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| 1 | Effect of Yiqi Tongyang Decoction(益气通阳方) on Blood T Cell Subsets in Patients with Chronic Immune Thrombocytopenia显示文摘Objective: To measure the proportions of blood T cel subsets, Th1, Th2, Th17, Th22, and Treg cel s, and other parameters in patients with chronic immune thrombocytopenia(CITP) before and after treatment with Yiqi Tongyang Decoction(益气通阳方, YTD) to explore T cel status of patients with CITP, and to define the mechanism of action of YTD. Methods: The changes in peripheral blood T lymphocyte subsets, and those of Th1, Th2, Th17, Th22, and Treg cel s in 30 patients with CITP(22 females and 8 males) were analyzed using multiparametric flow cytometry before and after treatment with YTD for 6 months, and 26 healthy volunteers(14 males and 12 females) acted as a control. T-box expressed in T-cel s(T-bet) and GATA binding protein 3(GATA-3) m RNA levels in patients and controls were analyzed using real-time reverse transcription-polymerase chain reaction. Results: The proportions of Th1, Th17, Th22, Th1/Th2, and Th17/Treg cells increased in the peripheral blood of patients with CITP compared to those in controls before YTD therapy(P<0.05). Th1 cel numbers and the Th1/Th2 ratio fel in the treated patients with CITP to approximate the values of the control group(P>0.05). Th17 cel numbers and the Th17/Treg ratio also decreased in the treatment group(P<0.05), but not to the levels of the controls. The number of Treg cel s in the peripheral blood of patients with CITP before treatment was lower than that in the control group(P<0.05), but increased after YTD treatment(P<0.05), but not to the level of controls. T-bet and GATA-3 m RNA levels in peripheral blood were initially higher in patients before treatment than controls(P<0.05), but decreased after YTD therapy(P<0.05). Conclusions: Imbalances in T lymphocyte levels, particularly those of Th1/Th2 and Th17/Treg cel s, play important roles in the pathogenesis of CITP. YTD efficiently regulated the dynamics of Th1/Th2 and Th17/Treg equilibria. | YANG Xiu-peng MA Rou YANG Xiao-hong ZHU Hui-lan XU Yong-gang | 2017 | Chinese Journal of Integrative Medicine2017，23，9： | 8 |
| 2 | Effect of Qinghuang Powder(青黄散) Combined with Bupi Yishen Decoction(补脾益肾方) in Treating Patients with Refractory Cytopenia with Multilineage Dysplasia through Regulating DNA Methylation显示文摘Objective: To explore the effect of Qinghuang Powder(QHP, 青黄散) combined with Bupi Yishen Decoction(BPYS, 补脾益肾方)on myelodysplastic syndromes(MDS) patients with refractory cytopenia with multilineage dysplasia(RCMD) and determine the change of DNA methylation in MDS-RCMD patients after the treatment of Chinese medicine formula. Methods: All 308 MDS-RCMD patients were treated with QHP combined with BPYS for 2 months at least, absolute neutrophil count(ANC), hemoglobin(Hb), platelets(PLT), primitive bone marrow cells and chromosome karyotype were chosen as the main evaluation indexes to analyze the treatment effect according to criteria from the MDS International Working Group. Then 43 bone marrow samples from 15 MDS-RCMD patients and 28 healthy donors were obtained for the examination of DNA methylation.Gene Ontology(GO) and Pathway analysis were applied to analyze the methylation data. Results: The overall MDS response rate to QHP was 61.68%(190/360) including hematologic improvement-neutrophil(HI-N) or hematologic improvement-erythroid(HI-E) or hematologic improvement-platelet(HI-P). Patients with anemia had a better response rate than patients with neutropenia or thrombocypenia(55.88% vs 31.54% or 55.88%vs. 36.9%). The DNA methylation microarray analysis disclosed that 4,257 