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| 1 | TNF-α Induces Transient Resistance to Fas-Induced Apoptosis in Eosinophilic Acute Myeloid Leukemia Cells显示文摘Tumor necrosis factor α (TNF-α) has been recognized as an activator of nuclear factor κB (NF-κB), a factor implicated in the protection of many cell types from apoptosis. We and others have presented evidence to suggest that Fas-induced apoptosis may be an important aspect of the resolution of inflammation, and that delayed resolution of inflammation may be directly associated with NF-κB-dependent resistance to Fas. Because TNF-α activates NF-κB in many cell types including inflammatory cells such as eosinophils, we examined effects of TNF-α signaling on the Fas-mediated killing of an eosinophilic cell line AML14. While agonist anti-Fas (CH11) treatment induced apoptosis in AML14 cells, no significant cell death occurred in response to TNF-α alone. Electrophoretic mobility shift assay (EMSA) revealed that TNF-α induced NF-κB transactivation in AML14 cells in a time- and dose-dependent fashion, and subsequent supershift assays indicated that the translocated NF-κB was the heterodimer p65 (RelA)/p50. Pre-treatment of cells with TNF-α dramatically decreased the CH11-induced cell death in a transient fashion, accompanied by suppression of activation of caspase-8 and caspase-3 activation. Inhibition of NF-κB transactivation by inhibitors, BAY 11-7085 and parthenolide, reversed the suppression of Fas-mediated apoptosis by TNF-α. Furthermore, TNF-α up-regulated X-linked inhibitor of apoptosis protein (XIAP) transiently and XIAP levels were correlated with the temporal pattern of TNF-α protection against Fas-mediated apoptosis. This finding suggested that TNF-α may contribute to the prolonged survival of inflammatory cells by suppression of Fas-mediated apoptosis, the process involved with NF-κB transactivation,anti-apoptotic XIAP up-regulation and caspase | Yimin Qin Sogyong Auh Lyubov Blokh Catherine Long Isabelle Gagnon Kimm J. Hamann | 2007 | Cellular & Molecular Immunology2007，4，1： | 19 |
| 2 | 钠-葡萄糖共转运蛋白-2抑制剂或胰高血糖素样肽-1受体激动剂治疗成人2型糖尿病:临床实践指南显示文摘临床问题对于存在不同心血管风险及肾脏结局的2型糖尿病患者,在原有生活方式干预和/或其他降糖药物的基础上加用钠-葡萄糖共转运蛋白2(SGLT-2)抑制剂和胰高血糖素样肽1(GLP-1)受体激动剂的获益及风险是什么?现行做法几十年来,2型糖尿病的治疗决策都以控制血糖为主导。SGLT-2抑制剂和GLP-1受体激动剂在传统观念中常被用于二甲双胍治疗后血糖仍控制不佳的患者。目前这一现状已经发生了改变,这得益于多项临床研究结果。研究显示SGLT-2抑制剂和GLP-1受体激动剂拥有独立于药物降糖作用之外的对于动脉粥样硬化性心血管病(CVD)和慢性肾脏病(CKD)的获益。建议本指南阐述了针对不同风险分层的成人2型糖尿病患者使用SGLT-2抑制剂或GLP-1受体激动剂的建议。•伴有3种或更少的心血管风险因素且不存在CVD或CKD:不建议启动SGLT-2抑制剂或GLP-1受体激动剂治疗。(推荐等级:弱)•伴有3种以上心血管风险因素且不存在CVD或CKD:建议启动SGLT-2抑制剂治疗,不建议启动GLP-1受体激动剂治疗。(推荐等级:弱)•已经存在CVD或CKD:建议启动SGLT-2抑制剂治疗和GLP-1受体激动剂治疗。(推荐等级:弱)•已经存在CVD和CKD:建议启动SGLT-2抑制剂治疗(推荐等级:强)和GLP-1受体激动剂治疗。(推荐等级:弱)•对于那些想要进一步降低CVD和CKD结局风险的患者:推荐优先启用SGLT-2抑制剂治疗而非GLP-1受体激动剂治疗。(推荐等级:弱)这项指南是如何制订的一个由患者、临床医生和方法学家共同组成的国际小组提出了这些推荐意见。这些推荐意见基于可信度较高的指南的标准,并使用GRADE分级方法进行评估。该小组采用了息者个体化的观点。证据一项关于获益与风险的系统综述和网络meta分析(764项随机对照研究,包括421346例参与者)发现SGLT-2抑制剂和GLP-1受体激动剂可以降低总体死亡率、心肌梗死发生率、终末期肾病或肾衰竭的发生率(中等至高等质量的证据)。在不同的亚组中这些药物对卒中、因心力衰竭所致住院和其他主要不良事件有不同的影响。药物绝对获益的程度因患者个体风险的不同有很大的差异。(例如,对于接受了超过5年药物治疗的1000例患者,在最低风险人群中死亡人数减少了5人,在最高风险人群中死亡人数减少了48人)。一项关于预后的综述确认了14种风险预测模型,其中一种(RECODe)在证据总结中报告了大部分基线风险评估数据,小组利用该模型以支持风险分层的建议。考虑到患者的价值观及个体差异,指南推荐的支撑证据包括一项对已发表论文的系统综述、一项患者焦点小组研究、一项临床问题总结,以及一项指南调查。