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| 1 | Trends in Lipids Level and Dyslipidemia among Chinese Adults, 2002-2015显示文摘Objective To investigate the trends of lipid profiles and dyslipidemia among Chinese adults from 2002 to 2015.Methods Data were collected from three nationally representative cross-sectional surveys.Fasting venous blood samples were collected and serum lipids were tested by biochemical analysis and enzymatic determination.Lipid levels and the prevalence of dyslipidemia among adults were analyzed with complex sampling weighting adjustment for age and gender.Results The weighted means of TC, TG, and LDL-c significantly increased linearly from 3.93, 1.12, and 2.12 mmol/L in 2002 to 4.59, 1.41, and 2.78 mmol/L in 2010 and then to 4.63, 1.47, and 2.87 mmol/L in 2015, respectively;by contrast, HDL-c levels decreased significantly from 1.30 mmol/L to 1.26 mmol/L over the same period.Similar trends in mean non-HDL-c and lipid-related ratios were observed.The weighted dyslipidemia prevalence linearly increased;in particular, hypercholesterolemia increased from 1.6% to 5.6% and then to 5.8%, hypertriglyceridemia increased from 5.7% to 13.6% and then to 15.0%, low HDL-c increased from 18.8% to 35.5% and then to 24.9%, and high LDL-c increased from 1.3% to 5.6% and then to 7.2%(P for trend <0.001).Conclusion Dyslipidemia increased among Chinese adults from 2002 to 2015.Development of a comprehensive strategy to decrease lipid levels in this population is urgently required. | SONG Peng Kun MAN Qing Qing LI Hong PANG Shao Jie JIA Shan Shan LI Yu Qian HE Li ZHAO Wen Hua ZHANG Jian | 2019 | Biomedical and Environmental Sciences2019，32，8： | 45 |
| 2 | The Association of Maternal Body Composition and Dietary Intake with the Risk of Gestational Diabetes Mellitus during the Second Trimester in a Cohort of Chinese Pregnant Women显示文摘Objective To investigate the association of maternal body composition and dietary intake with the risk of gestational diabetes mellitus(GDM). Methods A total 154 GDM subjects and 981 controls were enrolled in a prospective cohort study in 11 hospitals from May 20, 2012 to December 31, 2013. Bioelectrical impedance analysis and dietary surveys were used to determine body composition and to evaluate the intake of nutrients in subjects at 21-24 weeks' gestation(WG). Logistic regression analysis was applied to explore the relationships of maternal body composition and dietary intake with the risk of GDM morbidity. Results Age, pre-pregnant body weight(BW), and body mass index(BMI) were associated with increased risk of GDM. Fat mass(FM), fat mass percentage(FMP), extracellular water(ECW), BMI, BW, energy, protein, fat, and carbohydrates at 21-24 WG were associated with an increased risk of GDM. In contrast, fat free mass(FFM), muscular mass(MM), and intracellular water(ICW) were associated with a decreased risk of GDM. Conclusion Maternal body composition and dietary intake during the second trimester of pregnancy were associated with the risk of GDM morbidity. | Xu Qing Gao Zhi Ying Li Li Ming Wang Lu Zhang Qian Teng Yue Zhao Xia Ge Sheng Jing Hong Jiang Yang Yong Tao Liu Xiao Jun Lyu Chun Jian Mao Lun Yu Xiao Ming Liu Ying Hua Kong Ai Jing Yang Xue Yan Liu Zhao Zhang Yong Wang Jin Zhang Xin Sheng Xue Chang Yong Lu Yan Ping | 2016 | Biomedical and Environmental Sciences2016，29，1： | 29 |
