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| 1 | Very-High Color Rendering Index Hybrid White Organic Light-Emitting Diodes with Double Emitting Nanolayers显示文摘A very-high color rendering index white organic light-emitting diode(WOLED) based on a simple structure was successfully fabricated. The optimized device exhibits a maximum total efficiency of 13.1 and 5.4 lm/W at 1,000 cd/m2. A peak color rendering index of 90 and a relatively stable color during a wide range of luminance were obtained. In addition, it was demonstrated that the 4,40,400-tri(9-carbazoyl) triphenylamine host influenced strongly the performance of this WOLED.These results may be beneficial to the design of both material and device architecture for high-performance WOLED. | Baiquan Liu Miao Xu Lei Wang Hong Tao Yueju Su Dongyu Gao Linfeng Lan Jianhua Zou Junbiao Peng | 2014 | Nano-Micro Letters2014，6，4： | 4 |
| 2 | The Agpat4/LPA axis in colorectal cancer cells regulates antitumor responses via p38/p65 signaling in macrophages显示文摘Lipid metabolic reprogramming plays an essential role in regulating the progression of colorectal cancer(CRC).However,the effect of lysophosphatidic acid(LPA)metabolism on CRC development is incompletely characterized.Here,we compared the mRNA levels of human CRC tissues to those of paracarcinoma tissues and focused on the notably enriched LPA metabolic pathways.We identified and verified that 1-acylglycerol-3-phosphate O-acyltransferase 4(Agpat4)was aberrantly expressed in CRC tissues and predicted poor survival in CRC patients.Manipulating Agpat4 expression in CRC cells did not affect the growth or migration of CRC cells in vitro,whereas Agpat4 silencing suppressed CRC cell growth in subcutaneous and peritoneal xenograft models.Mechanistically,Agpat4 silencing-induced LPA release from CRC cells and polarized macrophages to an M1-like phenotype through LPA receptors 1 and 3.This M1 activation,characterized by elevated p38/p65 signaling and increased proinflammatory cytokines,promoted the infiltration and activation of CD4+and CD8+T cells in the tumor microenvironment.Modulation of the Agpat4/LPA/p38/p65 axis regulated macrophage polarization,T-cell activity and CRC progression.Notably,combined therapy with LPA and regular chemotherapy drugs synergistically suppressed CRC development.Taken together,our results showed that the Agpat4/LPA axis in CRC cells regulated p38/p65 signaling-dependent macrophage polarization,T-cell activation,and CRC progression.The Agpat4/LPA/p38/p65 axis might represent a potential target for therapy in the clinic. | Dapeng Zhang Rongchen Shi Wei Xiang Xia Kang Bo Tang Chuan Li Linfeng Gao Xuan Zhang Lili Zhang Rongyang Dai Hongming Miao | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 3 |
| 3 | The effect of spacer in hybrid white organic light emitting diodes显示文摘Two kinds of highly efficient,bright hybrid white organic light emitting diodes have been fabricated by utilizing ambipolar material 4,4-N,N-dicarbazolebiphenyl(CBP)and unipolar material N,N0-di(naphthalene-1-yl)-N,N0-diphenyl-benzidine(NPB)as the spacer,respectively.By adjusting the thickness of spacers together with effectively utilizing combinations of exciton-harnessed orangephosphorescence/blue-fluorescence,the current efficiency of optimal device with CBP spacer and device with NPB spacer are 31.0 and 38.9 cd/A,the maximum power efficiency are 23.9 and 29.1 lm/W,the maximum brightness are 87,249 and 75,501 cd/m2,and the Commission Internationale de l’Eclairage(CIE)coordinates are(0.42,0.43)and(0.47,0.44)at a voltage of 11 V,respectively.Furthermore,systematic investigations focused on the effects of spacers on device performance have been performed.By virtue of the multifunctional spacer,energy transfer between the phosphorescent and fluorescent emitters can be avoided while the carriers still can pass through this spacer bridge,which is important to realize such high device performance.In addition,a novel concept that both ambipolar materials and unipolar materials can be the promising candidates for spacers has been proposed if the thickness of spacers with high triplet energy is optimized. | Baiquan Liu Miao Xu Hong Tao Yueju Su Dongyu Gao Jianhua Zou Linfeng Lan Junbiao Peng | 2014 | Chinese Science Bulletin2014，59，25： | 2 |
