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| 1 | New Trends in Internal Migration in China: Profiles of the New-generation Migrants显示文摘 | Liqiu Zhao Shouying Liu Wei Zhang | 2018 | China & World Economy2018，26，1： | 19 |
| 2 | USP19 suppresses inflammation and promotes M2-like macrophage polarization by manipulating NLRP3 function via autophagy显示文摘Macrophage polarization to proinflammatory M1-like or anti-inflammatory M2-like cells is critical to mount a host defense or repair tissue.The exact molecular mechanisms controlling this process are still elusive.Here,we report that ubiquitin-specific protease 19(USP19)acts as an anti-inflammatory switch that inhibits inflammatory responses and promotes M2-like macrophage polarization.USP19 inhibited NLRP3 inflammasome activation by increasing autophagy flux and decreasing the generation of mitochondrial reactive oxygen species.In addition,USP19 inhibited the proteasomal degradation of inflammasome-independent NLRP3 by cleaving its polyubiquitin chains.USP19-stabilized NLRP3 promoted M2-like macrophage polarization by direct association with interferon regulatory factor 4,thereby preventing its p62-mediated selective autophagic degradation.Consistent with these observations,compared to wild-type mice,Usp19−/−mice had decreased M2-like macrophage polarization and increased interleukin-1βsecretion,in response to alum and chitin injections.Thus,we have uncovered an unexpected mechanism by which USP19 switches the proinflammatory function of NLRP3 into an anti-inflammatory function,and suggest that USP19 is a potential therapeutic target for inflammatory interventions. | Tao Liu Liqiu Wang Puping Liang Xiaojuan Wang Yukun Liu Jing Cai Yuanchu She Dan Wang Zhi Wang Zhiyong Guo Samuel Bates Xiaojun Xia Junjiu Huang Jun Cui | 2021 | Cellular & Molecular Immunology2021，18，10： | 15 |
| 3 | Promotion of spinosad biosynthesis by chromosomal integration of the Vitreoscilla hemoglobin gene in Saccharopolyspora spinosa显示文摘To promote spinosad biosynthesis by improving the limited oxygen supply during high-density fermentation of Saccharopolyspora spinosa, the open reading frame of the Vitreoscilla hemoglobin gene was placed under the control of the promoter for the erythromycin resistance gene by splicing using overlapping extension PCR. This was cloned into the integrating vector pSET152, yielding the Vitreoscilla hemoglobin gene expression plasmid pSET152EVHB. This was then introduced into S. spinosa SP06081 by conjugal transfer, and integrated into the chromosome by site-specific recombination at the integration site ΦC31 on pSET152EVHB. The resultant conjugant, S. spinosa S078-1101, was genetically stable. The integration was further confirmed by PCR and Southern blotting analysis. A carbon monoxide differential spectrum assay showed that active Vitreoscilla hemoglobin was successfully expressed in S. spinosa S078-1101. Fermentation results revealed that expression of the Vitreoscilla hemoglobin gene significantly promoted spinosad biosynthesis under normal oxygen and moderately oxygen-limiting conditions (P<0.01). These findings demonstrate that integrating expression of the Vitreoscilla hemoglobin gene improves oxygen uptake and is an effective means for the genetic improvement of S. spinosa fermentation. | LUO YuShuang KOU XiaoXiao DING XueZhi HU ShengBiao TANG Ying LI WenPing HUANG Fan YANG Qi CHEN HanNa XIA LiQiu | 2012 | Science China(Life Sciences)2012，55，2： | 14 |
| 4 | Profiling of microbial communities in a bioreactor for treating hydrocarbon-sulfide-containing wastewater显示文摘A technology of polymerase chain reaction-denaturing gradient gel electrophoresis(PCR-DGGE)was used to profile the structure and dynamic changes of microbial communities in a bioreactor for treating hydrocarbon-sulfide-containing(HSC)wastewater.The results showed that the heterotrophic genus of Acinetobacter and the autotrophic genera of Thiobacillus and Thiomonas could survive well in all of three operating conditions.Some special genera were also observed with changes of micro-ecoenvironment in the rea... | Liao Bo Ji Guodong Cheng Liqiu | 2008 | Journal of Environmental Sciences2008，20，8： | 10 |
