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| 1 | Passively mode-locked Er-doped fiber laser based on SnS2 nanosheets as a saturable absorber显示文摘In this paper, tin disulfide(SnS_2), a two-dimensional(2D) n-type direct bandgap layered metal dichalcogenide with a gap value of 2.24 eV, was employed as a saturable absorber. Its appearance and nonlinear saturable absorption characteristics were also investigated experimentally. SnS_2-PVA(polyvinyl alcohol) film was successfully prepared and employed as a mode-locker for achieving a mode-locked Er-doped fiber laser with a pulse width of 623 fs at a pulse repetition rate of 29.33 MHz. The results prove that SnS_2 nanosheets will have wide potential ultrafast photonic applications due to their suitable bandgap value and excellent nonlinear saturable absorption characteristics. | KANGDI NIU RuYI SUN QINGYUN CHEN BAOYUAN MAN AND HUANIAN ZHANG | 2018 | Photonics Research2018，6，2： | 7 |
| 2 | Lack of association between apolipoprotein C3 gene polymorphisms and risk of nonalcoholic fatty liver disease in a Chinese Han population显示文摘AIM:To investigate the association between two polymorphisms of apolipoprotein C3(APOC3)and risk of nonalcoholic fatty liver disease(NAFLD)in a Chinese Han population.METHODS:Genotypes for rs2854116 and rs2854117in APOC3 and the known rs738409 in patatin-like phospholipase domain-containing protein 3(PNPLA3)in 390patients with NAFLD and 409 control subjects were determined by sequencing and polymerase chain reaction analysis.Serum lipid profiles were determined using biochemical methods,and an index of insulin resistance(IR,HOMA-IR),serum APOC3 concentrations and total antioxidant status(TAS)were also assessed.RESULTS:No significant differences in genotype and allele frequencies of rs2854116 and rs2854117 were found between the NAFLD population and the controls(P>0.05).The OR for the association between-455Cand-482T allele carriers and the risk of NAFLD were1.06(95%CI:0.72-1.57,P>0.05)and 1.00(95%CI:0.68-1.48,P>0.05),respectively.The variant carriers did not have a significantly increased risk of NAFLD or elevated clinical and biochemical parameters such as APOC3 concentrations,IR(1.42±0.43 vs 1.48±0.52,P>0.05),liver enzymes and TAS(13.94±2.01vs 14.38±1.92,P>0.05)compared with the controls.Moreover,the results were similar when testing was carried out independent of the genetic variation in PNPLA3.CONCLUSION:The two polymorphisms of the APOC3gene are not associated with a risk of NAFLD,or with lipid profiles,IR and oxidative stress in the Chinese Han population. | Tong-Hong Niu Man Jiang Yong-Ning Xin Xiang-Jun Jiang Zhong-Hua Lin Shi-Ying Xuan | 2014 | World Journal of Gastroenterology2014，20，13： | 7 |
| 3 | VOCs evaporative emissions from vehicles in China:Species characteristics of different emission processes显示文摘Vehicle evaporation is an essential source of VOCs in cities but is not well understood in China.Reported emission factors from previous studies are not enough for understanding the atmospheric chemical process of vehicular evaporative VOCs.In this work,a serious of detailed VOCs speciation profiles are developed based on test processes and emission processes.A mass balance method was used to divide different emission processes during diurnal tests.The results show that headspace vapor of gasoline cannot represent the real-world vehicle evaporation because of the significant differences in VOCs speciation profiles,especially for aromatics.To further distinguish emissions from evaporation and exhaust,only the ratios of MTBE/benzene and MTBE/toluene can serve