| 3 | 5-Hydroxymethylcytosine signatures in circulating cell-free DNA as diagnostic biomarkers for human cancers显示文摘象 5-methylcytosine (5mC ) 和 5-hydroxymethylcytosine (5hmC ) 那样的 DNA 修正是知道在哺乳动物影响全球基因表示的 epigenetic 标记。在人的染色体,与基因表示的靠近的关联和高化学的稳定性给他们的流行,这些 DNA epigenetic 标记能为癌症用作理想的 biomarkers 诊断。利用一种高度敏感、选择的化学标记技术,我们这里报导在传播没有房间的 DNA ( cfDNA )并且在从最近与 colorectal 诊断的 260 个病人的一个队收集的配对的肿瘤和邻近的纸巾的 genomic DNA ( gDNA )的 5hmC 的染色体宽的介绍,胃,胰腺,从 90 个健康个人的肝或甲状腺癌症和正常纸巾。5hmC 主要在与开的染色质和容许的 histone 修正重合的 transcriptionally 活跃的区域被散布。柔韧的联系癌症的 5hmC 签名在 cfDNA 被识别为特定的癌症类型是特征的。传播 cfDNA 的 5hmC 底 biomarkers colorectal 和胃的癌症是高度预兆的并且比常规 biomarkers 优异并且比得上从织物活体检视的 5hmC biomarkers。因此,这新策略能从血样品的分析为癌症的诊断和预后导致有效、最低限度地侵略的方法的发展。 | Wenshuai Li Xu Zhang Xingyu Lu Lei You Yanqun Song Zhongguang Luo Jun Zhang Ji Nie Wanwei Zheng Diannan Xu Yaping Wang Yuanqiang Dong Shulin Yu Jun Hong Jianping Shi Hankun Hao Fen Luo Luchun Hua Peng Wang Xiaoping Qian Fang Yuan Lianhuan Wei Ming Cui Taiping Zhang Quan Liao Menghua Dai Ziwen Liu Ge Chen Katherine Meckel Sarbani Adhikari Guifang Jia Marc B Bissonnette Xinxiang Zhang Yupei Zhao Wei Zhang Chuan He Jie Liu | 2017 | Cell Research2017，27，10： | 30 |
| 4 | Chemerin and apelin are positively correlated with inflammation in obese type 2 diabetic patients显示文摘 | YU Shan ZHANG Ying LI Mei-zhen XU Hua WANG Qian SONG Jun LIN Peng ZHANG Li LIU Qian HUANG Qing-xian WANG Kun HOU Wei-kai | 2012 | Chinese Medical Journal2012，，19： | 27 |
| 5 | Synthesis of Methyl Glycolate by Hydrogenation of Dimethyl Oxalate over Cu-Ag/SiO_2 Catalyst显示文摘甲基乙二醇吃了是良溶剂并且能为一些重要器官的化学药品的合成被用作化工物品。在在硅石上支持的铜银催化剂上的暗淡乙醇盐(DMO ) 的催化加氢被学习。在硅溶胶上支持的 Cu-Ag/SiO2 催化剂被水的铜氨液建筑群和硅溶胶的混合的同类的免职降水准备。为 DMO 的加氢的 Cu-Ag/SiO2 催化剂的合适的活跃温度是 523-623 K。为乙二醇吃了的甲基(MG ) 的最更好的反应条件被优化:在 468-478 K 的温度, 40-60 网孔催化剂直径, H2/DMO 比率 40,和 1.0 h (? 1 ) LHSV。给词调音:暗淡乙醇盐;甲基乙二醇吃了;1;加氢;Cu-Ag/SiO2 | Baowei Wang Qian Xu Hua Song Genhui Xu | 2007 | Journal of Natural Gas Chemistry2007，16，1： | 22 |
| 6 | Paleoproterozoic reworking of ancient crust in the Cathaysia Block,South China:Evidence from zircon trace elements,U-Pb and Lu-Hf isotopes显示文摘A combined study of zircon LA-ICP-MS U-Pb dating, trace elements and Hf isotope was carried out for gneissic granite from the Sanzhishu area in Jingning, SW Zhejiang Province. Nearly all the zircons separated from the granite exhibited oscillatory zoning and high Th/U ratios (>0.1). The REE profile showed a pronounced positive Ce anomaly, negative Eu anomaly and an enrichment of HREE, which are typical characteristics of magmatic zircon. Thirteen concordant or nearly concordant analytical data yielded a weighted mean 207Pb/206Pb age of 1860±13 Ma (MSWD=0.084), representing the formation age of the granite. The magmatic zircons had negative εHf(t) values of -15.6 to -10.0 and two-stage Hf model ages of 3.1 to 3.4 Ga, indicating that the granites were formed by reworking of ancient crust. The major- and trace-element data indicate that the gneissic granites are metaluminous high-K calc-alkaline rocks and exhibit the same geochemical characteristics as aluminous A-type granites, implying the emplacement of the granite in a post-orogenic extensional tectonic setting. We conclude that the Pa-leoproterozoic crustal reworking event in the Cathaysia Block of South China marked the transition from assembly to break-up of the Columbia supercontinent. | LIU Rui ZHOU Han Wen ZHANG Li ZHONG ZengQiu ZENG Wen XIANG Hua JIN Song LU Xin Qian LI ChunZhong | 2009 | Chinese Science Bulletin2009，54，9： | 22 |
