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| 1 | 基于脾脏转录组筛选北京油鸡和广明白鸡抗热应激相关功能基因显示文摘旨在通过对北京油鸡(BY)和“广明2号”白羽肉鸡B系(广明白鸡,GM)在热应激和正常饲养条件下的脾脏转录组进行分析,鉴定两鸡种在应对热应激时的差异表达基因和信号通路,解析不同鸡种耐热性能差异的分子调控机制。试验动物采用相同饲养条件下的25日龄北京油鸡和广明白鸡,测定异嗜性粒细胞与淋巴细胞的比值(H/L)、超氧化物歧化酶(SOD)和总抗氧化能力(T-AOC)等表型数据,采集脾脏组织进行转录组测序(RNA-Seq)。基于RNA-Seq数据,结合表型进行加权基因共表达网络分析(WGCNA),筛选出与性状相关性较高的模块与基因。脾脏转录组测序结果表明,热应激组相比于对照组,北京油鸡中共鉴定到313个差异表达基因,其中169个上调表达,144个下调表达;广明白鸡中鉴定到235个差异表达基因,其中152个上调表达,83个下调表达。利用WGCNA分析,在北京油鸡中筛选出2个与H/L相关性较高的模块,在广明白鸡中筛选出4个与H/L和T-AOC强相关的模块。通过筛选模块中的Hub基因,发现两品种中均存在TRIM 29基因,说明该基因可能在抗热应激方面发挥重要作用。本研究通过转录组分析,揭示了不同鸡种在热应激下基因的表达差异规律,并鉴定到与耐热相关的候选基因,为进一步研究鸡的耐热机制提供了新的思路和线索。 | 王子渲 王巧 张锦 Astrid Lissette Barreto Sanchez 郑麦青 李庆贺 崔焕先 安炳星 赵桂苹 文杰 李和刚 | 2023 | 畜牧兽医学报2023，54，5： | 2 |
| 2 | The acute leptin response to GH显示文摘 | Lissett C Clayton P E Shalet S | 2001 | J Clin Endocrinol Metab2001，86，： | 1 |
| 3 | Receptor Tyrosine Kinases and TLR/IL1Rs Unexpectedly Activate Myeloid Cell PI3Kγ, A Single Convergent Point Promoting Tumor Inflammation and Progression显示文摘 | Michael C. Schmid Christie J. Avraamides Holly C. Dippold Irene Franco Philippe Foubert Lesley G. Ellies Lissette M. Acevedo Joan R.E. Manglicmot Xiaodan Song Wolfgang Wrasidlo Sara L. Blair Mark H. Ginsberg David A. Cheresh Emilio Hirsch Seth J. Field Ju | 2011 | Cancer Cell2011，，6： | 1 |
| 4 | Mechanism by which nuclear factor-kappa beta (NF-kB) regulates ovine fetal pulmonary vascular smooth muscle cell proliferation 显示文摘 | Uchenna D O Michael O Lissette S R | 2015 | Mol Genet Metab2015，4，9： | 1 |
| 5 | The insulin-like growth factor Ⅰgeneration test in adults显示文摘 | Lissett CA Gleeson H Shalet SM | 2004 | Horm Res2004，62，1： | 1 |
| 6 | The insulin-like growth factor-I generation test in adults显示文摘 | LISSETT C A GLEESON H SHALST S M | 2004 | Horm Res2004，62，1： | 1 |
| 7 | Antigen-capture blocking enzyme-linked immunosorbent assay based on a baculovirus recombinant antigen to differentiate Transmissible gastroenteritis virus from porcine respiratory coronavirus antibodies显示文摘 | Lissett L Angel V Marga G | 2009 | J Vet Diagn Invest2009，21，： | 1 |
| 8 | Ubiquitin immunoreactivity in cerebrospinal fluid after traumatic brain injury: Clinical and experimental findings显示文摘 | Matthias Majetschak David R. King Ulrich Krehmeier Lissette T. Busby Claudius Thome Susanne Vajkoczy Kenneth G. Proctor | 2005 | Critical Care Medicine2005，，7： | 1 |
| 9 | Low-dose GH replacement improves the adverse lipid profile associated with the adult GH deficiency syndrome显示文摘 | Murray RD Wieringa GE Lissett CA | 2002 | Clin Endocrinol (Oxf)2002，56，： | 1 |
| 10 | Management of pituitary tumours:strategy for investigation and follow-up显示文摘 | Lissett CA Shalet SM | 2000 | Horm Res2000，53，3： | 1 |
| 11 | Glucose disturbances in non-diabetic patients receiving acute treatment with methylprednisolone pulses显示文摘 | Hector Eloy Tamez Perez María Dolores Gómez de Ossio Dania Lizet Quintanilla Flores Mayra Ivonne Hernández Coria Alejandra Lorena Tamez Pe?a Gissén Jazmín Cuz Pérez Stephanie Lissette Proskauer Pe?a | 2012 | Revista da Associa??o Médica Brasileira2012，，1： | 1 |
| 12 | Antiretroviral drug resistance in HIV-1 therapy-naive patients in Cuba显示文摘 | Lissette Pérez Vivian Kourí Yoan Alemán Yeisel Abrahantes Consuelo Correa Carlos Aragonés Orlando Martínez Jorge Pérez Carlos Fonseca Jorge Campos Delmis álvarez Yoeri Schrooten Nathalie Dekeersmaeker Stijn Imbrechts Gertjan Beheydt Lore Vinken Yudira Sot | 2013 | Infection, Genetics and Evolution2013，，： | 1 |
| 13 | Skin picking behaviors: An examination of the prevalence and severity in a community sample显示文摘 | Stephania L. Hayes Eric A. Storch Lissette Berlanga | 2009 | Journal of Anxiety Disorders2009，，3： | 1 |
