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| 1 | Human monoclonal antibodies block the binding of SARS-CoV-2 spike protein to angiotensin converting enzyme 2 receptor显示文摘According to the World Health Organization(WHO)newly updated situation report on March 18th,2020,the coronavirus disease 2019(COVID-19)pandemic has confirmed 191,127 cases and claimed 7807 deaths worldwide.1 The etiological agent of COVID-19 has been identified as a novel coronavirus,the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),belonging to Sarbecovirus subgenus(genus Betacoronavirus,family Coronaviridae)and showing 79.6 and 96.2%sequence identity in nucleotide to SARS-CoV and a bat coronavirus(BatCoV RaTG13),respectively.2–4 Like SARS-CoV infection,a substantial fraction of COVID-19 patients exhibits severe respiratory symptoms and has to be hospitalized in intensive care unit.5–8 Although the mortality rate of COVID-19 is significantly lower than that of SARS-CoV infection,SARS-CoV-2 shows much higher human-to-human transmission rate,rapidly leading to a global pandemic declared by WHO on March 11th,2020. | Xiangyu Chen Ren Li Zhiwei Pan Chunfang Qian Yang Yang Renrong You Jing Zhao Pinghuang Liu Leiqiong Gao Zhirong Li Qizhao Huang Lifan Xu Jianfang Tang Qin Tian Wei Yao Li Hu Xiaofeng Yan Xinyuan Zhou Yuzhang Wu Kai Deng Zheng Zhang Zhaohui Qian Yaokai Chen Lilin Ye | 2020 | Cellular & Molecular Immunology2020，17，6： | 17 |
| 2 | Impedance Modeling and Stability Analysis of PV Grid-connected Inverter Systems Considering Frequency Coupling显示文摘Impedance analysis is an effective method to analyze the oscillation issue associated with grid-connected photovoltaic systems.However,the existing impedance modeling of a gridconnected photovoltaic inverter usually only considers the effect of a single perturbation frequency,ignoring the coupling frequency response between the internal control loops of a grid-connected inverter,which severely affects the accuracy of the stability analysis.Hence,a method of impedance modeling and stability analysis for grid-connected photovoltaic inverters considering cross-coupling frequency is proposed in this paper.First,the generation mechanism of frequency coupling in gridconnected photovoltaic inverters,and the relationship between the coupling frequency and perturbation frequency are analyzed.Secondly,a sequence impedance model of grid-connected photovoltaic systems considering the coupling frequency is established by using the harmonic linearization method.The impact of DC bus voltage control strategy on frequency coupling characteristics of a grid-connected photovoltaic system is evaluated,and the impact of a coupling frequency term on system stability is quantitatively analyzed.Finally,the advantages of the proposed method are verified by several simulations.The results show that the proposed impedance model can accurately predict the potential resonance points of the system,and the coupling frequency characteristics will become much stronger with smaller DC bus capacitance or larger bandwidth of the DC bus controller. | Shaojian Song Ze Wei Yuzhang Lin Bin Liu Hui Liu | 2020 | CSEE Journal of Power and Energy Systems2020，6，2： | 8 |
| 3 | Determination of erodible particles on cultivated soils by wind tunnel simulation显示文摘The erodible particle size distribution, diameter range and separate content of three soils from semi-arid regions of China were determined at different wind velocities through wind tunnel simulation and dry sieving. It was demonstrated that soil erodibility by wind depends not only on the intrinsic soil properties, but also on the extrinsic erosion effect of the erosive winds. It was supposed that there existed general consistency in the mechanics of wind erosion on different soils. | Lianyou Liu Jianhua Wang Xiaoyan Li Yuzhang Liu Wanquan Ta Haimei Peng | 1998 | Chinese Science Bulletin1998，43，19： | 4 |
