Study Among Children Aged 6 to 12 Years显示文摘This study aimed to obtain the first national estimate of the prevalence of autism spectrum disorder(ASD) in Chinese children.We targeted the population of 6 to 12-year-old children for this prevalence study by multistage convenient cluster sampling.The Modified Chinese Autism Spectrum Rating Scale was used for the screening process.Of the target population of 142,086 children,88.5%(n=125,806) participated in the study.A total of 363 children were confirmed as having ASD.The observed ASD prevalence rate was 0.29%(95% CI:0.26%-0.32%) for the overall population.After adjustment for response rates,the estimated number of ASD cases was867 in the target population sample,thereby achieving an estimated prevalence of 0.70%(95% CI:0.64%-0.74%).The prevalence was significantly higher in boys than in girls(0.95%;95% CI:0.87%-1.02% versus 0.30%;95%CI:0.26%-0.34%;P <0.001).Of the 363 confirmed ASD cases,43.3% were newly diagnosed,and most of those(90.4%) were attending regular schools,and 68.8% of the children with ASD had at least one neuropsychiatric comorbidity.Our findings provide reliable data on the estimated ASD prevalence and comorbidities in Chinese children. | Hao Zhou Xiu Xu Weili Yan Xiaobing Zou Lijie Wu Xuerong Luo Tingyu Li Yi Huang Hongyan Guan Xiang Chen Meng Mao Kun Xia Lan Zhang Erzhen Li Xiaoling Ge Lili Zhang Chunpei Li Xudong Zhang Yuanfeng Zhou Ding Ding Andy Shih Eric Fombonne Yi Zheng Jisheng Han Zhongsheng Sun Yong-hui Jiang Yi Wang LATENT-NHC Study Team | 2020 | Neuroscience Bulletin2020，36，9： | 158 |
| 3 | One-step generation of p53 gene biallelic mutant Cynomolgus monkey via the CRISPR/Cas system显示文摘 | Haifeng Wan Chunjing Feng Fei Teng Shihua Yang Baoyang Hu Yuyu Niu Andy Peng Xiang Weizhen Fang Weizhi Ji Wei Li Xiaoyang Zhao Qi Zhou | 2015 | Cell Research2015，25，2： | 39 |
| 4 | Anisotropic coding metamaterials and their powerful manipulation of differently polarized terahertz waves显示文摘Metamaterials based on effective media can be used to produce a number of unusual physical properties(for example,negative refraction and invisibility cloaking)because they can be tailored with effective medium parameters that do not occur in nature.Recently,the use of coding metamaterials has been suggested for the control of electromagnetic waves through the design of coding sequences using digital elements‘0’and‘1,'which possess opposite phase responses.Here we propose the concept of an anisotropic coding metamaterial in which the coding behaviors in different directions are dependent on the polarization status of the electromagnetic waves.We experimentally demonstrate an ultrathin and flexible polarization-controlled anisotropic coding metasurface that functions in the terahertz regime using specially designed coding elements.By encoding the elements with elaborately designed coding sequences(both 1-bit and 2-bit sequences),the x-and y-polarized waves can be anomalously reflected or independently diffused in three dimensions.The simulated far-field scattering patterns and near-field distributions are presented to illustrate the dual-functional performance of the encoded metasurface,and the results are consistent with the measured results.We further demonstrate the ability of the anisotropic coding metasurfaces to generate a beam splitter and realize simultaneous anomalous reflections and polarization conversions,thus providing powerful control of differently polarized electromagnetic waves.The proposed method enables versatile beam behaviors under orthogonal polarizations using a single metasurface and has the potential for use in the development of interesting terahertz devices. | Shuo Liu Tie Jun Cui Quan Xu Di Bao Liangliang Du Xiang Wan Wen Xuan Tang Chunmei Ouyang Xiao Yang Zhou Hao Yuan Hui Feng Ma Wei Xiang Jiang Jiaguang Han Weili Zhang Qiang Cheng | 2016 | Light(Science & Applications)2016，5，1： | 36 |