as indicators when considering species from all evaporative processes.Besides,emissions from different sources change significantly with the seasons.To solve these problems,we developed a monthly comprehensive evaporation speciation profile.The individual profiles at the emission processes are weighted by the emission of the in-use vehicle fleet in Beijing to derive the comprehensive speciation profile of evaporative VOCs.Ozone formation potential(OFP)and secondary organic aerosol potential(SOAP)were used to evaluate the environmental impact.For SOAP,100 g evaporative emissions are equal to 6.05-12.71 g toluene in different months,much higher than that given using headspace vapors,especially in winter(7.2 times higher in December).These findings would improve our understanding of the evaporative VOCs emissions in China and their environmental impacts(e.g.,O3 and SOA formation). | Hanyang Man Huan Liu He Niu Kai Wang Fanyuan Deng Xiaotong Wang Qian Xiao Jiming Hao | 2020 | Environmental Science and Ecotechnology2020，，1： | 4 |
| 4 | 3D-printable supramolecular hydrogels with shear-thinning property: fabricating strength tunable bioink via dual crosslinking显示文摘3-dimensional(3D)bioprinting technology provides promising strategy in the fabrication of artificial tissues and organs.As the fundamental element in bioprinting process,preparation of bioink with ideal mechanical properties without sacrifice of biocompatibility is a great challenge.In this study,a supramolecular hydrogel-based bioink is prepared by polyethylene glycol(PEG)grafted chitosan,α-cyclodextrin(α-CD)and gelatin.It has a primary crosslinking structure through the aggregation of the pseudo-polyrotaxane-like side chains,which are formed from the host-guest interactions betweenα-CD and PEG side chain.Apparent viscosity measurement shows the shear-shinning property of this bioink,which might be due to the reversibility of the physical crosslinking.Moreover,withβ-glycerophosphate at different concentrations as the secondary crosslinking agent,the printed constructs demonstrate different Young's modulus(p<0.001).They could also maintain the Young's modulus in cell culture condition for at least 21 days(p<0.05).By co-culturing each component with fibroblasts,CCK-8 assay demonstrate cellular viability is higher than 80%.After bioprinting and culturing,immunofluorescence staining with quantification indicate the expression of Ki-67,Paxillin,and N-cadherin is higher in day 14 than those in day 3(p<0.05).Oil red O and Nissl body specific staining reflect strength tunable bioink may have impact on the cell fate of mesenchymal stem cells(p<0.05).This work might provide new idea for advanced bioink in the application of re-establishing complicated tissues and organs. | Tian Hu Xiaoliang Cui Meng Zhu Man Wu Ye Tian Bin Yao Wei Song Zhongwei Niu Sha Huang Xiaobing Fu | 2020 | Bioactive Materials2020，5，4： | 3 |
| 5 | Clinical characteristics of 96 patients with drug-induced acute liver failure:a comparison between Traditional Chinese and Western Medicine显示文摘OBJECTIVE: To compare the causes, clinical symptoms, laboratory test results, and prognosis in patients with acute liver failure(ALF) induced by traditional Chinese medicines(TCM) and by Western Medicines(WM).METHODS: The medical histories of patients who were diagnosed with drug-induced ALF(DALF)(n =96) after hospitalization in the 302 Military Hospital between January 2010 and December 2015 were retrospectively examined.RESULTS: Fifty-eight of the 96 DALF patients(60.4%) had a hepatocellular pattern of DALF, 16 patients(16.7%) had a cholestatic