| 4 | A new recoverable Au(III) catalyst supported on magnetic polymer nanocomposite for aromatic bromination显示文摘 | Bai Li Linfeng Gao Fengling Bian Wei Yu | 2012 | Tetrahedron Letters2012，，： | 1 |
| 5 | Esrrb plays important roles in maintaining self-renewal of trophoblast stem cells (TSCs) and reprogramming somatic cells to induced TSCs显示文摘Trophoblast stem cells (TSCs), which can be derived from the trophoectoderm of a blastocyst, have the ability to sustain self-renewal and differentiate into various placental trophoblast cell types. Meanwhile, essential insights into the molecular mechanisms controlling the placental development can be gained by using TSCs as the cell model. Esrrb is a transcription factor that has been shown to play pivotal roles in both embryonic stem cell (ESC) and TSC, but the precise mechanism whereby Esrrb regulates TSC-specific transcriptome during differentiation and reprogramming is still largely unknown. In the present study, we elucidate the function of Esrrb in self-renewal and differentiation of TSCs, as well as during the induced TSC (iTSC) reprogramming. We demonstrate that the precise level of Esrrb is critical for stem state maintenance and further trophoblast differentiation of TSCs, as ectopically expressed Esrrb can partially block the rapid differentiation of TSCs in the absence of fibroblast growth factor 4. However, Esrrb depletion results in downregulation of certain key TSC-specific transcription factors, consequently causing a rapid differentiation of TSCs and these Esrrb-deficient TSCs lose the ability of hemorrhagic lesion formation in vivo. This function of Esrrb is exerted by directly binding and activating a core set of TSC-specific target genes including Cdx2, Eomes, Sox2, Fgfr4, and Bmp4. Furthermore, we show that Esrrb overexpression can facilitate the MEF-to-iTSC conversion. Moreover, Esrrb can substitute for Eomes to generate GEsTM-iTSCs. Thus, our findings provide a better understanding of the molecular mechanism of Esrrb in maintaining TSC self-renewal and during iTSC reprogramming. | Haibo Gao Rui Gao Linfeng Zhang Wenchao Xiu Ruge Zang Hong Wang Yong Zhang Jiayu Chen Yawei Gao Shaorong Gao | 2019 | Journal of Molecular Cell Biology2019，11，6： | 1 |
| 6 | Efficient self-assembly synthesis of uniform CdS spherical nanoparticles-Au nanoparticles hybrids with enhanced photoactivity显示文摘 | HAN Sancan HU Linfeng GAO Nan | 2014 | Advanced Functional Materials2014，24，24： | 1 |
| 7 | Study of the compatibility between light-cured repair materials and composite materials by holographic intefferometry 显示文摘 | Guo Linfeng Zhao Zhimin Gao Mingjuan | 2005 | Optical Engineering2005，44，10： | 1 |
| 8 | Study of the compatibility between light-cured repair materials and composite materials by holographic interferometry显示文摘 | Guo Linfeng Zhao Zhimin Gao Mingjuan | 2005 | Optical Engineering2005，44，10： | 1 |
| 9 | Lycium ruthenicum Murr. treatment attenuates APP_(SWE)/PS1ΔE9 mouse model-like mitochondrial dysfunction in Slc25a46 knockout mouse model显示文摘Mitochondrial dysfunction is proposed to be substantially associated with ageing and ageing-related diseases like Alzheimer's disease(AD). However, it is unclear whether different mouse models with mitochondrialrelated diseases have similar changes in mitochondrial morphology of the same tissues. Moreover, whether similarities in mitochondrial morphology can be a suitable marker for screening and/or discovering mitochondrial-protective substances remains unknown. Mitochondria morphology in different tissues of a novel mitochondrial outer membrane protein Slc25a46 knockout mouse and a traditional APP_(SWE)/PS1ΔE9 transgenic mouse were examined using transmission electron microscope(TEM). Both young Slc25a46 knockout mice and aged APP_(SWE)/PS1ΔE9 mice models showed similar mitochondrial damage in cerebellum tissues. The results indicated that different mitochondrial-related diseases shared similar alteration and defects in mitochondrial morphology. Furthermore, Lycium ruthenicum Murr. extract, a bioactive food substance