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| 1 | Cellular and molecular aspects of gastric cancer显示文摘胃的癌症与变的负担仍然是一个全球杀手从发展了到发展中的世界。癌症沿着被定义由的一个多级式的过程发展不同组织学并且 pathophysiological 阶段。几基因、渐成说的改变调停从一个的转变上演到另外一个,这些在 oncogenes 包括变化,瘤压制或基因和房间骑车并且错配修理基因。在对胃的癌症的战斗的最重要的进展为这癌症作为最重要的获得的病因论的代理人与 Helicobacter pylori (H pylori ) 的角色的识别来了。最近的工作在阐明上集中了位于肿瘤的过程下面的复杂 host/microbial 相互作用。现在进这癌症的致病和阻止并且根除的前景有可观的卓见疾病成为了现实。也许更重要地, H 导致 pylori 的胃的致癌作用的学习为理解更复杂的人的癌症提供一个范例。在这评论,我们检验位于 H 下面的分子、细胞的事件导致 pylori 的胃的癌症。 | Malcolm G Smith Georgina L Hold Eiichi Tahara Emad M El-Omar | 2006 | World Journal of Gastroenterology2006，12，19： | 29 |
| 2 | Utility of arthroscopic guided synovial biopsy in understanding synovial tissue pathology in health and disease states显示文摘The synovium is the soft tissue lining diarthrodial joints, tendon sheaths and bursae and is composed of intimal and subintimal layers. The intimal layer is composed of type A cells(macrophages) and type B cells(fibroblasts); in health, the subintima has few inflammatory cells. The synovium performs several homeostatic functions and is the primary target in several inflammatory arthritides. Inflammatory states are characterised by thickening of the synovial lining, macrophage recruitment and fibroblast proliferation, and an influx of inflammatory cells including lymphocytes, monocytes and plasma cells. Of the various methods employed to perform synovial biopsies arthroscopic techniques are considered the 'gold standard', and have an established safety record. Synovial biopsy has been of critical importance in understanding disease pathogenesis and has provided insight into mechanisms of action of targeted therapies by way of direct evidence about eventsin the synovial tissue in various arthritides. It has been very useful as a research tool for proof of concept studies to assess efficacy and mechanisms of new therapies, provide tissue for in vitro studies, proteomics and microarrays and allow evaluation for biomarkers that may help predict response to therapy and identify new targets for drug development. It also has diagnostic value in the evaluation of neoplastic or granulomatous disease or infection when synovial fluid analysis is noncontributory. | Mihir D Wechalekar Malcolm D Smith | 2014 | World Journal of Orthopedics2014，5，5： | 4 |
| 3 | A Functional Polymorphism of Toll-Like Receptor 4 Gene Increases Risk of Gastric Carcinoma and Its Precursors显示文摘 | Georgina L. Hold Charles S. Rabkin Wong–Ho Chow Malcolm G. Smith Marilie D. Gammon Harvey A. Risch Thomas L. Vaughan Kenneth E.L. McColl Jolanta Lissowska Witold Zatonski Janet B. Schoenberg William J. Blot N. Ashley G. Mowat Joseph F. Fraumeni Emad M. El | 2007 | Gastroenterology2007，，3： | 2 |
| 4 | Fracture pattern and fixation type related to loss of reduction in bicondylar tibial plateau fractures显示文摘 | Michael J. Weaver Mitchel B. Harris Adam C. Strom R. Malcolm Smith David Lhowe David Zurakowski Mark S. Vrahas | 2011 | Injury2011，，6： | 1 |
| 5 | Insect community composition and trophic guild structure in decaying logs from eastern Canadian pine-dominated forests 显示文摘 | Vanderwel M C Malcolm V J R Smith S M | 2006 | Forest Ecology and Management2006，225，13： | 1 |
| 6 | Ultrasound Guided Fascia Iliaca Block: A Comparison With the Loss of Resistance Technique显示文摘 | John Dolan Anne Williams Eileen Murney Malcolm Smith Gavin N.C. Kenny | 2008 | Regional Anesthesia and Pain Medicine2008，，6： | 1 |
| 7 | Transpyloric tube feeding in very low birthweight infants with suspected gastroeso-phageal reflux; impact on apnea and bradycardia显示文摘 | Malcolm WF Smith PB Means S | 2009 | J Perinatol2009，29，5： | 1 |
| 8 | The Posterior Shearing Tibial Plateau Fracture: Treatment and Results via a Posterior Approach显示文摘 | Timothy Bhattacharyya L Pearce McCarty Mitchell B Harris Suzanne M Morrison John J Wixted Mark S Vrahas R Malcolm Smith | 2005 | Journal of Orthopaedic Trauma2005，，： | 1 |
| 9 | Analytical solutions for optimal ride comfort and tyre grip for passive vehicle suspensions显示文摘 | Frank Scheibe Malcolm C. Smith | 2009 | Vehicle System Dynamics2009，，10： | 1 |
