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| 1 | miR-126 enhances the sensitivity of non-small cell lung cancer cells to anticancer agents by targeting vascular endothelial growth factor A显示文摘增加的证据建议 hsa-miR-126 (miR-126 ) 在房间衬里的非小的房间肺癌症(NSCLC ) 是下面调整的, miR-126 的恢复由指向特定的分子损害肿瘤房间增长,移植,侵略,和幸存。这里,我们第一次报导 miR-126 涉及调整 NSCLC 房间的反应到癌症化疗。在有 miR-126 的房间模仿的 transfected A549 或禁止者以后,我们发现 miR-126 的提高的水平显著地与减少的一半被联系 adriamycin ( ADM )和长春新碱的最大的禁止的集中, ADM 的增加的累积,脉管的 endothelial 生长因素 A ( VEGFA )和 multidrug 的下面规定联系抵抗的蛋白质 1 ( MRP1 ),并且 Akt 的 inactivation 发信号的小径。而且,提高了 miR-126 的表示压制了 A549 异种皮移植的生长并且禁止了 VEGFA 和 MRP1 的表示。miR-126 能高效地通过和 VEGFA 3-untranslated 区域的相互作用的下面调整 VEGFA 表示,而 VEGFA 的恢复能部分由 miR-126 稀释 MRP1 的抑制。然而, LY294002,表明小径的 PI3K/Akt 的一个禁止者,减少这效果,建议 miR-126 的那提高的表情通过发信号的 VEGF/PI3K/Akt/MRP1 的否定规定增加了 NSCLC 房间的敏感到 anticancer 代理人小径。 | Xiaolan Zhu Hao Li Lulu Long Lulu Hui Haining Chen Xuefeng Wang Huiling Shen Wenlin Xu | 2012 | Acta Biochimica et Biophysica Sinica2012，44，6： | 23 |
| 2 | The ChinaMAP analytics of deep whole genome sequences in 10,588 individuals显示文摘Metabolic diseases are the most common and rapidly growing health issues worldwide.The massive population-based human genetics is crucial for the precise prevention and intervention of metabolic disorders.The China Metabolic Analytics Project(ChinaMAP)is based on cohort studies across diverse regions and ethnic groups with metabolic phenotypic data in China.Here,we describe the centralized analysis of the deep whole genome sequencing data and the genetic bases of metabolic traits in 10,588 individuals from the ChinaMAP.The frequency spectrum of variants,population structure,pathogenic variants and novel genomic characteristics were analyzed.The individual genetic evaluations of Mendelian diseases,nutrition and drug metabolism,and traits of blood glucose and BMI were integrated.Our study establishes a large-scale and deep resource for the genetics of East Asians and provides opportunities for novel genetic discoveries of metabolic characteristics and disorders. | Yanan Cao Lin Li Min Xu Zhimin Feng Xiaohui Sun Jieli Lu Yu Xu Peina Du Tiange Wang Ruying Hu Zhen Ye Lixin Shi Xulei Tang Li Yan Zhengnan Gao Gang Chen Yinfei Zhang Lulu Chen Guang Ning Yufang Bi Weiqing Wang The ChinaMAP Consortium | 2020 | Cell Research2020，30，9： | 20 |
| 3 | miR-181a sensitizes a multidrug-resistant leukemia cell line K562/A02 to daunorubicin by targeting BCL-2显示文摘这研究的目的是调查 miR-181a 是否能调制白血病的敏感药抵抗的房间衬里 K562/A02 到化学疗法的代理人 daunorubicin (DNR ) ,并且在 K562/A02 房间的 DNR 敏感上探索 miR-181a 的机制。MicroRNA microarray 和茎环颠倒抄写聚合酶链反应被用来检测 miR-181a 的表示。3-(4,5-dimethylthiazol-2-yl )-2,5-diphenyl-2H-tetrazolium 溴化物试金被执行确定 K562 房间生长和生存能力上的 miR-181a 的效果。Apoptotic 房间是用 Annexin V/FITC 和 PI apoptosis 察觉工具包检测的份量上。BCL-2 蛋白质表示被西方的污点测量。有通常认为的 BCL-2 3 untranslated 区域的酶记者向量被构造探索 BCL-2 是否是 miR-181a 的直接目标基因。BCL-2 siRNA 是进房间的 transfected 探索在 BCL-2 和 DNR 抵抗之间的关系。miR-181a 表示水平比在 K562 房间在 K562/A02 房间是更低的(P < 0.05 ) 。是有 miR-181a 禁止者的 transfected 的 K562 房间比是有 miR-181a 的 transfected 的房间模仿的 K562 房间,和 K562/A02 比 K562/A02 房间有显著地更低的幸存的有显著地更高的幸存(P < 0.05 ) 。miR-181a 能在 K562/A02 房间提高导致 DNR 的 apoptosis。BCL-2 siRNA transfected K562/A02 房间减少了幸存与 K562/A02 控制组相比。在结论, miR-181a 能在 K562/A02 房间在 DNR 抵抗的发展起一个作用, miR-181a 的在表示上能由指向 BCL-2 敏化 K562/A02 房间到 DNR。 | Hao Li Lulu Hui Wenlin Xu | 2012 | Acta Biochimica et Biophysica Sinica2012，44，3： | 17 |
