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| 1 | The electromagnetic wave experiment for CSES mission: Search coil magnetometer显示文摘The seismic activities on the Earth can produce a disturbance of the electromagnetic field and particles in the ionosphere. The search coil magnetometer(SCM) mounted on China Seismo-Electromagnetic satellite(CSES) is designed to measure the magnetic field fluctuation of low frequency electromagnetic waves in the frequency range of 10 Hz–20 k Hz. The SCM comprises a three-axis search coil sensor mounted on a 4.5 m boom and an electronic box inside satellite module. The sampling rate of the SCM is 51.2 k Hz and the time resolution of the power spectrum density(PSD) is 2 s. The frequency resolution is 12.5 Hz.There are three operation modes: survey, detailed survey and calibration. In the survey mode, the SCM can provide a PSD in the whole frequency range of 10 Hz–20 k Hz and wave forms in the low frequency range below 2 k Hz while in the detailed survey mode the SCM can provide both PSD and wave forms in the whole frequency range of 10 Hz–20 k Hz. The sensitivity of the SCM instrument is 5.0×10^(-4) n T Hz^(-1/2) at 10 Hz, 5.0×10^(–5) n T Hz^(-1/2) at 200 Hz, 3.4×10^(-5) n T Hz^(-1/2) at 2 k Hz and 1.1×10^(-4) n T Hz^(-1/2) at 20 k Hz. The telemetry rate is ~0.85 Mbps in the survey mode and ~3.0 Mbps in the detailed survey mode. The phase difference between three axes can be made generally with a precision of less than 1.0°. The dynamic range of the SCM instrument is over 100 d B. The orthogonality of three mechanical axes of search coil senor is better than 0.13°. The performance of SCM can satisfy the requirement of scientific objectives of CSES mission. | CAO JinBin ZENG Li ZHAN Feng WANG ZuoGui WANG Yan CHEN Yu MENG QingChun JI ZhanQiang WANG PengFei LIU ZhongWei MA LingYu | 2018 | Science China(Technological Sciences)2018，61，5： | 13 |
| 2 | A temperature-activated nanocomposite metamaterial absorber with a wide tunability显示文摘新奇薄、灵活的宽带电磁的微波吸收器与 nanocomposites 被认识到并且完成宽频率 tunability (从 10 ~ 17.2 GHz ) 由活跃地调整抵抗。建议吸收器被可伸缩的屏幕打印优化 nanoparticle 墨水到灵活绝缘的合成底层上制作。基于底层的形状记忆效果和 nanocomposite 频率的 piezoresistive 效果选择表面,一个可控制的表电阻,和从而悦耳的波浪吸收性能,能以一种激活温度、动态地稳定的方式被认识到。结果由利用人工的材料和基于聚合物的 nanocomposites 的聪明的行为的以前低估的内在的性质为活跃电磁的设备的设计提供新尺寸。 | Weiwei Li Lingyu Zhao Zhaohe Dai Hao Jin Feng Duan Junchao Liu Zhihui Zeng Jun Zhao Zhong Zhang | 2018 | Nano Research2018，11，7： | 6 |
| 3 | Antifatigue,Antioxidant and Immunoregulatory Effects of Peptides Hydrolyzed from Manchurian Walnut(Juglans mandshurica Maxim.) on Mice显示文摘The Manchurian walnut(Juglans mandshurica Maxim.) is rich in proteins, whereas this resource has not been used efficiently. The antifatigue, antioxidative and immunoregulatory effects of Manchurian walnut hydrolysate peptides(MWHPs)were evaluated in this study. MWHPs with a degree of hydrolysis of 32.23% were ultrafiltered and divided into three fractions,namely, high(> 10 k Da), medium(3–10 kDa), and low molecular weight(< 3 kDa), and then fed to mice continuously at doses of 200, 400 or 800 mg/(kg·d). The antifatigue, antioxidative, and immunoregulatory effects of the peptides were tested on the second and fourth weeks of MWHP administration. Results showed that low-molecular-weight MWHPs exerted significant antifatigue(prolonging swimming time, elevating liver glycogen contents, and reducing lactic acid contents), antioxidative(enhancing superoxide dismutase(SOD), GSH-Px, and catalase(CAT) activities and reducing malondialdehyde(MDA) content), and immunoregulatory(raising the immune-organ index and promoting T-lymphocyte proliferation and s Ig A secretion in the intestinal tract) effects. This research indicates that MWHPs have potential applications in health care and may be developed as a base for new functional foods. | FANG Li REN Dayong CUI Lingyu LIU Chunlei WANG Ji LIU Wei MIN Weihong LIU Jingsheng | 2018 | Grain & Oil Science and Technology2018，1，1： | 6 |
