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| 1 | First dark matter search results from the PandaX-Ⅰ experiment显示文摘We report on the first dark-matter(DM)search results from PandaX-I,a low threshold dual-phase xenon experiment operating at the China JinPing Underground Laboratory.In the 37-kg liquid xenon target with 17.4 live-days of exposure,no DM particle candidate event was found.This result sets a stringent limit for low-mass DM particles and disfavors the interpretation of previously-reported positive experimental results.The minimum upper limit,3.7×10-44cm2,for the spin-independent isoscalar DM-particle-nucleon scattering cross section is obtained at a DM-particle mass of 49 GeV/c2at 90%confidence level. | XIAO MengJiao XIAO Xiang ZHAO Li CAO XiGuang CHEN Xun CHEN YunHua CUI XiangYi FANG DeQing FU ChangBo GIBONI Karl L. GONG HaoWei GUO GuoDong HU Jie HUANG XingTao JI XiangDong JU YongLin LEI SiAo LI ShaoLi LIN Qing LIU HuaXuan LIU JiangLai LIU Xiang LORENZON Wolfgang MA YuGang MAO YaJun NI KaiXuan PUSHKIN Kirill REN XiangXiang SCHUBNELL Michael SHEN ManBing STEPHENSON Scott TAN AnDi TARL Greg WANG HongWei WANG JiMin WANG Meng WANG XuMing WANG Zhou WEI YueHuan WU ShiYong XIE PengWei YOU YingHui ZENG XiongHui ZHANG Hua ZHANG Tao ZHU ZhongHua | 2014 | Science China(Physics,Mechanics & Astronomy)2014，57，11： | 10 |
| 2 | PandaX: a liquid xenon dark matter experiment at CJPL显示文摘PandaX is a large liquid-xenon detector experiment usable for direct dark-matter detection and 136Xe double-beta decay search.The central vessel was designed to accommodate a staged target volume increase from initially 120 kg(stage I)to 0.5 t(stage II)and eventually to a multi-ton scale.The experiment is located in the Jinping Deep-Underground Laboratory in Sichuan,China.The detector operates in dual-phase mode,allowing detection of both prompt scintillation,and ionization charge through proportional scintillation.In this paper a detailed description of the stage I detector design and performance as well as results established during the commissioning phase are presented. | CAO XiGuang CHEN Xun CHEN YunHua CUI XiangYi FANG DeQing FU ChangBo GIBONI Karl L. GONG HaoWei GUO GuoDong HE Ming HU Jie HUANG XingTao JI XiangDong JU YongLin LI ShaoLi LIN Qing LIU HuaXuan LIU JiangLai LIU Xiang LORENZON Wolfgang MA YuGang MAO YaJun NI KaiXuan PUSHKIN Kirill REN XiangXiang SCHUBNELL Michael SHEN ManBing SHI YuJie STEPHENSON Scott TAN AnDi TARLé Greg WANG HongWei WANG JiMing WANG Meng WANG XuMing WANG Zhou WEI YueHuan WU ShiYong XIAO MengJiao XIAO Xiang XIE PengWei YE Tao YOU YingHui ZEN XiongHui ZHANG Hua ZHANG Tao ZHAO HaiYing ZHAO Li ZHOU XiaoPeng ZHU ZhongHua | 2014 | Science China(Physics,Mechanics & Astronomy)2014，57，8： | 9 |
| 3 | Evidence based medicine and surgical approaches for colon cancer: Evidences, benefits and limitations of the laparoscopic vs open resection显示文摘AIM:To report a meta-analysis of the studies that compared the laparoscopic with the open approach for colon cancer resection.METHODS:Forty-seven manuscripts were reviewed,33 of which employed for meta-analysis according to the PRISMA guidelines.The results were differentiated according to the study design(prospective randomized trials vs case-control series)and according to the tu-mor’s location.Outcome measures included:(1)shortterm results(operating times,blood losses,bowel function recovery,post-operative pain,return to the oral intake,complications and hospital stay);(2)oncological adequateness(number of nodes harvested in the surgical specimens);and(3)long-term results(including the survivals’rates and incidence of incisional hernias)and(4)costs.RESULTS:Meta-analysis of trials provided evidences in support of the laparoscopic procedures for a several short-term outcomes including:a lower blood loss,an earlier recovery of the bowel function,an earlier