hypermethylated genes were demethylated upon the treatment with QHP and BPYS. GO analysis and Pathway analysis showed that these demethylated genes were involved in a lot of tumor-related pathways and functions. Conclusions: QHP combined with BPYS could effectively treat MDS-RCMD patients through hematologic improvement(HI-N, HI-P or HI-E)and PLT and RBC transfusion independence due to the demethylation, thereby providing another choice for the treatment of patients with MDS-RCMD. | ZHOU Qing-bing YANG Xiao-hong WANG Hong-zhi WANG De-xiu XU Yong-gang HU Xiao-mei XU Feng-qin MA Rou | 2019 | Chinese Journal of Integrative Medicine2019，0，5： | 7 |
| 3 | Relation of Blood Arsenic Concentration with Effect and Safety of Arsenic-Containing Qinghuang Powder (青黄散) in Patients with Myelodysplastic Syndrome显示文摘Objective: To investigate the relation of blood arsenic concentration (BAC) with clinical effect and safety of arsenic-containing Qinghuang Powder (青黄散,QHP) in patients with myelodysplastic syndrome (MDS). Methods: Totally 163 patients with MDS were orally treated with QHP for 2 courses of treatment, 3 months as 1 course. The BACs of patients were detected by atomic fluoresce nee spectrophotometry at 1, 3, and 6 months during the treatment, and the effective rate, hematological improvement and safety in patients after treatment with QHP were analyzed. Results: After 2 courses of treatment, the total effective rate was 89.6%(146/163), with 31.3%(51/163) of hematological improvement and 58.3%(95/163) of stable disease. The hemoglobin increased from 73.48 ± 19.30 g/L to 80.39 ± 26.56 g/L (P<0.05), the absolute neutrophil count increased from 0.81 ±0.48 × 10^9/L to 1.08 ±0.62 × 1O^9/L (P<0.05), and no significant changes were observed in platelet counts (P>0.05). Among 46 patients previously depended on blood transfusion, 28.3%(13/46) completely got rid of blood transfusion and 21.7%(10/46) reduced the volume of blood transfusion by more than 50% after treatment. The BACs were significantly increased in patients treated for 1 month with 32.17 ± 18.04 jig/L (P<0.05), 3 months with 33.56 ±15.28 μg/L (P<0.05), and 6 months with 36.78 ±11.92 μg/L (P<0.05), respectively, as compared with those before treatment (4.08 ±2.11 ag/L). There were no significant differences of BACs among the patients treated for 1, 3 and 6 months (P>0.05). The adverse reactions of digestive tract during the treatment were mild abdominal pain and diarrhea in 14 cases (8.6%), and no patients discontinued the treatment. The BACs of patients with gastrointestinal adverse reactions were significantly lower than those without gastrointestinal adverse reactions (22.39 ±10.38 vs. 37.89 ± 11.84,μg/L, P<0.05). The BACs of patients with clinical effect were significantly higher than those failed to treatment (40.41 ± 11.69 vs. 23.84 ± 12.03,μg/L, P<0.05). Conclusion: QHP was effective and safe in the treatment of patients with MDS and the effect was associated with BACs of patients. | DENG Zhong-yang ZHU Shi-rong WANG Ming-jing FANG Su ZHAO Pan ZHU Qian-zhe WANG Hong-zhi GUO Xiao-qing XU Yong-gang YI Bo-wen SHANG Xiao-hong MA Rou HU Xiao-mei | 2019 | Chinese Journal of Integrative Medicine2019，25，7： | 7 |