| 5 | The hydrological effect between Jingjiang River and Dongting Lake during the initial period of Three Gorges Project operation显示文摘从 1951 ~ 2008 基于测量水文学数据,在 Jingjiang 河和东廷·莱克之间的链水文学效果被比较方法在三峡工程操作以后分析。结果显示那 1 ) 用 Yichang 在 78.9% 总数上面做到 Chenglingji 的 Jingjiang 河里的搜索数量,和它搜索紧张的一般水准比后者高;2 ) 在 Jingjiang 河的三个插头的水和沙转向率被 2.33% 和 2.78% 独立减少;3 ) 通过总共进东廷·莱克的三个插头的多年一般水准流量和沉积的比例分别地在 7.7% 和 24.4% 减少了;4 ) 在东廷·莱克,,沉积累积的速度被 26.7% 降低在洪水季节,流量数量是 20.2% 不到多年一般水准价值,逐年导致水的季节的缺乏。当后者在连续的年,喝的缺乏和工业水里在夏天和秋天导致了干旱时,前者延长了湖生活,装运象鸟的减少和 Microtus 的快增加那样的紧张,以及生态的问题强音;5 ) 在湖插头的沉积和洪水搬运能力的多年一般水准价值被 26.6% 和 3.7% 分别地增加,堤有效地被保护。然后,适应河湖关系的新变化,一些建议被提出例如优化三座峡水库的进一步的操作节目,再考河的想法和湖规定,和河和湖的维持的连接。 | CHANG Jiang LI Jingbao LU Dianqing ZHU Xiang LU Chengzhi ZHOU Yueyun DENG Chuxiong | 2010 | Journal of Geographical Sciences2010，20，5： | 33 |
| 6 | Phosphorus forms and distribution in the sediments of Poyang Lake,China显示文摘The forms and distribution of phosphorus in the sediments of Poyang Lake were studied using chemical extraction methods to understand the potential release and adsorption of phosphorus.The results showed that phosphorus in the sediments mainly consisted of inorganic phosphorous species, including iron bound phosphorus,calcium bound phosphorus,aluminium bound phosphorus and dissolved phosphorus,as well as organic phosphorous species.The spatial distribution of phosphorus species in surface sediments showed a decreasing trend from the outlet to the entrance of Poyang Lake.The content of total phosphorus in the surface sediments ranged from 688.29 to 825.36 mg/kg, and inorganic phosphorous was the major phosphorus species.Iron bound phosphorus was the dominant form of inorganic phosphorous,accounting for greater than 40%of the total phosphorus, while calcium bound phosphorus and aluminium bound phosphorus accounted for more than 20%, and dissolved phosphorus accounted for less than 5%.The content of organic phosphorus in surface sediments was lower,accounting for less than 15%.Total phosphorus was positively correlated with iron bound phosphorus,aluminium bound phosphorus,calcium bound phosphorus and organic phosphorous,while organic phosphorous was positively correlated with iron bound phosphorus and aluminium bound phosphorus,but only weakly related to calcium bound phosphorus.For all six sites, the contents of total phosphorus and phosphorus forms in the core sediments obviously decreased with depth,while they were significantly enriched in the surface sediments.The total phosphorus and phosphorus forms contents were significantly higher in the upper layers and had a tendency to decrease toward the bottom of the core,regardless of the phosphorus species.In addition,the average contents of total phosphorus and various phosphorus forms decreased rapidly with sediment depth from 0-20 cm,and then decreased slightly from 20-30 cm. | XIANG Su-lin ZHOU Wen-bin | 2011 | International Journal of Sediment Research2011，26，2： | 31 |
| 7 | Function of microglia and macrophages in secondary damage after spinal cord injury显示文摘Spinal cord injury(SCI) is a devastating type of neurological trauma with limited therapeutic opportunities.The pathophysiology of SCI involves primary and secondary mechanisms of injury.Among all the secondary injury mechanisms,the inflammatory response is the major contributor and results in expansion of the lesion and further loss of neurologic function.Meanwhile,the inflammation directly and indirectly dominates the outcomes of SCI,including not only pain and motor dysfunction,but also preventingneuronal regeneration.Microglia