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| 1 | 胆固醇酯转移蛋白基因的蛋白质截断型变异体与冠状动脉性心脏病风险的关系显示文摘随机对照试验结果表明,抑制胆固醇酯转运蛋白(cholesteryl ester transfer protein,CETP)的疗法并不能降低冠状动脉性心脏病(coronary heart disease,CHD)的发生风险。研究失败的可能原因包括靶目标无效、靶目标外小分子的不良反应和随机对照设计因素影响等。在编码药物靶点的基因中具有天然存在的遗传变异,以此为基础,人类研究可以深入了解针对基因产物的治疗的潜在功效和安全性。 | Nomura A Won HH Khera AV Takeuchi F Ito K McCarthy S Emdin CA Klarin D Natarajan P Zekavat SM Gupta N Peloso GM Borecki IB Teslovich TM Asselta R Duga S Merlini PA Correa A Kessler T Wilson JG Bown MJ Hall AS Braund PS Carey DJ Murray MF Kirchner HL Leader JB Lavage DR Manus JN Hartze DN Samani NJ Schunkert H Marrugat J Elosua R McPherson R Farrall M Watkins H Juang JJ Hsiung CA Lin SY Wang JS Tada H Kawashiri MA Inazu A Yamagishi M Katsuya T Nakashima E Nakatochi M Yamamoto K Yokota M Momozawa Y Rotter JI Lander ES Rader DJ Danesh J Ardissino D Gabriel S Willer CJ Abecasis GR Saleheen D Kubo M Kato N Ida Chen YD Dewey FE Kathiresan S 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，9： | 2 |
| 2 | In vivo pharmacody namic characterization of anidulafungin in a neutropenic murine Candidiasis model 显示文摘 | Andes D Diekema DJ Pfaller MA | 2008 | Antimicrob Agents Chemother2008，52，： | 1 |
| 3 | Interleukin-1 alpha as a potent inhibitor of gonadotropin action in porcine Leydig cells: sites of action显示文摘 | Mauduit C Chauvin MA Hartmann DJ | 1992 | Biol Reprod1992，46，51： | 1 |
| 4 | Osteonecrosis of the hip:management in the twenty-first century显示文摘 | Lieberman JR Berry DJ Mont MA | | 0，，01： | 1 |
| 5 | New anti-inflammatory therapies and targets for asthma and chronic obstructive pulmonary disease 显示文摘 | BELVISI MG HELE DJ BIRRELL MA | 2004 | Expert Opin Ther Targets2004，8，4： | 1 |
| 6 | Reduced basal ganglia volumes in Tourette's syndrome using three-dimensional reconstruction techniques from magnetic resonance images 显示文摘 | Peterson B Riddle MA Cohen DJ | 1993 | Neurology1993，43，5： | 1 |
| 7 | Survey of infections due to Staphylococcus species:frequency of occurrence and antimicrobial susceptibility of isolates collected in the United States,Canada,Latin America,Europe,and the Western Pacific Region for the SENTRY antimicrobial surveillance program,1997 -1999显示文摘 | Diekema DJ Pfaller MA Schmitz FJ | 2001 | Clin Infect Dis2001，，： | 1 |
| 8 | The incretin system: Glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4inhibitors in type 2 diabetes 显示文摘 | Drueker DJ Nauek MA | 2006 | Lancet2006，368，9548： | 1 |
| 9 | Phase II trial of ge- fitinib for recurrent or metastatic esophageal or gastroesophageal junction (GEJ) cancer 显示文摘 | Adelstein DJ Rybicki LA Carroll MA | 2005 | Proc Am SocClin 0ncol2005，23，16： | 1 |
| 10 | Overexpression of eukaryotic initiation factor 5A2 enhances cellmotility and promotes tu- mor metastasis in hepatocellular carcinoma显示文摘 | Tang DJ Dong SS Ma NF | 2010 | Hepatology2010，51，4： | 1 |
| 11 | The incretin system: gluca- gon-like peptide-1 receptor agonists and dipeptidyl peptidase-d inhibitors in type 2 diabetes 显示文摘 | Drucker DJ Nauck MA | 2006 | Lancet2006，368，9548： | 1 |
| 12 | Glutamate-based depression GBD显示文摘 | Mccarthy DJ Alexander R Smith MA | | Med Hypotheses0，78，5： | 1 |
| 13 | 显示文摘 | Peet DJ Turley SD Ma W | 1998 | Ce111998，93，： | 1 |
| 14 | Endothelial keratoplasty a simplified technique to minimize graft dislocation, iatrogenic graft failure, and pupillary block 显示文摘 | Terry MA Shamie N Chen ES Hoar KL Friend DJ | 2008 | Ophthalmology2008，115，7： | 1 |
| 15 | Plasma homocysteine concentrations in the acute and convalescent periodes of atherothrombotic stroke显示文摘 | Meiklejohn DJ Vickers MA Dijkhuisen R | 2001 | Stroke2001，32，： | 1 |
| 16 | Association of interleukin-6 and C- reactive protein with subclinical carotid atherosclerosis ( the rancho bcmardo study) 显示文摘 | Lee WY Allison MA Kim DJ | 2007 | Am J Cardiol2007，99，1： | 1 |
| 17 | H1N1 2009 influ-enza vims infection during pregnancy in the USA显示文摘 | Jamieson DJ Honein MA Rasmussen SA | 2009 | Lancet2009，374，： | 1 |
| 18 | Epidemiology of invasive candidiasis a persistent public health problem 显示文摘 | Pfaller MA Diekema DJ | 2007 | Clin Microbiol Rev2007，20，1： | 1 |
| 19 | In vitro activities of voriconazole,pasoconazole and four licensed systemic antifungal agents against candida species infrequently isolated form blood显示文摘 | Pfallerr MA Diekema DJ Masser SA | 2003 | J Clin Microb2003，41，： | 1 |
| 20 | The incretin system:glucagon-like peptide-1 receptor agonists and didpeptidyl peptidase4 inhibitors in type 2 diabetes 显示文摘 | Drucker DJ Nauck MA | 2006 | Lancet2006，368，9548： | 1 |
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