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| 1 | Proline with or without Hydroxyproline Influences Collagen Concentration and Regulates Prolyl 4-Hydroxylase α(I) Gene Expression in Juvenile Turbot(Scophthalmus maximus L.)显示文摘This study was conducted to investigate the effect of dietary proline(Pro), and Pro and hydroxyproline(Hyp) in combination on the growth performance, total Hyp and collagen concentrations of tissues, and prolyl 4-hydroxylase α(I)(P4H α(I)) gene expression in juvenile turbot feeding high plant protein diets. A diet containing 50% crude protein and 12% crude lipid was formulated as the basal and control, on which other two protein and lipid contents identical experimental diets were formulated by supplementing the basal with either 0.75% Pro(Pro-0.75) or 0.75% Pro and 0.75% Hyp(Pro+Hyp). Four groups of fish in indoor seawater recirculating systems, 35 individuals each, were fed twice a day to apparent satiation for 10 weeks. The results showed that dietary Pro and Hyp supplementation had no significant effect on growth performance and feed utilization of juvenile turbot(P > 0.05). Total Hyp and collagen concentrations in muscle were significantly increased when dietary Pro and Hyp increased(P < 0.05), and fish fed diet Pro+Hyp showed significantly higher free Hyp content in plasma than those fed other diets(P < 0.05). The expression of P4 H α(I) gene in liver and muscle was significantly up regulated in fish fed diet Pro-0.75 in comparison with control(P < 0.05); however the gene was significantly down regulated in fish fed diet Pro+Hyp in muscle in comparison with fish fed diet Pro-0.75(P < 0.05). It can be concluded that supplement of crystal L-Pro and L-Hyp to high plant protein diets did not show positive effects on growth performance of juvenile turbot, but enhanced total collagen concentrations in muscle. | ZHANG Kaikai MAI Kangsen XU Wei ZHOU Huihui LIUFU Zhiguo ZHANG Yanjiao PENG Mo AI Qinghui | 2015 | Journal of Ocean University of China2015，14，3： | 4 |
| 2 | Exploring the network structure and nodal centrality of China’s air transport network: A complex network approach显示文摘 | Jiaoe Wang Huihui Mo Fahui Wang Fengjun Jin | 2010 | Journal of Transport Geography2010，，4： | 3 |
| 3 | Spatiotemporal evolution of China’s railway network in the 20th century: An accessibility approach显示文摘 | Jiaoe Wang Fengjun Jin Huihui Mo Fahui Wang | 2009 | Transportation Research Part A2009，，8： | 1 |
| 4 | Spatiotemporal evolution of China’s railway network in the 20th century: An accessibility approach显示文摘 | Jiaoe Wang Fengjun Jin Huihui Mo Fahui Wang | 2009 | Transportation Research Part A2009，，8： | 1 |
| 5 | Exploring the network structureand nodal centrality of China ’ s air transport network ?? acomplex network approach 显示文摘 | Wang Jiaoe Mo Huihui | 2011 | Journal of Transport Geo-graphy2011，19，4： | 1 |
| 6 | E- volution of Air Transport Network of China 1930-- 2012显示文摘 | WANG JIAO'E MO HUIHUI WANG FAHUI | 2014 | Journal of Transport Geography2014，40，： | 1 |
| 7 | Spatiotemporal evolution of China' s railway network in the 20th century: an accessibility approach显示文摘 | Wang Jiaoe Jin Fengjun Mo Huihui | 2009 | Transportation Research Part A2009，43，： | 1 |
| 8 | Exploring the network structure and nodal centrality of China’s air transport network: A complex network approach显示文摘 | Jiaoe Wang Huihui Mo Fahui Wang Fengjun Jin | 2010 | Journal of Transport Geography2010，，4： | 1 |
| 9 | Exploring the network structure and nodal centrality of China's air transport network: A complex network approach显示文摘 | Wang Jiaoe Mo Huihui Jin Fengjun | 2011 | Journal of Transport Geogra- phy2011，19，4： | 1 |
| 10 | Methylation of PLK1 by SET7/9 ensures accurate kinetochore–microtubule dynamics显示文摘Faithful segregation of mitotic chromosomes requires bi-orientation of sister chromatids, which relies on the sensing of correct attachments between spindle microtubules and kinetochores. Although the mechanisms underlying PLK1 activation have been extensively studied, the regulatory mechanisms that couple PLK1 activity to accurate chromosome segregation are not well understood. In particular, PLK1 is implicated in stabilizing kinetochore–microtubule attachments, but how kinetochore PLK1 activity is regulated to avoid hyperstabilized kinetochore–microtubules in mitosis remains elusive. Here, we show that kinetochore PLK1 kinase activity is modulated by SET7/9 via lysine methylation during early mitosis. The SET7/9-elicited dimethylation occurs at the Lys191 of PLK1, which tunes down its activity by limiting ATP utilization. Overexpression of the non-methylatable PLK1 mutant or chemical inhibition of SET7/9 methyltransferase activity resulted in mitotic arrest due to destabilized kinetochore–microtubule attachments. These data suggest that kinetochore PLK1 is essential for stable kinetochore–microtubule attachments and methylation by SET7/9 promotes dynamic kinetochore–microtubule attachments for accurate error correction. Our findings define a novel homeostatic regulation at the kinetochore that integrates protein phosphorylation and methylation with accurate chromosome segregation for maintenance of genomic stability. | Ruoying Yu Huihui Wu Hazrat Ismail Shihao Du Jun Cao Jianyu Wang Tarsha Ward Fengrui Yang Ping Gui Mahboob Ali Lingluo Chu Fei Mo Qi Wang Youjun Chu Jianye Zang Yun Zhao Mingliang Ye Guowei Fang Peng RChen Zhen Dou Xinjiao Gao Wenwen Wang Xing Liu Xuebiao Yao | 2020 | Journal of Molecular Cell Biology2020，12，6： | 0 |