and macrophages play very important roles in secondary injury.Microglia reside in spinal parenchyma and survey the microenvironment through the signals of injury or infection.Macrophages are derived from monocytes recruited to injured sites from the peripheral circulation.Activated resident microglia and monocyte-derived macrophages induce and magnify immune and inflammatory responses not only by means of their secretory moleculesand phagocytosis,but also through their influence on astrocytes,oligodendrocytes and demyelination.In this review,we focus on the roles of microglia and macrophages in secondary injury and how they contribute to the sequelae of SCI. | Xiang Zhou Xijing He Yi Ren | 2014 | Neural Regeneration Research2014，9，20： | 31 |
| 8 | Effect of hepatocyte apoptosis induced by TNF-α on acute severe hepatitis in mouse models显示文摘AIM To study the effect of hepatocyteapoptosis and necrosis induced by TNF-α on thepathogenesis of acute severe hepatitis(ASH).METHODS The model of ASH was prepared inD-galactosamine(GAIN)sensitized BALB/c miceby injection of either endotoxin(ET)or tumornecrosis factor-α(TNF-α).Morphologicalchanges of apoptotic hepatocytes were studiedby both light and electron microscope and in siteend labeling method(ISEL).Molecular biologicalchanges of DNA ladder were observed byelectrophoresis of extract from liver tissues.Biochemical changes were measured by alanineaminotransferase(ALT),asparticaminotransferase(AST)and TNF-α.The relationbetween apoptosis and necrosis was evaluatedsimultaneously.RESULTS The sequence of hepatocyteapoptosis,necrosis,and final death from ASHwas observed both in GAIN/ET and GAIN/TNF-agroup.Apoptosis was prominent at 3.5 h and 5 hafter injection of inducer,while necrosis becamedominant at 9 h after challenge.The appearanceof apoptosis was earlier in GAIN/TNF-α groupthan that in GAIN/ ET group.Pretreatment ofmice with antiTNF IgG1 may completely preventthe liver injury induced by GalN/ET.CONCLUSION TNF-α can cause liver damageby inducing hepatic apoptosis and necrosis inmice with endotoxemia. | Guo Qing Zang Xia Qiu Zhou Hong Yu Qing Xie Guo Ming Zhao Bin Wang Qing Guo Yue Qin Xiang Dan Liao Department of Infectious Diseases,Rujin Hospital,Shanghai Second Medical University,Shanghai 200025,China | 2000 | World Journal of Gastroenterology2000，6，5： | 30 |
| 9 | High entropy defective fluorite structured rare-earth niobates and tantalates for thermal barrier applications显示文摘Rare-earth tantalates and niobates(REjTaO7 and REjNbO7)have been considered as promising candidate thermal barrier coating(TBC)materials in next generation gas-turbine engines due to their ultra-low thermal conductivity and better thermal stability than yttria-stabilized zirconia(YSZ).However,the low Vickers hardness and toughness are the main shortcomings of RE;TaO-and REjNbOr that limit their applications as TBC materials.To increase the hardness,high entropy(Yu3Ybu3Er/3)sTaOr,(Y13YbnErns)NbO,and(Sm1/6Eu1/6Y 1/6Yb1/6Lu1/6Er1/6)3(Nb1/2Ta1/2)O7 are designed and synthesized in this study.These high entropy ceramics exhibit high Vickers hardness(10.912.0 GPa),close thermal expansion coefficients to that of single-principal-component RE3TaO,and RE;NbO,(7.9×10^-6-10.8×10-6 C-1 at room temperature),good phase stability,and good chemical compatibility with thermally grown Al2O3,which make them promising for applications as candidate TBC materials. | Zifan ZHAO Heng CHEN Huimin XIANG Fu-Zhi DAI Xiaohui WANG Wei XU Kuang SUN Zhjjian PENG Yanchun ZHOU | 2020 | Journal of Advanced Ceramics2020，9，3： | 27 |
