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| 1 | Dietary fats suppress the peritoneal seeding of colorectal cancer cells through the TLR4/Cxcl10 axis in adipose tissue macrophages显示文摘Peritoneal carcinomatosis(PC)of colorectal cancer(CRC)is a terminal phase of malignancy with no effective strategies for the prevention of this condition.Here we established PC models in mice by intraperitoneal engraftment of CRC cells and revealed an unexpected role for a high-fat diet(HFD)in preventing metastatic seeding in the visceral fat.Mechanistically,the HFD stimulated the activation of adipose tissue macrophages(ATMs)toward an M1-like phenotype and enhanced ATM tumor phagocytosis in a TLR4-dependent manner.Furthermore,the TLR4–Cxcl10 axis in ATMs promoted T cell recruitment,and M1-like macrophages stimulated T cell activation in tumor-seeded fats.The inhibitory effect of the HFD on tumor seeding was abolished with the ablation of macrophages,inactivation of T cells,or blockade of the TLR4–Cxcl10 axis in macrophages.Finally,we showed that a HFD and conventional chemotherapeutic agents(oxaliplatin or 5-fluorouracil)synergistically improved the survival of tumor-seeded mice.Collectively,our findings demonstrate that peritoneal seeding of CRC can be suppressed by short-term treatment with a HFD in the early phase,providing a novel concept for the management of these patients in the clinic. | Wei Xiang Rongchen Shi Dapeng Zhang Xia Kang Lili Zhang Jing Yuan Xuan Zhang Hongming Miao | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 3 |
| 2 | The Agpat4/LPA axis in colorectal cancer cells regulates antitumor responses via p38/p65 signaling in macrophages显示文摘Lipid metabolic reprogramming plays an essential role in regulating the progression of colorectal cancer(CRC).However,the effect of lysophosphatidic acid(LPA)metabolism on CRC development is incompletely characterized.Here,we compared the mRNA levels of human CRC tissues to those of paracarcinoma tissues and focused on the notably enriched LPA metabolic pathways.We identified and verified that 1-acylglycerol-3-phosphate O-acyltransferase 4(Agpat4)was aberrantly expressed in CRC tissues and predicted poor survival in CRC patients.Manipulating Agpat4 expression in CRC cells did not affect the growth or migration of CRC cells in vitro,whereas Agpat4 silencing suppressed CRC cell growth in subcutaneous and peritoneal xenograft models.Mechanistically,Agpat4 silencing-induced LPA release from CRC cells and polarized macrophages to an M1-like phenotype through LPA receptors 1 and 3.This M1 activation,characterized by elevated p38/p65 signaling and increased proinflammatory cytokines,promoted the infiltration and activation of CD4+and CD8+T cells in the tumor microenvironment.Modulation of the Agpat4/LPA/p38/p65 axis regulated macrophage polarization,T-cell activity and CRC progression.Notably,combined therapy with LPA and regular chemotherapy drugs synergistically suppressed CRC development.Taken together,our results showed that the Agpat4/LPA axis in CRC cells regulated p38/p65 signaling-dependent macrophage polarization,T-cell activation,and CRC progression.The Agpat4/LPA/p38/p65 axis might represent a potential target for therapy in the clinic. | Dapeng Zhang Rongchen Shi Wei Xiang Xia Kang Bo Tang Chuan Li Linfeng Gao Xuan Zhang Lili Zhang Rongyang Dai Hongming Miao | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 3 |
| 3 | Experimental study on the milling of thin parts of titanium alloy (TC4) 显示文摘 | Zhang Guimu Yu Chao Shi Rongchen | 2003 | Journal of Materials Processing Technology2003，138，13： | 1 |
| 4 | Experimental study on the milling of thin parts of titanium alloy (TC4)显示文摘 | Zhang Guimu Yu Chao Shi Rongchen | 2003 | Journal of Materials Processing Technology2003，138，23： | 1 |
| 5 | Experimental study on the milling of thin parts of titanium alloy (TC4) 显示文摘 | Zhang Guimu Yu Chao Shi Rongchen | 2003 | Journal of Materials Processing Technology2003，138，123： | 1 |
| 6 | Experimental study on the milling of thin parts of titanium alloy (TC4)显示文摘 | Zhang Guimu Yu Chao Shi Rongchen | 2003 | Journal of Materials Processing Technology2003，，： | 1 |
| 7 | Experimental study on the milling of thin parts of titanium alloy ( TC4 ) 显示文摘 | Zhang Guimu Yu Chao Shi Rongchen | 2003 | Journal of Materials Processing Technology2003，138，13： | 1 |
| 8 | 巨噬细胞促红细胞生成素信号通路促进凋亡细胞清除及免疫耐受显示文摘机体每秒钟约有10^6个细胞凋亡,如被及时清除则维持机体稳定,反之则导致自身免疫病、慢性炎症、发育异常等,但凋亡细胞吞噬清除机制目前尚未阐明。 | Bangwei Luo Woting Gan Zongwei Liu Zigang Shen Jinsong Wang Rongchen Shi Yuqi Liu Yu Liu Man Jiang 张志仁 吴玉章 | 2017 | 科学新闻2017，19，4： | 0 |
| 9 | Dietary intervention,a promising adjunct for cancer therapy显示文摘A recent study by Irene Caffa and colleagues published in Nature demonstrated that fasting-mimicking diet(FMD)could enhance the effect of endocrine therapeutics(ET)tamoxifen and fulvestrant for breast cancer(BC)and reduce their side effects,which might provide a new adjunct to endocrine therapy for BC1. | Rongchen Shi Hongming Miao | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 0 |
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