| 4 | Deformation Mechanism and Vertical Sealing Capacity of Fault in the Mudstone Caprock显示文摘The petrophysical property of mudstone often transforms from ductile to brittle in the process of burial-uplift. The deformation mechanism of fault in brittle and ductile mudstone caprock is different, which leads to the formation of different types of fault zone structure. Different methods are required to evaluate the sealing mechanism of those fault zones. Based on the caprock deformation mechanism, fault sealing mechanism, quantitative evaluation method of vertical fault sealing capacity is put forward in this study. Clay smear is formed in the process of plastic deformation and its continuity controls the sealing capacity of fault. The outcrop and oil field data have confirmed that when sealing parameter SSF is less than 4–7, the clay smear becomes discontinuous and then oil and gas go through the caprock and migrate vertically. Quantities of fractures are formed in mudstone in the process of brittle deformation. The fracture density increases with the increase of the fault displacement. When the fractures are connected, oil and gas go through the caprock and migrate vertically. The connectivity of fault depends on the displacement and the thickness of caprock. On the basis of the above, a method is put forward to quantify the connectivity of fault with the juxtaposition thickness of caprock after faulting. The research on the juxtaposition thickness of caprock after faulting of the member II of Dongying Formation in Nanpu depression and the distribution of oil and gas indicates when the juxtaposition thickness of caprock is less than 96.2 m, the fault becomes leaking vertically. In the lifting stage, with the releasing and unloading of the stress, the caprock becomes brittle generally and then forms through going fault which will lead to a large quantity of oil and gas migrate vertically. | Xiaofei Fu Lingyu Yan Lingdong Meng Xiaobo Liu | 2019 | Journal of Earth Science2019，30，2： | 5 |
| 5 | Nuclear m^(6)A reader YTHDC1 regulates the scaffold function of LINE1 RNA in mouse ESCs and early embryos显示文摘N^(6)-methyladenosine(m^(6)A)on chromosome-associated regulatory RNAs(carRNAs),including repeat RNAs,plays important roles in tuning the chromatin state and transcription,but the intrinsic mechanism remains unclear.Here,we report that YTHDC1 plays indispensable roles in the self-renewal and differentiation potency of mouse embryonic stem cells(ESCs),which highly depends on the m^(6)A-binding ability.Ythdcl is required for sufficient rRNA synthesis and repression of the 2-cell(2C)transcriptional program in ESCs,which recapitulates the transcriptome regulation by the LINE1 scaffold.Detailed analyses revealed that YTHDC1 recognizes m^(6)A on LINE1 RNAs in the nucleus and regulates the formation of the LINE1-NCL partnership and the chromatin recruitment of KAP1.Moreover,the establishment of H3K9me3 on 2C-related retrotrans-posons is interrupted in Ythdcl-depleted ESCs and inner cell mass(ICM)cells,which consequently increases the transcriptional activities.Our study reveals a role of m^(6)A in regulating the RNA scaffold,providing a new model for the RNA-chromatin cross-talk. | Chuan Chen Wenqiang Liu Jiayin Guo Yuanyuan Liu Xuelian Liu Jun Liu Xiaoyang Dou Rongrong Le Yixin Huang Chong Li Lingyue Yang Xiaochen Kou Yanhong Zhao You Wu Jiayu Chen Hong Wang Bin Shen Yawei Gao Shaorong Gao | 2021 | Protein & Cell2021，12，6： | 4 |
| 6 | Relative dynamics estimation of non-cooperative spacecraft with unknown orbit elements and inertial tensor显示文摘The state estimation for relative motion with respect to non-cooperative spacecraft in rendezvous and docking(RVD) is a challenging problem. In this paper, a completely non-cooperative case is considered, which means that both orbit elements and inertial tensor of target spacecraft are unknown. By formulating the equations of relative translational dynamics in the orbital plane of chaser spacecraft, the issue of unknown orbit elements is solved. And for the problem for unknown inertial tensor, we propose a novel robust estimator named interaction cubature Kalman filter(In CKF) to handle it. The novel filter consists of multiple concurrent CKFs interlacing with a maximum