| 10 | High-entropy ceramics:Present status,challenges,and a look forward显示文摘High-entropy ceramics (HECs) are solid solutions of inorganic compounds with one or more Wyckoff sites shared by equal or near-equal atomic ratios of multi-principal elements.Although in the infant stage,the emerging of this new family of materials has brought new opportunities for material design and property tailoring.Distinct from metals,the diversity in crystal structure and electronic structure of ceramics provides huge space for properties tuning through band structure engineering and phonon engineering.Aside from strengthening,hardening,and low thermal conductivity that have already been found in high-entropy alloys,new properties like colossal dielectric constant,super ionic conductivity,severe anisotropic thermal expansion coefficient,strong electromagnetic wave absorption,etc.,have been discovered in HECs.As a response to the rapid development in this nascent field,this article gives a comprehensive review on the structure features,theoretical methods for stability and property prediction,processing routes,novel properties,and prospective applications of HECs.The challenges on processing,characterization,and property predictions are also emphasized.Finally,future directions for new material exploration,novel processing,fundamental understanding,in-depth characterization,and database assessments are given. | Huimin XIANG Yan XING Fu-zhi DAI Hongjie WANG Lei SU Lei MIAO Guojun ZHANG Yiguang WANG Xiwei QI Lei YAO Hailong WANG Biao ZHAO Jianqiang LI Yanchun ZHOU | 2021 | Journal of Advanced Ceramics2021，10，3： | 28 |
| 11 | Ability of Agrogyron elongatum to accumulate the single metal of cadmium, copper, nickel and lead and root exudation of organic acids显示文摘Agrogyron elongatum were grown in nutrient solution containing moderate to high amounts of separate heavy metal of Cd, Cu, Ni and Pb in a greenhouse for a 9-day. Cd, Cu, Ni and Pb generally led to decrease in the elongation of roots although the length of seedlings exposed to Cd and Pb at 0.05 and 0 5 mg/L showed to be slightly greater than that of controls. Of the four metals in the experiment, Pb was absorbed and accumulated to the highest level, with the concentrations of 92754 mg/kg dry weight (DW) in roots and 11683 mg/kg DW in shoots. Cd was moderately accumulated in Agrogyron elongatum, but the maximum bioaccumulation coefficients (BCs) for roots and shoots were observed. The patterns for Cu and Ni uptake and distribution in plants differed from those of Pb and Cd, as it was showed that the shoot accumulation of Cu and Ni was significantly higher than in roots. A. elongatum had the highest Ni concentration in shoots (30261 mg/kg DW) at the external concentration of 250 mg/L. Cu ranked second, with a shoot concentration of 12230 mg/kg DW when 50 mg/L Cu in solution was applied. For the four trace elements tested, the highest concentrations in shoots decreased by the order of Ni>Cu>Pb>Cd (mg/kg DW), and those in roots were Pb>Cd>Ni>Cu (mg/kg DW). Malic, oxalic and citric acids exuded by roots exposed to 1 and 50 mg/L of the metals were detected. Release of organic acids from plants significantly differed among the metal treatments. Cu was most effectively in inducing root exudation of the three types of organic acids. Cd, and Ni were also the inducers of secretion of malic and oxalic acids. With reference of Pb, a small amounts of malic and oxalic acids were detected in the root exudates, but few quantities of citric acid were found. However, no correlation between alternations in root exudation of organic acids and metal accumulation could be established. | YANG Hong 1, Jongathan W.C.Wong 2, YANG Zhi min\+1, ZHOU Li xiang 1(1. College of Science, Nanjing Agricultural University, Nanjing\ 210095, China. 2. Department of Biology, Hong Kong Baptist University, China) | 2001 | Journal of Environmental Sciences2001，13，3： | 26 |