| 7 | Ten cities cross-sectional questionnaire survey of children asthma and other allergies in China显示文摘Asthma,rhinitis and eczema(allergic or non-allergic)have increased throughout the world during the last decades,especially among children.Changes in the indoor environment are suspected to be important causes.China has experienced a dramatic change in indoor environmental exposures during the past two decades.However,such changes and their associations with children’s asthma and other health aspects have not been thoroughly studied.China,Children,Homes,Health(CCHH),Phase I,was a cross-sectional questionnaire survey of 48219 children 1–8 years old in 10 Chinese cities during 2010–2012.The questionnaire includes the International Study of Asthma and Allergies in Childhood(ISAAC)core health questions and additional questions regarding housing,life habits and outdoor environment.In health analyses,children aged 3–6 years old were included.The prevalences of doctor diagnosed asthma varied from 1.7%to 9.8%(mean 6.8%),a large increase from 0.91%in 1999 and 1.50%in2000.The prevalence of wheeze,rhinitis and atopic eczema(last 12 months)varied from 13.9%to 23.7%,24.0%to 50.8%and4.8%to 15.8%,respectively.Taiyuan had the lowest prevalences of all illnesses and Shanghai the highest,except for wheezewhere the highest value was for Urumqi.We found(1)no obvious association between disease prevalences and ambient PM10concentrations and(2)higher prevalences of disease in humid climates with hot summers and cold winters,but with no centrally heated buildings.Associations between the diseases and economic status as indexed by Gross Domestic Product(GDP)requires further study. | ZHANG YinPing LI BaiZhan HUANG Chen YANG Xu QIAN Hua DENG QiHong ZHAO ZhuoHui LI AnGui ZHAO JiaNing ZHANG Xin QU Fang HU Yu YANG Qin WANG Juan ZHANG Ming WANG Fang ZHENG XiaoHong LU Chan LIU ZhiJian SUN YueXia MO JinHan ZHAO YiLi LIU Wei WANG TingTing NORBCK Dan BORNEHAG Carl-Gustaf SUNDELL Jan | 2013 | Chinese Science Bulletin2013，58，34： | 22 |
| 8 | Expression of insulin-like growth factor Ⅱ and its receptor in liver cells of chronic liver diseases显示文摘ExpressionofinsulinlikegrowthfactorⅡanditsreceptorinlivercelsofchronicliverdiseasesYANGDongHua1,XIUChong1,YANGBo1,GUJianR... | YANG Dong Hua 1, XIU Chong 1, YANG Bo 1, GU Jian Ren 2, QIAN Lian Fang 2 and QU Shu Ming 2 | 1997 | World Journal of Gastroenterology1997，3，2： | 21 |
| 9 | Biochar: A review of its impact on pesticide behavior in soil environments and its potential applications显示文摘Biochar is produced from the pyrolysis of carbon-rich plant- and animal-residues under low oxygen and high temperature conditions and has been increasingly used for its positive role in soil compartmentalization through activities such as carbon sequestration and improving soil quality. Biochar is also considered a unique adsorbent due to its high specific surface area and highly carbonaceous nature. Therefore, soil amendments with small amounts of biochar could result in higher adsorption and, consequently, decrease the bioavailability of contaminants to microbial communities, plants, earthworms, and other organisms in the soil. However, the mechanisms affecting the environmental fate and behavior of organic contaminants, especially pesticides in biochar-amended soil, are not well understood. The purpose of this work is to review the role of biochar in primary processes, such as adsorption–desorption and leaching of pesticides. Biochar has demonstrable effects on the fate and effects of pesticides and has been shown to affect the degradation and bioavailability of pesticides for living organisms. Moreover, some key aspects of agricultural and environmental applications of biochar are highlighted. | Mahdi Safaei Khorram Qian Zhang Dunli Lin Yuan Zheng Hua Fang Yunlong Yu | 2016 | Journal of Environmental Sciences2016，28，6： | 20 |
