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| 1 | Association of farnesyl diphosphate synthase polymorphisms and response to alendronate treatment in Chinese postmenopausal women with osteoporosis显示文摘 | Liu Y Li M Zhou PR Xing XP Xia WB Xu L Liu H J Zhang ZL LiaoEY Chen DC Liu J Tao TZ Wu W | 2014 | Chinese Medical Journal2014，，4： | 16 |
| 2 | The herbal compound geniposide rescues formaldehyde-induced apoptosis in N2a neuroblastoma cells显示文摘The herbal medicine Tong Luo Jiu Nao(TLJN)contains geniposide(GP)and ginsenoside Rg1 at a molar ratio of 10:1.Rg1 is the major component of another herbal medicine,panax notoginseng saponin(PNS).TLJN has been shown to strengthen brain function in humans,and in animals it improves learning and memory.We have previously shown that TLJN reduces amyloidogenic processing in Alzheimer’s disease(AD)mouse models.Together this suggests TLJN may be a potential treatment for patients with dementia.Because chronic damage of the central nervous system by formaldehyde(FA)has been presented as a risk factor for age-associated cognitive dysfunction,in the present study we investigated the protective effect of both TLJN and GP in neuron-like cells exposed to FA.FA-exposed murine N2a neuroblastoma cells were incubated with TLJN,its main ingredient GP,as well as PNS,to measure cell viability and morphology,the rate of apoptosis and expression of genes encoding Akt,FOXO3,Bcl2 and p53.The CCK-8 assay,cytoskeletal staining and flow cytometry were used to test cell viability,morphology and apoptosis,respectively.Fluorescent quantitative real-time PCR(qRT-PCR)was used to monitor changes in gene expression,and HPLC to determine the rate of FA clearance.Treatment of N2a cells with 0.09 mmol L?1 FA for 24 h significantly reduced cell viability,changed cell morphology and promoted apoptosis.Both TLJN and GP conferred neuroprotection to FA-treated N2a cells,whereas PNS,which had to be used at lower concentrations because of its toxicity,did not.Our data demonstrate that TLJN can rescue neuronal damage caused by FA and that its main ingredient,GP,has a major role in this efficacy.This presents purified GP as a drug or lead compound for the treatment of AD. | CHEN JinYan SUN MengRu WANG XingHua LU Jing WEI Yan TAN Yan LIU Ying GTZ Jürgen HE RongQiao HUA Qian | 2014 | Science China(Life Sciences)2014，57，4： | 15 |
| 3 | Mechanism of variations in environmental magnetic proxies of lake sediments from Nam Co, Tibet during the Holocene显示文摘High-resolution environmental records from the Tibetan Plateau are essential to understand past global climatic and environmental changes. Magnetic minerals in lake sediments are important proxies to reconstruct environmental and climatic changes. Nam Co (lake) is a typical great lake in the transitional region of southwest monsoon in the Tibetan Plateau. Previous studies have extensively focused on geochemistry, microfossils, sedimentology and biochemistry analysis of Nam Co, which provides sound interpretation of paleoclimatic and paleoenvironmental changes. However, up to now, no systematic environmental magnetic studies have been carried out. Therefore, high-resolution and systematic magnetic studies combined with geochemical parameters were carried on lake sediments of core NC 08/01 from Nam Co for the Holocene period (11.3 cal ka BP) in order to explore how magnetic properties of the sediments respond to climatic changes. Based on variations of magnetic proxies, the sequence can be separated into 3 units. Unit 1 (236-199 cm, 11.3-7.8 cal ka BP) contains dominantly coarse-grained magnetite with homogeneous grain size. A positive correlation between magnetite and Ti strongly suggests that these coarse-grained detrital magnetites reflect detrital input signals due to insignificant effects of postdepositional dissolution processes on these coarse-grained magnetite particles. For Unit 2 (198-102 cm, 7.8-2.1 cal ka BP), magnetic grain size is finer and the