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| 1 | A unique sequence in the N-terminal regulatory region controls the nuclear localization of KLF8 by cooperating with the C-terminal zinc-fingers显示文摘Kr 眉 p 像像素的因素 8 (KLF8 ) 抄写因素在房间周期前进起一个关键作用, oncogenic 转变,对间充质的转变和侵略上皮。然而,它的原子本地化信号(NLS ) 没被识别。有另外的 KLF monopartite NLS (mNLS ) 和 C2H2 锌手指(ZF ) 的 KLF8 份额,哪个被显示了是为一些另外的 KLF 的 NLS。在这份报告,用指导 PCR 的 mutagenesis 和 immunofluorescent 显微镜学,我们显示出 mNLSs,任何单个 ZF 的删除,或变化的那混乱 Zn2+ 有约束力或联系 DNA 主题没影响 KLF8 的原子本地化。删除 > 然而,从 C 终点的 1.5 ZF 引起了 KLF8 的细胞质的累积。令人惊讶地,氨基酸(aa ) 的删除 151-200 区域几乎从原子核消除了 KLF8。有 PKC 禁止者的 S165A, K171E 或 K171R 变化,或处理导致了部分细胞质的累积。Co-immunoprecipitation 证明 KLF8 与 importin- 交往了,这个相互作用要求了 ZF 主题。aa 1-150 或 201-261 区域的删除独自没改变原子本地化。BrdU 加入和 cyclin D1 倡导者酶试金作为野类型的 KLF8 证明在原子本地化的 KLF8 异种有缺陷者不能支持 DNA 合成或 cyclin D1 倡导者激活。一起拿,这些结果建议 KLF8 有二 NLS,一包围 S165 和 K171 并且另外的是二双人脚踏车 ZF,它为 KLF8 原子本地化和它的细胞的功能的规定是批评的。 | Tina S Mehta Heng Lu Xianhui Wang Alison M Urvalek Kim-Hang H Nguyen Farah Monzur Jojo D Hammond Jameson Q Ma Jihe Zhao | 2009 | Cell Research2009，19，9： | 10 |
| 2 | 1型糖尿病患者的血糖控制,心脏自身免疫和心血管病的长期风险显示文摘血糖控制不佳与1型糖尿病(type 1diabetes mellitus,T1DM)患者的心血管病风险增加有关;然而,对T1DM的特异性机制知之甚少。在T1DM中,心肌损伤可诱发持续的心脏自身免疫。慢性高血糖症引起心肌损伤,高血糖诱导的心脏自身免疫可能导致长期心血管病并发症的可能性。 | Sousa GR Pober D Galderisi A Lv H Yu L Pereira AC Doria A Kosiborod M Lipes MA 刘莉 叶鹏 | 2019 | 中华高血压杂志2019，27，1： | 8 |
| 3 | HBV vaccine efficacy and detection and genotyping of vaccineé asymptomatic breakthrough HBV infection in Egypt显示文摘AIM:To evaluate the impact of mass vaccination against the hepatitis B virus (HBV) in Egypt,and to search for vaccinee asymptomatic breakthrough HBV infection and its genotype.METHODS:Seven hundred serum samples from vaccinated children and adults (aged 2-47 years) were used for quantitative and qualitative detection of HBsAb by ELISA.Three hundred and sixty serum samples representing undetectable or low or high HBsAb were screened for markers of active HBV infection (HBsAg,HBcAb (IgG) and HBeAb by ELISA,plus HBsAg by AxSYM) and HBV-DNA genotyping by nested multiplex PCR and by DNA sequencing.RESULTS:It was found that 65% of children aged 2-4 years,and 20.5% aged 4-13 years,as well as 45% adults were good responders to HBV vaccination mounting protective level HBsAb.Poor responders were 28%,59.5% and 34%,and non-responders were 7%,20% and 21% respectively,in the three studied groups.Markers of asymptomatic HBV infections were HBsAg detected by ELISA in 2.5% vs 11.39% by AxSYM.Other markers were HBcAb (IgG) in 1.38%,HBeAb in 0.83%,and HBV-DNA in 7.8%.All had HBV genotype E infection.CONCLUSION:It is concluded that HBV vaccine is efficient in controlling HBV infection among children and adults.The vaccine breakthrough infection was by HBV genotype E.A booster dose of vaccine is recommended,probably four years after initial vaccination. | Eman AE Abushady Magda MA Gameel John D Klena Salwa F Ahmed Kouka SE Abdel-wahab Sanya M Fahmy | 2011 | World Journal of Hepatology2011，3，6： | 5 |