| 10 | Effects of arbuscular mycorrhizal fungi inoculation on arsenic accumulation by tobacco (Nicotiana tabacum L.)显示文摘A pot experiment was conducted to study the effects of arbuscular mycorrhizal(AM) fungi(from contaminated or uncontaminated soils) on arsenic(As) uptake of tobacco(Nicotiana tabacum L.) in As-contaminated soil.Mycorrhizal colonization rate,dry weight,As and P uptake by plants,concentrations of water-extractable As and As fractions were determined.A low mycorrhizal colonization rate(<25%) was detected.Our research indicated that AM fungi isolated from polluted soils were no more effective than those from unpolluted soils when grown in symbiosis with tobacco.No significant differences were observed in roots and stalks dry weights among all treatments.Leaves and total plant dry weights were much higher in Glomus versiforme treatment than that in control treatment.As contents in roots and stalks from mycorrhizal treatments were much lower than that from control treatment.Total plant As content exhibited the same trend.P concentrations in tobacco were not affected by colonization,nor were stalks,leaves and total plant P contents.Roots P contents were remarkably lower in HN treatments than in other treatments.Meanwhile,decreased soil pH and lower water-extractable As concentrations and higher levels of As fraction bound to well-crystallized hydrous oxides of Fe and Al were found in mycorrhizal treatments than in controls.The protective effect of mycorrhiza against plant As uptake may be associated with changes in As solubility mediated by changing soil pH.These results indicated that under As stress,proper mechanisms employed by AM fungi can protect tobacco against As uptake.Results confirmed that AM fungi can play an important role in food quality and safety. | HUA Jianfeng LIN Xiangui YIN Rui JIANG Qian SHAO Yufang | 2009 | Journal of Environmental Sciences2009，21，9： | 19 |
| 11 | Connective tissue diseases in primary biliary cirrhosis:A population-based cohort study显示文摘AIM:To establish the frequency and clinical features of connective tissue diseases(CTDs)in a cohort of Chinese patients with primary biliary cirrhosis(PBC).METHODS:Three-hundred and twenty-two Chinese PBC patients were screened for the presence of CTD,and the systemic involvement was assessed.The differences in clinical features and laboratory findings between PBC patients with and without CTD were documented.The diversity of incidence of CTDs in PBC of different countries and areas was discussed.For the comparison of normally distributed data,Student’s t test was used,while non-parametric test(Wilcoxon test)for the non-normally distributed data and 2×2χ2or Fisher’s exact tests for the ratio.RESULTS:One-hundred and fifty(46.6%)PBC patients had one or more CTDs.The most common CTD was Sj gren’s syndrome(SS,121 cases,36.2%).There were nine cases of systemic sclerosis(SSc,2.8%),12of systemic lupus erythematosus(SLE,3.7%),nine of rheumatoid arthritis(RA,2.8%),and 10 of polymyositis(PM,3.1%)in this cohort.Compared to patients with PBC only,the PBC+SS patients were more likely to have fever and elevated erythrocyte sedimentation rate(ESR),higher serum immunoglobulin G(IgG)levels and more frequent rheumatoid factor(RF)and interstitial lung disease(ILD)incidences;PBC+SSc patients had higher frequency of ILD;PBC+SLE patients had lower white blood cell(WBC)count,hemoglobin(Hb),platelet count,γ-glutamyl transpeptidase and immunoglobulin M levels,but higher frequency of renal involvement;PBC+RA patients had lower Hb,higher serum IgG,alkaline phosphatase,faster