pattern, and 22 patients(22.9%) had a mixed pattern. DALF resolved in 24 patients(25.0%). Twenty-five patients(26.0%)developed chronic liver injury, 43 patients(44.8%)died, and 4 patients(4.2%) underwent liver transplantation. There were 42 ALF patients(43.8%) who received WM, and 32 ALF patients(33.3%) who received TCM. TCM-induced ALF patients had a higher average age [42.4 ± 18.4) vs(33.5 ± 17.9) years,P = 0.04] and higher creatinine and urine nitrogen levels [(155.2 ± 108.8) vs(97.5 ± 130.4) mmol/L, P =0.047;(9.1 ± 7.7) vs(4.3 ± 5.0) mmol/L, P = 0.002, respectively]. Patients with TCM-induced ALF exhibited an increased risk of renal injury [odds ratio(OR),3.75; 95% confidence interval(CI), 1.330-10.577].The 14 patients with TCM-induced ALF who died exhibited higher creatinine levels than the 18 patients with TCM-induced ALF patients who survived[(218.7 ± 111.6) vs(105.8 ± 78.4) mmol/L, P =0.002]. They were also more likely to exhibit ascites(85.7% vs 44.4%, P = 0.017) and hepatorenal syndrome(78.6% vs 22.2%, P = 0.002).CONCLUSION: TCM-induced ALF was more likely to be accompanied by renal injury than was WM-induced ALF, especially in TCM-induced ALF patients who died. | He Tingting Zhu Yun Wang Jiabo Gong Man Wang Ruilin Niu Ming Jing Jing Wang Lifu Wang Zhongxia Zhang Ning Bai Zhaofang Bai Yunfeng Li Yonggang Xiao Xiaohe | 2017 | Journal of Traditional Chinese Medicine2017，37，3： | 3 |
| 6 | Landing site topographic mapping and rover localization for Chang’e-4 mission显示文摘This paper presents the techniques and results of landing-site topographic mapping and rover localization using orbital,descent and rover images in the Chang’e-4 mission.High-resolution maps of the landing site are generated from orbital and descent images.Local digital elevation models and digital orthophoto maps with 0.02 m resolution are generated at each waypoint.The location of the lander is determined as(177.588?E,45.457?S)using festure-matching techniques.The cross-site visual localization method is routinely used to localize the rover at each waypoint to reduce error accumulation from wheel slippage and IMU drift in dead reckoning.After the first five lunar days,the rover travels 186.66 m from the lander,according to the cross-site visual localization.The developed methods and results have been directly utilized to support the mission’s operations.The maps and localization information are also valuable for supporting multiple scientific explorations of the landing site. | Zhaoqin LIU Kaichang DI Jian LI Jianfeng XIE Xiaofeng CUI Luhua XI Wenhui WAN Man PENG Bin LIU Yexin WANG Sheng GOU Zongyu YUE Tianyi YU Lichun LI Jia WANG Chuankai LIU Xin XIN Mengna JIA Zheng BO Jia LIU Runzhi WANG Shengli NIU Kuan ZHANG Yi YOU Bing LIU Jiangang LIU | 2020 | Science China(Information Sciences)2020，63，4： | 3 |
| 7 | miR-511 promotes the proliferation of human hepatoma cells by targeting the 3'UTR of B cell translocation gene 1 (BTG1) mRNA显示文摘miR-511 的异常表示涉及癌症的发展,但是在 hepatocellular 癌(HCC ) 的 miR-511 的角色不是记录的井。在这研究,我们在 hepatocarcinogenesis 探索了 miR-511 的分子的机制。我们生物信息学分析的结果建议了那 B 房间 translocation 基因 1 (BTG1 ) , anti-proliferative 基因家庭的一个成员,是 miR-511 的通常认为的目标之一。miR-511 的表示层次比在相应 peritumor 纸巾在 30 临床的 HCC 纸巾是显著地更高的,并且否定地在 HCC 纸巾 BTG1 与那些被相关(r=-0.6105, P < 0.01 ) 。在人的 hepatoma 房间线 HepG2 和 H7402, miR-511 的 overexpression dose-dependently 禁止了 BTG1 的表示,而 dose-dependently 增加的 miR-511 击倒 BTG1 的表示。酶记者基因试金证实 miR-511 指向了 BTG1 mRNA 的 3UTR。在 hepatoma 房间, miR-511 的 overexpression 显著地减少了导致 BTG1 的 G 1 阶段逮捕,它被 BTG1 的 overexpression 救。而且, miR-511 的 overexpression 支持了 hepatoma 房间的增长,它被 BTG1 的 overexpression 救。相反地, miR-511 击倒禁止的房间增长,它被颠倒由 BTG1 击倒。在结论, miR-511 由指向 BTG1 mRNA 的 3UTR 在 vitro 支持人的 hepatoma 房间的增长。 | Shu-qin ZHANG Zhe YANG Xiao-li CAI Man ZHAO Ming-ming SUN Jiong LI Guo-xing FENG Jin-yan FENG Li-hong YE Jun-qi NIU Xiao-dong ZHANG | 2017 | Acta Pharmacologica Sinica2017，38，8： | 2 |