| 4 | Energy dependence on modes of electric activities of neuron driven by different external mixed signals under electromagnetic induction显示文摘Energy supply and release play an important role in individual neuron and neural network. In this paper, the electrical activities and Hamilton energy of neuron are investigated when external mixed signals(i.e., the periodic stimulus current and the periodic electromagnetic field) are imposed on the neuron under the electromagnetic induction. As a result, the Hamilton energy is much dependent on the mode transition, the multiple electric activity modes and the numerical analysis of Hamilton energy are more complicated under various parameters. When the periodic high-low frequency electromagnetic radiation is imposed in neuron, it is found that the electrical activities are more complex, and the changing of energy is obvious. In addition, the response of electrical activity and Hamilton energy is much dependent on the changing of amplitude A, B when the external high-low frequency signal is imposed on the neuron, meanwhile, the energy of bursting state is lower than the one of spiking state. It can be used for investigation about the energy coding in the neuron even the neuron networks. | LU LuLu JIA Ya XU Ying GE MengYan YANG LiJian ZHAN Xuan | 2019 | Science China(Technological Sciences)2019，62，3： | 8 |
| 5 | Synthesis, mechanical investigation, and application of nitrogen and phosphorus co-doped carbon dots with a high photoluminescent quantum yield显示文摘有高 photoluminescent 量收益(PLQY ) 的做 Heteroatom 的碳点(CD ) 最近在化学传感器,光催化, bioimaging,和药交货中由于他们的应用吸引了注意。氮和磷在到在周期表的碳的靠近的最近并且是关键的在生物医学的成像的地里追踪元素。这二个元素改变 CD 的光、电子的性质并且帮助改进他们的 PLQY 的基本理解。这能也在 photoimaging 和 photothermal 治疗导致多功能的用法。然而,源于做 P 的 CD 的合成的大多数 PLQY 当前低于 50% 。这些 CD 在 bioimaging 和药交货的地里限制了实用性。在这研究,一个单个步的、高效率的热水的方法被使用综合氮和磷药的碳点((N, P ) 有有独立排放的多达 53.8% 的 PLQY 的 -CDs) 行为。而且, CD 在一个大 pH 范围上介绍了高 monodispersity,柔韧的刺激无关的光,和稳定性。分光镜的调查显示 PLQY (N, P ) CD 主要由于 P 的增加和氧化表面的钝化效果。优秀荧光性质(N, P ) CD 能被 Hg 2+ 离子有效地并且有选择地熄灭。如此的系统与一短反应时间在 0-900 nM 集中范围显示出线性回答,显示他们为化学和生物学的领域里的应用程序的潜力。 | Quan Xu Bofan Li Yingchun Ye Wei Cai Weijun Li Chuanyao Yang Yusheng Chen Meng Xu Neng Li Xusheng Zheng Jason Street Yan Luo Lulu Cai | 2018 | Nano Research2018，11，7： | 7 |
| 6 | Copper as a single metal atom based photo-,electro-,and photoelectrochemical catalyst decorated on carbon nitride surface for efficient CO_(2) reduction:A review显示文摘The processes of photocatalytic CO_(2) reduction(pCO_(2)R)and electrochemical CO_(2) reduction(ECO_(2)R)have attracted considerable interest owing to their high potential to address many environmental and energy-related issues.In this aspect,a single Cu atom decorated on a carbon nitride(CN)surface(Cu-CN)has gained increasing popularity because of its unique advantages,such as excellent atom utilization and ultrahigh catalytic activity.CN-particularly graphitic CN(g-C_(3)N_(4))-is a photo-and electrocatalyst and used as an important support material for single Cu atom-based catalysts.These key functions of Cu-CN-based catalysts can improve the catalytic performance and stability in the pCO_(2)R and ECO_(2)R during the application process.In this review,we focus on Cu as a single metal atom decorated on CN for efficient photoelectrochemical CO_(2) reduction(pECO_(2)R),where ECO_(2)R increases the electrocatalytic active area and promotes electron transfer,while pCO_(2)R enhances the surface redox reaction by efficiently using photogenerated charges and offering integral activity as well as an active interface between Cu and CN.Interactions of single Cu atom-based photo-,electro-,and photoelectrochemical catalysts with g-C_(3)N_(4) are discussed.Moreover,for a deeper understanding of the history of the development of pCO_(2)R and ECO_(2)R,the basics of CO_(2) reduction,including pCO_(2)R and ECO_(2)R over g-C_(3)N_(4),as well as the structural composition,characterization,unique design,and mechanism of a single atom site are reviewed in detail.Finally,some future prospects and key challenges are discussed. | Lulu Li Israr Masood ul Hasan Farwa Ruinan He Luwei Peng Nengneng Xu Nabeel Khan Niazi Jia-Nan Zhang Jinli Qiao | 2022 | Nano Research Energy2022，1，2： | 7 |