corresponding concentration of magnetite is also reduced. This is mainly due to significant dissolution of these fine-grained detrital magnetite particles, which were transported under reduced water flow conditions during this period. For Unit 3 (101-0 cm, 2.1-0 cal ka BP), the bulk magnetic properties are dominated by a mixture of single domain biogenic magnetite and detrital magnetite. The concentration of magnetic minerals is not correlated with the Ti content. In conclusion, the preservation of magnetic minerals in the lake sediment and thus the corresponding magnetic properties are related to the initial grain size. Combination of magnetic properties (including variation of grain size and concentration) and other proxies of detrital inputs (e.g. Ti) can be used to infer the variation of redox conditions in Nam Co. These results provide a viable framework for reconstructing the paleoenvironmental changes of this lake. | SU YouLiang GAO Xing LIU QingSong HU PengXiang DUAN ZongQi JIANG ZhaoXia WANG JunBo ZHU LiPing DOBERSCHüTZ Stefan MUSBACHER Roland DAUT Gerhard HABERZETTL Torsten | 2013 | Chinese Science Bulletin2013，58，13： | 2 |
| 4 | Surgical treatment of pectus excavatum:30 years 398 patients of experiences 显示文摘 | Hu TZ Li Y Liu WY | 2008 | J Pediatr Surg2008，43，7： | 1 |
| 5 | Surgical treatment of pectus excavatum: 3 years 398 patients of experiences 显示文摘 | Hu TZ Li Y Liu WY | 2008 | J Pediatr Surg2008，43，7： | 1 |
| 6 | influenza pandemics:past,present and future显示文摘 | Hsieh YC Wu TZ Liu DP | 2006 | J Formos Med Assoc2006，105，1： | 1 |
| 7 | MiR-125b expression affects the proliferation and apoptosis of human glioma cells by targeting Bmf显示文摘 | Xia HF He TZ Liu CM | 2009 | Cell Physiol Biochem2009，23，46： | 1 |
| 8 | Influenza pandemics: past, present and future显示文摘 | Hsieh YC Wu TZ Liu DP | 2006 | J Formos Med Assoc2006，105，1： | 1 |
| 9 | Influenza pandemics: past, present and future 显示文摘 | Hsieh YC Wu TZ Liu DP | 2006 | J Formos Med Assoc2006，105，1： | 1 |
| 10 | MiR-125b expression affects the proliferation and apoptosis of human glioma cells by targeting Bmf 显示文摘 | Xia I-IF He TZ Liu CM | 2009 | Cell Physiol Biochem2009，23，： | 1 |
| 11 | Numerical simulation of the solar chimney power plant systems coupled with turbine显示文摘 | Ming TZ Liu W Xu GL | 2008 | Renewable Energy2008，33，5： | 1 |
| 12 | Pulmonary function for pectus excavatum at long-term follow-up显示文摘 | Jiang XP Hu TZ Liu WY | | 0，，： | 1 |
| 13 | MiR-125b expression affects the proliferation and apoptosis of human glioma cells by targeting Bmf 显示文摘 | Xia HF He TZ Liu CM | 2009 | Cell Physiol Biochem2009，23，： | 1 |
| 14 | White matter integrity of the whole brain is disrupted in first-episode schizophrenia 显示文摘 | Hao YH Liu ZN Jiang TZ | 2006 | Neuroreport2006，17，1： | 1 |
| 15 | Influenza pandemics: past,present and future 显示文摘 | EIsieh YC Wu TZ Liu DP | 2006 | J Formosan Med Assoc2006，105，： | 1 |
| 16 | Myricetin, a naturally occurring flavono], ameliorates insulin resistance induced by a high-fructose dietin rats显示文摘 | Liu 1 M Tz~eng T F Liou S S | 2007 | Life Sci2007，81，2122： | 1 |
| 17 | Intraoperative monitoring of motor symptoms using surface electromyography during stereotactic surgery for movement disorders 显示文摘 | Liu X Aziz TZ Bain PG | 2005 | J Clin Neurophysiol2005，22，3： | 1 |
| 18 | Evidence for accelerated generation of hydroxyl radical in experimental obstructive jaundice of rats显示文摘 | Tsaily Lee KT Liu TZ | 1998 | Free Radic Biol Med1998，24，5： | 1 |
| 19 | A modified Gabor filter design method for fingerprint image enhancement显示文摘 | YANG JW LIU LF JIANG TZ | 2003 | Pattern Recognition Letters2003，24，12： | 1 |
| 20 | Free radical-triggered hepatic injury of experimental obstructive jaundice of rats involves overproduction of proinflammatory cytokines and enhanced activation of nuclear factor kappaB 显示文摘 | Liu TZ Lee KT Chern CL | 2001 | Ann Clin Lab Sci2001，31，4： | 1 |
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