| 8 | Auto-ignition route to thermoelectric oxide NaxCo2O4 powder with high eompactibility显示文摘 | Weihua Wang Yang Jiang Man Niu | 2008 | Powder Technology2008，184，1： | 1 |
| 9 | Auto-ignition route to thermoelectric oxide NaxCo2O4 powder with high compactibility显示文摘 | Wang Weihua Jiang Yang Niu Man | | 0，，01： | 1 |
| 10 | IntCall 3 and Marine 13 Radicarxm Age Calibration Curves 0-50,000 Years cal BP显示文摘 | REIMER P J BARD E BAYLISS A BECK J W BLACKWELL P G RAMSEY C B BUCK C E CHENG H EDWARDS R L FRIEDRICH M GROOTES P M GUILDERSON T P HAFLIDASON H HAJDAS 1 HATTt C HEATON T J HOFFMANN 1) L HOGG A G HUGHEN K A KAISER K F KROMER B MANNING S M NIU M REIMER R W RICHARDS D A SCOTF EM SOUTHON J R STAFF R A TURN EY CSM VAN I)ER Plicht | 2013 | Radiocarbon2013，55，： | 1 |
| 11 | PRMT5 confers lipid metabolism reprogramming,tumour growth and metastasis depending on the SIRT7-mediated desuccinylation of PRMT5 K387 in tumours显示文摘The protein arginine methyltransferase 5(PRMT5),which is highly expressed in tumour tissues,plays a crucial role in cancer development.However,the mechanism by which PRMT5 promotes cancer growth is poorly understood.Here,we report that PRMT5 contributes to lipid metabolism reprogramming,tumour growth and metastasis depending on the SIRT7-mediated desuccinylation of PRMT5 K387 in tumours.Mass spectrometric analysis identified PRMT5 lysine 387 as its succinylation site.Moreover,the desuccinylation of PRMT5 K387 enhances the methyltransferase activity of PRMT5.SIRT7 catalyses the desuccinylation of PRMT5 in cells.The SIRT7-mediated dessuccinylation of PRMT5 lysine 387 fails to bind to STUB1,decreasing PRMT5 ubiquitination and increasing the interaction between PRMT5 and Mep50,which promotes the formation of the PRMT5-Mep50 octamer.The PRMT5-Mep50 octamer increases PRMT5 methyltransferase activity,leading to arginine methylation of SREBP1a.The symmetric dimethylation of SREBP1a increases the levels of cholesterol,fatty acid,and triglyceride biogenesis in the cells,escaping degradation through the ubiquitin-proteasome pathway.Functionally,the desuccinylation of PRMT5 K387 promotes lipid metabolism reprogramming,tumour growth and metastasis in vitro and in vivo in tumours. | Hong-feng Yuan Man Zhao Li-na Zhao Hao-lin Yun Guang Yang Yu Geng Yu-fei Wang Wei Zheng Ying Yuan Tian-qiang Song Jun-qi Niu Xiao-dong Zhang | 2022 | Acta Pharmacologica Sinica2022，43，9： | 1 |
| 12 | P-glycoprotein associates with Anxa2 and promotes invasion in multidrug resistant breast cancer cells显示文摘 | Fei Zhang Haichang Zhang Zhiyong Wang Man Yu Ran Tian Wei Ji Yi Yang Ruifang Niu | 2013 | Biochemical Pharmacology2013，，： | 1 |
| 13 | Differential transcriptomic landscapes of multiple organs from SARS-CoV-2 early infected rhesus macaques显示文摘SARS-CoV-2 infection causes complicated clinical manifestations with variable multi-organ injuries,how-ever,the underlying mechanism,in particular immune responses in different organs,remains elusive.In this study,comprehensive transcriptomic alterations of 14 tissues from rhesus macaque infected with SARS-CoV-2 were analyzed.Compared to normal controls,SARS-CoV-2 infection resulted in dysregulation of genes involving diverse functions in various examined tissues/organs,with drastic transcriptomic changes in cerebral cortex and right