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| 1 | It is safe to use transdermal glyceryl trinitrate to lower blood pressure in patients with acute ischaemic stroke with carotid stenosis显示文摘Background There is concern that blood pressure(BP)lowering in acute stroke may compromise cerebral perfusion and worsen outcome in the presence of carotid stenosis.We assessed the effect of glyceryl trinitrate(GTN)in patients with carotid stenosis using data from the Efficacy of Nitric Oxide in Stroke(ENOS)Trial.Methods ENOS randomised 4011 patients with acute stroke and raised systolic BP(140-220 mm Hg)to transdermal GTN or no GTN within 48 hours of onset.Those on prestroke antihypertensives were also randomised to stop or continue their medication for 7 days.The primary outcome was the modified Rankin Scale(mRS)at day 90.Ipsilateral carotid stenosis was split:<30%;30-<50%;50-<70%;≥70%.Data are ORs with 95%CIs adjusted for baseline prognostic factors.results 2023(60.5%)ischaemic stroke participants had carotid imaging.As compared with<30%,≥70%ipsilateral stenosis was associated with an unfavourable shift in mRS(worse outcome)at 90 days(OR 1.88,95%CI 1.44 to 2.44,p<0.001).Those with≥70%stenosis who received GTN versus no GTN had a favourable shift in mRS(OR 0.56,95%CI 0.34 to 0.93,p=0.024).In those with 50-<70%stenosis,continuing versus stopping prestroke antihypertensives was associated with worse disability,mood,quality of life and cognition at 90 days.Clinical outcomes did not differ across bilateral stenosis groups.Conclusions Following ischaemic stroke,severe ipsilateral carotid stenosis is associated with worse functional outcome at 90 days.GTN appears safe in ipsilateral or bilateral carotid stenosis,and might improve outcome in severe ipsilateral carotid stenosis. | Jason P Appleton Lisa J Woodhouse Andrew Belcher Daniel Bereczki Eivind Berge Valeria Caso Hui Meng Chang Hanne K Christensen Ronan Collins John Gommans Ann C Laska George Ntaios Serefnur Ozturk Gillian M Sare Szabolcs Szatmari Yongjun Wang Joanna M Wardlaw Nikola Sprigg Philip M Bath for the ENOS investigators | 2019 | Stroke & Vascular Neurology2019，4，1： | 6 |
| 2 | GI symptoms in diabetes mellitus are associated with both poor glycemic control and diabetic complications显示文摘 | Peter Bytzer Nicholas J Talley Johann Hammer Lisa J Young Michael P Jones Michael Horowitz | 2002 | The American Journal of Gastroenterology2002，，3： | 2 |
| 3 | Ovomucoid is not Superior to egg white testing in Predicting Tolerance to Baked Egg显示文摘 | Lisa M B William J S Wanda P | 2013 | The Journal of Allergy and Clinical Immunology:In Practice2013，1，4： | 1 |
| 4 | Riparian woody plant diversity and forest structure along an urban-rural gradient显示文摘 | Michele L B Lisa J S Shufen P | 2005 | Urban E- cosystems2005，8，： | 1 |
| 5 | Efficacy of infliximab in acute severe ulcerative colitis:A single-centre experience显示文摘AIM:To suggest infliximab(IFX) is effective for acute severe ulcerative colitis,from real-life clinical practice.METHODS:All patients receiving IFX for the treatment of acute severe ulcerative colitis in a single centre were included.Data were extracted from clinical records in order to assess response to IFX therapy.The primary endpoint was colectomy-free survival,and secondary outcomes included glucocorticosteroid-free remission and safety,which was evaluated by recording deaths and adverse events.Demographic and clinical characteristics of those who underwent colectomy and those who were colectomy-free,both at discharge from their index admission,and during follow-up after an initial response to IFX were compared.RESULTS:Forty-four patients(16 females,mean age 36 years) received IFX between May 2006 and January 2012 for acute severe ulcerative colitis.The median duration of follow-up post-first infusion was 396 d(interquartile range = 173-828 d).There were 21(47.7%) patients with < 1 year of follow-up,10(22.7%) with 1 years to 2 years of follow-up,and 13(29.5%) with > 2 years of follow-up post-first infusion of IFX.Overall,35(79.5%) responded to IFX,avoiding colectomy during their index admission,29(65.9%) were colectomyfree at last point of