| 4 | The histone methyltransferase EZH2 primes the early differentiation of follicular helper T cells during acute viral infection显示文摘Epigenetic modifications to histones dictate the differentiation of naïve CD4^(+) T cells into different subsets of effector T helper(TH)cells.The histone methyltransferase enhancer of zeste homolog 2(EZH2)has been implicated in the mechanism regulating the differentiation of TH1,TH2 and regulatory T(Treg)cells.However,whether and how EZH2 regulates follicular helper T(TFH)cell differentiation remain unknown.Using a mouse model of acute lymphocytic choriomeningitis virus(LCMV)infection,we observed abundant EZH2 expression and associated H3K27me3 modifications preferentially in the early committed virus-specific TFH cells compared to those in TH1 cells.Ablation of EZH2 in LCMV-specific CD4^(+) T cells leads to a selective impairment of early TFH cell fate commitment,but not late TFH differentiation or memory TFH maintenance.Mechanistically,EZH2 specifically stabilizes the chromatin accessibility of a cluster of genes that are important for TFH fate commitment,particularly B cell lymphoma 6(Bcl6),and thus directs TFH cell commitment.Therefore,we identified the chromatin-modifying enzyme EZH2 as a novel regulator of early TFH differentiation during acute viral infection. | Xiangyu Chen Guoshuai Cao Jialin Wu Xinxin Wang Zhiwei Pan Jianbao Gao Qin Tian Lifan Xu Zhirong Li Yaxing Hao Qizhao Huang Pengcheng Wang Minglu Xiao Luoyingzi Xie Shupei Tang Zhenyu Liu Li Hu Jianfang Tang Ran He Li Wang Xinyuan Zhou Yuzhang Wu Mengjie Chen Beicheng Sun Bo Zhu Jun Huang Lilin Ye | 2020 | Cellular & Molecular Immunology2020，17，3： | 4 |
| 5 | The trajectory parameters analysis of saltating sand grains driven by wind显示文摘The study of trajectory parameters of saltating sand grains is of great importance to forming the kinematic theory of wind-sand current. By establishing the simplified theoretical pattern and probing into the relationship between lift-off angle (α) and landing angle (β), relationship between the ratio of saltation length ( L) to maximum height (H) and lift-off angle as | Xueyong Zou Qingzhen Hao Chunlai Zhang Bao Yang Yuzhang Liu Guangrong Dong Shaoxiang Zhou | 1999 | Chinese Science Bulletin1999，44，18： | 2 |
| 6 | Preformed particle gel for conformance control: factors affecting its properties and applications显示文摘 | Bai Baojun Li Liangxiong Liu Yuzhang | 2004 | SPE 893892004，，： | 1 |
| 7 | Preformed particle gel for conformance control: transport mechanism through porous media显示文摘 | Bai Baojun Liu Yuzhang Coste J P | 2004 | SPE894682004，，： | 1 |
| 8 | Preformed particle gel for conformance control:factors affecting its properties and applications显示文摘 | Bai Baojun Li Liangxiong Liu Yuzhang | 2004 | SPE 893892004，，： | 1 |
| 9 | Investiga- tion on the adaptability of the polymer microspheres for fluid flow diversion in porous media 显示文摘 | Li Junjian Liu Yuzhang Na Zhang | 2014 | Journal of Dis- persion Science and Technology2014，35，1： | 1 |
| 10 | Salt-induced fabrication of superhydrophilic and underwater superoleo- phobic PAA-g-PVDF membranes for effective separation of oil-in-water emulsions 显示文摘 | Zhang Wenbin Zhu Yuzhang Liu Xia | 2014 | Angewandte Chemie-Inter- national Edition2014，53，： | 1 |