| 12 | Cryo-electron microscopy structures of the SARS-CoV spike glycoprotein reveal a prerequisite conformational state for receptor binding显示文摘在 2002-2003 的 SARS 的全球爆发被新人的 coronavirus SARS-CoV 的感染引起。SARS-CoV 的感染主要通过病毒的表面 glycoproteins 被调停,它由 S1 和 S2 子单元组成并且在 virions 的信封上形成更整齐的尖铁。这里,我们报导处于单个粒子的 cryo 电子显微镜学决定的不同 conformational 状态更整齐的 SARS-CoV 表面尖铁的 ectodomain 结构。1 在 4.3 点决定了的符合构造?分辨率是三方面的对称并且有所有三受体绑定 C 终端域 1 (CTD1s ) S1 子单元在在位置下面。绑定下面到 SARS-CoV 受体 ACE2 的 CTD1s 不由于位的碰撞是可能的,建议 1 代表的符合构造受体绑定不活跃的状态。在 7.3, 5.7 和 6.8 点坚定的符合构造 2-4?决定都是不对称的,在哪个 RBD 旋转离开下面由不同角度到的位置一起来位置。起来 CTD1 为 ACE2 约会暴露受体绑定地点,建议符合构造 2-4 代表受体绑定活跃状态。这个 conformational 变化也为抵销指向 CTD1 的抗体的 SARS-CoV 的绑定被要求。这现象能被扩大到为受体绑定利用 S1 子单元的 CTD1 的另外的 betacoronaviruses,它提供新卓见进在感染期间更整齐的 coronavirus 熔化前尖铁的中间的状态。 | Miao Gui Wenfei Song Haixia Zhou Jingwei Xu Silian Chen Ye Xiang XinquanWang | 2017 | Cell Research2017，27，1： | 25 |
| 13 | (La0.2Ce0.2Nd0.2Sm0.2Eu0.2)2Zr2O7:A novel high-entropy ceramic with low thermal conductivity and sluggish grain growth rate显示文摘Fine grains and slow grain growth rate are beneficial to preventing the thermal stress-induced cracking and thermal conductivity increase of thermal barrier coatings.Inspired by the sluggish diffusion effect of high-entropy materials,a novel high-entropy(HE)rare-earth zirconate solid solution(La0.2Ce0.2Nd0.2Sm0.2Eu0.2)2 Zr2 O7 was designed and successfully synthesized in this work.The as-synthesized(La0.2Ce0.2Nd0.2Sm0.2Eu0.2)2 Zr2 O7 is phase-pure with homogeneous rare-earth element distribution.The thermal conductivity of as-synthesized(La0.2Ce0.2Nd0.2Sm0.2Eu0.2)2 Zr2 O7 at room temperature is as low as 0.76 W m^-1 K^-1.Moreover,after being heated at 1500℃for 1-18 h,the average grain size of(La0.2Ce0.2Nd0.2Sm0.2Eu0.2)2 Zr2 O7 only increases from 1.69μm to 3.92μm,while the average grain size of La2Zr2O7 increases from 1.96μm to 8.89μm.Low thermal conductivity and sluggish grain growth rate indicate that high-entropy(La0.2Ce0.2Nd0.2Sm0.2Eu0.2)2Zr2O7 is suitable for application as a thermal barrier coating material and it may possess good thermal stress-induced cracking resistance. | Zifan Zhao Huimin Xiang Fu-Zhi Dai Zhijian Peng Yanchun Zhou | 2019 | Journal of Materials Science & Technology2019，35，11： | 25 |
| 14 | U-Pb zircon geochronology and Hf isotope study of metamorphosed basic-ultrabasic rocks from metamorphic basement in southwestern Zhejiang:The response of the Cathaysia Block to Indosinian orogenic event显示文摘A combined study using LA-ICP-MS U-Pb dating, Hf isotopes, trace elements and the Ti-in-zircon geo-thermometer was carried out on zircons from the metamorphosed basic-ultrabasic rocks in the meta-morphic basement of the Cathaysia Block, southwestern Zhejiang Province. The formation and meta-morphic ages of the rocks from the metamorphic basement of the Cathaysia Block were determined based on zircon U-Pb geochronology. The age for the magmatic crystalline zircons from the protolith is about 1.85 Ga. The εHf(t) values of the older zircons were from ?7 to ?3, with two-stage model Hf ages (TDM2LC) of about 2.9 to 3.4 Ga, indicating that the source material was derived from anatexis and recy-cling of the Archean crust. The newly formed metamorphic zircons yielded U-Pb ages of 260―230 Ma. The metamorphic temperature calculated using the Ti-in-zircon geothermometer ranged from 610 to 720℃, consistent with the results from petrographic observations, indicating that the Cathaysia Block experienced an amphibolite facies metamorphism during the Indosinian. Results from this study pro-vided an important timeframe for the tectonic evolution in South China and the Southeast Asia during the Late Permian and Early Triassic times. | XIANG Hua ZHANG Li ZHOU HanWen ZHONG ZengQiu ZENG Wen LIU Rui JIN Song | 2008 | Science China Earth Sciences2008，51，6： | 24 |