| 7 | PHF8 is a histone H3K9me2 demethylase regulating rRNA synthesis显示文摘histone H3 离氨酸 9 的 Dimethylation (H3K9me2 ) 是与抄写压抑联系的一个重要 epigenetic 标记。这里,我们识别了 PHF8, JmjC-domain-containing 蛋白质,为这个镇压标记特定的 histone demethylase。Recombinant 全身的野类型蛋白质能把 methylation 从 H3K9me2 移开,但是到丙氨酸 H247A 的保存 histidine 的变化废除 demethylase 活动。Overexpressed 外长的 PHF8 是 colocalized, B23 染色。内长的 PHF8 也是有 B23 和 fibrillarin 的 colocalized,二生长得很好的核蛋白质,建议那 PHF8 在核是局部性的并且可以调整 rRNA 抄写。确实, PHF8 跳了到 rDNA 基因的倡导者区域。减少的 PHF8 击倒 rRNA 的表示,和基因的 overexpression 导致了 rRNA 的 upregulation 抄本。附随地, H3K9me2 水平在 PHF8 击倒的房间在 rDNA 基因的倡导者区域被提高并且当野类型然而并非催化地不活跃的 H247A 变异的 PHF8 是 overexpressed 时,显著地减少了。因此,我们的学习为调整 rRNA 抄写的 H3K9me2 识别了 histone demethylase。 | Ziqi Zhu Yanru Wang Xia Li Yiqin Wang Longyong Xu Xiang Wang Tianliang Sun Xiaobin Dong Lulu Chen Hailei Mao Yi Yu Jingsong Li Pin Adele Chen Charlie Degui Chen | 2010 | Cell Research2010，20，7： | 7 |
| 8 | Histological, hormonal and transcriptomic reveal the changes upon gibberellin-induced parthenocarpy in pear fruit显示文摘Phytohormones play crucial roles in fruit set regulation and development.Here,gibberellins(GA4+7),but not GA3,induced pear parthenocarpy.To systematically investigate the changes upon GA4+7 induced pear parthenocarpy,dynamic changes in histology,hormone and transcript levels were observed and identified in unpollinated,pollinated and GA4+7-treated ovaries.Mesocarp cells continued developing in both GA4+7-treated and pollinated ovaries.In unpollinated ovaries,mesocarp cells stopped developing 14 days after anthesis.During fruit set process,GA4+7,but not GA1+3,increased after pollination.Abscisic acid(ABA)accumulation was significantly repressed by GA4+7 or pollination,but under unpollinated conditions,ABA was produced in large quantities.Moreover,indole-3-acetic acid biosynthesis was not induced by GA4+7 or pollination treatments.Details of this GA–auxin–ABA cross-linked gene network were determined by a comparative transcriptome analysis.The indole-3-acetic acid transport-related genes,mainly auxin efflux carrier component genes,were induced in both GA4+7-treated and pollinated ovaries.ABA biosynthetic genes of the 9-cis-epoxycarotenoid dioxygenase family were repressed by GA4+7 and pollination.Moreover,directly related genes in the downstream parthenocarpy network involved in cell division and expansion(upregulated),and MADS-box family genes(downregulated),were also identified.Thus,a model of GA-induced hormonal balance and its effects on parthenocarpy were established. | Lulu Liu Zhigang Wang Jianlong Liu Fengxia Liu Rui Zhai Chunqin Zhu Huibin Wang Fengwang Ma Lingfei Xu | 2018 | Horticulture Research2018，5，1： | 7 |
| 9 | Lingguizhugan Decoction, a Chinese herbal formula, improves insulin resistance in overweight/obese subjects with non-alcoholic fatty liver disease: a translational approach显示文摘Lingguizhugan Decoction(LGZG)has been investigated in basic studies,with satisfactory effects on insulin resistance in non-alcoholic fatty liver disease(NAFLD).This translational approach aimed to explore the effect and underlying mechanism of LGZG in clinical setting.A randomized,double-blinded,placebo-controlled trial was performed.A total of 243 eligible participants with NAFLD were equally allocated to receive LGZG(two groups:standard dose and low dose)or placebo for 12 weeks on the basis of lifestyle modifications.The primary efficacy variable was homeostasis model assessment of insulin resistance(HOMA-IR).Analyses were performed in two populations in accordance with body mass index(BMI;overweight/obese,BMI 24 kg/m^(2);lean,BMI<24 kg/m^(2)).For overweight/obese