| 4 | Overview of bile acid signaling in the cardiovascular system显示文摘Bile acids(BAs)are classically known to play a vital role in the metabolism of lipids and in absorption.It is now well established that BAs act as signaling molecules,activating different receptors(such as farnesoid X receptor,vitamin D receptor,Takeda G-protein-coupled receptor 5,sphingosine-1-phosphate,muscarinic receptors,and big potassium channels)and participating in the regulation of energy homeostasis and lipid and glucose metabolism.In addition,increased BAs can impair cardiovascular function in liver cirrhosis.Approximately 50%of patients with cirrhosis develop cirrhotic cardiomyopathy.Exposure to high concentrations of hydrophobic BAs has been shown to be related to adverse effects with respect to vascular tension,endothelial function,arrhythmias,coronary atherosclerotic heart disease,and heart failure.The BAs in the serum BA pool have relevant through their hydrophobicity,and the lipophilic BAs are more harmful to the heart.Interestingly,ursodeoxycholic acid is a hydrophilic BA,and it is used as a therapeutic drug to reverse and protect the harmful cardiac effects caused by hydrophobic elevated BAs.In order to elucidate the mechanism of BAs and cardiovascular function,abundant experiments have been conducted in vitro and in vivo.The aim of this review was to explore the mechanism of BAs in the cardiovascular system. | Rou Zhang Wen-Qi Ma Meng-Jun Fu Juan Li Chun-Hua Hu Yi Chen Mi-Mi Zhou Zhi-Jie Gao Ying-Li He | 2021 | World Journal of Clinical Cases2021，9，2： | 4 |
| 5 | Arsenic concentration in peripheral blood is correlated with efficacy of a Traditional Chinese Medicine regimen containing realgar for the treatment of myelodysplastic syndromes显示文摘OBJECTIVE:To explore the relationship between the efficacy of realgar for the treatment of myelodysplastic syndromes with multilineage dysplasia(MDS-MLD)and arsenic concentration in the peripheral blood of patients.METHODS:In this prospective study,a total of 50 MDS-MLD patients were treated with traditional Chinese drugs containing realgar for 3 months in Xiyuan Hospital from March 2018 to January 2019.Routine blood examination as well as liver and kidney function were monitored before and after treatment.The concentration of arsenic in the peripheral blood was measured using an atomic fluorescence spectrometer after treatment.The correlation between clinical effect and arsenic concentration was analyzed by Spearman’s method.RESULTS:The treatment response rate was 54%.Two patients(4%)achieved complete remission,50%(25 of 50)showed hematologic improvement,and 23 patients had stable disease(23%).No disease progression was observed.Arsenic concentration in the peripheral blood ranged from 14.60 to 85.96μg/L.Clinical efficacy was positively correlated with arsenic concentration(P<0.05).The incidence of mild adverse reactions was 16%.CONCLUSION:A relatively high concentration of arsenic in the peripheral blood may improve the clinical efficacy of realgar in MDS-MLD patients. | WANG Dexiu XU Yonggang DU Yu WANG Hongzhi LI Liu HU Xiaomei YANG Xiupeng MA Rou ZHOU Qingbing | 2021 | Journal of Traditional Chinese Medicine2021，41，4： | 3 |
| 6 | Antithymocyte globulin/antilymphocyte globulin plus kidney-nourishing Chinese Medicinal:effect on severe aplastic anemia显示文摘OBJECTIVE:To explore the effect of antithymocyte globulin(ATG)/antilymphocyte globulin(ALG) plus kidney-nourishing Chinese medicinal(KNCM) on severe aplastic anemia(SAA).METHODS:Twenty-five subjects of severe aplastic anemia were treated with ATG/ALD plus KNCM between 1992 and 2009,and the clinical data before and after treatment were collected and analyzed.RESULTS:Of the 25 patients,9 were nearly cured,6 were improved,5 were in remission,and 5 failed.The overall effective rate was 80.0%.The 3-year,5-year,10-year,15-year survival rate were respectively 98.6%,97.3%,97.3%,67.5%,and median survival time was 180 months.Compared to the conditions before administering the medication of ATG/ALG plus KNCM,after 2 weeks,reticulocyte was first improved(P=0.001);one month later,followed by palette(P=0.037);two months later,by neutrophil cell in peripheral blood(P=0.001);three months later,then by the hemoglobin(P=0.012).By conducting 1-year follow-up,1 case of complication-paroxysmal nocturnal hemoglobinuria(PNH) was identified and the patient still alive today.CONCLUSION:ATG/ALG plus KNCM had better effect on SAA and could improve patients' survival rate. | Xudong Tang Feng Liu Liu Li Chi Liu Shanshan Zhang Haiyan Xiao Chunmei Zheng Shu Xu Rou Ma | 2012 | Journal of Traditional Chinese Medicine2012，32，4： | 3 |