| 15 | Comparison study of two diagnostic and grading systems for conjunctivochalasis显示文摘 | ZHANG Xing-ru ZOU Hai-dong LI Qing-song ZHOU Huan-ming LIU Bin HAN Zhu-mei XIANG Min-hong ZHANG Zheng-yong WANG Han-min | 2013 | Chinese Medical Journal2013，，16： | 24 |
| 16 | Advances on strategies for searching for next generation thermal barrier coating materials显示文摘Thermal barrier coating(TBC) materials play important roles in gas turbine engines to protect the Nibased super-alloys from the high temperature airflow damage. High melting point, ultra-low thermal conductivity, large thermal expansion coefficient, excellent damage tolerance and moderate mechanical properties are the main requirements of promising TBC materials. In order to improve the efficiency of jet and/or gas turbine engines, which is the key of improved thrust-to-weight ratios and the energysaving, significant efforts have been made on searching for enhanced TBC materials. Theoretically, density functional theory has been successfully used in scanning the structure and properties of materials, and at the same time predicting the mechanical and thermal properties of promising TBC materials for high and ultrahigh temperature applications, which are validated by subsequent experiments. Experimentally,doping and/or alloying are also widely applied to further decrease their thermal conductivities. Now, the strategy through combining theoretical calculations and experiments on searching for next generation thermal insulator materials is widely adopted. In this review, the common used techniques and the recent advantages on searching for promising TBC materials in both theory and experiments are summarized. | Bin Liu Yuchen Liu Changhua Zhu Huimin Xiang Hongfei Chen Luchao Sun Yanfeng Gao Yanchun Zhou | 2019 | Journal of Materials Science & Technology2019，35，5： | 24 |
| 17 | Paleoproterozoic reworking of ancient crust in the Cathaysia Block,South China:Evidence from zircon trace elements,U-Pb and Lu-Hf isotopes显示文摘A combined study of zircon LA-ICP-MS U-Pb dating, trace elements and Hf isotope was carried out for gneissic granite from the Sanzhishu area in Jingning, SW Zhejiang Province. Nearly all the zircons separated from the granite exhibited oscillatory zoning and high Th/U ratios (>0.1). The REE profile showed a pronounced positive Ce anomaly, negative Eu anomaly and an enrichment of HREE, which are typical characteristics of magmatic zircon. Thirteen concordant or nearly concordant analytical data yielded a weighted mean 207Pb/206Pb age of 1860±13 Ma (MSWD=0.084), representing the formation age of the granite. The magmatic zircons had negative εHf(t) values of -15.6 to -10.0 and two-stage Hf model ages of 3.1 to 3.4 Ga, indicating that the granites were formed by reworking of ancient crust. The major- and trace-element data indicate that the gneissic granites are metaluminous high-K calc-alkaline rocks and exhibit the same geochemical characteristics as aluminous A-type granites, implying the emplacement of the granite in a post-orogenic extensional tectonic setting. We conclude that the Pa-leoproterozoic crustal reworking event in the Cathaysia Block of South China marked the transition from assembly to break-up of the Columbia supercontinent. | LIU Rui ZHOU Han Wen ZHANG Li ZHONG ZengQiu ZENG Wen XIANG Hua JIN Song LU Xin Qian LI ChunZhong | 2009 | Chinese Science Bulletin2009，54，9： | 22 |
| 18 | Long non-coding RNAs in cancer显示文摘Long non-coding RNAs (lncRNAs) are a group of RNA transcripts that exceed 200 nt in length, yet lack significant open reading frames (ORFs) [1–4]. In contrast | GONG ZhaoJian ZHANG ShanShan ZHANG WenLing HUANG HongBin LI Qiao DENG Hao MA Jian ZHOU Ming XIANG Juan Juan WU MingHua LI XiaYu XIONG Wei LI XiaoLing LI Yong ZENG ZhaoYang LI GuiYuan | 2012 | Science China(Life Sciences)2012，55，12： | 22 |