| 5 | Effect of additive boron on type-Ib gem diamond single crystals synthesized under HPHT显示文摘The boron-doped type-Ib gem diamond crystals were synthesized successfully by adding amorphous boron into a system of graphite and Kovar catalyst under high pressure and high temperature (HPHT).The effect of additive boron on type-Ib gem diamond was extensively studied including the growth characteristic,morphology and nitrogen concentration.The synthesized boron-doped type-Ib gem diamond crystals were characterized by optical microscope (OM),scanning electron microscope (SEM) and infrared spectrometer (IR).The results show that the growth region of the {111} face becomes wide,whereas the growth region of the {100} face becomes narrow and nearly disappears as increasing additive boron in the sample.The crystal will be opaque and imperfect,and the concentration of nitrogen will be decreased when the boron atoms are incorporated into gem diamond lattice.These techniques are very important and will be widely applied. | MA LiQiu MA HongAn XIAO HongYu LI ShangSheng LI Yong JIA XiaoPeng | 2010 | Chinese Science Bulletin2010，55，8： | 8 |
| 6 | Influencing factors and degradation products of antipyrine chlorination in water with free chlorine显示文摘Owing to its low cost, free chlorine is one of the most common disinfectants for wastewater and drinking water treatment. However, the formation of disinfection byproducts has been found to occur after free chlorine disinfection in recent decades. Antipyrine (ANT), an anti-inflammatory analgesic, has been frequently detected in the aquatic environment. In this work, the removal efficiency of ANT by free chlorine oxidation in ultrapure water was investigated with batch experiments. The influencing factors on the removal of ANT were explored at initial concentrations of ANT from 0.04 to 0.64 mg/L, free chlorine dosage from 0.30 to 1.31 mg/L, and pH from 1.5 to 9.0. The main degradation products were identified by solid phase extraction-gas chromatography-mass spectrometry. The results showed that ANT reacted rapidly with free chlorine in ultrapure water systems and up to 90.6% removal efficiency of ANT was achieved after 25 sec (initial free chlorine 1 mg/L, ANT 0.5 mg/L, pH 7.0). Higher oxidant dosage, lower ANT initial concentration and low pH favor the ANT removal. The main degradation product in ANT chlorination was a monochlorine substitution product (4-chloro-1,2-dihydro- 1,5-dimethyl-2-phenyl-3H-pyrazol-3-one), which can be further chlorinated by free chlorine. In addition, the total organic carbon result indicated that ANT is difficult to be mineralized using chlorine. | Meiquan Cai Liqiu Zhang Fei Qi Li Feng | 2013 | Journal of Environmental Sciences2013，25，1： | 7 |
| 7 | Effects of carbon diffusing field in alloy solvent on the growth of tower-shape diamond single crystal显示文摘High-quality type-Ib tower-shape diamond single crystals were synthesized in cubic anvil high pressure apparatus (SPD-6×1200) at 5.4 GPa and 1250-1450°C. The (100) face of seed crystal was used as the growth face, and FeNiMnCo alloy was used as the solvent/catalyst. Two kinds of carbon diffusing fields (type-B and type-G) were simulated by finite element method (FEM). Using the two kinds of carbon diffusing fields, many diamond single crystals were synthesized. The effects of carbon diffusing fields on the crystal quality and β value (the ratio of height to diameter of diamond crystal) were studied. The results show that using type-B diffusing field, considerable inclusions appeared in tower-shape diamond crystals with high β values; however, using type- G diffusing field, inclusions were reduced markedly in high β values tower-shape diamond crystals, and the crystal, up to 0.6 carat in weight and 5.3 mm in size, was synthesized. Experimental phenomena were explained well with the help of the FEM. | XIAO HongYu MA HongAn TIAN Yu LI Rui LI ShangSheng MA LiQiu LI Yong JIA XiaoPeng | 2010 | Chinese Science Bulletin2010，55，1： | 5 |
