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| 1 | Selective blockade of NF-kappa B by novel mutated I kappa B alpha suppresses CD3/CD28-induced activation of memory CD4(+) T cells in asthma显示文摘Background:Nuclear factor kappa B(NF-kappa B) overactivation plays a crucial role in T-helper 2 (Th2)-biased allergic airway inflammation by increased activation and decreased apoptosis of CD4(+) T cells. We have shown that targeted NF-kappa B suppression in dendritic cells by adenoviral gene transfer of a novel mutated inhibitor of NF-kappa B(I kappa B alpha) (AdI kappa B alpha M) contributes to T-cell tolerance, but the immunosuppressive action of AdI kappa B alpha M on memory(CD45RO(+)) CD4(+) T cells remains enigmatic. Methods:CD45RO(+) T cells from Dermatophagoides farinaei-sensitized asthmatic patients, untransfected or transfected with AdI kappa B alpha M or AdLacZ(beta-galactosidase) for 24 h, were stimulated with anti-CD3(1.0 mu g/ml) plus anti-CD28(0.5 mu g/ml) monoclonal antibody for an additional 24 h. I kappa B alpha M transgene expression and NF-kappa B activation were detected by polymerase chain reaction(PCR), reverse transcription-PCR(RT-PCR), Western blot analysis, and electrophoretic mobility shift assay. Phenotype and apoptosis were measured by flow cytometry, annexin V binding, and terminal deoxyribonucleotidyl transferase-mediated dUTP nick end labeling analyses. Cytokine production and cell proliferation were determined using enzyme-linked immunosorbent assay andH-3 thymidine incorporation. Results:A unique 801-bp I kappa B alpha M cDNA and a dose-dependent increase in I kappa B alpha M transgene expression were observed in AdI kappa B alpha M-transfected CD45RO(+) T cells. Significantly, AdI kappa B alpha M inhibited CD3/CD28-mediated NF-kappa B activation in CD45RO(+) T cells, leading to evident apoptosis, reduction of eotaxin, RANTES, Th1 interferon (IFN)-gamma and interleukin (IL)-2, and Th2 (IL-4, IL-5, and IL-13 despite a slight decrease in IL-10) cytokines and secondary proliferative response. AdI kappa B alpha M also upregulated cytotoxic T lymphocyte-associated antigen 4(CTLA-4) and downregulated CD69 besides no change in CD28. Conclusion:I kappa B alpha M might be beneficial to augment memory CD4(+) T-cell tolerance through modulating B7-CD28/CTLA-4 co-stimulatory pathways and NF-kappa B-dependent cytokine profiles in allergic inflammatory diseases including asthma. | Zhou,L. F. Zhang,M. S. Hu,A. H. Zhu Z. Yin,K. S. | 2008 | 南京医科大学学报(自然科学版)2008，28，6： | 40 |
| 2 | 青藏高原中东部古近纪盆地封闭的构造-沉积-岩浆活动和古气候响应显示文摘青藏高原中东部分布着一系列中小型古近纪盆地,详细的野外地质调查、盆地构造-沉积学和生物地层学、地球化学和岩浆岩的40Ar/39Ar年代学结果表明,盆内充填了紫红色的陆源碎屑岩夹火山碎屑岩、碳酸盐岩和石膏层,并被晚期岩浆岩所切割,盆缘地层发生大规模掀斜而形成高陡地层和挤压向斜,盆内地层发生褶皱变形。地层内部细碎屑岩孢粉和古植物、火山碎屑岩和侵入岩的40Ar/39Ar年代学揭示盆地充填沉积物形成于38~28Ma(晚始新世—早渐新世)。古近纪紫红色沉积物、碳酸盐岩和石膏层的出现代表干旱-炎热的古气候环境。印度-欧亚板块碰撞过程中因陆壳变形和高原早期构造隆升产生的走滑拉分和逆冲挤压是导致高原中东部古近纪盆地裂解和封闭的主要原因。 | 周江羽 王江海 B. K. HORTON An YIN M. S. SPURLIN | 2011 | 地质学报2011，85，2： | 12 |