| 19 | Age-related rhesus macaque models of COVID-19显示文摘Background:Since December 2019,an outbreak of the Corona Virus disease 2019(COVID-19)caused by severe acute respiratory syndrome coronavirus(SARS-CoV-2)in Wuhan,China,has become a public health emergency of international concern.The high fatality of aged cases caused by SARS-CoV-2 was a need to explore the possible age-related phenomena with non-human primate models.Methods:Three 3-5 years old and two 15 years old rhesus macaques were intratracheally infected with SARS-CoV-2,and then analyzed by clinical signs,viral replication,chest X-ray,histopathological changes and immune response.Results:Viral replication of nasopharyngeal swabs,anal swabs and lung in old monkeys was more active than that in young monkeys for 14 days after SARS-CoV-2 challenge.Monkeys developed typical interstitial pneumonia characterized by thickened alveolar septum accompanied with inflammation and edema,notably,old monkeys exhibited diffuse severe interstitial pneumonia.Viral antigens were detected mainly in alveolar epithelial cells and macrophages.Conclusion:SARS-CoV-2 caused more severe interstitial pneumonia in old monkeys than that in young monkeys.Rhesus macaque models infected with SARS-CoV-2 provided insight into the pathogenic mechanism and facilitated the development of vaccines and therapeutics against SARS-CoV-2 infection. | Pin Yu Feifei Qi Yanfeng Xu Fengdi Li Peipei Liu Jiayi Liu Linlin Bao Wei Deng Hong Gao Zhiguang Xiang Chong Xiao Qi Lv Shuran Gong Jiangning Liu Zhiqi Song Yajin Qu Jing Xue Qiang Wei Mingya Liu Guanpeng Wang Shunyi Wang Haisheng Yu Xing Liu Baoying Huang Wenling Wang Li Zhao Huijuan Wang Fei Ye Weimin Zhou Wei Zhen Jun Han Guizhen Wu Qi Jin Jianwei Wang Wenjie Tan Chuan Qin | 2020 | Animal Models and Experimental Medicine2020，3，1： | 22 |
| 20 | Caledonian reworking of Paleoproterozoic basement in the Cathaysia Block: Constraints from zircon U-Pb dating, Hf isotopes and trace elements显示文摘A combined study of zircon U-Pb dating, Hf isotopes and trace elements has been carried out for granodioritic neosomes of migmatites from the Tianjingping area in northwestern Fujian Province. Zircons are characterized by zoning, higher Th/U ratios (mostly ≥0.1), HREE enrichment, and positive Ce and negative Eu anomalies, and show features similar to magmatic or anatectic zircons. Apparent 206Pb/238U ages for the zircons are 447±2 Ma (95% conf., MSWD = 0.88), corresponding to a Caledonian event. εHf(t) values are ?13.3 to ?9.7, indicating a crustal source. Two-stage Hf model ages are 1.7 to 1.9 Ga, suggesting that protolith of the migmates was probably formed in the Paleoproterozoic. The granodioritic neosomes have the characteristics of peraluminous calc-alkaline granite, and their REE patterns and trace elements spidergrams show features of middle to upper crustal rocks. Together with previous studies, we conclude that the protolith of the Cathaysia basement in the Tianjingping area was likely formed in the middle-late Paleoproterozoic and experienced partial melting during the Caledonian period. The recognition of Caledonian reworking of the Paleoproterozoic basement in the Cathaysia Block provides a new insight into the tectonic evolution of the Cathaysia Block in the Caledonian pe- riod and the interaction between the Cathaysia Block and the Yangtze Block. | ZENG Wen ZHANG Li ZHOU HanWen ZHONG ZengQiu XIANG Hua LIU Rui JIN Song LU XinQian LI ChunZhong | 2008 | Chinese Science Bulletin2008，53，6： | 21 |
您所在的机构暂未开通此部分的功能，请联系管理员