| 8 | Dependence of nitrogen concentration in type Ib diamonds on synthesis temperature显示文摘Type Ib diamonds were grown by the temperature gradient method (TGM) at 5.5 GPa and 1500-1560 K in a china-type cubic anvil high pressure apparatus using Ni70Mn25Co5 alloy as solvent/catalyst. The concentration of nitrogen (CN) in type Ib diamonds synthesized at different synthesis temperatures was measured by a Fourier transform infrared (FTIR) spectrometer. The dependence of CN in diamond on synthesis temperature was studied. For the type Ib diamonds synthesized using Ni70Mn25Co5 as catalyst, its CN decreases along with the increase of synthesis temperature. | TIAN Yu JIA XiaoPeng ZANG ChuanYi LI ShangSheng XIAO HongYu ZHANG YaFei HUANG GuoFeng LI Rui HAN QiGang MA LiQiu LI Yong CHEN XiaoZhou ZHANG Chong MA HongAn | 2009 | Chinese Science Bulletin2009，54，9： | 5 |
| 9 | Purification and Characterization of an Antibacterial Protein from the Cultured Mycelia of Cordyceps sinensis显示文摘抗菌剂蛋白质从 Cordycepssinensi.f 的有教养的 mycelia 被孤立,并且被指定为 Cordyceps sinensis 抗菌剂蛋白质(CSAP ) 。CSAP 锁住 wassingle,与 35 x 10 ~ 的一个明显的分子的团, 3 由 SDS 页和新奇恐水病的 N 终端顺序 N-ALATQHGAP 揭示了。抗菌剂试金证明 CSAP 能对真菌或酵母禁止克积极、克否定的细菌而是没有重要抑制的生长。而且, CSAP 的抗菌剂活动不杀菌却细菌抑制。抗菌剂蛋白质在 Cordyceps 种类被描述的 Itwas 第一次,它可能在主人的化学防卫机制包含。 | HU Zheng YE Maoqing XIA Liqiu TU Wenjuan LI Liang ZOU Guolin | 2006 | Wuhan University Journal of Natural Sciences2006，11，3： | 5 |
| 10 | Downregulation of long non-coding RNA MEG3 promotes proliferation, migration, and invasion of human hepatocellular carcinoma cells by upregulating TGF-β1显示文摘Hepatocellular carci no ma is a common malig nant can cer with high incide nee. And long noncoding RNAs (lncRNAs) play pivotal roles in the development of different types of cancers. In this study, we aimed to investigate the role of lncRNA maternally expressed gene 3 (MEG3) in the development and progression of hepatocellular carcinoma. Expression of MEG3 in tumor tissues and adjacent healthy tissues of hepatocellular carcinoma patients, as well as the serum of both hepatocellular carcinoma patients and healthy controls, was detected by quantitative reverse transcriptase-polymerase chain reaction. The results showed that expression level of MEG3 was significantly lower in tumor tissues than in adjacent healthy tissues. Serum level of MEG3 was also significantly lower in hepatocellular carci noma patients tha n in normal controls. The receiver operating characteristic curve analysis was used to evaluate the diagnostic value of MEG3 for hepatocellular carcinoma, and the prognostic value of MEG3 for this disease was analyzed using Kaplan-Meier method. The results indicated that serum level of MEG3 was a diagnostic and prognostic marker for hepatocellular carcinoma. We also found that MEG3 small interfering Ribonucleic Acid (siRNA) silencing promoted the proliferation, migration, and invasi on of hepatocellular carci noma cells by CCK-8 assay, transwell migration, and invasion assay, respectively, while TGF-β inhibitor treatment reduced those enhancing effects. MEG3 siRNA silencing also increased the expression level of TGF-β1. These results indicated that downregulation of MEG3 can promote proliferation, migration, and invasion of human hepatocellular carcinoma cells by upregulating TGF-β1 expression. | Hui Dong Yue Zhang Yan Xu Ruixia Ma Liqiu Liu Congjuan Luo Wei Jiang | 2019 | Acta Biochimica et Biophysica Sinica2019，51，6： | 4 |
| 11 | The role of β18-β19 loop structure in insecticidal activity of Cry1Ac toxin from Bacillus thuringiensis显示文摘The β18-β19 loop in domain III of Cry1Ac toxin is unique among Bacillus thuringiensis Cry proteins. In this study, the role of the loop structure in insecticidal activity of Cry1Ac toxin was investigated. Alanine scanning mutations within the loop were initially generated and most mutants were over-expressed and reduced toxicity at different degrees, except mutant N546A that showed almost 2 times enhanced toxicity against Helicoverpa armigera larvae. Further mutagenic analysis of N546 revealed that a charged amino acid in this position would cause very unfavorable influence on insecticidal activity. In addition, the deletion of N546 led to protein instability because of destruction of the loop integrity. Besides, mutant W544F was much more toxic than W544Y, indicating that hydrophobic nature of the position was important for maintaining the stability and activity of Cry1Ac protein. These findings are the first biological evidence for a structural function of β18-β19 loop in insecticidal activity of the Cry1Ac toxin. | XIA LiQiu WANG FaXiang DING XueZhi ZHAO XinMin FU ZuJiao QUAN MeiFang YU ZiNiu | 2008 | Chinese Science Bulletin2008，53，20： | 4 |