| 4 | 急性儿茶酚胺暴露引起可逆的无心脏细胞再生的心肌细胞损伤显示文摘儿茶酚胺增加心脏收缩力,但暴露于高浓度儿茶酚胺或长时间暴露可引起心脏损伤。最近的一项研究表明,小鼠单次皮下注射异丙肾上腺素(isoproterenol,ISO;200 mg/kg)导致急性心肌细胞死亡(8%-10%),但在1个月之内心脏完整修复。心脏再生是通过内源性原癌基因蛋白质cKit+心脏干细胞介导新的心肌细胞形成。 | 刘莉 叶鹏 Wallner M Duran JM Mohsin S Troupes CD Vanhoutte D Borghetti G Vagnozzi RJ Gross P Yu D Trappanese DM Kubo H Toib A Sharp TE Harper SC Volkert MA Starosta T Feldsott EA Berretta RM Wang T Barbe MF Molkentin JD Houser SR | 2016 | 中华高血压杂志2016，24，8： | 4 |
| 5 | Diffusion- and perfusionweighted magnetic resonance imaging of focal cerebral ischemia and cortical spreading depression under conditions of mild hypothermia显示文摘 | Yenari MA Onley D Hedehus M | 2000 | Brain Res2000，885，2： | 3 |
| 6 | 地中海膳食干预研究中来自胆碱通路的血浆代谢物与心血管病风险的关系显示文摘血浆甜菜碱水平以及胆碱代谢水平与主要心血管病终点之间的联系仍不清楚。研究者评估了胆碱通路的代谢物与偶发心血管病风险以及地中海膳食干预的潜在调节效应之间的相关性。 | 黄洁 叶鹏 Guasch-Ferré M Hu FB Ruiz-Canela M Bulló M Toledo E Wang DD Corella D Gómez-Gracia E Fiol M Estruch R Lapetra J Fitó M Arós F Serra-Majem L Ros E Dennis C Liang L Clish CB Martínez-González MA Salas-Salvadó J | 2017 | 中华高血压杂志2017，25，12： | 2 |
| 7 | 胆固醇酯转移蛋白基因的蛋白质截断型变异体与冠状动脉性心脏病风险的关系显示文摘随机对照试验结果表明,抑制胆固醇酯转运蛋白(cholesteryl ester transfer protein,CETP)的疗法并不能降低冠状动脉性心脏病(coronary heart disease,CHD)的发生风险。研究失败的可能原因包括靶目标无效、靶目标外小分子的不良反应和随机对照设计因素影响等。在编码药物靶点的基因中具有天然存在的遗传变异,以此为基础,人类研究可以深入了解针对基因产物的治疗的潜在功效和安全性。 | Nomura A Won HH Khera AV Takeuchi F Ito K McCarthy S Emdin CA Klarin D Natarajan P Zekavat SM Gupta N Peloso GM Borecki IB Teslovich TM Asselta R Duga S Merlini PA Correa A Kessler T Wilson JG Bown MJ Hall AS Braund PS Carey DJ Murray MF Kirchner HL Leader JB Lavage DR Manus JN Hartze DN Samani NJ Schunkert H Marrugat J Elosua R McPherson R Farrall M Watkins H Juang JJ Hsiung CA Lin SY Wang JS Tada H Kawashiri MA Inazu A Yamagishi M Katsuya T Nakashima E Nakatochi M Yamamoto K Yokota M Momozawa Y Rotter JI Lander ES Rader DJ Danesh J Ardissino D Gabriel S Willer CJ Abecasis GR Saleheen D Kubo M Kato N Ida Chen YD Dewey FE Kathiresan S 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，9： | 2 |
| 8 | Chronic cold stress sensitizes brain noradrenergic reactivity and noradrenergic facilitation of the HPA stress response in Wistar Kyoto rats显示文摘 | Pardon M C Ma S Morilak D A | 2003 | Brain Res2003，971，1： | 2 |