a posteriori(MAP) estimator. The initial estimations provided by the multiple CKFs are used in a Bayesian framework to form description of posteriori probability about inertial tensor and the MAP estimator is applied to giving the optimal estimation. By exploiting special property of spherical-radial(SR) rule, a novel method with respect to approximating the likelihood probability of inertial tensor is presented. In addition, the issue about vision sensor's location inconformity with center mass of chaser spacecraft is also considered. The performance of this filter is demonstrated by the estimation problem of RVD at the final phase. And the simulation results show that the performance of In CKF is better than that of extended Kalman filter(EKF) and the estimation accuracy of pose and attitude is relatively high even in the completely non-cooperative case. | Yu Han Zhang Xiujie Liu Lingyu Wang Shuo Song Shenmin | 2016 | Chinese Journal of Aeronautics2016，29，2： | 4 |
| 7 | Pharmacological and cardiovascular perspectives on the treatment of COVID-19 with chloroquine derivatives显示文摘The novel severe acute respiratory syndrome coronavirus-2(SARS-CoV-2)causes coronavirus disease 2019(COVID-19)and an ongoing severe pandemic.Curative drugs specific for COVID-19 are currently lacking.Chloroquine phosphate and its derivative hydroxychloroquine,which have been used in the treatment and prevention of malaria and autoimmune diseases for decades,were found to inhibit SARS-CoV-2 infection with high potency in vitro and have shown clinical and virologic benefits in COVID-19 patients.Therefore,chloroquine phosphate was first used in the treatment of COVID-19 in China.Later,under a limited emergencyuse authorizati on from the FDA,hydroxychloro quine in combi nation with azithromyci n was used to treat COVID-19 patie nts in the USA,although the mechanisms of the anti-COVID-19 effects remain unclear.Preliminary outcomes from clinical trials in several countries have gen erated con troversial results.The desperatio n to control the pan demic overrode the con cerns regardi ng the serious adverse effects of chloro quine derivatives and combi nation drugs,i ncluding lethal arrhythmias and cardiomyopathy.The risks of these treatments have become more complex as a result of findings that COVID-19 is actually a multisystem disease.While respiratory symptoms are the major clin ical man ifestati ons,cardiovascular abno rmalities,in eluding arrhythmias,myocarditis,heart failure,and ischemic stroke,have been reported in a significant number of COVID-19 patients.Patients with preexisting cardiovascular conditions(hypertension,arrhythmias,etc.)are at increased risk of severe COVID-19 and death.From pharmacological and cardiovascular perspectives,therefore,the treatment of COVID-19 with chloroquine and its derivatives should be systematically evaluated,and patients should be routinely monitored for cardiovascular conditions to prevent lethal adverse events. | Xiao-lei Zhang Zhuo-ming Li Jian-tao Ye Ji ng Lu Lingyu Linda Ye Chun-xiang Zhang Pei-qing Liu Dayue D Duan | 2020 | Acta Pharmacologica Sinica2020，41，11： | 3 |
| 8 | Study on the Detection Methods of DC Series Arc Fault显示文摘It is difficult to detect and extinguish direct current(DC)arc in power electronics systems,and the arc could easily lead to a fire and cause great damage to surrounding equipment.A DC arc generation simulation unit is established,in which DC series arcs are generated by dragging the moving electrode away from the fixed one with the help of the stepper motor.In addition,a ferrite rod antenna is used to receive the electromagnetic radiation signals induced by the arcs.Based on experiments using the unit,the general characteristics of DC arc,including the pulse characteristics of arc current and source output in corresponding time window,and the frequency-domain characteristics of arc current,are studied.With discussion on three detection methods,it is concluded that the variation of current and voltage of arc,the spectrum of the arc current during the discontinuous intervals and the radiating electromagnetic signal are all features that can be adopted for detecting DC series arc.Therefore,a synthetic judgment method is suggested for further study. | JI Shengchang LIU Yuan ZHU Yeye ZHU Lingyu | 2013 | 高电压技术2013，39，9： | 3 |