ESR and a higher ratio of RF positivity;PBC+PM patients had higher WBC count and a tendency towards myocardial involvement.CONCLUSION:Besides the common liver manifestation of PBC,systemic involvement and overlaps with other CTDs are not infrequent in Chinese patients.When overlapping with other CTDs,PBC patients manifested some special clinical and laboratory features which may have effect on the prognosis. | Li Wang Feng-Chun Zhang Hua Chen Xuan Zhang Dong Xu Yong-Zhe Li Qian Wang Li-Xia Gao Yun-Jiao Yang Fang Kong Ke Wang | 2013 | World Journal of Gastroenterology2013，19，31： | 18 |
| 12 | Celastrus orbiculatus extract induces mitochondrial-mediated apoptosis in human hepatocellular carcinoma cells显示文摘OBJECTIVE:To investigate the apoptotic effects and underlying molecular mechanisms of Celastrus orbiculatus(C.orbiculatus) extract in human hepatocellular carcinoma cells.METHODS:Human hepatocellular carcinoma cells(HCCLM6) were treated with C.orbiculatus extract(COE) at different nontoxic concentrations(10,20,40,80,and 160 μg/mL).The effect of COE on HC-CLM6 viability was examined using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide(MTT) assays.Cellular apoptosis following COE treatment was assessed by flow cytometry and western blot analysis.RESULTS:COE significantly inhibited cell viability and induced apoptosis of HCCLM6 cells in a dose-dependent manner.Apoptosis was accompanied by increased Bax expression and decreased Bcl-2 expression.In addition,COE treatment led to the release of cytochrome c,activation of caspase-3,and cleavage of poly(ADP-ribose) polymerase(PARP).Furthermore,activation of extracellular signal-regulated kinase(ERK),p38 kinase,and c-Jun N-terminal kinase(JNK) phosphorylation,and down-regulation of Akt phosphorylation was observed.CONCLUSION:COE induces mitochondrial-mediated,caspase-dependent apoptosis in HCCLM6 cells,which might be attributed to the activation of mitogen-activated protein kinase(MAPK) and inhibition of Akt signaling pathways.These data suggest that COE may be a potential treatment for human hepatocellular carcinoma. | Hua Zhang Yayun Qian Yanqing Liu Guoqing Li Pingfang Cui Yaodong Zhu Hui Ma Xue Ji Shiyu Guo Hisamits Tadashi | 2012 | Journal of Traditional Chinese Medicine2012，32，4： | 18 |
| 13 | Salidroside inhibits H2O2-induced apoptosis in PC12 cells by preventing cytochrome c release and inactivating of caspase cascade显示文摘我们使用了老鼠 pheochromocytoma (PC 12 ) 在氢过氧化物上学习 salidroside 的效果的房间线(H 2 O 2)-induced apoptosis。在 PC12 房间, H 2 O 2-induced apoptosis 被 Bcl-2, Bax 的起来规定,到 cytosol 的 mitochondrial 细胞色素 c 的版本,和 caspase-3, -8 和 -9 的激活的下面规定伴随。然而, salidroside 压制了 Bcl-2, Bax 的起来规定和 mitochondrial 细胞色素 c 的版本的下面规定到 cytosol。而且, salidroside 对 H 2 O 2-induced apoptosis。总起来说,这些结果建议有 salidroside 的 PC12 房间的处理能堵住 H 2 由调整 Bcl-2 家庭成员并且由压制细胞色素 c 版本和 caspase 串联激活的 O 2-induced apoptosis。 | Lei Cai Hua Wang Qin Li Yunfei Qian Wenbing Yao | 2008 | Acta Biochimica et Biophysica Sinica2008，40，9： | 18 |
| 14 | Suppression of m6A reader Ythdf2 promotes hematopoietic stem cell expansion显示文摘 | Zhenrui Li Pengxu Qian Wanqing Shao Hailing Shi Xi C. He Madelaine Gogol Zulin Yu Yongfu Wang Meijie Qi Yunfei Zhu John M. Perry Kai Zhang Fang Tao Kun Zhou Deqing Hu Yingli Han Chongbei Zhao Richard Alexander Hanzhang Xu Shiyuan Chen Allison Peak Kathyrn Hall Michael Peterson Anoja Perera Jeffrey S. Haug Tari Parmely Hua Li Bin Shen Julia Zeitlinger Chuan He Linheng Li | 2018 | Cell Research2018，28，9： | 18 |