return to the oral intake,a shorter hospital stay and a lower morbidity rate.Opposite the operating time has been confirmed shorter in open surgery.The same trend has been reported investigating case-control series and cancer by sites,even though there are some concerns regarding the power of the studies in this latter field due to the small number of trials and the small sample of patients enrolled.The two approaches were comparable regarding the mean number of nodes harvested and long-term results,even though these variables were documented reviewing the literature but were not computable for meta-analysis.The analysis of the costs documented lower costs for the open surgery,however just few studies investigated the incidence of postoperative hernias.CONCLUSION:Laparoscopy is superior for the majority of short-term results.Future studies should better differentiate these approaches on the basis of tumors’location and the post-operative hernias. | Laura Lorenzon Marco La Torre Vincenzo Ziparo Francesco Montebelli Paolo Mercantini Genoveffa Balducci Mario Ferri | 2014 | World Journal of Gastroenterology2014，20，13： | 8 |
| 4 | Human papillomavirus does not have a causal role in colorectal carcinogenesis显示文摘AIM: To investigate the presence of human papillomavirus(HPV) DNA along with the integration,the quantification and the expression of the HPV16 in colorectal cancers.METHODS: A prospective series of colorectal tumors were genotyped for HPV DNA.The clinical and pathological variables of the HPV-positive tumors were compared to those of HPV-negative samples.The integration status of HPV16 was evaluated by calculating E2/E6 ng ratios.HPV16-positive tumors were also evaluated for(1) E2,E4,E5,E6 and E7 viral gene ng quantification;(2) relative quantification compared to W12 cells; and(3) viral E2,E4,E5,E6 and E7 mR NA transcripts by real-time polymerase chain reaction.RESULTS: HPV infection was detected in 16.9% of all tumors examined,and HPV16 was the most frequent type detected(63.6% of positive tissues).Notably,the clinical and pathological features of HPV-positive colorectal cancers were not significantly different than those of HPV-negative cancers(χ2 and t-test for all clinical and pathological features of HPV-positive vs HPV-negative colorectal cancers: p ns).HPV16 DNA was present exclusively in episomal form,and the HPV16 E2,E4,E5,E6 and E7 genes were detected in tracenanogram quantities.Furthermore,the HPV16 genes ranged from 10-3 to 10-9 compared to W12 cells at an episomal stage.Although the extractions were validated by housekeeping gene expression,all the HPV16 positive tissues were transcriptionally inactive for the E2,E4,E5,E6 and E7 mR NAs.CONCLUSION: Based on our results,HPV is unlikely involved in colorectal carcinogenesis. | Laura Lorenzon Francesca Mazzetta Emanuela Pilozzi Giordana Uggeri Maria Rosaria Torrisi Mario Ferri Vincenzo Ziparo Deborah French | 2015 | World Journal of Gastroenterology2015，21，1： | 3 |
| 5 | Compound and Digenic Heterozygosity Contributes to Arrhythmogenic Right Ventricular Cardiomyopathy显示文摘 | Tianhong Xu Zhao Yang Matteo Vatta Alessandra Rampazzo Giorgia Beffagna Kalliopi Pillichou Steven E. Scherer Jeffrey Saffitz Joshua Kravitz Wojciech Zareba Gian Antonio Danieli Alessandra Lorenzon Andrea Nava Barbara Bauce Gaetano Thiene Cristina Basso Hu | 2010 | Journal of the American College of Cardiology2010，，6： | 2 |