| 9 | The integration of transcriptomic and transgenic analyses reveals the involvement of the SA response pathway in the defense of chrysanthemum against the necrotrophic fungus Alternaria sp.显示文摘Chrysanthemum morifolium cv.‘Huaihuang’has ornamental,edible,medicinal,and tea product uses.However,its field growth,yield,and quality are negatively affected by black spot disease caused by Alternaria sp.(Strain:HQJH10092301;GenBank accession number:KF688111).In this study,we transcriptionally and transgenically characterized a new cultivar,‘Huaiju 2#’(Henan Traditional Chinese Medicine Plant Cultivar identification number:2016002),which was bred from‘Huaihuang’and shows resistance to Alternaria sp.Numerous‘Huaiju 2#’plants were inoculated with Alternaria sp.for three or five days.Metabolic analysis showed increases in both salicylic acid(SA)and jasmonic acid(JA)in infected plants compared to the control.Protein activity analysis also revealed a significant increase in defense enzyme activities in infected plants.RNA-Seq of plants infected for 3 or 5 days produced a total of 58.6 GB of clean reads.Among these reads,16,550 and 13,559 differentially expressed genes(DEGs)were identified in Cm_3 dpi(sample from 3 days post-inoculation labeled as Cm_3 dpi)and Cm_5 dpi(sample from 5 days post-inoculation labeled as Cm_5 dpi),respectively,compared with their controls(Cm_0 d:a mixture samples from 0 d(before inoculation)and those treated with sterile distilled water at 3 dpi and 5 dpi).Gene annotation and cluster analysis of the DEGs revealed a variety of defense responses to Alternaria sp.infection,which were characterized by increases in resistance(R)proteins and the reactive oxygen species(ROS),Ca2+,mitogen-activated protein kinase(MAPK),and JA signaling pathways.In particular,SA signaling was highly responsive to Alternaria sp.infection.The qPCR analysis of 12 DEG candidates supported their differential expression characterized by using the RNA-Seq data.One candidate was CmNPR1(nonexpressor of pathogenesis-related gene 1),an important positive regulator of SA in systemic acquired resistance(SAR).Overexpression of CmNPR1 in‘Huaiju 2#’increased the resistance of transgenic plants to black spot.These findings indicate that the SA response pathway is likely involved in the defense of‘Huaiju 2#’against Alternaria sp.pathogens. | Xiting Zhao Lingyu Song Liwei Jiang Yuting Zhu Qinghui Gao Dandan Wang Jing Xie Meng Lv Ping Liu Mingjun Li | 2020 | Horticulture Research2020，7，1： | 3 |
| 10 | Thermal stability of different texture components in extruded Mg-3Al-1Zn alloy显示文摘Grain growth can modify the texture orientation and the fraction of different texture component.The thermal stability of two texture component in an extruded magnesium AZ31 alloy was investigated.Three types samples with different texture distribution were prepared.The results show that normal grain growth takes place in the magnesium AZ31 alloy during annealing at 300℃ and 450℃.But the grain growth does not lead to the strengthening of either texture component.Both the<0002>⊥ED texture and<0002>//ED texture components show good thermal stability,without influence of the texture volume fraction.The two different texture component possess comparable boundary migration ability,so grains of the two texture component consume indifferently the other grains,or are equally consumed during annealing. | Lingyu Zhao Yunchang Xin Zhaoyang Jin Jian Wang Bo Feng Qing Liu | 2019 | Journal of Magnesium and Alloys2019，7，4： | 3 |