指南解读我们依据不同的CVD和CKD风险水平,综合考虑获益、风险和其他因素的平衡,以及每一个风险组别的实际问题,来对推荐意见进行分层。本指南强烈建议CVD和CKD患者使用SGLT-2抑制剂治疗,这说明专家组认为其具有显著的获益。而对于其他成人2型糖尿病患者,推荐等级较弱,这说明专家组想要在获益、风险及治疗花费上取得一个更好的平衡。临床医生通过该指南可以使用可靠的风险计算模型,如RECODe,来明确其患者的个体心血管和肾脏疾病风险。医患交互式总结临床证据和制订决策有助于患者知晓治疗选择,包括进行共同决策。2型糖尿病人群(全球患病率不断增长1-2)正面临着不断增加的心血管疾病、肾脏病和其他并发症的风险3。数十年来,2型糖尿病的管理始终以控制血糖及糖化血红蛋白(HbA1c)为治疗目标4-5,但是,最近的高质量随机对照研究已经对这种以血糖为中心的治疗模式发起了挑战。研究结果显示,强化血糖控制未必会降低大血管不良事件,它还可能带来不利影响监管机构现在要求新型糖尿病药物必须证明其具有心血管和肾脏获益才能获得批准。对两类新药--钠-葡萄糖共转运蛋白2(SGLT-2)抑制剂和胰高血糖素样肽1(GLP-1)受体激动剂(见框图1)的临床试验结果显示,在现有治疗方案(常规治疗)之上加用这些药物,对死亡、心肌梗死、卒中、心力衰竭和肾脏的结局(如进展为终末期肾病)都有获益8-12。 | Sheyu Li Per Olav Vandvik Lyubov Lytvyn Gordon H Guyatt Suetonia C Palmer Rene Rodriguez-Gutierrez Farid Foroutan Thomas Agoritsas Reed A C Siemieniuk Michael Walsh Lawrie Frere David J Tunnicliffe Evi V Nagler Veena Manja Bjφrn Olav Asvold Vivekanand Jha Mieke Vermandere Karim Gariani Qian Zhao Yan Ren Emma Jane Cartwright Patrick Gee Alan Wickes Linda Fems Robin Wright Ling Li Qiukui Hao Reem A Mustafa 无 郭鹤鸣(译) | 2021 | 英国医学杂志中文版2021，24，9： | 7 |
| 3 | Impact of air drought on photosynthesis efficiency of the Siberian crabapple(Malus baccata L. Borkh.) in the forest-steppe zone of Transbaikalia, Russia显示文摘The adaption of photosynthesis, being a key metabolic process, plays an important role in plant resistance to air drought. In this study, the Siberian crabapple(Malus baccata L. Borkh.) in the forest-steppe zone of Transbaikalia region, Russia, was subjected to air drought stress and its photosynthesis characteristics were analyzed. The results show that air drought and sufficient soil moisture supply lead to the decrease in the total chlorophyll(Chl) content, while the ratio of Chls to carotenoids is constant in the Siberian crabapple tree. The function of photosystem II(PS-II) in the crabapple trees is characterized by a decrease in the fraction of absorbed light energy spent on the photochemical work and an increase in the proportion of non-photosynthetic thermal quenching. These changes indicate the photosynthetic down-regulation that acts as a universal photoprotective mechanism. During the midday hours, the combination of high air temperature and low air humidity leads to the decrease in the maximum photochemical quantum yield of photosystem II(Fv/Fm) and the efficiency of photosynthesis(PABS). The parameters of leaf gas exchange show the significant differences in these values between the control and experimental variants. During the morning hours, the Siberian crabapple, growing in the Irkutsk City,assimilates carbon dioxide more intensively. Due to the higher air humidity, the stomata are kept open and the necessary amount of carbon dioxide entries the sites of carboxylation. The low air humidity combined with wind in the experimental variants leads to the unreasonably high water loss in the crabapple leaves by more than 27% as compared to the control variant(Irkutsk City). However, water use efficiency in the morning hours increases during plant photosynthetic processes, i.e., 42% higher than that of control. This,apparently, is a reflection of the adaptation processes of the Siberian crabapple to the air drought and parching wind. | Alexandr RUDIKOVSKII Elena RUDIKOVSKAYA Lyubov DUDAREVA | 2019 | Journal of Arid Land2019，11，2： | 2 |