| 10 | Value-Relevance of Presenting Changesin Fair Value of Investment Propertiesin the Income Statement:Evidence from Hong Kong显示文摘 | Stella So Malcolm Smith | 2009 | Accounting and Business Research2009，39，2： | 1 |
| 11 | Placental mRNA in maternal plasma: prospects for fetal screening显示文摘 | MALCOLM A SMITH F | 2003 | Proc Natl Acad Sci2003，100，8： | 1 |
| 12 | Treatment of Complicated Henoch-Sch?nlein Purpura with Mycophenolate Mofetil: A Retrospective Case Series Report显示文摘 | A. A. Nikibakhsh H. Mahmoodzadeh M. Karamyyar S. Hejazi M. Noroozi A. A. Macooie A. Gholizadeh L. Gholizadeh Malcolm Smith | 2010 | International Journal of Rheumatology2010，，： | 1 |
| 13 | The Impact of Presentation Format and Individual Differences on The Communication of Information for Management Decision Making显示文摘 | Stella So Malcolm Smith | 2003 | Managerial Auditing Journal2003，，18： | 1 |
| 14 | Synthesis of Mechanical Networks: The Inerter显示文摘 | Malcolm C Smith | 2002 | IEEE Transaction on Automatic Control2002，47，10： | 1 |
| 15 | Synthesis of Mechanical Networks: The Inerter 显示文摘 | Malcolm C Smith | 2002 | IEEE Transaction on Automatic Control2002，47，10： | 1 |
| 16 | Does variable stand structure associated with multi-cohort forests support diversity of ground beetle (Coleoptera, Carabidae) communities in the central Nearctic boreal forest?显示文摘Multi-cohort management(MCM) that retains a range of stand structures(age and size class) has been proposed to emulate natural disturbance and improve management in the Nearctic boreal forest.Although MCM forests contain both single-and multi-aged stands of mixed tree sizes,little is known about how variable stand structure affects associated fauna and biodiversity.Here,we examine the relationship between ground beetle(Coleoptera,Carabidae) communities and stand characteristics across a range of forest structure(=cohort classes).Given that MCM classes are defined by the distribution of their tree–stem diameters,we ask whether parameters associated with these distributions(Weibull) could explain observed variation in carabid communities,and if so,how this compares to traditional habitat variables such as stand age,foliage complexity or volume of downed woody debris.We sampled carabids using weekly pitfall collections and compared these with structural habitat variables across a range of cohort classes(stand structure and age since disturbance) in 18 sites of upland mixed boreal forests from central Canada.Results showed that richness and diversity of carabid communities were similar among cohort classes.Weibull parameters from the diameter distribution of all stems were the strongest predictors of variation in carabid communities among sites,but vertical foliage complexity,understory thickness,and percentage of deciduous composition were also significant.The abundance of several carabid forest specialists was strongly correlated with tree canopy height,the presence of large trees,and high vertical foliage complexity.Our results demonstrate that variable forest structure,as expected under MCM,may be useful in retaining the natural range of ground beetle species across the central Nearctic boreal forest. | Erica P. Barkley Jay R. Malcolm Sandy M. Smith M. Isabel Bellocq | 2016 | Journal of Forestry Research2016，27，5： | 1 |
| 17 | Performance Benefits in Passive Vehicle Suspension Employing Inerters显示文摘 | Malcolm C Smith WANG Fucheng | 2004 | Vehicle System Dynamics2004，42，4： | 1 |
| 18 | Positive Real Synthesis Using Matrix Inequalities for Mechanical Networks: Application to Vehicle Suspension显示文摘 | Christakis Papageorgiou Malcolm C Smith | 2006 | IEEE Transaction on Control Systems Technology2006，14，3： | 1 |
| 19 | Germline mutations in the Von Hippel‐Lindau disease (VHL) gene in families from North America, Europe, and Japan显示文摘 | BertonZbar TakeshiKishida FanChen LauraSchmidt Eamonn R.Maher Frances M.Richards Paul A.Crossey Andrew R.Webster Nabeel A.Affara Malcolm A.Ferguson‐Smith HiltrudBrauch DamjanGlavac Hartmut P.H.Neumann SamTisherman John J.Mulvihill David J.Gross TaroShuin | 1999 | Hum Mutat1999，，4： | 1 |
| 20 | Retinoids in cancer therapy显示文摘 | Malcolm A Smith David R Parkinson Bruce D Cheson | 1992 | Journal of clinical oncology1992，10，5： | 1 |
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