follow-up(median follow-up 396 d),and 25(56.8%) were in glucocorticosteroid-free remission at end of follow-up.There was one death from post-operative sepsis,20 d after a single IFX infusion.Colectomy rates were generally lower among those 'bridging' to thiopurine.Of 18 patients 'bridged' to thiopurine therapy,17(94.4%) were colectomyfree,and 15(83.3%) were in glucocorticosteroid-free remission at study end.No predictors of response were identified.CONCLUSION:IFX is effective for acute severe ulcerative colitis in real-life clinical practice.Two-thirds of patients avoided colectomy,and more than 50% were in glucocorticosteroid-free remission. | Stephen J Halpin P John Hamlin Daniel P Gree Lisa Warren Alexander C Ford | 2013 | World Journal of Gastroenterology2013，19，7： | 1 |
| 6 | Obesity-related Differential Gene Expression in the Visceral Adipose Tissue显示文摘 | Ancha Baranova Rochelle Collantes Shobha J Gowder Hazem Elariny Karen Schlauch Abraham Younoszai Steve King Manpreet Randhawa Sitapati Pusulury Tariq Alsheddi Janus P Ong Lisa M Martin Vikas Chandhoke Zobair M Younossi | 2005 | Obesity Surgery2005，，6： | 1 |
| 7 | Antigen-driven murine CD4+ T lymphocyte proliferation and interleukin-2 production are diminished by dietary (n-3) polyunsaturated fatty acids 显示文摘 | Lisa J P Kevin L F | 2002 | J Nutr2002，32，： | 1 |
| 8 | Monitoring organichlorines with semi-permeable membrane devices (SPMDs) and mussels (Mytilus edulis) in Corio Bay,Victoria,Australia显示文摘 | HARRY F P BRUCE J R LISA A J | 1995 | Marine Pollution Bulletin1995，30，8： | 1 |
| 9 | An assessment of monitoring efforts in endangered species recovery plans 显示文摘 | Steven P C Clark J A Lisa H C | 2002 | Ecological Applications2002，12，： | 1 |
| 10 | Biofunctionalized magnetic nanoparticle inte-grated mid-infrared pathogen sensor for food matrices显示文摘 | Sandeep P Ravindranath Lisa J Mauer Joseph Irudayaraj | | 0，，8： | 1 |
| 11 | Detection rates of clinically significant genomic alterations by microarray analysis for specific anomalies detected by ultrasound显示文摘 | Lisa G Shaffer Jill A Rosenfeld Mindy P Dabell Justine Coppinger Anne M Bandholz Jay W Ellison J Britt Ravnan Beth S Torchia Blake C Ballif Allan J Fisher | 2012 | Prenat Diagn2012，，10： | 1 |
| 12 | Generation of Angiostatin by reductionand proteolysis of Plasmin 显示文摘 | Stathakis P Fitzgerald M Lisa J | 1997 | J biolog chemi1997，272，20： | 1 |
| 13 | Adiponectin is produced by lymphocytes and is a negative regulator of granulopoiesis 显示文摘 | Lisa J A Roy P Susan P | 2010 | Journal of Leukocyte Biology2010，88，4： | 1 |
| 14 | The T dependent antibody response to keyhole limpet hemoeyanin in rodents 显示文摘 | Lisa M P Danuta J H | 2010 | Methods Mol Biol2010，598，： | 1 |
| 15 | Overexpression of a Blueberry-derived CBF Gene Enhances Cold Tolerance in a Southern Highbush Blueberry Cultivar 显示文摘 | Aaron E W Lisa J R James J P | 2012 | Mol Breeding2012，，30： | 1 |
| 16 | Obesity and Non-Alcoholic Fatty Liver Disease in Chronic Hepatitis C显示文摘 | Zobair M Younossi Arthur J McCullough Janus P Ong David S Barnes Anthony Post Anthony Tavill Diane Bringman Lisa M Martin Jennifer Assmann Terry Gramlich Kevin D Mullen Robert O’Shea William D Carey Roy Ferguson | 2004 | Journal of Clinical Gastroenterology2004，，8： | 1 |
| 17 | Versatile inlet system for on-line compound-specific δD and δ^13C gas chromato-graphy-oxidation/reduction-isotope ratio mass spectrometry analysis of gaseous mixtures显示文摘 | Henning M Strapoc D Lis G P Sauer P Fong J Schimmelmann A Pratt Lisa M | 2007 | Rapid Communications in Mass Spectrometry2007，21，： | 1 |
| 18 | Role of Tnromboxane A2 in the induction of apoptosis of immature thymocyles by lipopolysaccharide 显示文摘 | Aulo N R Troy J P Lisa A R | 2005 | Clin Diagn Lab Immunol2005，12，8： | 1 |
| 19 | Monitoring Organochlorines with Semipermeable Membrane Devices (SPMDs) AND Mussels (Mytilus Edulis) in Corio Bay,Victoria,Australia显示文摘 | Harry F P Bruce J R lisa A J | 1995 | Marine Pollution Bulletin1995，30，8： | 1 |
| 20 | A functional IL-12 receptor subunit 显示文摘 | DAVID H P HONG Y LISA J | 1996 | Proc Nat l Acad Sic USA1996，93，14： | 1 |
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