| 12 | Long non-coding RNA LINC-PINT attenuates paclitaxel resistance in triple-negative breast cancer cells via targeting the RNA-binding protein NONO显示文摘The treatment of triple-negative breast cancer(TNBC)relies largely on chemotherapies.However,it is frequent that TNBC patients develop resistance to the chemotherapy drugs.Generation of drug-resistant cell lines facilitates the identification of drug resistance.Here,we established two paclitaxel(PTX)-resistant TNBC cancer cell lines using an intermittent and stepwise method and found that long non-coding RNA long intergenic non-protein-coding RNA p53-induced transcript(LINC-PINT)was significantly decreased in PTX-resistant cancer cells.Ectopic expression of LINC-PINT sensitized both PTX-resistant TNBC and wild-type TNBC to PTX.Moreover,RNA immunoprecipitation showed that LINC-PINT bound to RNA-binding protein NONO.Overexpression of LINC-PINT resulted in the degradation of NONO in a proteasome-dependent manner and vice versa.Knockdown of NONO with siRNA sensitized TNBC to PTX.We further analyzed the expression level of LINC-PINT and NONO in patient samples via online database and found that LINC-PINT and NONO may function antagonistically in all types of breast cancers.Taken together,our data illustrated a tumor suppressor role of LINC-PINT in sensitizing TNBC to chemotherapies via destabilizing NONO. | Jinghua Chen Meiqin Zhu Liqiu Zou Junxian Xia Jiacheng Huang Quantong Deng Ruilian Xu | 2020 | Acta Biochimica et Biophysica Sinica2020，52，8： | 4 |
| 13 | A biomass carbon material with microtubule bundling and natural O-doping derived from goldenberry calyx and its electrochemical performance in supercapacitor显示文摘A promising biomass carbon material,manufactured by the carbonation of Physalis peruviana L.calyx at 700℃,is presented in this wo rk.Morphology characterization shows that the carbon material possesses long microtubule bundling and above 30%natural O-atom component on the surface.After KOH chemical etching,the materials maintain the oxygen content but exhibit more micropores and higher specific surface area up to 1732.6 m^2/g.Using as an electrode material for supercapacitor,the active carbon material exhibits high specific capacitance up to 339.7 F/g at 0.5 A/g in 3 mol/L KOH aqueous solution through three-electrode system.The active carbon material also exhibits excellent cycling stability(97%retention)by 10,000 cycles at 10 A/g.The outstanding electrochemical performances are attributing to the unique long microtubule bundling with much more pores and the abundant Oelement on the surface.This biomass carbon material with excellent electrochemical properties could be a useful material for multiple applications. | Yang Liu Mengyi Zhang Liqiu Wang Yajuan Hou Chenxiao Guo Haiying Xin Shuang Xu | 2020 | Chinese Chemical Letters2020，31，3： | 4 |
| 14 | Performance and fouling mechanism of direct contact membrane distillation(DCMD) treating fermentation wastewater with high organic concentrations显示文摘In this study,direct contact membrane distillation(DCMD)was used for treating fermentation wastewater with high organic concentrations.DCMD performance characteristics including permeate flux,permeate water quality as well as membrane fouling were investigated systematically.Experimental results showed that,after 12 hr DCMD,the feed wastewater was concentrated by about a factor of 3.7 on a volumetric basis,with the permeate flux decreasing from the initial 8.7 L/m^2/hr to the final 4.3 L/m^2/hr due to membrane fouling;the protein concentration in the feed wastewater was increased by about 3.5 times and achieved a value of 6178 mg/L,which is suitable for reutilization.Although COD and TOC in permeate water increased continuously due to the transfer of volatile components from wastewater,organic rejection of over 95%was achieved in wastewater.GC–MS results suggested that the fermentation wastewater contained 128kinds of organics,in which 14 organics dominated.After 12 hr DCMD,not only volatile organics including trimethyl pyrazine,2-acetyl pyrrole,phenethyl alcohol and phenylacetic acid,but also non-volatile dibutyl phthalate was detected in permeate water due to membrane wetting.FT-IR and SEM–EDS results indicated that the deposits formed on the membrane inner surface mainly consisted of Ca,Mg,and amine,carboxylic acid and aromatic groups.The fouled membrane could be recovered,as most of the deposits could be removed using a HCl/Na OH chemical cleaning method. | Yan Wu Yun Kang Liqiu Zhang Dan Qu Xiang Cheng Li Feng | 2018 | Journal of Environmental Sciences2018，30，3： | 4 |