| 6 | 低剂量白细胞介素-2在11种自身免疫疾病中的免疫学和临床疗效:单中心开放临床试验显示文摘背景调节性T(Tregs)细胞可以预防自身免疫并控制炎症,在各种自身免疫性或自身炎症性疾病中的研究都表明Treg细胞不足。由于低剂量白细胞介素-2(low-dose interleukin-2,ld-IL2)能够扩增并激活Tregs细胞,因此ld-IL2具有广泛的治疗潜力。目的我们通过一项临床试验观察ld-IL2治疗11种自身免疫性疾病中1种的效果,旨在评估ld-IL2的治疗潜力并选择疾病,以用于进一步的临床开发。方法本研究为前瞻开放性Ⅰ~Ⅱa期临床观察,入选了46例轻中度患者,诊断分别为类风湿关节炎、强直性脊柱炎、系统性红斑狼疮、牛皮癣、白塞病、肉芽肿性多血管炎、大动脉炎、克罗恩病、溃疡性结肠炎、自身免疫性肝炎或硬化性胆管炎。所有患者都接受了ld-IL2(100万IU/天)5天,然后每两周注射一次,维持6个月。所有患者均接受了深入的免疫监测和临床评估。结果在任何疾病类型以及任何合并药物治疗的患者中,ld-IL2都显示出了良好的耐受性。通过经典的免疫表型分析和广泛的免疫表型分析发现所有患者的Tregs细胞均被特异性地扩增激活,而效应T细胞没有被活化,提示ld-IL2具有临床疗效的前景。结论本研究中所采用的IL-2剂量和治疗方案可以选择性地激活和扩增Tregs细胞,并且对于不同的疾病种类以及不同的合并用药都是安全的。这一临床疗效以及初步结果可以为ld-IL2在各种自身免疫和自身炎症性疾病中开展Ⅱ期临床试验观察疗效提供了依据。试验注册号NCT01988506. | Michelle Rosenzwajg Roberta Lorenzon Patrice Cacoub Hang Phuong Pham Fabien Pitoiset Karim El Soufi Claire RIbet Claude Bernard Selim Aractingi Beatrice Banneville Laurent Beaugerie Francis Berenbaum Julien Champey Olivier Chazouilleres Christophe Corpechot Bruno Fautrel Arsfene Mekinian Elodie Regnier David Saadoun Joe-Elie Salem Jeremie Sellam Philippe Seksik Anne Daguenel-Nguyen Valene Doppler Jeremie Mariau Eric Vicaut David Klatzmann 杨新蕾(译) 张卓莉(校) | 2019 | 英国医学杂志中文版2019，22，2： | 2 |
| 7 | A specific PCR for the identification of Mycoplasma capricolum subsp. capripneumoniae , the causative agent of contagious caprine pleuropneumonia (CCPP)显示文摘 | S. Woubit S. Lorenzon A. Peyraud L. Manso-Silván F. Thiaucourt | 2004 | Veterinary Microbiology2004，，1： | 2 |
| 8 | A specific PCR for the identification of Mycoplasma capricolum subsp, capripneumoniae, the causative agent of contagious caprine pleuropneumonla (CCPP) 显示文摘 | S Woubit S Lorenzon A Peyraud | 2004 | Veterinary Microbiology2004，104，12： | 1 |
| 9 | Evaluation of E6andE7mRNA expression in HPV DNA positive breast cancer显示文摘 | Frega A Lorenzon L Bononi M | 2012 | Eur J Gynaecol Oncol2012，33，2： | 1 |
| 10 | A specific PCR for the identification of Mycoplasma capricolum subsp capripneumoniae, the causative agent of contagious caprine pleuropneumonia (CCPP) 显示文摘 | Woubit S Lorenzon S Peyraud A | 2004 | Veterinary Microbiology2004，，104： | 1 |
| 11 | A specific PCR for the identification of Mycoplasma capricolum subsp, capripneumoniae, the causative agent of contagious caprine pleuropneumonia (CCPP) 显示文摘 | WOUBIT S LORENZON S PEYRAUD A | 2004 | Vet Microbiol2004，104，12： | 1 |
| 12 | Gastrointestinal stromal tumors:correlation between symptoms at presentation,tumor location and prognostic factors in 47 consecutive patients显示文摘 | Caterino S Lorenzon L Petrucciani N | 2011 | World J Surg Oncol2011，9，1： | 1 |
| 13 | The wide spectrum of hyperechoic lesions of the breast 显示文摘 | Linda A Zuiani C Lorenzon M | 2011 | Clin Radiol2011，66，6： | 1 |
| 14 | Desmin mutations and arrhythmogenic right ventricular cardiomyopathy显示文摘 | Lorenzon A Beffagna G Bauce B et aI | 2013 | AmJ Cardiol2013，，40： | 1 |
| 15 | Hyperechoic lesions of the breast:not always benign 显示文摘 | Linda A Zuiani C Lorenzon M | 2011 | AJR Am J Roentgenol2011，196，5： | 1 |
| 16 | Salivary gland echography in primary and secondary Sjogren's syndrome 显示文摘 | De Vita S Lorenzon G Rossi G | 1992 | Clin Exp Rheumatol1992，10，4： | 1 |
| 17 | MULTIMERIN2 impairs tumor angiogenesis and growth by interfering with VEGF-A/VEGFR2 pathway显示文摘 | Lorenzon E Colladel R Andreuzzi E | 2012 | Oncogene2012，31，26： | 1 |
| 18 | Heavy metal toxicity and differential effects on the hyperglycemic stress response in the shrimp Palaemon elegans显示文摘 | LORENZON S FRANCESE M FERRERO E A | 2000 | Archives of Environmental Contamination and Toxicology2000，39，2： | 1 |
| 19 | Compound and Digenic Heterozygosity Predicts Lifetime Arrhythmic Outcome and Sudden Cardiac Death in Desmosomal Gene–Related Arrhythmogenic Right Ventricular Cardiomyopathy显示文摘 | Ilaria Rigato Barbara Bauce Alessandra Rampazzo Alessandro Zorzi Kalliopi Pilichou Elisa Mazzotti Federico Migliore Martina Perazzolo Marra Alessandra Lorenzon Marzia De Bortoli Martina Calore Andrea Nava Luciano Daliento Dario Gregori Sabino Iliceto Gaet | 2013 | Circulation: Cardiovascular Genetics2013，，6： | 1 |
| 20 | Correlation of physiologically and morphologically identified neuronal types in human association cortex in vitro 显示文摘 | Foehring RC Lorenzon NM Herron P | 1991 | J Neurophysiol1991，66，： | 1 |
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