| 7 | 2020 roadmap on two-dimensional materials for energy storage and conversion显示文摘Energy storage and conversion have attained significant intere st owing to its important applications that reduce CO2 emission through employing green energy.Some promising technologies are included metalair batteries,metal-sulfur batteries,metal-ion batteries,electrochemical capacitors,etc.Here,metal elements are involved with lithium,sodium,and magnesium.For these devices,electrode materials are of importance to obtain high performance.Two-dimensional(2 D) materials are a large kind of layered structured materials with promising future as energy storage materials,which include graphene,black phosporu s,MXenes,covalent organic frameworks(COFs),2 D oxides,2 D chalcogenides,and others.Great progress has been achieved to go ahead for 2 D materials in energy storage and conversion.More researchers will join in this research field.Under the background,it has motivated us to contribute with a roadmap on ’two-dimensional materials for energy storage and conversion. | Baolin Xu Shihan Qi Mengmeng Jin Xiaoyi Cai Linfei Lai Zhouting Sun Xiaogang Han Zifeng Lin Hui Shao Peng Peng Zhonghua Xiang Johan E.ten Elshof Rou Tan Chen Liu Zhaoxi Zhang Xiaochuan Duan Jianmin Ma | 2019 | Chinese Chemical Letters2019，30，12： | 2 |
| 8 | Adaptive finite element approximation for distributed elliptic optimal control problems显示文摘 | LI Rou LIU Wen-bin MA He-ping | 2003 | SIAM Journal of Control and Optimization2003，41，5： | 1 |
| 9 | Karyotype and DNA- methylation responses in myelodysplastic syndromes following treatment with traditional Chinese formula containing arsenic 显示文摘 | Sun Shuzhen Ma Rou Hu Xiaomei etal | 2012 | Evidence-Based Complementary and Alternative Medicine2012，，9： | 1 |
| 10 | Karyotype and DNA-Methylation Responses in Myelodysplastic Syndromes following Treatment with Traditional Chinese Formula Containing Arsenic显示文摘 | Sun Shuzhen Ma Rou Hu Xiaomei Yang Xiao-hong Xu Yong-gang Wang Hongzhi Yang Xiu-Peng Shao Li | 2012 | <journal-title>Evidence-Based Complementary and Alternative Medicine2012，，： | 1 |
| 11 | Controlling the morphology, size and phase of Nb_2O_5 crystals for high electrochemical performance显示文摘The morphology, size and phase of the material play a crucial role in its electrochemical performance.Herein, the nano-sized niobium pentoxide(Nb_2O_5) with different morphologies and phase structures are synthesized through a very simple thermal treatment method, including the pseudo hexagonal Nb_2O_5 nanosheets and pseudo hexagonal Nb_2O_5 nanoparticles, orthorhombic Nb_2O_5 nanoparticles. The synthesized pseudohexagonal Nb2O5 nanosheets and orthorhombic Nb_2O_5 nanoparticles exhibit better cycling and rate performance than the pseudohexagonal Nb2 O5 nanoparticles due to the different morphologies and phase structures. The T-Nb_2O_5-700 nanoparticles show the higher capacity(175 mAh/g) than that of TT-Nb_2O_5-500 nanosheets(127 mAh/g) and TT-Nb_2O_5-600 nanoparticles(39 mAh/g) at a current density of 50 mA/g and good rate performance with a capacity of 140 mAh/g at 1.0 A/g. The excellent rate capability and cycling stability of orthorhombic T-Nb_2O_5 may be ascribed to the dominant contribution of pseudocapacitive effect. This material has the great potential as a practical high-rate anode material for lithium-ion batteries. | Jiaqin Liao Rou Tan Zhixiang Kuang Chunyu Cui Zengxi Wei Xiaolan Deng Zhanheng Yan Yuezhan Feng Fang Li Caiyun Wang Jianmin Ma | 2018 | Chinese Chemical Letters2018，29，12： | 1 |