| 15 | Metagenome analysis reveals potential microbial functions in topsoil of wheat-maize rotation system with five-year application of fertilizers显示文摘Fertilization mode affects soil quality and ecological health.The effects of four fertilization regimens on lignocellulose content,readily degradable carbohydrate decomposition,and potential microbial functions in the topsoil of a wheat-maize rotation system between 2012 and 2017 were investigated.The fertilization regimens of control(control NFNB),high chemical fertilizer(HCF),high biochar plus low chemical fertilizer(HBLCF),and biochar-based fertilizer(BBF)were compared on soil fundamental properties,microbial structure,and potential function in soil carbohydrate degradation based on metagenome analysis.The diversity of carbohydrate-active enzyme genes in the topsoil microbial consortia in the four trials was primarily distributed within the ten ecologically most dominant phyla.Application of BBF was associated with the lowest decline in total nitrogen and P2O5(2012-2017:6.5%and 28.1%,respectively)and the most effective carbohydrate decomposition(2015-2017:67.0%for cellulose and 59.9%for readily degradable carbohydrate).Carbohydrate transport and metabolism accounted for 6.0%of reads assigned functional classification under the BBF regimen.These findings reveal the ecologically functional diversity of topsoil microorganisms and suggest BBF application as a promising strategy for sustainable agriculture and beneficial to soil health. | Yujun Shen Lixin Zhao Haibo Meng Hongsheng Cheng Jingtao Ding Jiarui Wang Shanshan Dong Xi Zhang Liqiu Song Shengwei Zheng | 2019 | International Journal of Agricultural and Biological Engineering2019，12，6： | 3 |
| 16 | Proliferation of Cartographic Education in the Age of Big Data显示文摘Maps have long been a part of everyday life for the general public,and even more so in today’s knowledge society.No doubt,cartography as a profession of map design is assuming a more important role in the formation of intellectual skills in terms of spatial reasoning.Since its emergence as an academic discipline about 100 years ago,cartography has undergone many paradigm shifts.Its interaction with other disciplines has also constantly unfolded.These changes have left traces in cartographic education programs.In the age of big data,however,we are facing four fundamental challenges:(1) cartographic courses are being marginalized or even disappearing from degree programs in geospatial sciences;(2) the role of cartographers is increasingly eclipsed as a side effect of participatory cartography;(3) cartographers are blamed whenever something goes wrong with map use;and(4) professional map publishers can hardly compete with online mapping platforms dominated by Internet giants.Based on a contextual analysis of this seemingly gloomy situation,the paper reveals a number of proliferation points for the design of future cartographic curricula.First,cartography,once dedicated to supporting geospatial sciences,is thriving in the soil of data science,mapping not only the earth or other celestial bodies,but literally any kind of virtual space.Second,cartography has benefited from theoretical and technological advances in cognitive sciences,especially non-intrusive user studies,so that spatial cognition is becoming an integral component of cartographic education.Third,the role of scapegoat for wrongdoing of maps has accentuated cartographer’s overarching responsibility for quality and ethical issues in the geodata value chain.Finally,the diversification of the labor market requires new approaches to prepare future talents for a coopetition-oriented ecosystem in the marketplace. | Liqiu MENG | 2022 | Journal of Geodesy and Geoinformation Science2022，5，3： | 3 |