| 3 | OsMADS16 Genetically Interacts with OsMADS3 and OsMADS58 in Specifying Floral Patterning ~in Rice显示文摘瑞斯(Oryza sativa ) 有贡献谷物产量的唯一的花的模式。然而,在米饭位于花的机关身份的说明下面的分子的机制,特别地在花的 homeotic 基因之中的相互作用,遗体糟糕理解。这里,我们证明花的 homeotic 基因 OsMADS16 (也叫的 SUPERWOMAN1, SPW1, B 班基因) 和在指定花的机关 patterning 的米饭 C 班基因 OsMADS3 和 OsMADS58 的行为。OsMADS16 和二 C 班基因在第三个锭盘创始人房间有一个重叠表示模式。与单个异种相比, spw1-1 osmads3-4 和 spw1-1 osmads58 加倍异种在花以内展出像颖的机关的另外的锭盘,特别地,六像颖的结构的额外的锭盘在野类型的雄蕊的位置形成了。这些宫外的像颖的结构被显示用标记基因通过细胞的观察并且在 situ 杂交分析有 palea 身份。我们的结果建议 B 班和 C 班基因在在花的分裂组织以内压制不确定的生长起一个关键作用,特别地 whorl-3 primordia。我们也假设那,与以前的假设相对照,在米饭的专业化小穗状花小穗机关, palea,在 eudicots 的萼片的对应物,和词根对苞相应。 | Dapeng Yun Wanqi Liang Ludovico Dreni Changsong Yin Zhigang Zhou Martin M. Kater Dabing Zhang | 2013 | Molecular Plant2013，6，3： | 11 |
| 4 | Geographical distribution of red and green Noctiluca scintillans显示文摘The dinoflagellate Noctiluca scintillans is one of the most important and abundant red tide organisms and it is distributed world-wide. It occurs in two forms. Red Noctiluca is heterotrophic and fills the role of one of the microzooplankton grazers in the foodweb. In contrast, green Noctiluca contains a photosynthetic symbiont Pedinomonas noctilucae (a prasinophyte), but it also feeds on other plankton when the food supply is abundant. In this review, we document the global distribution of these two forms and include the first maps of their global distribution. Red Noctiluca occurs widely in the temperate to sub-tropical coastal regions of the world. It occurs over a wide temperature range of about 10°C to 25°C and at higher salinities (generally not in estuaries). It is particularly abundant in high productivity areas such as upwelling or eutrophic areas where diatoms dominate since they are its preferred food source. Green Noctiluca is much more restricted to a temperature range of 25°C-30°C and mainly occurs in tropical waters of Southeast Asia, Bay of Bengal (east coast of India), in the eastern, western and northern Arabian Sea, the Red Sea, and recently it has become very abundant in the Gulf of Oman. Red and green Noctiluca do overlap in their distribution in the eastern, northern and western Arabian Sea with a seasonal shift from green Noctiluca in the cooler winter convective mixing, higher productivity season, to red Noctiluca in the more oligotrophic warmer summer season. | P. J. HARRISON K. FURUYA P. M. GLIBERT J. Xu H. B. LIU K. YIN J. H. W. LEE D. M. ANDERSON R. GOWEN A. R. AL-AZRI A. Y. T. HO | 2011 | Chinese Journal of Oceanology and Limnology2011，29，4： | 8 |
| 5 | Field trial of an HTS filter system on a CDMA base station显示文摘This paper presents the field trial results of a high temperature superconductor filter system (HTSFS) in a code division multiple access (CDMA) mobile communication base station (BTS) in Tangshan, China. The center frequency of the HTSFS is 830 MHz with 1.4% fractional bandwidth. The noise figure (NF) of the HTSFS, including connectors and cables, is 0.8 dB. The field trial results show that after the HTSFS was installed in the receiver front-end of a CDMA base station, the transmitting power of handset was decreased by 3.1 dB on average. Up to now, the HTSFS has been running steadily in the base station for more than 22 months, demonstrating the reliability and stability of the system. | YIN ZheSheng WEI Bin CAO BiSong WANG Xin GUO XuBo ZHANG XiaoPing GAO LongMa PIAO YunLong ZHU MaFeng LIANG Yong WANG Fan H. PIEL B. AMINOV F. AMINOVA M. GETTA S. KOLESOV A. KNACK N. PUPETER D. WEHLER | 2007 | Chinese Science Bulletin2007，52，2： | 7 |