| 4 | Endo-microscopy beyond the Abbe and Nyquist limits显示文摘For several centuries,far-field optical microscopy has remained a key instrument in many scientific disciplines,including physical,chemical,and biomedical research.Nonetheless,far-field imaging has many limitations:the spatial resolution is controlled by the diffraction of light,and the imaging speed follows the Nyquist–Shannon sampling theorem.The recent development of super-resolution techniques has pushed the limits of spatial resolution.However,these methods typically require complicated setups and long acquisition times and are still not applicable to deeptissue bioimaging.Here,we report imaging through an ultra-thin fibre probe with a spatial resolution beyond the Abbe limit and a temporal resolution beyond the Nyquist limit simultaneously in a simple and compact setup.We use the random nature of mode coupling in a multimode fibre,the sparsity constraint and compressive sensing reconstruction.The new approach of super-resolution endo-microscopy does not use any specific properties of the fluorescent label,such as depletion or stochastic activation of the molecular fluorescent state,and therefore can be used for label-free imaging.We demonstrate a spatial resolution more than 2 times better than the diffraction limit and an imaging speed 20 times faster than the Nyquist limit.The proposed approach can significantly expand the realm of the application of nanoscopy for bioimaging. | Lyubov V.Amitonova Johannes F.de Boer | 2020 | Light(Science & Applications)2020，9，1： | 2 |
| 5 | Effect of chronic alcohol consumption on the ethanol and acetaldehydemetabolizing systems in the rat gastrointestinal tract 显示文摘 | Pronko Pavel Bardina Lyubov Satanovskaya Valentina | 2002 | AlcoholAlcohol2002，37，3： | 1 |
| 6 | Ordered coalescence of nano-crystals in alkaline niobate ceramics with high remanent polarization显示文摘Lead-free alkali niobates Na_(0.5)K_(0.5)NbO_(3)(NKN)ceramics,with significantly enhanced ferroelectric remanent polarization(Pr),were prepared using Spark Plasma Sintering(SPS).Three types of boundaries were observed in the ceramics,being grain boundaries between faceted grains,domain boundaries that separate ferroelectric domains inside individual grains,and nanoscale sub-grain boundaries that reveal the nano-scale mosaicity of individual grains.Part of the sub-grain boundaries were from initial powder particles.The other sub-grain boundaries were built by ordered coalescence of nano-crystals during rapid SPS process.It was worthwhile to emphasize that the ordered coalescence of nano-crystals in bulk ceramics during sintering takes place and completes within minutes.These sub-grain features would disappear at higher temperature by long time sintering.Rapid Spark Plasma Sintering allowed us to capture this transient microstructure.The significantly enhanced ferroelectric Pr of NKN was attributed to nanoscale sub-boundaries,which stimulated the dynamics of ferroelectric domain formation and switching. | Zhijian Shen Daniel Gruner Mirva Eriksson Lyubov M.Belova Ce-Wen Nan Haixue Yan | 2017 | Journal of Materiomics2017，3，4： | 1 |
| 7 | Sixty years of environmental change in the world's largest freshwater lake:Lake Baikal, Siberia显示文摘 | HAMPTON S E IZMEST E LYUBOV R | 2008 | Global Change Biology2008，14，8： | 1 |