participants,low-dose LGZG significantly decreased their HOMA-IR level compared with placebo(0.19(1.47)versus 0.08(1.99),P=0.038).For lean subjects,neither dose of LGZG showed a superior effect compared with placebo.Methylated DNA immunoprecipitation sequencing and real-time qPCR found that the DNA N6-methyladenine modification levels of protein phosphatase 1 regulatory subunit 3A(PPP1R3A)and autophagy related 3(ATG3)significantly increased after LGZG intervention in overweight/obese population.Low-dose LGZG effectively improved insulin resistance in overweight/obese subjects with NAFLD.The underlying mechanism may be related to the regulation of DNA N6-methyladenine modification of PPP1R3A and ATG3.Lean subjects may not be a targeted population for LGZG. | Liang Dai Jingjuan Xu Baocheng Liu Yanqi Dang Ruirui Wang Lijie Zhuang Dong Li Lulu Jiao Jianying Wang Lei Zhang Linda LDZhong Wenjun Zhou Guang Ji | 2022 | Frontiers of Medicine2022，16，5： | 7 |
| 10 | miR-137 restoration sensitizes multidrug-resistant MCF-7/ADM cells to anticancer agents by targeting YB-1显示文摘到化学疗法的代理人的 Multidrug 抵抗(MDR ) 是到在乳癌病人的成功的治疗的一个主要障碍。这研究的目的是调查 miR-137 是否涉及 MDR 的规定,并且在 MCF-7/ADM 房间的敏感上探索 miR-137 的机制。miR-137 是在 MCF-7/ADM 房间的 downregulated,并且它的表达式被发现相反地在乳癌房间与 Y 盒子有约束力的 protein-1 (YB-1 ) 和 P-glycoprotein (P-gp ) 层次相关。而且, YB-1 被酶记者试金和西方的污点分析作为 miR-137 的一个目标证实。而且, miR-137 的提高的表示减少了 YB-1 和 P-gp 的蛋白质表示层次, mimicking 在到 anticancer 代理人的 MCF-7/ADM 房间的敏感击倒的 YB-1 的效果,而 YB-1 的恢复减少了这效果。在结论,我们的结果证明 miR-137 被指向 YB-1 通过 P-gp 的调整在癌症涉及 MDR,建议 miR-137 可能是为阻止并且逆行在肿瘤房间的 MDR 的一个潜在的目标。 | Xiaolan Zhu Yuefeng Li Huiling Shen Hao Li Lulu Hui Wenlin Xu | 2013 | Acta Biochimica et Biophysica Sinica2013，45，2： | 6 |
| 11 | Red/orange dual-emissive carbon dots for pH sensing and cell imaging显示文摘The dual-emissive N,S co-doped carbon dots (N,S-CDs) with a long emission wavelength were synthesized via solvothermal method.The N,S-CDs possess relatively high photoluminescence (PL) quantum yield (QY) (35.7%) towards near-infrared fluorescent peak up to 648 nm.With the advanced characterization techniques including X-ray photoelectron spectroscopy (XPS),Fourier transform infrared spectroscopy (FTIR),etc.It is found that the doped N,S elements play an important role in the formation of high QY CDs.The N,S-CDs exist distinct pH-sensitive feature with reversible fluorescence in a good linear relationship with pH values in the range of 1.0-13.0.What is more,N,S-CDs can be used as an ultrasensitive Ag+ probe sensor with the resolution up to 0.4 μM.This finding will expand the application of as prepared N,S-CDs in sensing and environmental fields. | Miaoran Zhang Rigu Su Jian Zhong Ling Fei Wei Cai Qingwen Guan Weijun Li Neng Li Yusheng Chen Lulu Cai Quan Xu | 2019 | Nano Research2019，12，4： | 6 |
| 12 | miR-106a confers cisplatin resistance by regulating PTEN/Akt pathway in gastric cancer cells显示文摘最近的研究证明了 microRNA-106a (miR-106a ) 是在胃的癌症的 overexpressed 并且贡献肿瘤生长。在这研究,我们调查了 miR-106a 是否调停了到化学疗法的代理人 cisplatin (DDP ) 的胃的癌症房间线 SGC7901 的抵抗。MiR-106a 表示与它的父母线 SGC7901 相比在 DDP 抵抗房间线 SGC7901/DDP 是起来调整的。miR-106a 的 Transfection 在 SGC7901 导致了 DDP 抵抗,当在 SGC7901/DDP 的 miR-106a 的抑制导致了提高的 DDP cytotoxicity 时。进一步的学习显示 miR-106a-induced DDP 抵抗的机制包含了从染色体 10 删除的磷酸酶和 tensin 相当或相同的事物(PTEN ) 的表示蛋白质和它的下游的 phosphatidylinositol 3 kinase (PI3K )/protein kinase B (AKT ) 小径。这研究在胃的癌症提供 DDP 抵抗的新奇机制。 | Yue Fang Huiling Shen Hao Li Yuan Cao Rong Qin Lulu Long Xiaolan Zhu Chanjuan Xie Wenlin XU | 2013 | Acta Biochimica et Biophysica Sinica2013，45，11： | 6 |