| 6 | Acanthomorph Biostratigraphic Succession of the Ediacaran Doushantuo Formation in the East Yangtze Gorges,South China显示文摘大 acanthomorphic acritarchs 在华南在几个地区在 Ediacaran Doushantuo 形成的燧石被发现了,包括湖北省的东方 Yangtze 峡,贵州省的 Weng'an 区域,并且在其它地方。然而,他们为 biostratigraphic 分和 Ediacaran 继任的关联的潜力被外形控制, taphonomic 偏爱,和分类问题限制。在 Yangtze 峡, Doushantuo 形成通常被细分进四个 lithologic 成员。在 Weng'an 区域,然而, Doushantuo 形成包括就 mid-Doushantuo erosional 表面分开的更低、上面的部分。在在 Zhangcunping 节的 Yangtze 峡, Doushantuo 继任在 Weng'an 类似于那。到目前为止,在 Yangtze 之间的关联塞满并且 Weng'an 区域,并且在其它地方是争论的一个问题。解决争论,我们在 Yangtze 峡区域选择了八节并且全身地取样了 Doushantuo 形成的燧石小瘤,特别地集中于上面的 Doushantuo 形成。我们的数据证实在第二和第三个成员独立出现的二个不同集合,它被一次否定 13C 旅行(EN2 ) 分开。更低的集合被 Tianzhushania 和大 acanthomorphic acritarchs 的一间多样的套房描绘。上面的集合与更低的集合被区分开来,由(1 ) Tianzhushania 的缺席;(2 ) 出现丰富, 100150 m,光滑墙的球形的微化石;(3 ) 包括种类在这个成员从第二个成员和新形式延长的高度多样的 acanthomorphic acritarchs 的出现;(4 ) 原生生物的未命名的新形式的出现;并且(5 ) 管状的微化石 Sinocyclocylicus guizhouensis 的出现。因为统治 Tianzhushania 的集合不是在澳大利亚的现在,看起来仅仅上面的 acanthomorph 集合是在场的,因此,更低的 Doushantuo acanthomorph 集合在澳大利亚失踪。 | YIN Chongyu LIU Pengju Stanley M. AWRAMIK CHEN Shouming TANG Feng GAO Linzhi WANG Ziqiang Leigh A. RIEDMAN | 2011 | Acta Geologica Sinica(English Edition)2011，85，2： | 6 |
| 7 | Sedimentology and Chronology of Paleogene Coarse Clastic Rocks in East-Central Tibet and Their Relationship to Early Tectonic Uplift显示文摘系统的 sedimentological 和在东方中央的西藏的典型 Paleogenebasins 的按年代先后的学习建议 depositional 特征广泛地 床developedhuge ,在地区性的推进的一个构造背景形成的略呈紫色红的粗糙的碎屑岩并且滑倒罢工代表在泥石流和扇子表面在近似、快速积累的沉积身体形成的典型干燥、热的地面上的冲积扇环境编织的河。从盆地,硫充满序列的联合结果, seq 床widespreadmassive 的粗糙的碎屑岩,褶层在东方中央的西藏的早第三纪盆推进和走向滑倒,弄短的戳,和火的活动显示那早 diachronous 构造高举可能从对始新世的中间发生在西藏的高原渐新世,与印度、亚洲的盘子的碰撞的原始期有关。 | ZHOU Jiangyu WANG Jianghai K. H. BRIAN A. YIN M. S. MATTHEW | 2007 | Acta Geologica Sinica(English Edition)2007，81，3： | 6 |
| 8 | Elevated Expressions of 15-Lipoxygenase and Lipoxin A(4) in Children with Acute Poststreptococcal Glomerulonephritis显示文摘 | Wu, S.H. Liao, P. Y. Yin, P. L. Zhang, Y. M. Dong, L. | 2009 | 南京医科大学学报(自然科学版)2009，29，3： | 5 |
| 9 | EFFECTS OF DIFFERENT FUNCTIONAL GROUP-CONTAINING ORGANICS ON MORPHOLOGY-CONTROLLED SYNTHESIS OF SILVER NANOPARTICLES AT ROOM TEMPERATURE显示文摘Silver nanoparticles with average particles sizes ranging from 2 to 131nm were manipulatively synthesized starting from silver nitrate using different functional group-containing organic modifiers at room temperature. The effects of the organic modifiers on the morphology of the resulting silver nanoparticles were strongly dependent on the intrinsic properties of the functional groups and the reducibility of the reductant. Numerous ether bonds (-O-) present in polyethylene glycol and Tween-80 were beneficial to the formation of silver nanoparticles with particle sizes of several nanometers in a narrow size distribution in both weak and strong reducing environments. Cetyltrimethylammonium bromide induced the formation of nanosized silver triangle plates in a weak reducing environment. The crystal growth of the silver nanoparticles with particle sizes of more than 10nm was postulated through an adhesion process of small-sized particles followed by a subsequent coalescence process under the present reaction conditions. | A.L. Wang H.B. Yin M. Ren X.N. Cheng Q.F. Zhou X.F. Zhang | 2006 | Acta Metallurgica Sinica(English Letters)2006，19，5： | 5 |