| 8 | On the nonlocal stabilization by starting control of the normal equation generated from the Helmholtz system显示文摘We consider the problem of stabilization near zero of semilinear normal parabolic equations connected with the 3D Helmholtz system with periodic boundary conditions and arbitrary initial datum.This problem was previously studied in Fursikov and Shatina(2018).As it was recently revealed,the control function suggested in that work contains a term impeding transferring the stabilization construction on the 3D Helmholtz system.The main concern of this paper is to prove that this term is not necessary for the stabilization result,and therefore the control function can be changed by a proper way. | ANDrey Fursikov Lyubov Osipova | 2018 | Science China Mathematics2018，61，11： | 1 |
| 9 | Protein Kinase C Inhibition Ameliorates Posttransplantation Preservation Injury in Rat Renal Transplants显示文摘 | Tom Florian Fuller Angelika Kusch Lyubov Chaykovska Rusan Catar Jennifer Pützer Martina Haller Jakob Troppmair Uwe Hoff Duska Dragun | 2012 | Transplantation Journal2012，，7： | 1 |
| 10 | Synthesis,characterization and hydrogen adsorp tion on metal-organic frameworks A1,Cr,Fe and Ga-BTB显示文摘 | Dipendu Saha Renju Zachafia Lyubov Lafi Daniel Cossement Richard Chahine | | 0，，： | 1 |
| 11 | Cytotoxicity of natural ginseng glycosides and semisynthetic analogus显示文摘 | Lyubov NA Galina VM Gcorgi BE | 1999 | Planta Medi1999，65，： | 1 |
| 12 | 血浆置换和糖皮质激素治疗抗中性粒细胞胞质抗体相关性血管炎:临床实践指南显示文摘对于抗中性粒细胞胞质抗体(antineutrophil cytoplasmic antibody,ANCA)相关性血管炎(ANCA-associated vasculitis,AAV)患者,血浆置换的作用是什么?接受治疗前6个月糖皮质激素的最佳剂量是多少?一项新发表的随机对照试验(randomised controlled trial,RCT)引起本次指南的制订。 | 曾力楠 Michael Walsh Gordon H Guyatt Reed A C Siemieniuk David Collister Michelle Booth Paul Brown Lesha Farrar Mark Farrar Tracy Firth Lynn A Fussner Karin Kilian Mark A Little Thomas A Mavrakanas Reem A Mustafa Maryam Piram Lisa K Stamp 肖瑛琪 Lyubov Lytyn Thomas Agoritsas Per O Vandvik Alfred Mahr 刘峥(译) 徐佩佩(译) 张伶俐(校) | 2022 | 英国医学杂志中文版2022，25，12： | 1 |
| 13 | Eukaryotic elongation 1A interacts with the upstream pseudoknot domain in the 3'-untranslated region of tobacco mosaic virus RNA显示文摘 | Vladimir V Zeenko Lyubov A | 2002 | Journal of Virology2002，76，11： | 1 |
| 14 | Nearshore benthic blooms of filamentous green algae in Lake Baikal 显示文摘 | Lyubov S Kravtsova Lyudmila Izhboldina L | 2014 | Journal of Great Lakes Research2014，40，2： | 1 |
| 15 | 联合阿司匹林及氯吡格雷双抗治疗急性高危短暂性脑缺血发作及轻度缺血性卒中:一份临床实践指南显示文摘双抗治疗对于高危的短暂性脑缺血发作及轻度卒中患者的治疗效果如何?更具体来说,24小时内给予联合阿司匹林及氯吡格雷的双抗治疗与单用阿司匹林相比,是否会降低高危短暂性脑缺血发作及轻度卒中患者的卒中再发生率及病死率?专家团队目前积极推荐发病后24小时内开启双抗治疗,并持续治疗10-21天。而目前的临床实践一般使用单抗。 | Kameshwar Prasad Reed Siemieniuk Qiukui Hao Gordon Guyatt Martin O Donnell Lyubov Lytvyn Anja Fog Heen Thomas Agoritsas Per Olav Vandvik Sankar Prasad Gorthi Loraine Fisch Mirza Jusufovic Jennifer Muller Brenda Booth Eleanor Horton Auxiliadora Fraiz Jillian Siemieniuk Awah Cletus Fobuzi Neelima Katragunta Bram Rochwerg 李洁(译) 毛晨晖(校) | 2019 | 英国医学杂志中文版2019，22，5： | 1 |