| 11 | Research on cloud computing and services framework of marine environmental information management显示文摘Based on the features of marine environmental data and processing requirements,a cloud computing architecture of marine environment information is proposed,which provides a new cloud technology framework for the integration and sharing of marine environmental information resources.A physical layer,software platform layer and an application layer are illustrated systematically,at the same time,a corresponding solutions for many difficult technical problems such as parallel query processing of multi-dimensional,spatiotemporal information,data slice storage,software service flow customization,analysis,reorganization and so on.A prototype system is developed and many different data-size experiments and a comparative analysis are done based on it.The experiment results show that the cloud platform based on this framework can achieve high performance and scalability when dealing with large-scale marine data. | SHI Suixiang LIU Yang WEI Hongyu QIAO Baiyou WANG Guoren XU Lingyu | 2013 | Acta Oceanologica Sinica2013，32，10： | 3 |
| 12 | Chartrenoline, a novel alkaloid isolated from a marine Streptomyces chartreusis NA02069显示文摘A novel alkaloid, chartrenoline(1), featuring an unusual 6/6/5/5-tetracyclic nucleus, was isolated from a marine Streptomyces chartreusis NA02069. The structure of 1 including its absolute configurations was established by extensive analyses of its high resolution mass, NMR and single-crystal X-ray diffraction data. A plausible biosynthetic pathway for chartrenoline(1) is proposed. | Chengli Liu Chenglong Yang Yingjie Zeng Jing Shi Lingyu Li Wei Li Ruihua Jiao Renxiang Tan Huiming Ge | 2019 | Chinese Chemical Letters2019，30，1： | 3 |
| 13 | Loss of FOXC1 contributes to the corneal epithelial fate switch and pathogenesis显示文摘Forkhead box C1(FOXC1)is required for neural crest and ocular development,and mutations in FOXC1 lead to inherited Axenfeld-Rieger syndrome.Here,we find that FOXC1 and paired box 6(PAX6)are co-expressed in the human limbus and central corneal epithelium.Deficiency of FOXC1 and alternation in epithelial features occur in patients with corneal ulcers.FOXC1 governs the fate of the corneal epithelium by directly binding to lineage-specific open promoters or enhancers marked by H3K4me2.FOXC1 depletion not only activates the keratinization pathway and reprograms corneal epithelial cells into skin-like epithelial cells,but also disrupts the collagen metabolic process and interferon signaling pathways.Loss of interferon regulatory factor 1 and PAX6 induced by FOXC1 dysfunction is linked to the corneal ulcer.Collectively,our results reveal a FOXC1.mediated regulatory network responsible for corneal epithelial homeostasis and provide a potential therapeutic target for corneal ulcer. | Mingsen Li Liqiong Zhu Jiafeng Liu Huaxing Huang Huizhen Guo Li Wang Lingyu Li Sijie Gu Jieying Tan Jing Zhong Bowen Wang Zhen Mao Yong Fan Chunqiao Liu Jin Yuan Hong Ouyang | 2021 | Signal Transduction and Targeted Therapy2021，6，2： | 2 |
| 14 | New Discovery of the Late Triassic Terrigenous Sediments in the Great Xing''an Range Region,NE China and its Geological Significance显示文摘Objective The Great Xing'an Range is located in the eastern section of Central Asian Orogenic Belt(CAOB).As a superposed position of multiple tectonic domains,its structural evoIlution has always been a focused issue of geological research.The Triassic is a critical turning | LI Shichao ZHANG Lingyu LIU Zhenghong XU Zhongyuan | 2017 | Acta Geologica Sinica(English Edition)2017，91，5： | 2 |
| 15 | Novel mi- crostrip lowpass filter using stepped impedance resonator and spurline resonator显示文摘 | Li Lingyu Liu Haiwen Teng Baohua | 2009 | Microwave and Optical Technol- ogy Letters2009，51，1： | 1 |
| 16 | Extensively Drug-Resistant(XDR)Salmonella Typhi Outbreak by Waterborne Infection——Beijing Municipality,China,January-February 2022显示文摘Summary What is already known about this topic?Typhoid fever remains a major public health problem in developing countries.Waterborne typhoid fever affects an estimated 27 million people worldwide each year.Decades of indiscriminate antibiotic usage has driven the emergence and spread of multidrug-resistant(MDR)and even extensively drug-resistant(XDR)Salmonella Typhi(S.Typhi)strains. | Yu Wang Dan Lu Yingying Jin Huanxin Wang Bing Lyu Xin Zhang Ying Huang Gaolin Shu Baiwei Liu Changying Lin Hao Zhao Mingqiang Zhao Lingyu Shen Zhiyong Gao Daitao Zhang Quanyi Wang Mei Qu Lei Jia | 2022 | China CDC weekly2022，4，12： | 1 |