| 9 | Effect of Annealing Atmosphere on Magnetism for Fe-doped BaTiO3 Ceramic显示文摘 | Lin F T Jiang D M Ma X M | 2008 | Physica B2008，403，： | 1 |
| 10 | Complete genomes of two clinical Staphylococcus aureus strains:evidence for the rapid evolution of virulence and drug resistance显示文摘 | Holden MT Feil EJ Lindsay JA Peacock SJ Day NP Enright MC Foster TJ Moore CE Hurst L Atkin R Barron A Bason N Bentley SD Chillingworth C Chillingworth T Churcher C Clark L Corton C Cronin A Doggett J Dowd L Feltwell T Hance Z Harris B Hauser H Holroyd S Jagels K James KD Lennard N Line A Mayes R Moule S Mungall K Ormond D Quail MA Rabbinowitsch E Rutherford K Sanders M Sharp S Simmonds M Stevens K Whitehead S Barrell BG Spratt BG Parkhill J | 2004 | Proc Natl Acad Sci USA2004，101，26： | 1 |
| 11 | Effect of CO2 Addition to Raw Milk on Proteolysis and Lipolysis at 4℃显示文摘 | MA Y BARBANO D M SANTOS M V | 2003 | J Dairy Sci2003，86，： | 1 |
| 12 | The effects of catalyst free fatty acids and water on transesterlfieation of beef tallow显示文摘 | MA F CLEMENTS I D HANNA M A | 1998 | Trans ASAE1998，41，： | 1 |
| 13 | HOPS: a novel cAMP - dependent shuttling protein involved in protein synthesis regulation显示文摘 | Della Fazia MA Castelli M Bartoli D | 2005 | J Cell Sci2005，118，14： | 1 |
| 14 | A distributed mechanical system simulation platform based on a 'gluing algorithm'显示文摘 | Wang J Z Ma Z D Hulbert G M | 2005 | Journal of Computing and Information Science in Engineering2005，5，： | 1 |
| 15 | Reduced plasma fibrinolytic potential in patients with recurrent implanta- tion failure after IVF and embryo transfer 显示文摘 | Mart nez-Zamora MA Creus M Tassies D | 2011 | Hum Reprod2011，26，3： | 1 |
| 16 | Dexmedetomidine produces its neuroprotective effect via the alpha 2A-adrenoceptor subtype显示文摘 | Ma D Hossain M Rajakumaraswamy N | 2004 | European journal of pharmacology2004，502，12： | 1 |
| 17 | A fem that hyperaccumulates arsenic显示文摘 | Ma L Q Komar K M Tu C Zhang W H Cai Y Kennelley E D | 2001 | Nature2001，409，： | 1 |
| 18 | Narrowband interference miti gatlon in DS-UWB systems显示文摘 | Wang C Ma M Ying R D | 2010 | IEEE Signal Processing Let- ters2010，17，5： | 1 |
| 19 | Application of the simulated annealing algorithm to the combinatorial optimization problem with permutation property:an investigation of generation mechanism显示文摘 | TIAN P MA J ZHANG D M | | 0，，01： | 1 |
| 20 | Reduced plasma fibrinolytic potential in patients with recurrent implantation failure after IVF and embryo transfer显示文摘 | Martínez-Zamora MA Creus M Tassies D | 2011 | Hum Reprod2011，26，： | 1 |
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