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| 1 | Characterization of submicron aerosols in the urban outflow of the central Pearl River Delta region of China显示文摘 | Zhaoheng GONG Zijuan LAN Lian XUE Liwu ZENG Lingyan HE Xiaofeng HUANG | 2012 | Frontiers of Environmental Science & Engineering2012，6，5： | 9 |
| 2 | Adsorptive removal of hydrophobic organic compounds by carbonaceous adsorbents:A comparative study of waste-polymer-based,coal-based activated carbon,and carbon nanotubes显示文摘Adsorption of the hydrophobic organic compounds(HOCs) trichloroethylene(TCE),1,3-dichlorobenzene(DCB),1,3-dinitrobenzene(DNB) and γ-hexachlorocyclohexane(HCH) on five different carbonaceous materials was compared.The adsorbents included three polymer-based activated carbons,one coal-based activated carbon(F400) and multiwalled carbon nanotubes(MWNT).The polymerbased activated carbons were prepared using KOH activation from waste polymers:polyvinyl chloride(PVC),polyethyleneterephthalate(PET) and tire rubber(TR).Compared with F400 and MWNT,activated carbons derived from PVC and PET exhibited fast adsorption kinetics and high adsorption capacity toward the HOCs,attributed to their extremely large hydrophobic surface area(2700 m 2 /g) and highly mesoporous structures.Adsorption of small-sized TCE was stronger on the tire-rubber-based carbon and F400 resulting from the pore-filling effect.In contrast,due to the molecular sieving effect,their adsorption on HCH was lower.MWNT exhibited the lowest adsorption capacity toward HOCs because of its low surface area and characteristic of aggregating in aqueous solution. | Fei Lian Chun Chang Yang Du Lingyan Zhu Baoshan Xing Chang Liu | 2012 | Journal of Environmental Sciences2012，24，9： | 4 |
| 3 | Synthesis and characterization of a novel MnO x -loaded biochar and its adsorption properties for Cu 2+ in aqueous solution显示文摘 | Zhengguo Song Fei Lian Zhihong Yu Lingyan Zhu Baoshan Xing Weiwen Qiu | 2014 | Chemical Engineering Journal2014，，： | 3 |
| 4 | Identification of secondary organic aerosols based on aerosol mass spectrometry显示文摘Secondary organic aerosol (SOA) is one of the major components of aerosols in the atmosphere and has not been well understood so far.Due to the complex chemical composition of organic aerosols,the identification of SOA has been a hotspot and difficult issue in the field of aerosol study.This study attempts to quantitatively identify SOA in winter of Shenzhen based on positive matrix factorization (PMF) analysis.Major sources were resolved and SOA was identified subsequently according to the characteristic ion fragments measured by highly time-resolved aerosol mass spectrometer measurement.It showed that in the winter of Shenzhen the average SOA concentration was 9.41±6.33 g/m 3,accounting for 39.9±21.8% of the total organic mass.Compared with primary organic aerosol (POA),the SOA concentrations had no large variation,suggestive of characteristics of regional secondary pollutants.The ratio of SOA/BC had pronounced diurnal variation,similar to that of O x (O3+NO2),indicating SOA formation was significantly controlled by activity of photochemistry in the atmosphere.The most effective period for SOA formation was from 9 am~3 pm since the SOA/BC ratio increased by 122% during this period.This study provides a new technical method and a new idea for SOA investigation. | HUANG XiaoFeng 1,ZHAO QianBiao 1,2,HE LingYan 1,HU Min 2,BIAN QiJing 3,XUE Lian 1 & ZHANG YuanHang 2 1 Key Laboratory for Urban Habitat Environmental Science and Technology School of Environment and Energy,Peking University Shenzhen Graduate School,Shenzhen 518055,China 2 State Key Joint Laboratory of Environmental Simulation and Pollution Control College of Environmental Sciences and Engineering,Peking University,Beijing 100871,China 3 Division of Environment,Hong Kong University of Science & Technology,Hong Kong,China | 2010 | Science China Chemistry2010，53，12： | 2 |