| 13 | Recent advances in carbon-based electrocatalysts for oxygen reduction reaction显示文摘Fuel cells are one of the most promising clean energy devices to substitute for fossil fuel in the future to alleviate energy crisis and environmental pollution.As the key reaction on the cathode in the fuel cells,oxygen reduction reaction(ORR)still requires efficient noble metal catalysts such as the comme rcial Pt/C to boost the reaction for its sluggish kinetics.Therefore,it is critical to design earth-abundant carbonbased catalysts with high efficiency and long-term stability to replace the noble metal-based catalysts.This review focuses on the recent progress about carbon-based ORR catalysts including non-metal doped carbon materials,transition metal-nitrogen-carbon species,transition metal carbides/carbon,single atom catalysts,and other carbon hybrids.And we further infer that the excellent ORR performances can be achieved by the balance of geometric and electronic structures of catalysts such as conductivity,surface area,hierarchical porous structure,defect and doping effect.Additionally,the perspective development trend is also proposed to guide the rational designation of carbon-based catalysts for ORR and even extend to other energy storage and conversion fields in the future. | Lulu Chen Xiaolong Xu Wenxiu Yang Jianbo Jia | 2020 | Chinese Chemical Letters2020，31，3： | 5 |
| 14 | Simultaneous determination of 35 constituents and elucidation of effective constituents in a multi-herb Chinese medicine formula Xiaoer-Feire-Kechuan显示文摘Xiaoer-Feire-Kechuan(XFK) is an 11-herb Chinese medicine formula to treat cough and pulmonary inflammation.The complicated composition rendered its chemical analysis and effective-component elucidation.In this study,we combined quantitative analysis and bioactivity test to reveal the antiinflammatory constituents of XFK.First,UPLC-DAD and UHPLC/Q-Orbitrap-MS methods were established and validated to quantify 35 analytes(covering 9 out of 11 herbs) in different XFK formulations.Parallel reaction monitoring mode built in Q-Orbitrap-MS was used to improve the sensitivity and selectivity.Then,anti-inflammatory activities of the 35 analytes were analyzed using in vitro COX-2 inhibition assay.Finally,major analytes forsythosides H,I,A(8-10),and baicalin(15)(total contents varied from 21.79 to 91.20 mg/dose in different formulations) with significant activities(inhibitory rate ≥ 80%) were proposed as the anti-inflammatory constituents of XFK.The present study provided an effective strategy to discover effective constituents of multi-herb formulas. | Zhanpeng Shang Lulu Xu Yi Kuang Yan Lin Shuang Liu Long Sun Tao Bo Min Ye Xue Qiao | 2021 | Journal of Pharmaceutical Analysis2021，11，6： | 4 |
| 15 | Responses of Yellow Sea Cold Water Mass to Typhoon Bolaven显示文摘A two-month seabed-mounted observation(YSG1 area) was carried out in the western Yellow Sea Cold Water Mass(YSCWM) using an RDI-300 K acoustic Doppler current profiler(ADCP) placed at a water depth of 38 m in late summer, 2012. On August 2012, Typhoon Bolaven passed east of YSG1 with a maximum wind speed of 20 m s-1. The water depth, bottom temperature, and profile current velocities(including u, v and w components) were measured, and the results showed that the typhoon could induce horizontal current with speed greater than 70 cm s-1 in the water column, which is especially rare at below 20 meters above bottom(mab). The deepening velocity shear layer had an intense shear velocity of around 10 cm s-1 m-1, which indicated the deepening of the upper mixed layer. In the upper water column(above 20 mab), westward de-tide current with velocity greater than 30 cm s-1 was generated with the typhoon's onshore surge, and the direction of current movement shifted to become southward. In the lower water column, a possible pattern of eastward compensation current and delayed typhoon-driven current was demonstrated. During the typhoon, bottom temperature