| 10 | A sperm GPI-anchored protein elicits sperm-cumulus cross-talk leading to the acrosome reaction显示文摘 | Yin, L. Chung, C. M. Huo, R. Liu, H. Zhou, C. Xu, W. Zhu, H. Zhang, J. Shi, Q. Wong, H. Y.C. Chen, J. Lu, Y. Bi, Y. Zhao, C. Du, Y. Ma, M. Cai, Y. Chen, W. Y. Fok, K. L. Tsang, L. L. Li, K. Ni, Y. Chung, Y. W. Zhou, Z. Sha, J. Chan, H. C. | 2009 | 南京医科大学学报(自然科学版)2009，29，4： | 5 |
| 11 | Customer value, satisfaction, loyalty, and switching costs: An illustration from a business-to-business service context显示文摘 | Shun Yin Lam Venkatesh Shankar M. Krishna Erramilli Bvsan Murthy | 2004 | Journal of the Academy of Marketing Science2004，，3： | 4 |
| 12 | Propofol enhances the field excitatory postsynaptic potentials in CA1 hippocampal slices of young and aged mice显示文摘 | Yin Yiqing William J Middleton Carlos M. Florez Peter L. Carlen Hossam EI-Beheiry | 2014 | Chinese Medical Journal2014，，1： | 3 |
| 13 | The Cost Effectiveness of Radiofrequency Ablation for Barrett’s Esophagus显示文摘 | Chin Hur Sung Eun Choi Joel H. Rubenstein Chung Yin Kong Norman S. Nishioka Dawn T. Provenzale John M. Inadomi | 2012 | Gastroenterology2012，，3： | 2 |
| 14 | Inhaled nitric oxide versus aerosolized iloprost for the treatment of pulmonary hypertension with left heart disease显示文摘 | Ning Yin Stephanie Kaestle Jun Yin Thomas Hentschel Axel R. Pries Hermann Kuppe Wolfgang M. Kuebler | 2009 | Critical Care Medicine2009，，3： | 2 |
| 15 | Functions of autophagy in normal and diseased liver显示文摘 | Mark J. Czaja Wen-Xing Ding Terrence M. Donohue Scott L. Friedman Jae-Sung Kim Masaaki Komatsu John J. Lemasters Antoinette Lemoine Jiandie D. Lin Jing-hsiung James Ou David H. Perlmutter Glenn Randall Ratna B. Ray Allan Tsung Xiao-Ming Yin | 2013 | Autophagy2013，，8： | 2 |
| 16 | Key Points in Design of the Sheet Space Structure System显示文摘 | H. L. Zhao C. Q. Zhao Y. H. She X. M. Guo L. F. Yin | 2009 | International Journal of Space Structures2009，，3： | 1 |
| 17 | Measurement of permeability and ferrite/austenite phase fraction using a multi-frequency electromagnetic sensor显示文摘 | W. Yin X.J. Hao A.J. Peyton M. Strangwood C.L. Davis | 2008 | NDT and E International2008，，1： | 1 |
| 18 | Mechanical properties of the icosahedral phase reinforced duplex Mg–Li alloy both at room and elevated temperatures显示文摘 | D.K. Xu T.T. Zu M. Yin Y.B. Xu E.H. Han | 2014 | Journal of Alloys and Compounds2014，，： | 1 |
| 19 | MR Elastography in Renal Transplant Patients and Correlation with Renal Allograft Biopsy显示文摘 | Christine U. Lee James F. Glockner Kevin J. Glaser Meng Yin Jun Chen Akira Kawashima Bohyun Kim Walter K. Kremers Richard L. Ehman James M. Gloor | 2012 | Academic Radiology2012，，7： | 1 |
| 20 | Double knockout pigs deficient in N ‐glycolylneuraminic acid and G alactose α‐1,3‐ G alactose reduce the humoral barrier to xenotransplantation显示文摘 | Andrew J. Lutz Ping Li Jose L. Estrada Richard A. Sidner Ray K. Chihara Susan M. Downey Christopher Burlak Zheng‐Yu Wang Luz M. Reyes Bess Ivary Fuqin Yin Ross L. Blankenship Leela L. Paris A. Joseph Tector | 2013 | Xenotransplantation2013，，1： | 1 |
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