ventricle.Intriguingly,cerebral cortex exhibited a hyperinflammatory state evidenced by sig-nificant upregulation of inflammation response-related genes.Meanwhile,expressions of coagulation,angio-genesis and fibrosis factors were also up-regulated in cerebral cortex.Based on our findings,neuropilin 1(NRP1),a receptor of SARS-CoV-2,was significantly elevated in cerebral cortex post infection,accompanied by active immune response releasing inflammatory factors and signal transmission among tissues,which enhanced infection of the central nervous system(CNS)in a positive feedback way,leading to viral encephalitis.Overall,our study depicts a multi-tissue/organ tran-scriptomic landscapes of rhesus macaque with early infection of SARS-CoV-2,and provides important insights into the mechanistic basis for COVID-19-asso-ciated clinical complications. | Chun-Chun Gao Man Li Wei Deng Chun-Hui Ma Yu-Sheng Chen Yong-Qiao Sun Tingfu Du Qian-Lan Liu Wen-Jie Li Bing Zhang Lihong Sun Si-Meng Liu Fengli Li Feifei Qi Yajin Qu Xinyang Ge Jiangning Liu Peng Wang Yamei Niu Zhiyong Liang Yong-Liang Zhao Bo Huang Xiao-Zhong Peng Ying Yang Chuan Qin Wei-Min Tong Yun-Gui Yang | 2022 | Protein & Cell2022，13，12： | 1 |
| 14 | Association between circulating specific leukocyte types and blood pressure: the Atherosclerosis Risk in Communities (ARIC) study显示文摘 | Niu Tian Alan D. Penman Anthony R. Mawson R. Davis Manning Michael F. Flessner | 2010 | Journal of the American Society of Hypertension2010，，6： | 1 |
| 15 | New modulator for the optical signal in a fiber显示文摘A new modulator for the optical signal in a fiber based on multi-beam interference is designed.In the experiment,the distance of a couple of abutted fibers was modulated through a piezoelectric ceramic pipe driven by 50 Hz AC voltage,so that the amplitude of the transmitted optical signal was modulated.The modulation ratio is about 10%,S/N ratio is about 60 dB and the bandwidth is about 200 KHz. | ZHANG Tian-hao JIA Feng WANG Shun-li MAN Jiang-wei NIU Kai WANG Xu-cheng YANG Jia | 2006 | Optoelectronics Letters2006，2，6： | 0 |
| 16 | Research on Driver Monitoring Systems Based on Vital Signs and Behavior Detection显示文摘Aiming at drivers’dangerous driving behavior monitoring and health monitoring,this paper designs an intelligent steering wheel that can monitor dan-gerous driving behavior and a steering wheel sleeve that can monitor physical health.The MTCNN model is primarily used to obtain a driver’s face image in real time.The PFLD algorithm was used to obtain the facial model positioning feature points,and the degree of driver fatigue was determined by combining the relevant parameters.The fatigue algorithm proposed in this paper can improve the effectiveness and accuracy of monitoring.Then,according to the LSTM network model,11 groups of key point information of the human body are obtained,and the human motion track is identified and then combined with the facial information to complete the judgment of driving behavior such as drinking water,smoking and walking.Through the PPG and ECG fusion algorithm based on LSTM,the reliability of the system to collect vital signs such as body temperature,blood pressure,heart rate and blood oxygen of the driver is improved.It was determined that the system could monitor a driver’s driving behavior in real time and consider its health management. | Man Niu Yanqing Wang Xinya Shu Xiaofeng Gao | 2023 | 国际计算机前沿大会会议论文集2023，，2： | 0 |
| 17 | Tubulin inhibitors: pharmacophore modeling, virtua screening and molecular docking显示文摘 | Miao-miao NIU Jing-yi QIN Cai-ping TIAN Xia-fei YAN Feng-gong DONG Zheng-qi CHENG Guissi FIDA Man YANG Hai-yan CHEN Yue-qing GU | 2014 | Acta Pharmacologica Sinica2014，35，7： | 0 |