| 16 | BCD020 rituximab bioanalog compared to standard treatment in juvenile systemic lupus erythematosus: The data of 12 months casecontrol study显示文摘BACKGROUND Systemic lupus erythematosus(SLE)is the most frequent and serious systemic connective tissue disease.Nowadays there is no clear guidance on its treatment in childhood.There are a lot of negative effects of standard-of-care treatment(SOCT),including steroid toxicity.Rituximab(RTX)is the biological B-lymphocyte-depleting agent suggested as a basic therapy in pediatric SLE.AIM To compare the benefits of RTX above SOCT.METHODS The data from case histories of 79 children from the Saint-Petersburg State Pediatric Medical University from 2012 to 2022 years,were analyzed.The diagnosis of SLE was established with SLICC criteria.We compared the outcomes of treatment of SLE in children treated with and without RTX.Laboratory data,doses of glucocorticosteroids,disease activity measured with SELENA-SLEDAI,RESULTS Patients,treated with RTX initially had a higher degree of disease activity with prevalence of central nervous system and kidney involvement,compared to patients with SOCT.One year later the disease characteristics became similar between groups with a more marked reduction of disease activity(SELENA-SLEDAI activity index)in the children who received RTX[-19 points(17;23)since baseline]compared to children with SOCT[-10(5;15.5)points since baseline,P=0.001],the number of patients with active lupus nephritis,and daily proteinuria.During RTX therapy,infectious diseases had three patients;one patient developed a bi-cytopenia.CONCLUSION RTX can be considered as the option in the treatment of severe forms of SLE,due to its ability to arrest disease activity compared to SOCT. | Elvira Kalashnikova Eugenia Isupova Ekaterina Gaidar Lyubov Sorokina Maria Kaneva Vera Masalova Margarita Dubko Tatiana Kornishina Natalia Lubimova Ekaterina Kuchinskaya Irina Chikova Rinat Raupov Olga Kalashnikova Mikhail Kostik | 2024 | World Journal of Clinical Pediatrics2024，13，1： | 0 |
| 17 | On the Roof of the World显示文摘My dream to go to Tibet,where I could experience the local people and culture,came true when Kazakhstan’s We-Media delegates,including me,were invited by the Chinese embassy in Kazakhstan to visit China.We obtained firsthand knowledge that China is Kazakhstan’s friendly neighbor and a close strategic partner.At the same time,China’s development is impressive to us.-Lyuboy | Lyubov Dovrotar | 2016 | Voice of Friendship2016，，2： | 0 |
| 18 | Karyotypes and recombination patterns of the Common Swift(Apus apus Linnaeus,1758) and Eurasian Hobby(Falco subbuteo Linnaeus, 1758)显示文摘Background: Meiotic recombination is an important source of genetic variability.Studies on mammals demonstrate a substantial interspecies variation in overall recombination rate, which is dependent mainly on chromosome(2 n) and chromosome arm number(FN).Bird karyotypes are very conservative with 2 n being about 78–82 and FN being 80–90 in most species.However, some families such as Apodidae(swifts) and Falconidae(falcons) show a substantial karyotypic variation.In this study, we describe the somatic and pachytene karyotypes of the male Common Swift(Apus apus) and the pachytene karyotype of the male Eurasian Hobby(Falco subbuteo) and estimate the overall number and distribution of recombination events along the chromosomes of these species.Methods: The somatic karyotype was examined in bone marrow cells.Pachytene chromosome