| 15 | Spatial characteristics of development efficiency for urban tourism in eastern China: A case study of six coastal urban agglomerations显示文摘传统的数据包封分析(DEA ) , bootstrap-DEA 和 Malmquist 模型被采用在东方中国在六沿海的城市的凝块测量不同旅游效率和他们 61 个城市的空间特征。下列结论被得出。(1 ) 用 bootstrap-DEA 模型的城市的旅游的全面效率(CE ) 是比用 DEA-CRS 模型的 CE 水平低的,它证实 DEA-CRS 模型的重要趋势过高估计结果。( 2 )在长江三角洲( YRD )和珀尔河三角洲( PRD )的城市的旅游的几何 CE 一般水准变化了从对无效自从 2000 有效,在 Beijing-Tianjin-Hebei ( BTH )和山东半岛( SDP )的一般水准变化了从对无效自从 2000 中等有效,并且自从 2000 ,在中央、南部的辽宁( CSL )和台湾海峡( WBTS )的西岸的那些是无效的。( 3 )在 PRD , YRD , BTH 和 SDP 的城市的旅游的 CE 价值被纯技术效率( PTE )稍微影响了,而自从 2000 ,在 CSL 和 WBTS 的 CE 价值被规模效率( SE )稍微影响了。( 4 )空间地,为 PRD , YRD , BTH , SDP , WBTS 和 CSL 的全部的因素生产率( TFP )的几何一般水准的范围顺序减少了,当为在六城市的凝块的大多数城市的展出了时一向下趋势自从 2000 。(5 ) 一起,自然条件,经济政策和旅游首都驾驶 CSL 和 WBTS 的城市的旅游的 SE 变化。为增加回来可伸缩并且模仿创新技术的旅游企业在 BTH 和 SDP 在城市的旅游的 CE 变化上有效果。旅游市场比赛在 PRD 和 YRD 驾驶城市的旅游的 PTE 变化。尽管 PTE 和在六沿海的城市的凝块的城市的旅游的 SE 受不了不明确的事件,自从 2000, CE 维持了全面健全动量。 | LI Rui GUO Qian WU Dianting YIN Hongmei ZHANG Hua ZHU Taoxing | 2014 | Journal of Geographical Sciences2014，24，6： | 16 |
| 16 | Evaluation Method and Mitigation Strategies for Shrinkage Cracking of Modern Concrete显示文摘The complex compositions and large shrinkage of concrete,as well as the strong constraints of the structures,often lead to prominent shrinkage cracking problems in modem concrete structures.This paper first introduces a multi-field(hydro-thermo-hygro-constraint)coupling model with the hydration degree of cementitious materials as the basic state parameter to estimate the shrinkage cracking risk of hardening concrete under coupling effects.Second,three new key technologies are illustrated:temperature rise inhibition,full-stage shrinkage compensation,and shrinkage reduction technologies.These technologies can efficiently reduce the thermal,autogenous,and drying shrinkages of concrete.There after,a design process based on the theoretical model and key technologies is proposed to control thecracking risk index below the threshold value.Finally,two engineering application examples are provided that demonstrate that concrete shrinkage cracking can be significantly mitigated by adopting the proposed methods and technologies. | Jiaping Liu Qian Tian Yujiang Wang Hua Li Wen Xu | 2021 | Engineering2021，7，3： | 15 |
| 17 | The herbal compound geniposide rescues formaldehyde-induced apoptosis in N2a neuroblastoma cells显示文摘The herbal medicine Tong Luo Jiu Nao(TLJN)contains geniposide(GP)and ginsenoside Rg1 at a molar ratio of 10:1.Rg1 is the major component of another herbal medicine,panax notoginseng saponin(PNS).TLJN has been shown to strengthen brain function in humans,and in animals it improves learning and memory.We have previously shown that TLJN reduces amyloidogenic processing in Alzheimer’s disease(AD)mouse models.Together this suggests TLJN may be a potential treatment for patients with dementia.Because chronic damage of the central nervous system by formaldehyde(FA)has been presented as a risk factor for age-associated cognitive dysfunction,in the present study we investigated the protective effect of both TLJN and GP in neuron-like cells exposed to FA.FA-exposed murine N2a neuroblastoma cells were incubated with TLJN,its main ingredient GP,as well as PNS,to measure cell viability and morphology,the rate of apoptosis and expression of genes encoding Akt,FOXO3,Bcl2 and p53.The CCK-8 assay,cytoskeletal staining and flow cytometry were used to test cell viability,morphology and apoptosis,respectively.Fluorescent quantitative real-time PCR(qRT-PCR)was used to monitor changes in gene expression,and HPLC to determine the rate of FA clearance.Treatment of N2a cells with 0.09 mmol L?1 FA for 24 h significantly