variation was changed into diurnal pattern because of the combined influence of typhoon and tidal current. The passage of Bolaven greatly intensified local sediment resuspension in the bottom layer. In addition, low-density particles constituted the suspended particulate matter(SPM) around 10 mab, which may be transported from the central South Yellow Sea by the typhoon. Overall, the intensive external force of the Typhoon Bolaven did not completely destroy the local thermocline, and most re-suspended sediments during the typhoon were restricted within the YSCWM. | LI Jianchao LI Guangxue XU Jishang QIAO Lulu MA Yanyan DING Dong LIU Shidong | 2019 | Journal of Ocean University of China2019，18，1： | 3 |
| 16 | Ridge subduction, magmatism, and metallogenesis显示文摘Modern oceans contain large bathymetric highs(spreading oceanic ridges,aseismic ridges or oceanic plateaus and inactive arc ridges)that,in total,constitute more than 20–30%of the total area of the world’s ocean floor.These bathymetric highs may be subducted,and such processes are commonly referred to as ridge subduction.Such ridge subduction events are not only very common and important geodynamic processes in modern oceanic plate tectonics,they also play an important role in the generation of arc magmatism,material recycling,the growth and evolution of continental crust,the deformation and modification of the overlying plates,and metallogenesis at convergent plate boundaries.Therefore,these events have attracted widespread attention.The perpendicular or high-angle subduction of mid-ocean spreading ridges is commonly characterized by the occurrence of a slab window,and the formation of a distinctive adakite–high-Mg andesite–Nb-enriched basalt-oceanic island basalt(OIB)or a mid-oceanic ridge basalt(MORB)-type rock suite,and is closely associated with Au mineralization.Aseismic ridges or oceanic plateaus are traditionally considered to be difficult to subduct,to typically collide with arcs or continents or to induce flat subduction(low angle of less than 10°)due to the thickness of their underlying normal oceanic crust(>6–7 km)and high topography.However,the subduction of aseismic ridges and oceanic plateaus occurred on both the western and eastern sides of the Pacific Ocean during the Cenozoic.On the eastern side of the Pacific Ocean,aseismic ridges or oceanic plateaus are being subducted flatly or at low angles beneath South and Central American continents,which may cause a magmatic gap.But slab melting can occur and adakites,or an adakite–high-Mg andesite–adakitic andesite–Nb-enriched basalt suite may be formed during the slab rollback or tearing.Cu-Au mineralization is commonly associated with such flat subduction events.On the western side of the Pacific Ocean,however,aseismic ridges and oceanic plateaus are subducted at relatively high angles(>30°).These subduction processes can generate large scale eruptions of basalts,basaltic andesites and andesites,which may be derived from fractional crystallization of magmas originating from the subduction zone fluid-metasomatized mantle wedge.In addition,some inactive arc ridges are subducted beneath Southwest Japan,and these subduction processes are commonly associated with the production of basalts,high-Mg andesites and adakites and Au mineralization.Besides magmatism and Cu-Au mineralization,ridge subduction may also trigger subduction erosion in subduction zones.Future frontiers of research will include characterizing the spatial and temporal patterns of ridge subduction events,clarifying the associated geodynamic mechanisms,quantifying subduction zone material recycling,establishing the associated deep crustal and mantle events that generate or influence magmatism and Cu-Au mineralization,establishing criteria to recognize pre-Cenozoic ridge subduction,the onset of modernstyle plate tectonics and the growth mechanisms for Archean continental crust. | Qiang WANG Gongjian TANG Lulu HAO Derek WYMAN Lin MA Wei DAN Xiuzheng ZHANG Jinheng LIU Tongyu HUANG Chuanbing XU | 2020 | Science China Earth Sciences2020，63，10： | 3 |