with cognition-improving property, could effectively improve muscle strength and increase body weight in the Slc25a46 knockout mice. These findings suggest that mitochondrial morphology defects in mice models, particularly in the mitochondrial compartment, represent a unified and effective marker for screening and validating natural product-derived functional substances with mitochondrial protective properties. It also holds potential application in mitochondrial-impaired senile neurodegenerative diseases, especially in AD. | Min Wang Tianxiong Xu Li Gao Chujun Huang Piao Xu Congcong Gong William Kwame Amakye Linfeng Liao Maojin Yao Jiaoyan Ren | 2023 | Food Science and Human Wellness2023，12，5： | 0 |
| 10 | Two-dimensional ferromagnetic superlattices显示文摘Mechanically exfoliated two-dimensional ferromagnetic materials(2D FMs)possess long-range ferromagnetic order and topologically nontrivial skyrmions in few layers.However,because of the dimensionality effect,such few-layer systems usually exhibitmuch lower Curie temperature(TC)compared to their bulk counterparts.It is therefore of great interest to explore effective approaches to enhance their TC,particularly in wafer-scale for practical applications.Here,we report an interfacial proximity-induced high-TC 2D FM Fe3GeTe2(FGT)via A-type antiferromagnetic material CrSb(CS)which strongly couples to FGT.A superlattice structure of(FGT/CS)n,where n stands for the period of FGT/CS heterostructure,has been successfully produced with sharp interfaces by molecular-beam epitaxy on 2-inch wafers.By performing elemental specific X-ray magnetic circular dichroism(XMCD)measurements,we have unequivocally discovered that TC of 4-layer Fe3GeTe2 can be significantly enhanced from 140 K to 230 K because of the interfacial ferromagnetic coupling.Meanwhile,an inverse proximity effect occurs in the FGT/CS interface,driving the interfacial antiferromagnetic CrSb into a ferrimagnetic state as evidenced by double-switching behavior in hysteresis loops and the XMCD spectra.Density functional theory calculations show that the Fe-Te/Cr-Sb interface is strongly FMcoupled and doping of the spin-polarized electrons by the interfacial Cr layer gives rise to the TC enhancement of the Fe3GeTe2 films,in accordance with our XMCDmeasurements.Strikingly,by introducing rich Fe in a 4-layer FGT/CS superlattice,TC can be further enhanced to near room temperature.Our results provide a feasible approach for enhancing the magnetic order of few-layer 2D FMs in wafer-scale and render opportunities for realizing realistic ultra-thin spintronic devices. | Shanshan Liu Ke Yang Wenqing Liu Enze Zhang Zihan Li Xiaoqian Zhang Zhiming Liao Wen Zhang Jiabao Sun Yunkun Yang Han Gao Ce Huang Linfeng Ai Ping Kwan Johnny Wong Andrew Thye Shen Wee Alpha TN’Diaye Simon AMorton Xufeng Kou Jin Zou Yongbing Xu Hua Wu Faxian Xiu | 2020 | National Science Review2020，7，4： | 0 |
| 11 | Boosting Plasmonic Hot Electron Utilization for Visible-Light Photocatalysis Using Polarized Ag-TiO_(2) Nanoparticles显示文摘Plasmonic hot electrons have long been regarded as a promising energy source for inducing chemical transformations.However,because of the mismatch between the electron cloud of reactant molecules and the hot-electron gas of metal nanoparticles(NPs),the highly localized and short-lived hot electrons are dif-ficult to utilize in bulk synthesis when the reactant molecules do not have a strong affinity for the metal surface.Here,we propose the concept of polarized nanocatalysts to mimic chemical polarity at the nanometer scale.Under plasmonic photorecycling conditions,the rationally designed asymmetric Ag-TiO_(2) hybrid NPs enable six-electron reduction of molecules in bulk solution.This hot-electron-driven reaction does not require a conventional hydrogen or hydride reducing agent.As a proof-of-concept,one-pot photocatalytic syntheses of amides,such as paracetamol,using nitro reactants were performed.This provides a new opportunity to enable challenging multielectron transformations in organic chemistry. | Yonglong Li Linfeng Yu Ying Wang Cancan Zhang Yangxuan Gao Teng Wang Wei Xie | 2023 | CCS Chemistry2023，5，8： | 0 |