| 14 | Effects of growth hormone on bone and muscle显示文摘 | Lissett CA Shalet SM | 2000 | Growth Horrm IGF Res2000，10，： | 1 |
| 15 | Towards rapid and automated vulnerability classification of concrete buildings显示文摘With the overwhelming number of older reinforced concrete buildings that need to be assessed for seismic vulnerability in a city,local governments face the question of how to assess their building inventory.By leveraging engineering drawings that are stored in a digital format,a well-established method for classification reinforced concrete buildings with respect to seismic vulnerability,and machine learning techniques,we have developed a technique to automatically extract quantitative information from the drawings to classify vulnerability.Using this technique,stakeholders will be able to rapidly classify buildings according to their seismic vulnerability and have access to information they need to prioritize a large building inventory.The approach has the potential to have significant impact on our ability to rapidly make decisions related to retrofit and improvements in our communities.In the Los Angeles County alone it is estimated that several thousand buildings of this type exist.The Hassan index is adopted here as the method for automation due to its simple application during the classification of the vulnerable reinforced concrete buildings.This paper will present the technique used for automating information extraction to compute the Hassan index for a large building inventory. | Lissette Iturburu Jean Kwannandar Shirley J.Dyke Xiaoyu Liu Xin Zhang Julio Ramirez | 2023 | Earthquake Engineering and Engineering Vibration2023，22，2： | 0 |
| 16 | Transcriptome analysis of the spleen of heterophils to lymphocytes ratio-selected chickens revealed their mechanism of differential resistance to Salmonella显示文摘Salmonella is one of the most common food-borne pathogens and its resistance in chicken can be improved through genetic selection.The heterophils/lymphocytes(H/L)ratio in the blood reflects the immune system status of chicken.We compared the genome data and spleen transcriptomes between the H/L ratio-selected and non-selected chickens,after Salmonella infection,aiming to identify the key genes participating in the antibacterial activity in the spleen.The results revealed that,the selected population had stronger(P<0.05)liver resistance to Salmonella typhimurium(ST)than the non-selected population.In the selected and non-selected lines,the identified differentiation genes encode proteins involved in biological processes or metabolic pathways that included the TGF-beta signaling pathway,FoxO signaling pathway,and Salmonella infection pathway.The results of the analysis of all identified differentially expressed genes(DEGs)of spleen revealed that the G protein-coupled receptor(GPCR)and insulin-like growth factor(IGF-I)signaling pathways were involved in the Salmonella infection pathway.Integrated analysis of DEGs and FST(fixation index),identified candidate genes involved in Salmonella infection pathway,such as GPR39,NTRK2,and ANXA1.The extensive genomic changes highlight the polygenic genetic of the immune response in these chicken populations.Numerous genes related to the immune performance are differentially expressed in the selected and non-selected lines and the selected lines has a higher resistance to Salmonella. | WANG Jie ZHANG Qi Astrid Lissette BARRETO SANCHEZ ZHU Bo WANG Qiao ZHENG Mai-qing LI Qing-he CUI Huan-xian WEN Jie ZHAO Gui-ping | 2022 | Journal of Integrative Agriculture2022，21，8： | 0 |
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