| 17 | Structural insights into a dual-specificity histone demethylase ceKDM7A from Caenorhabditis elegans显示文摘Histone 离氨酸 methylation 能被 JmjC 包含域的蛋白质在 sequence-state-specific 和 methylation-state-specific 举止移开。然而,底层特性怎么样,决定,酶怎么被调整,大部分是未知的。我们最近发现了那 ceKDM7A,一个哲学博士 -- 并且 JmjC 包含域的蛋白质,是为 H3K9me2 特定的 histone demethylase, H3K27me2,和 PHD 摸绑定到 H3K4me3 指南在 vivo 的 demethylation 活动。为了为酶的活动和 PHD 的功能提供结构的卓见进分子的机制,摸,我们与包含 H3K4me3, H3K9me2,和 H3K27me2 修正的各种各样的联合的单身者或二肽一起在 apo 形式并且在建筑群解决了酶的六水晶结构。结构显示 H3K9me2 和 H3K27me2 以一种类似的方式与 ceKDM7A 交往,并且肽绑定特性被特定的相互作用的一个网络决定。结构的几何测量也揭示了与 PHD 手指和 H3K9me2 界限联系到 JmjC 领域的那 H3K4me3 从二个分开的分子,建议 trans-histone 肽绑定机制。因此,我们的全身的结构的研究重要地由催化领域而且更多揭示底层识别不仅,为 H3K9me2 和 H3K27me2 的 ceDKM7A 的双特性的分子的机制。 | Ying Yang Lulu Hu Ping Wang Haifeng Hou Yan Lin Yi Liu Ze Li Rui Gong Xiang Feng Lu Zhou Wen Zhang Yuhui Dong Huirong Yang Hanqing Lin Yiqin Wang Charlie Degui Chen Yanhui Xu | 2010 | Cell Research2010，20，8： | 3 |
| 18 | The Marine Dynamics and Changing Trend off the Modern Yellow River Mouth显示文摘Topography around the Yellow River mouth has changed greatly in recent years, but studies on the current state of ma- rine dynamics off the Yellow River mouth are relatively scarce. This paper uses a two-dimension numerical model(MIKE 21) to reveal the tidal and wave dynamics in 2012, and conducts comparative analysis of the changes from 1996 to 2012. The results show that M2 amphidromic point moved southeastward by 11 km. It further reveals that the tides around the Yellow River mouth are relatively stable due to the small variations in the tidal constituents. Over the study period, there is no noticeable change in the distribution of tidal types and tidal range, and the mean tidal range off the river mouth during the period studied is 0.5–1.1 m. However, the tidal currents changed greatly due to large change in topography. It is observed that the area with strong tidal currents shifted from the old river mouth(1976–1996) to the modern river mouth(1996–present). While the tidal current speeds decreased continually off the old river mouth, they increased off the modern river mouth. The Maximum Tidal Current Speed(MTCS) reached 1.4 m s-1, and the maximum current speed of 50-year return period reached 2.8 m s-1. Waves also changed greatly due to change in topography. The significant wave height(H1/3) of 50-year return period changed proportionately with the water depth, and the ratio of H1/3 to depth being 0.4–0.6. H1/3 of the 50-year return period in erosion zone increased continually with increasing water depth, and the rate of change varied between 0.06 and 0.07 m yr-1. Based on the results of this study, we infer that in the future, the modern river mouth will protrude gradually northward, while the erosion zone, comprising the old river mouth and area between the modern river mouth and the old river mouth(Intermediate region) will continue to erode. As the modern river mouth protrudes towards the sea, there will be a gradual increase in the current speed and decrease in wave height. Conversely, the old river mouth will retreat, with gradual decrease in current speed and increase in wave height. As more coastal constructions spring up around the Yellow River mouth in the future, we recommend that variation in hydrodynamics over time should be taken into consideration when designing such coastal constructions. | WANG Nan LI Guangxue XU Jishang QIAO Lulu DADA Olusegun A. ZHOU Chunyan | 2015 | Journal of Ocean University of China2015，14，3： | 3 |