| 17 | Using attack graphs for correlating, hypothesizing, and predicting intrusion a- lerts显示文摘 | Wang Lingyu Liu Anyi Jajodia S | 2006 | Computer Communications2006，29，15： | 1 |
| 18 | Stability of HIV-1 subtype B and C Tat is associated with variation in the carboxyl-terminal region显示文摘The multifunctional trans-activator Tat is an essential regulatory protein for HIV-1 replication and is characterized by high sequence diversity. Numerous experimental studies have examined Tat in HIV-1 subtype B, but research on subtype C Tat is lacking, despite the high prevalence of infections caused by subtype C worldwide. We hypothesized that amino acid differences contribute to functional differences among Tat proteins. In the present study, we found that subtype B NL4-3Tat and subtype C isolate HIV1084 i Tat exhibited differences in stability by overexpressing the fusion protein Tat-Flag. In addition, 1084 i Tat can activate LTR and NF-κB more efficiently than NL4-3 Tat. In analyses of the activities of the truncated forms of Tat, we found that the carboxylterminal region of Tat regulates its stability and transactivity. According to our results, we speculated that the differences in stability between B-Tat and C-Tat result in differences in transactivation ability. | Xuechao Zhao Lingyu Qian Deyu Zhou Di Qi Chang Liu Xiaohong Kong | 2016 | Virologica Sinica2016，31，3： | 1 |
| 19 | Round-trip oscillation triboelectric nanogenerator with high output response and low wear to harvest random wind energy显示文摘Triboelectric nanogenerator(TENG)has made significant progress in wind energy harvesting.As the most advantageous rotary TENG among wind energy harvesters,the severe material wear and the output that fluctuates with wind speed seriously hinder the application of TENG wind energy harvesters.In this study,we propose a round-trip oscillation triboelectric nanogenerator(RTO-TENG)consisting of a crank transmission mechanism and a power generation unit.The RTO-TENG utilizes a simple crank transmission mechanism combined with a zigzag-laminated triboelectric nanogenerator(Z-TENG)to achieve high-performance constant output and low material wear.The crank transmission mechanism can realize the transformation from circular motion to arc reciprocating motion,converting the random wind energy into bi-directional kinetic energy,driving the vertical contact and separation of the Z-TENG.Due to the low transmission ratio(1:1)of the crank transmission mechanism and the consistent frequency of the Z-TENG contact–separation with that of the pendulum,the RTO-TENG’s power generation unit(10 Z-TENGs)is insensitive to changes in wind speed,resulting in a constant and stable output response at various speeds.After 480,000 cycles,the output of RTO-TENG decreased by only 0.9%compared to the initial value of 6μC,and the scanning electron microscopy(SEM)images of the polytetrafluoroethylene(PTFE)film showed no significant wear on the surface of the friction layer,demonstrating excellent output stability and abrasion resistance of the RTO-TENG wind energy collector’s material.The equipped energy management module,based on a gas discharge tube switch,can further enhance the output performance of the RTO-TENG.After optimizing its inductor parameter L to match the load capacitor,it can charge a 220μF load capacitor to 13.4 V in 40 s,resulting in a 298%improvement in charging speed compared to the voltage of 4.48 V without the management module.Therefore,the RTO-TENG can efficiently provide power to low-power small electronic devices for Internet of Things(IoTs),such as road traffic warning signs and thermo-hygrometers. | Xinyu Hu Junrui Feng Chuangjian Liang Heng Ning Chunjin Chen Jiayu Li Honggui Wen Huilu Yao Lingyu Wan Guanlin Liu | 2023 | Nano Research2023，16，8： | 1 |
| 20 | Adsorption of L-phenylalanine on single-walled carbon nanotubes 显示文摘 | PIAO Lingyu LIU Quanrun LI Yongdan | 2008 | J Phys Chem C2008，112，8： | 1 |
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