reduced cell viability,changed cell morphology and promoted apoptosis.Both TLJN and GP conferred neuroprotection to FA-treated N2a cells,whereas PNS,which had to be used at lower concentrations because of its toxicity,did not.Our data demonstrate that TLJN can rescue neuronal damage caused by FA and that its main ingredient,GP,has a major role in this efficacy.This presents purified GP as a drug or lead compound for the treatment of AD. | CHEN JinYan SUN MengRu WANG XingHua LU Jing WEI Yan TAN Yan LIU Ying GTZ Jürgen HE RongQiao HUA Qian | 2014 | Science China(Life Sciences)2014，57，4： | 15 |
| 18 | Leukotriene D4 induces brain edema and enhances CysLT2 receptor- mediated aquaporin 4 expression显示文摘 | Wang Meng - Ling Yuan Yu - Mei Huang Xiao - Jia Fang San - Hua Zhang Wei-Ping Lu Yu-Bi Ding Qian Wei Er-Qing | 2006 | 中国药理通讯2006，23，4： | 14 |
| 19 | Increased RhoGDI2 and peroxiredoxin 5 levels in asthmatic murine model of β2-adrenoceptor desensitization: A proteomics approach显示文摘背景:贝它(2 )-adrenoceptor (贝它(2 ) AR ) 不敏感性是在临床的实践的一个普通问题。贝它(2 ) AR 不敏感性继续由至少象由许多 serine/threonine 家族 ases 的异种的不敏感性,相应不敏感性和一种导致收缩筋的快速的磷酸化的如此的三机制。是否有另外的机制,不是清楚的。这研究试图调查贝它(2 ) 的潜在的机制 AR 不敏感性。方法:24 BALB/c (6-8 星期旧) 老鼠被划分成三组,是,组织 A,磷酸盐对待的缓冲 saline (PBS ) ;组 B,卵白蛋白(卵) 导致了;并且组织 C,对待 salbutamol。煽动性的房间计数, bronchoalveolar 洗室年龄液体(BALF ) 的 cytokine 集中,病理学的节,全部的浆液 IgE,航线应答的海角,膜受体数字和贝它(2 ) 的全部的数量 AR 被观察。气喘的老鼠当模特儿,气喘的老鼠建模的贝它(2 ) AR 不敏感性被建立。组 B 和 C 被选择 fortwo 维的胶化电气泳动(2DE ) 分析与贝它(2 ) 有关看到以便发现关键蛋白质 AR 不敏感性。结果:气喘的老鼠当模特儿,气喘的老鼠建模的贝它(2 ) AR 不敏感性被煽动性的房间计数验证, BALF 的 cytokine 集中,浆液 IgE 水平,航线亢奋的反应测量, radioligand 受体绑定试金,西方的污点分析,和病理学的检查。然后,二个组(组 B 和 C ) 受到 2DE。二个关键蛋白质点把 AR 不敏感性与贝它(2 ) 联系了, Rho GDP 分离禁止者 2 (RhoGDI (2 )) 并且 peroxiredoxin 5,被比较 proteomics (2DE 和集体光谱分析) 发现。结论:氧化应力和小 G 蛋白质管理者可以在贝它(2 ) 的过程起一个重要作用 AR 不敏感性。 | LIU Hua ZHOU Lin-fu ZHANG Qian QIAN Fen-hong YIN Kai-sheng HUANG Mao ZHANG Xi-long | 2008 | Chinese Medical Journal2008，，4： | 14 |
| 20 | “Quartus scale” of hot-rolled strip steels and its formation mechanism显示文摘The types and growth of various oxide scales formed during the different phases of the production of hot- rolled strip steel products are reviewed.Similarities and differences between the'tertiary scale'on the surface of carbon steels at high temperatures and the oxide scale on pure iron are compared.The micro-structural features of the'final oxide scale'on the surface of strip steels at room temperature as well as the relationship between these features and the position of the steel coil(plate)and the subsequent processes of recoiling,temper rolling and trimming,etc, are summarized.The actual oxide scales retained on the commercial hot-rolled strip steels at room temperature have been proposed to define as'quartus scale'for the first time.The micro-structural development and phase transformation of the initial'tertiary scale'during and after cooling and coiling are described.The reasons for the'tertiary scale'on carbon steels differing from the oxide scale formed on pure iron,and the major influencing factors in the formation of various types of'quartus scales'are analyzed from both thermodynamic and dynamic viewpoints.The development mechanism of'quartus scales'is discussed and the potential effects of the'quartus scale'state (thickness,constitution,structure and defects),on the rusting and pickling properties of commercial hot-rolled strip steel,as well as on the mechanical properties of oxide scales are analyzed. | Huibin Qi Yuhai Qian Wei Wang Hua Zhang | 2007 | Baosteel Technical Research2007，1，1： | 13 |
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