| 12 | MBD2 promotes Th2 differentiation in ovalbumin-induced CD4+T cells显示文摘Introduction:Allergen-specific CD4+T cells play a central role in autoimmune disorders,allergies and asthma,with Th2-type immunity being the typical functional response of CD4+T cells.This study aimed to investigate the role of MBD2 in regulating Th2 cell differentiation.Methods:Splenic mononuclear cells were extracted from C57BL/6 mice,and CD4+T cells were isolated using magnetic beads and confirmed through flow cytometry.Lentivirus was employed to construct MBD2-silenced CD4+T cells.In vitro experiments were performed to treat splenogenic mononuclear cells and CD4+T cells with Ovalbumin(OVA),and Th2 cell ratios and IL-4 levels were assessed using flow cytometry and ELISA.Results:The purity of the isolated CD4+T cells was 95.73%,confirming successful isolation of primary CD4+T cells.Compared to the control group,the Th2 cell ratio exhibited an increase in the Th2-induced group.Treatment with 5-Aza(concentrations,1-100μM)promoted Th2 cell differentiation and increased IL-4 levels.Notably,when combined with Th2 induction and 10μM 5-Aza treatment,silencing MBD2 further amplified Th2 cell ratios and elevated IL-4 levels in cell supernatants.Furthermore,OVA(concentration,200μg/mL)induced the differentiation of CD4+T cells into Th2 cells and increased IL-4 secretion.Interestingly,silencing MBD2 significantly increased the Th2 cell ratio and IL-4 levels in OVA-treated CD4+T cells.Conclusion:In summary,OVA promoted CD4+T cell differentiation into Th2 cells and enhanced IL-4 levels.MBD2 was identified as a mediator of Th2 cell differentiation in splenic-derived CD4+T cells,influenced by OVA or 5-Aza treatment. | QILU PAN YAN JIANG LINQIAO LI XIAOJING DU QIAN HAN FEIXIANG LING ROU LI SHUYUAN CHU LIN MAI JIANWEI HUANG LIBING MA | 2023 | BIOCELL2023，47，11： | 0 |
| 13 | How Do Herbal Medicines Tonify the Kidney and Ameliorate the Marrow Microenvironment Work on Hemopoiesis显示文摘HowDoHerbalMedicinesTonifytheKidneyandAmelioratetheMarrowMicroenvironmentWorkonHemopoiesisXieRen-fu(谢仁敷);LiaoJun-xian(廖军鲜)and... | Xie Ren-fu (谢仁敷) Liao Jun-xian(廖军鲜) and Ma Rou (麻柔) (China-Japan Friendship Hospital , Beijing) ( 100029) | 1995 | Chinese Journal of Integrative Medicine1995，1，2： | 0 |
| 14 | Oral Arsenic-Containing Qinghuang Powder:A Potential Drug for Myelodysplastic Syndromes显示文摘Qinghuang Powder(QHP),an oral arsenic,has become an effective drug in the treatment of myelodysplastic syndromes(MDS)in Xiyuan Hospital,China Academy of Chinese Medical Sciences for many years,and the action mechanism of the compound or active ingredient AsSof QHP has been elucidated.Considering the relatively safety,chemotherapy-free and convenient oral profile,QHP is widely used in the clinical treatment for MDS patients,especially for elderly patients.In this review,the authors document the efficacy and safety of oral arsenic-containing compound QHP in the treatment of MDS,with a special focus on the association of efficacy of QHP with the cytogenetics,prognostic risk,DNA methylation,gene mutation,blood arsenic concentration,mechanism of action of AsSand the countermeasures against adverse reactions of gastrointestinal tract. | MING Jing LIU Wei-yi XIAO Hai-yan XU Yong-gang MA Rou HU Xiao-mei | 2022 | Chinese Journal of Integrative Medicine2022，28，8： | 0 |
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