| 5 | KLF2 inhibits TGF-β-mediated cancer cell motility in hepatocellular carcinoma显示文摘Feedback regulation plays a pivotal role in determining the intensity and duration of TGF-p signaling and subsequently affecting the pathophysiological roles of TGF-p,including those in liver malignancy.KLF2,a member of the Kruppel-like factor(KLF)fam ily transcription factors,has been implicated in impeding hepatocellular carcinoma(HCC)development.However,the underlying molecular mechanisms are not fully understood.In the present study,we found that TGF-p stimulates the expression of KLF2 gene in several HCC cell lines.KLF2 protein is able to inhibit TGF-p/Smad signaling in HCC cells as assessed by luciferase reporter assay.Further studies indicated that KLF2 inhibits the transcriptional activity of Smad2/3 and Smad4 and ameliorates TGF-p-induced target gene expression,therefore creating a novel negative feedback loop in TGFp signaling.Functionally,stably expression of KLF2 in HCCLM3 cells attenuated TGF-卜induced cancer cell motility in wound-healing and transwell assays by interfering with TGF-p-mediated upregulation of MMP2.Together,our results revealed that KLF2 protein has a tumor-suppressive function in HCC through a negative feedback loop over TGF-p signaling. | Yining Li Shuo Tu Yi Zeng Cheng Zhang Tian Deng Weicheng Luo Lingyan Lian Ling Chen Xiangyang Xiong Xiaohua Yan | 2020 | Acta Biochimica et Biophysica Sinica2020，52，5： | 2 |
| 6 | Artificial Intelligence in Pharmaceutical Sciences显示文摘Drug discovery and development affects various aspects of human health and dramatically impacts the pharmaceutical market.However,investments in a new drug often go unrewarded due to the long and complex process of drug research and development(R&D).With the advancement of experimental technology and computer hardware,artificial intelligence(AI)has recently emerged as a leading tool in analyzing abundant and high-dimensional data.Explosive growth in the size of biomedical data provides advantages in applying AI in all stages of drug R&D.Driven by big data in biomedicine,AI has led to a revolution in drug R&D,due to its ability to discover new drugs more efficiently and at lower cost.This review begins with a brief overview of common AI models in the field of drug discovery;then,it summarizes and discusses in depth their specific applications in various stages of drug R&D,such as target discovery,drug discovery and design,preclinical research,automated drug synthesis,and influences in the pharmaceutical market.Finally,the major limitations of AI in drug R&D are fully discussed and possible solutions are proposed. | Mingkun Lu Jiayi Yin Qi Zhu Gaole Lin Minjie Mou Fuyao Liu Ziqi Pan Nanxin You Xichen Lian Fengcheng Li Hongning Zhang Lingyan Zheng Wei Zhang Hanyu Zhang Zihao Shen Zhen Gu Honglin Li Feng Zhu | 2023 | Engineering2023，，8： | 1 |
| 7 | Comparative study of layered 0.65Li[Li 1/3 Mn 2/3 ]O 2 ·0.35LiMO 2 (M显示文摘 | Lingyan Yu Weihua Qiu Fang Lian Wei Liu Xiaoli Kang Jiayuan Huang | 2008 | Materials Letters2008，，17： | 1 |
| 8 | Understanding the phenomenon of increasing capacity of layered 0.65Li[Li 1/3 Mn 2/3 ]O 2 ·0.35Li(Ni 1/3 Co 1/3 Mn 1/3 )O 2显示文摘 | Lingyan Yu Weihua Qiu Fang Lian Jiayuan Huang Xiaoli Kang | 2008 | Journal of Alloys and Compounds2008，，1： | 1 |
| 9 | Simultaneousadsorption and degradation of y-HCH by nZVI/Cu bi- metallic nanoparticles with activated carbon support 显示文摘 | Chang Chun Lian Fei Zhu Lingyan | 2011 | Environ Pollut2011，159，10： | 1 |
| 10 | OsNRAMP2 facilitates Cd efflux from vacuoles and contributes to the difference in grain Cd accumulation between japonica and indica rice显示文摘Cadmium(Cd)accumulation in rice grain is of health concern.Identifying genes involved in grain Cd accumulation and performing molecular breeding may reduce it.In this study,knockout of OsNRAMP2,a member of the NRAMP family,reduced grain Cd concentrations by more than 38%,and overexpressing OsNRAMP2 increased grain Cd concentrations by more than 50%.Physiological experiments showed that OsNRAMP2 facilitated Cd translocation from root to shoot by positively regulating Cd efflux from the vacuoles.At filling stage,OsNRAMP2 was highly expressed in all tissues except for husk,suggesting its role in Cd remobilization.Changes in OsNRAMP2 expression affected the concentrations of Fe,Mn,Zn,and Cu in grain and also affected rice growth.Phylogenetic analysis showed that the distribution of OsNRAMP2 haplotypes between japonica and indica was different.Among the four haplotypes of OsNRAMP2,Hap 1,with a 6-bp nucleotide insertion in exon 1,had grain Cd concentration at least 45.3%lower than any of the other three haplotypes.Almost all(99.3%)japonica accessions but rare indica accessions(4.44%)from the 3K sequenced rice genomes carry Hap 1 of OsNRAMP2.Our study sheds light on the molecular mechanism of grain Cd accumulation and provides a promising target for low-Cd rice breeding. | Wu Yang Luo Chen Yamei Ma Rui Hu Jian Wang Wenhui Li Jingfang Dong Tifeng Yang Lian Zhou Jiansong Chen Dilin Liu Ning Yu Zhixia Liu Lingyan Zhou Shaohong Zhang Junliang Zhao Bin Liu | 2023 | The Crop Journal2023，11，2： | 0 |
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