| 12 | Thiourea-assisted coating of dispersed copper electrocatalysts on Si photocathodes for solar hydrogen production显示文摘Photoelectrochemical water splitting can convert solar energy into clean hydrogen energy for storage.It is desirable to explore non-precious electrocatalysts for practical applications of a photoelectrode in a large scale.Here,we developed a facile spin-coating and in-situ photoelectrochemical reduction method to prepare a dispersed Cu electrocatalyst on a Si photocathode,which improves the performance remarkably.We find that thiourea in the precursor solution for spin-coating plays an important role in obtaining dispersed Cu particles on the surface of a Si photoelectrode.With thiourea in the precursor,the Cu/Si photocathode shows higher performance than the one without thiourea.Moreover,the Cu/Si photocathode also indicates good stability after 16 h illumination. | Pin Wang Ziyu Yin Linfeng Gao Hui Li Tongyu Zhang Qing Shen Jun Lv Yingfang Yao Wenjun Luo Zhigang Zou | 2020 | Journal of Energy Chemistry2020，29，1： | 0 |
| 13 | BCI+VR Rehabilitation Design of Closed-Loop Motor Imagery Based on the Degree of Drug Addiction显示文摘After abusing drugs for long,drug users will experience deteriorated self-control cognitive ability,and poor emotional regulation.This paper designs a closed-loop virtual-reality(VR),motorimagery(MI)rehabilitation training system based on brain-computer interface(BCI)(MI-BCI+VR),aiming to enhance the self-control,cognition,and emotional regulation of drug addicts via personalized rehabilitation schemes.This paper is composed of two parts.In the first part,data of 45 drug addicts(mild:15;moderate:15;and severe:15)is tested with electroencephalogram(EEG)and near-infrared spectroscopy(NIRS)equipment(EEG-NIRS)under the dual-mode,synchronous signal collection paradigm.Using these data sets,a dual-modal signal convolutional neural network(CNN)algorithm is then designed based on decision fusion to detect and classify the addiction degree.In the second part,the MIBCI+VR rehabilitation system is designed,optimizing the Filter Bank Common Spatial Pattern(FBCSP)algorithm used in MI,and realizing MI-EEG intention recognition.Eight VR rehabilitation scenes are devised,achieving the communication between MI-BCI and VR scene models.Ten subjects are selected to test the rehabilitation system offline and online,and the test accuracy verifies the feasibility of the system.In future,it is suggested to develop personalized rehabilitation programs and treatment cycles based on the addiction degree. | Xuelin Gu Banghua Yang Shouwei Gao Honghao Gao Linfeng Yan Ding Xu Wen Wang | 2022 | China Communications2022，19，2： | 0 |
| 14 | Chemical inhibition of Arabidopsis PIN-FORMED auxin transporters by the anti-inflammatory drug naproxen显示文摘The phytohormone auxin plays central roles in many growth and developmental processes in plants.Development of chemical tools targeting the auxin pathway is useful for both plant biology and agriculture.Here we reveal that naproxen,a synthetic compound with anti-inflammatory activity in humans,acts as an auxin transport inhibitor targeting PIN-FORMED(PIN)transporters in plants.Physiological experiments indicate that exogenous naproxen treatment affects pleiotropic auxin-regulated developmental processes.Additional cellular and biochemical evidence indicates that naproxen suppresses auxin transport,specifically PIN-mediated auxin efflux.Moreover,biochemical and structural analyses confirm that naproxen binds directly to PIN1 protein via the same binding cavity as the indole-3-acetic acid substrate.Thus,by combining cellular,biochemical,and structural approaches,this study clearly establishes that naproxen is a PIN inhibitor and elucidates the underlying mechanisms.Further use of this compound may advance our understanding of the molecular mechanisms of PIN-mediated auxin transport and expand our toolkit in auxin biology and agriculture. | Jing Xia Mengjuan Kong Zhisen Yang Lianghanxiao Sun Yakun Peng Yanbo Mao Hong Wei Wei Ying Yongxiang Gao Jiri Friml Jianping Weng Xin Liu Linfeng Sun Shutang Tan | 2023 | Plant Communications2023，4，6： | 0 |
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