| 17 | Synthesis and thermal conductivity of microfluidic copper nanofluids显示文摘A microfluidic chemical solution method is developed for the synthesizing Cu nanofluids. The method replaces batch-based macroreactors in the conventional chemical solution method by continuous-flow microfluidic microreactors, thereby enabling the synthesis of nanofluids with various microstructures. The Cu nanofluids synthesized by this technology show a better stability, remaining stable even after more than 100 h standing. The measured thermal conductivity shows that the presence of nanoparticles can either upgrade or downgrade fluid conductivity, a phenomenon predicted by the recent thermal-wave theory of nanofluids. | Xiaohao Wei Liqiu Wang | 2010 | Particuology2010，8，3： | 3 |
| 18 | Shell Model Representation as a Substitute of LoD3 for 3D Modeling in CityGML显示文摘The OGC standard for 3D city modeling is widely used in an increasing number of applications.It defines five consecutive Levels of Detail(LoD0 to LoD4 with increasing accuracy and structural complexity),in which LoD3 includes all exterior appearances and geometrical details and subsequently requires much storage space.A new LoD is introduced as shell model with the exterior shell of the LoD3 model and the opening objects like windows,doors as well as smaller faade objects are projected onto walls.In this paper,a user survey is presented.The results of this survey show that the shell model can give users almost the same visual impression as the LoD3 model.Furthermroe,algorithms are developed to extract the shell model from LoD3 model.Experiments show that this shell model can reduce up to 90% storage of the original LoD3 model.Therefore,on one hand it can be used as a substitute for a LoD3 model for the visualization on small displays.On the other hand,it can be treated as a sub-level of detail(SLoD3) in CityGML,since it retains almost the same amount of information but requires much less storage space. | FAN Hongchao MAO Bo SHEN Jie MENG Liqiu | 2011 | Geo-Spatial Information Science2011，14，2： | 2 |
| 19 | Investigation and analysis of the linkage mechanism and whole process cost of livestock manure organic fertilizer显示文摘In recent years,the utilization of manure resources for livestock and poultry farming has attracted a widespread attention,and manure resources utilization models suitable for different regional characteristics have formed gradually.Among them,the production of organic fertilizer from animal manure is a vital utilization method.However,there are still some problems such as high production costs,difficult sales,and the unwillingness of farmers to use organic fertilizers which have affected the breeding cycle and the sustainability of manure treatment in livestock and poultry breeding.This article selected 371 organic fertilizer plants,related farms and farmers in China,focusing on the main links of the entire process of livestock manure-organic fertilizer-farm application,and studied the mode of animal manure collection by organic fertilizer plants.The costs of organic fertilizer production and farmland application were discussed.Moreover,suggestions were made for the promotion and implementation of large-scale organic fertilizers to make good utilization of manure resources in livestock and poultry farming. | Shanshan Dong Bin Sui Yujun Shen Haibo Meng Lixin Zhao Jingtao Ding Haibin Zhou Xi Zhang Hongsheng Cheng Jian Wang Ran Li Liqiu Song Pengxiang Xu Ji Li | 2020 | International Journal of Agricultural and Biological Engineering2020，13，2： | 2 |
| 20 | FIBRED MAGNESIUM HYDROXIDE AND FLAME-RESISTANT POLYENE MATERIAL显示文摘The fibred mangesiun hydroxide from the bracite was treated with a surface active agent. The modified fibred magesium hydroxide as flame-retardant, boric acid, barium stearate, polydimethyl siloxane fluid, vinyltriethoxysilane as synergists of the flame-retardant were added to polyene resin. The flame-resistance polyene material prepared meets the requirements of EWCZ-6287-1. | Zhang, Jin'an Wang, Liqiu Li, Qingshan
| 1999 | Journal of Wuhan University of Technology(Materials Science)1999，14，2： | 2 |
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