| 11 | The gut microbiome and microbial metabolites in acute myocardial infarction显示文摘Emerging evidence has highlighted the role of gut microbiome in human health.However,the integrative role of gut microbiome and microbial metabolites in acute myocardial infarction(AMI)remains unclear.The current study profiles the microbial community through 16S rRNA gene sequencing and shotgun metagenomic sequencing and measures fecal short-chain fatty acids and circulating choline pathway metabolites among 117 new-onset AMI cases and 78 controls.Significant microbial alternations are observed in AMI patients compared with controls(P=0.001).The abundances of nine species(e.g.,Streptococcus salivarius and Klebsiella pneumoniae)are positively associated,and one species(Roseburia hominis)is inversely associated with AMI status and severity.A gut microbial score at disease onset is associated with the risk of major adverse cardiovascular events in 3.2 years(hazard ratio[95%CI]:2.01[1.04-4.24])in AMI patients.The molar proportions of fecal acetate and butyrate are higher,and the circulating levels of choline and carnitine are lower in AMI patients than in controls.In addition,disease classifiers show that AMI cases and controls have a more distinct pattern in taxonomical composition than in pathways or metabolites.Our findings suggest that microbial composition and functional potentials are associated with AMI status and severity. | Chenglin Liu Zhonghan Sun Shalaimaiti Shali Zhendong Mei Shufu Chang Hanjun Mo Lili Xu Yanni Pu Huihui Guan Guo-Chong Chen Qibin Qi Zhexue Quan Ji Qi Kang Yao Yuxiang Dai Yan Zheng Junbo Ge | 2022 | Journal of Genetics and Genomics2022，49，6： | 0 |
| 12 | A Cluster of Rhabdomyolysis Syndrome Resulting from Carp Consumption in Gongcheng Yao Autonomous County,Guangxi,2016显示文摘What is already known about this topic?A common food that has been associated globally with rhabdomyolysis syndrome is freshwater fish including freshwater cod,barracuda,buffalo fish,and pomfret.However,cases caused by freshwater fish have been relatively rare in China.What is added by this report?In this investigation,a cluster of five cases of rhabdomyolysis syndrome were found that were linked to consumption of carp testes and eggs,one of the first carp-related rhabdomyolysis syndrome cases reported in China.What are the implications for public health practice?To avoid similar incidents,food safety education for local residents needs to be prioritized and implemented.In addition,case monitoring of rhabdomyolysis syndrome should be strengthened through more thorough collection of epidemiological data and monitoring of pathogenic foods. | Jinshui Zeng Yinpin Liu Huilai Ma Huihui Liu Yonghong Li Shunli Mo Yuqiao Qin Lijie Zhang | 2020 | China CDC weekly2020，2，2： | 0 |
| 13 | A synthetic light-inducible photorespiratory bypass enhances photosynthesis to improve rice growth and grain yield显示文摘Bioengineering of photorespiratory bypasses is an effective strategy for improving plant productivity by modulating photosynthesis.In previouswork,two photorespiratory bypasses,theGOC andGCGT bypasses,increased photosynthetic rates but decreased seed-setting rate in rice(Oryza sativa),probably owing to excess photosynthate accumulation in the stem.To solve this bottleneck,we successfully developed a newsynthetic photorespiratory bypass(called theGMAbypass)in rice chloroplasts by introducing Oryza sativa glycolate oxidase 1(OsGLO1),Cucurbita maxima malate synthase(CmMS),and Oryza sativa ascorbate peroxidase7(OsAPX7)into the rice genome using a high-efficiency transgene stacking system.Unlike the GOC and GCGT bypass genes driven by constitutive promoters,OsGLO1 in GMA plants was driven by a light-inducible Rubisco small subunit promoter(pRbcS);its expression dynamically changed in response to light,producing a more moderate increase in photosynthate.Photosynthetic rates were significantly increased inGMA plants,and grain yieldswere significantly improved under greenhouse and field conditions.Transgenic GMA rice showed no reduction in seed-setting rate under either test condition,unlike previous photorespiratory-bypass rice,probably reflecting proper modulation of the photorespiratory bypass.Together,these results imply that appropriate engineering of the GMA bypass can enhance rice growth and grain yield without affecting seed-setting rate. | Huawei Xu Huihui Wang Yanwen Zhang Xiaoyi Yang Shufang Lv Dianyun Hou Changru Mo Misganaw Wassie Bo Yu Tao Hu | 2023 | Plant Communications2023，4，6： | 0 |
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