| 19 | Geological controls of shale gas accumulation and enrichment mechanism in Lower Cambrian Niutitang Formation of western Hubei, Middle Yangtze, China显示文摘The lower Cambrian Niutitang Formation is of crucial importance for shale gas target reservoirs in western Hubei,China;however,little work has been done in this field,and its shale gas accumulation and enrichment mechanism are still unclear.Based on survey wells,outcrop data,and large numbers of tests,the geological conditions of shale gas accumulation were studied;moreover,the factors that influence the gas content were thoroughly discussed.The results show that the Niutitang Formation(Є1n)can be divided into three sections:the first section(Є_(1)n^(1)),the second section(Є_(1)n^(2)),and the third section(Є1n3).TheЄ_(1)n^(2) is the main shale gas reservoir.The deep shelf facies is the main sedimentary facies and can be divided into three main lithofacies:argillaceous siltstone,carbonaceous shale and carbonaceous siliceous rock.The total organic carbon(TOC)content shows gentle growth trends until bottom of theЄ_(1)n^(2) and then decreases rapidly within theЄ_(1)n^(1),and the TOC content mainly ranges from 2%to 4%horizontally.The calcite and dolomite dissolution pores,clay intergranular pores and organic pores are the main pore types and the micropore types are clearly related to the mineral compositions and the TOC content.Vertically,the gas content is mainly affected by the TOC content.Horizontally,wells with high gas contents are distributed only southeast of the Huangling anticline,and the combination of structural styles,fault and fracture development,and the distribution of the regional unconformity boundary between the upper Sinian Dengying Formation(Z2d)and theЄ_(1)n^(2) are the three most important factors affecting the gas content.The favorable areas must meet the following conditions:a deep shelf environment,the presence of theЄ_(1)n^(1),wide and gentle folds,far from large normal faults that are more than 5 km,moderate thermal evolution,and greater than 500 m burial depth;this includes the block with the YD2–ZD2 wells,and the block with the Y1 and YD4 wells,which are distributed in the southern portion of the Huangling anticline and northern portion of the Xiannvshan fault. | Lulu XU Saipeng HUANG Zaoxue LIU Yaru WEN Xianghui ZHOU Yanlin ZHANG Xiongwei LI Deng WANG Fan LUO Cheng CHEN | 2021 | Frontiers of Earth Science2021，15，2： | 3 |
| 20 | Surface characterization of steel/steel contact lubricated by PA06 with novel black phosphorus nanocomposites显示文摘In the present work,two types of novel nano additives,titanium sulfonate ligand/black phosphorus(TiLi/BP)and titanium dioxide/black phosphorus(TiCVBP)nanocomposites,were prepared.The tribological behavior of the steel/steel friction pairs lubricated by polyalphaolefins type 6(PA06)containing the nanocomposites under boundary lubrication was studied.The worn surfaces were analyzed using modem surface techniques.The experimental results show that the rubbed surfaces became smooth and showed little wear with the addition of the nanocomposites.TiO_(2)/BP nanocomposites can significantly improve the lubricity of BP nanosheets under high contact stress.The synergistic roles of the load-bearing abilities and rolling effect of TiO_(2) nanoparticles,the slip induced by the BP with its layered structure,and the establishment of a tribofilm on the sliding interface are the basis of the tribological mechanisms. | Zhiheng LUO Jingyuan YU Yufu XU He XI Gang CHENG Lulu YAO Ruhong SONG Karl D DEARN | 2021 | Friction2021，9，4： | 2 |
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