| 18 | N-n-Butyl haloperidol iodide ameliorates liver fibrosis and hepatic stellate cell activation in mice显示文摘N-n-Butyl haloperidol iodide(F_(2))is a novel compound that has antiproliferative and antifibrogenic activities.In this study we investigated the therapeutic potential of F_(2) against liver fibrosis in mice and the underlying mechanisms.Two widely used mouse models of fibrosis was established in mice by injection of either carbon tetrachloride(CCl4)or thioacetamide(TAA).The mice received F_(2)(0.75,1.5 or 3 mg·kg^(−1)·d^(−1),ip)for 4 weeks of fibrosis induction.We showed that F_(2) administration dose-dependently ameliorated CCl4-or TAA-induced liver fibrosis,evidenced by significant decreases in collagen deposition and c-Jun,TGF-βreceptor II(TGFBR2),α-smooth muscle actin(α-SMA),and collagen I expression in the liver.In transforming growth factor beta 1(TGF-β1)-stimulated LX-2 cells(a human hepatic stellate cell line)and primary mouse hepatic stellate cells,treatment with F_(2)(0.1,1,10μM)concentration-dependently inhibited the expression ofα-SMA,and collagen I.In LX-2 cells,F_(2) inhibited TGF-β/Smad signaling through reducing the levels of TGFBR2;pretreatment with LY2109761(TGF-βsignaling inhibitor)or SP600125(c-Jun signaling inhibitor)markedly inhibited TGF-β1-induced induction ofα-SMA and collagen I.Knockdown of c-Jun decreased TGF-βsignaling genes,including TGFBR2 levels.We revealed that c-Jun was bound to the TGFBR2 promoter,whereas F_(2) suppressed the binding of c-Jun to the TGFBR2 promoter to restrain TGF-βsignaling and inhibitα-SMA and collagen I upregulation.In conclusion,the therapeutic benefit of F_(2) against liver fibrosis results from inhibition of c-Jun expression to reduce TGFBR2 and concomitant reduction of the responsiveness of hepatic stellate cells to TGF-β1.F_(2) may thus be a potentially new effective pharmacotherapy for human liver fibrosis. | Dai-fei Shen He Cheng Bo-zhi Cai Wen-feng Cai Bin Wang Qing Zhu Yue-bin Wu Man Liu Run-ji Chen Fen-fei Gao Yan-mei Zhang Yong-dong Niu Gang-gang Shi | 2022 | Acta Pharmacologica Sinica2022，43，1： | 0 |
| 19 | INFLUENCE OF SILVER-DOPING ON THE SUPERCONDUCTIVITY FOR YBa_2Cu_30_(7-y)显示文摘The effect of substituting silver for barium on the structure and superconducting properties of YBa2Cu3O7-y has been studied. The structure of the silver-doping system (YBa2-xAgxCu3O7-y) with x<0.3 is orthorhombic. For x>0.3, YBCO, Y2BaCuO5 phase and metallic silver ro-exist in the system. The superconducting transition temperature T (R=0) decrease with increasing silver content. However, the critic current density Jc is found to be enhanced from 56.6 A/cm2 to 195 A/cm2 | Jian MENG, Yu Fang REN and Man Zhi NIU Changchun Institute of Applied Chemistry, Academia Sinica, 130022 | 1991 | Chinese Chemical Letters1991，2，5： | 0 |
| 20 | HIV encephalopathy is contributed by macrophages and microglia显示文摘Dear Editor,Acquired immunodeficiency syndrome(AIDS),characterized by a significant decrease in the number of CD4^(+)T cells,causes a defective T cell immune response,which subsequently leads to various conditional pathogenic infections and tumors(Calmy et al.,2018;Seligmann et al.,1987).Neurological disorders have been reported in 70%–80%of patients with AIDS(Saylor et al.,2016)。 | Si-Meng Liu Man Li Chunhui Ma Chunying Liu An Lv Qing Li Yamei Niu Peng Wang Bo Huang Wei-Min Tong | 2024 | Science China(Life Sciences)2024，67，4： | 0 |
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