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| 1 | Portal vein embolization by fine needle ethanol injection :experimental and clinicalstudies显示文摘AIM To improve the technique of intraportal embolization (PVE) therapy, a new embolic method, was devised and the safety, effectiveness and feasibility were evaluated. METHODS PVE with intraportal ethanol injection via a fine needle was performed in 28 normal dogs, 22 SD rats, and 24 cirrhotic SD rats. After PVE, portography, histological and functional alteration of the liver were evaluated in dogs and rats, and the changes in portal hemodynamics as well as hepatic anatomy were observed in rats. In the clinical study, PVE by ethanol injection was performed in 61 patients with hepatocellular carcinoma under the guidance of portoechography with intraportal injection of CO 2. The effect of PVE was evaluated by ultrasonography and laparotomy. RESULTS The effectiveness and toxicity were dependent on the dose of ethanol. In the dogs, 0 25*!mg/*!kg of ethanol caused incomplete embolization with least liver damage, while 1 0*!mg/*!kg induced complete embolization with a high mortality of 57 1% (4/*!7) due to respiratory arrest. The dose of 0 5*!mg/*!kg resulted in complete embolization with slight toxicity to the liver. In the rats, the survival rate was 100% in normal group but 40 9% in cirrhotic models after ethanol injection by dose of 0 05*!mg/*!100*!g . PVE for cirrhotic rats with 0 03*!mg/*!100*!g of ethanol induced satisfactory embolization with significant hypertrophy in nonembolized lobes, and only slight damage to the hepatic parenchyma, and transient alteration in liver function, portal pressure and portal flow. In the clinical study, 12 cases with reverse portal flow were excluded judged by portoechography. Satisfactory embolization was gained in 90 2% (55/*!61) of the remaining patients determined by ultrasonography and surgery. All cases ran an uneventful postembolization course with no aberrant embolization. CONCLUSION PVE with intraportal ethanol injection of appropriate dosage via a fine needle is safe and effective and has several advantages comparing with transcatheter method. Portoechography is a mandatory approach for the prevention of aberrant embolization. | Lu MD Chen JW Xie XY Liang LJ Huang JF | 1999 | World Journal of Gastroenterology1999，5，6： | 15 |
| 2 | Withdrawal of GnRH ag- onist decreases oestradioland VEGF concentrations in high responders 显示文摘 | Ding LJ Wang B Shen XY | 2013 | Reproductive BioMedicine Online2013，27，2： | 1 |
| 3 | Comparative proteomics and correlated signaling network of rat hippocampus in the pilocarpine model of temporal lobe epilepsy 显示文摘 | Liu XY YangJL Chen LJ | 2008 | proteomics2008，8，3： | 1 |
| 4 | Activated human hydroxy‐carboxylic acid receptor‐3 signals to MAP kinase cascades via the PLC‐dependent PKC and MMP‐mediated EGFR pathways显示文摘 | Q Zhou G Li XY Deng XB He LJ Chen C Wu Y Shi KP Wu LJ Mei JX Lu NM Zhou | 2012 | British Journal of Pharmacology2012，，6： | 1 |
| 5 | Comparative proteomics and corre- lated signaling network of rat hippocampus in the pilocarpine model of temporal lobe epilepsy 显示文摘 | Liu XY Yang JL Chen LJ | 2008 | Proteomics2008，8，3： | 1 |
| 6 | Comparative proteomics and correlated signaling network of rat hippocampus in the pilocar- pine model of temporal lobe epilepsy显示文摘 | Liu XY Yang JL Chen LJ | 2008 | Proteomics2008，8，3： | 1 |
| 7 | The mechanics of left ventricular filling during the strain phase of the Valsalva maneuver in healthy subjects 显示文摘 | Zhang XY Cao 'IS Yuan LJ | 2013 | Am J Med Sci2013，346，3： | 1 |
| 8 | Withdrawal of GnRH agonist decreases oestradiol and VEGF concentrations in high responders 显示文摘 | Ding LJ Wang B Shen XY | 2013 | Reprod Biomed Online2013，27，2： | 1 |
| 9 | Annual financial impact of thy- roidectomies for nodular thyroid disease in China显示文摘 | Liu XY Zhu LJ Cui D | 2014 | Asian Pac J Cancer Prey2014，15，14： | 1 |
| 10 | Metabolic Signature of Pregnant Women with NeuralTube defects in Offspring显示文摘 | Zheng XY Su MM Pei LJ etal | 2011 | J Proteome Res2011，10，10： | 1 |
| 11 | P ilo ts electronystagmogram s for different sit2 ting head po sition and their indications显示文摘 | W ang XY Xu DJ You XQ M iao DM Zhang JL Zuo LJ M i XH | 1998 | Di2si Junyi Daxue Xuebao (J Fourth Mil Med Univ)1998，19，6： | 1 |
| 12 | Knockdown of UHRF1 by lentivirus- mediated shRNA inhibits ovarian cancer cell growth显示文摘 | Yan F Shao LJ Hu XY | 2015 | Asian PacJ Cancer Prev2015，16，4： | 1 |
| 13 | Anti-depressant effect of aqueousextract from Acanthopanax senticosus in mice显示文摘 | JIN LJ WU FF LI XY | 2013 | Phytother Re-sear2013，21，12： | 1 |
| 14 | Association between plasma adiponectin levels and coronary lesion complexity显示文摘 | Wang XY Guo YH Guo LJ | 2007 | Bei jing Da Xue Xue Bao2007，39，： | 1 |
| 15 | Reconstruction of finger-pulp defect with a homodigital laterodorsal fascio-cutaneous flap distally based on the dorsal branchesof the proper palmar digital artery 显示文摘 | Meng XY Chen L Lu LJ | 2009 | Injury2009，40，12： | 1 |
| 16 | Association between plasma adiponectin levels and coronary lesion complexity显示文摘 | Wang XY Guo YH Guo LJ | 2007 | Beijing Da Xue Xue Bao2007，39，6： | 1 |
| 17 | Characterization of twoNADPH: cytochrome P450 reductases from cotton (Gossypium hirsutum)显示文摘 | Yang CQ Lu S Mao YB Wang LJ Chen XY | 2010 | Phytochemistry2010，71，1： | 1 |
| 18 | Treatment of Bactericide Wastew- ater By Combined Process Chemical Coagulation, Electrochemical Oxidation And Membrane Bioreactor 显示文摘 | Han WQ Wang LJ Sun XY | 2008 | J Hazard Mater2008，151，23： | 1 |
| 19 | H2AX-A novel biomarker for DNA double- strand breaks显示文摘 | Kuo LJ Li XY | 2008 | In Vivo2008，22，： | 1 |
| 20 | Occurrence and characteristics of class 1 and class 2 integrons in resistant Escherichla coli iso- lates frrm animals and farm workers in northeastern china显示文摘 | Zhang XY Ding LJ Yue J | 2009 | Microb Drug Resist2009，15，4： | 1 |
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