spreads were prepared from spermatocytes of adult males.Synaptonemal complexes and mature recombination nodules were visualized with antibodies to SYCP3 and MLH1 proteins correspondingly.Results: The karyotype of the Common Swift consists of three metacentric, three submetacentric and two telocentric macrochromosomes and 31 telocentric microchromosomes(2 n = 78; FN = 90).It differs from the karyotypes of related Apodidae species described previously.The karyotype of the Eurasian Hobby contains one metacentric and 13 telocentric macrochromosomes and one metacentric and ten telocentric microchromosomes(2 n = 50; FN = 54) and is similar to that described previously in 2 n, but differs for macrochromosome morphology.Despite an about 40% difference in 2 n and FN, these species have almost the same number of recombination nodules per genome: 51.4 ± 4.3 in the swift and 51.1 ± 6.7 in the hobby.The distribution of the recombination nodules along the macrochromosomes was extremely polarized in the Common Swift and was rather even in the Eurasian Hobby.Conclusions: This study adds two more species to the short list of birds in which the number and distribution of recombination nodules have been examined.Our data confirm that recombination rate in birds is substantially higher than that in mammals, but shows rather a low interspecies variability.Even a substantial reduction in chromosome number does not lead to any substantial decrease in recombination rate.More data from different taxa are required to draw statistically supported conclusions about the evolution of recombination in birds. | Lyubov Malinovskaya Elena Shnaider Pavel Borodin Anna Torgasheva | 2018 | Avian Research2018，9，1： | 0 |
| 19 | 对于有症状重度主动脉瓣狭窄且外科手术风险低至中危的患者,是选择经导管还是外科主动脉瓣置换:临床实践指南显示文摘对于有症状重度主动脉瓣狭窄且外科心脏手术风险相对较低的患者,微创操作同直视手术相比孰优孰劣?结合最近的一项临床试验结果,专家组根据3个相关综述文献提出了如下几条建议。 | Per O Vandvik Catherine M Otto Reed A Siemieniuk Rodrigo Bagur Gordon H Guyatt Lyubov Lytvyn Richard Whitlock Trond Vardal David Brieger Bert Aertgeerts Susanna Price Farid Foroutan Michael Shapiro Ray Mertz 郑骏楠 李伟栋 | 2018 | 英国医学杂志中文版2018，21，1： | 0 |
| 20 | A preliminary investigation of fossil wood from Lower Mekong Basin of Southeast Asia显示文摘Nine fossil wood samples from the Mesozoic bedrock and the Quaternary terrace deposits of the Lower Mekong Basin in Southeast Asia including Thailand,Laos and Cambodia were investigated in order to assist in developing a hypothesis about the Mekong River palaeocourses. Six of the samples were conifers assigned to Aga-thoxylon sp.,and three were dicots of cf. Pahudioxylon sp. and two unknown taxa( Dicotyloxylon sp.).The preservation of two dicotyledonous wood samples is insufficient for precise identification to family level,such that the samples are not suitable with respect to investigation of the river palaeocourse. However,these findings increase the systematic data of the fossil wood from the Mekong Basin. Further investigations of fossil wood from the Mekong Basin are in progress to gain a regional perspective on the plant communities and to form better reconstruction of the palaeoenvironment. | Nareerat Boonchai Marc Philippe Paul A. Carling Lyubov Meshkova | 2017 | Global Geology2017，20，3： | 0 |
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