| 11 | A new method of in-depth profile modification for high-temperature and high-salinity reservoir显示文摘 | Tang Xiacfen Liu Yuzhang Qin He st al | 2004 | SPE 884862004，，： | 1 |
| 12 | Identification and modification of an HLA-A*0201-restricted cytotoxic T lymphocyte epitope from Ran antigen显示文摘 | Fan Li Di Yang Yiqin Wang Baohua Liu Yijing Deng Li Wang Xiaoyun Shang Weidong Tong Bing Ni Yuzhang Wu | 2009 | Cancer Immunology Immunotherapy2009，，12： | 1 |
| 13 | Preformed particle gel for conformance control:Factors affecting its properties and application显示文摘 | Bai Baojun Li Liangxiong Liu Yuzhang | 2007 | SPE/DOC 893892007，，： | 1 |
| 14 | Preformed par- ticle gel for conformance control transport mechanism through porousmedia显示文摘 | Bai Baojun Liu Yuzhang Coste J P | 2004 | SPE 894682004，，： | 1 |
| 15 | Preformed particle gel for conformance control factors affecting its properties and applications 显示文摘 | Bai Baojun Li Liangxiong Liu Yuzhang | 2004 | SPE 893892004，，： | 1 |
| 16 | Diffusion barrier performances of thin Mo, Mo-N and Mo/Mo-N film between Cu and Si显示文摘 | Song Shuangxi Liu Yuzhang Mao Dail | 2005 | The Soild Films2005，476，： | 1 |
| 17 | Diffusion barrier performance of W/Ta-W-N double layers for Cu metallization显示文摘 | Song Shuangxi Liu Yuzhang Li Ming | 2006 | Microelectron Eng2006，83，： | 1 |
| 18 | Preformed particle gel for conformance control: Transport mechanism through porous media显示文摘 | Bai Baojun Liu Yuzhang Coste J-P | 2007 | SPE Reservoir Evaluation & Engineering2007，10，2： | 1 |
| 19 | Efficient control of chronic LCMV infection by a CD4 T cell epitope-based heterologous prime-boost vaccination in a murine model显示文摘CD4^(+)T cells are essential for sustaining CD8^(+)T cell responses during a chronic infection.The adoptive transfer of virus-specific CD4^(+)T cells has been shown to efficiently rescue exhausted CD8^(+)T cells.However,the question of whether endogenous virus-specific CD4^(+)T cell responses can be enhanced by certain vaccination strategies and subsequently reinvigorate exhausted CD8^(+)T cells remains unexplored.In this study,we developed a CD4^(+)T cell epitope-based heterologous prime-boost immunization strategy and examined the efficacy of this strategy using a mouse model of chronic lymphocytic choriomeningitis virus(LCMV)infection.We primed chronically LCMV-infected mice with a Listeria monocytogenes vector that expressed the LCMV glycoprotein-specific I-Ab-restricted CD4^(+)T cell epitope GP61–80(LM-GP61)and subsequently boosted the primed mice with an influenza virus A(PR8 strain)vector that expressed the same CD4^(+)T cell epitope(IAV-GP61).This heterologous prime-boost vaccination strategy elicited strong anti-viral CD4^(+)T cell responses,which further improved both the quantity and quality of the virusspecific CD8^(+)T cells and led to better control of the viral loads.The combination of this strategy and the blockade of the programmed cell death-1(PD-1)inhibitory pathway further enhanced the anti-viral CD8^(+)T cell responses and viral clearance.Thus,a heterologous prime-boost immunization that selectively induces virus-specific CD4^(+)T cell responses in conjunction with blockade of the inhibitory pathway may represent a promising therapeutic approach to treating patients with chronic viral infections. | Ran He Xinxin Yang Cheng Liu Xiangyu Chen Lin Wang Minglu Xiao Jianqiang Ye Yuzhang Wu Lilin Ye | 2018 | Cellular & Molecular Immunology2018，15，9： | 1 |
| 20 | Salt-induced fabrication of superhydrophilic and underwater superoleophobic PAA-g-PVDF membranes for effective separation of oil-in-water emulsions显示文摘 | Zhang Wenbin Zhu Yuzhang Liu Xia | | 0，，： | 1 |
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