|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Role of(~(18)F)2-fluoro-2-deoxyglucose positron emission tomography in upper gastrointestinal malignancies显示文摘The role of whole-body FDG [(~(18)F)2-fluoro-2-deoxy-glucose] positron emission tomography(PET)scan-ning as an imaging modality in the management of patients with malignancy has evolved enormously over the past two decades.FDG-PET has demonstrated signifi cant effi cacy in the staging,prognostication and detection of occult metastatic disease in malignancies of the gastrointestinal tract,in addition to assessment of the response to cytotoxic chemotherapy in a more timely manner than has traditionally been possible by more conventional imaging tools.The sensitivity and specif icity of FDG-PET for the detection and staging of malignancy depend not only on the site and size of the primary tumor and metastases,but also on histologi-cal cell type,reflecting underlying disparities in glucose metabolism.The metabolic response to neo-adjuvant chemotherapy or to chemo-radiotherapy in cancers of the gastro-esophageal junction or stomach has been demonstrated in several prospective studies to correlate signifi cantly with both the histological tumor response to treatment and with consequent improvements in overall survival.This may offer a future paradigm ofpersonalized treatment based on the PET response to chemotherapy.FDG-PET has been less successful in efforts to screen for and detect recurrent upper gastro-intestinal malignancies,and in the detection of low vol-ume metastatic peritoneal disease.Efforts to improve the accuracy of PET include the use of novel radiotrac-ers such as(~(18)F)FLT(3-deoxy-3-fluorothymidine)or 11C-choline,or fusion PET-CT with concurrent high-res-olution computed tomography.This review focuses on the role of FDG-PET scanning in staging and response assessment in malignancies of the upper gastrointesti-nal tract,specif ically gastric,esophageal and pancreas carcinoma. | Elizabeth C Smyth Manish A Shah | 2011 | World Journal of Gastroenterology2011，17，46： | 6 |
| 2 | Low hypoxia inducible factor-1α(HIF-1α)expression in testicular germ cell tumors--a major reason for enhanced chemosensitivity?显示文摘The molecular basis for enhanced chemosensitivity of testicular germ cell tumors(GCT)has been an area of great interest,as it could potentially give us therapeutic leads in other resistant malignancies.Thus far,however,the increased sensitivity of GCT has been variously attributed to multiple factors—an inability to detoxify cisplatin,a lack of export pumps,an inability to repair the DNA damage,an intact apoptotic cascade and lack of p53 mutation;but a unifying underlying etiology leading to the aforementioned processes and having a translational implication has so far been elusive.Herein,we offer evidence to support a potential significant role for the previously demonstrated low hypoxia inducible factor-1α(HIF-1α)expression in mediating the general exquisite chemosensitivity of testicular GCT,through the aforementioned processes.This molecular mechanism based hypothesis could have a significant translational implication in platinum refractory GCT as well as other platinum resistant malignancies. | niraj shenoy roxana dronca fernando quevedo stephen a boorjian john cheville brian costello manish kohli thomas witzig lance pagliaro | 2017 | Chinese Journal of Cancer Research2017，29，4： | 4 |
| 3 | Para-aortic lymph node involvement should not be a contraindication to resection of pancreatic ductal adenocarcinoma显示文摘BACKGROUND Para-aortic lymph nodes(PALN)are found in the aortocaval groove and they are staged as metastatic disease if involved by pancreatic ductal adenocarcinoma(PDAC).The data in the literature is conflicting with some studies having associated PALN involvement with poor prognosis,while others not sharing the same results.PALN resection is not included in the standard lymphadenectomy during pancreatic resections as per the International Study Group for Pancreatic Surgery and there is no consensus on the management of these cases.AIM To investigate the prognostic significance of PALN metastases on the oncological outcomes after resection for PDAC.METHODS This is a retrospective cohort study of data retrieved from a prospectively maintained database on consecutive patients undergoing pancreatectomies for PDAC where PALN was sampled between 2011 and 2020.Statistical comparison of the data between PALN+and PALN-subgroups,survival analysis with the Kaplan-Meier method and risk analysis with univariable and multivariable time to event Cox regression analysis were performed,specifically assessing oncological outcomes such as median overall survival(OS)and disease-free survival(DFS).RESULTS 81 cases had PALN sampling and 17(21%)were positive.Pathological N stage was significantly different between PALN+and PALN-patients(P=0.005),while no difference was observed in any of the other characteristics.Preoperative imaging diagnosed PALN positivity in one case.OS and DFS were comparable between PALN+and PALN-patients with lymph node positive disease(OS:13.2 mo vs 18.8 mo,P=0.161;DFS:13 mo vs 16.4 mo,P=0.179).No difference in OS or DFS was identified between PALN positive and negative patients when they received chemotherapy either in the neoadjuvant or in the adjuvant setting(OS:23.4 mo vs 20.6 mo,P=0.192;DFS:23.9 mo vs 20.5 mo,P=0.718).On the contrary,when patients did not receive chemotherapy,PALN disease had substantially shorter OS(5.5 mo vs 14.2 mo;P=0.015)and DFS(4.4 mo vs 9.8 mo;P<0.001).PALN involvement was not identified as an independent predictor for OS after multivariable analysis,while it was for DFS doubling the risk of recurrence.CONCLUSION PALN involvement does not affect OS when patients complete the indicated treatment pathway for PDAC,surgery and chemotherapy,and should not be considered as a contraindication to resection. | Rupaly Pande Shafiq Chughtai Manish Ahuja Rachel Brown David C Bartlett Bobby V Dasari Ravi Marudanayagam Darius Mirza Keith Roberts John Isaac Robert P Sutcliffe Nikolaos A Chatzizacharias | 2022 | World Journal of Gastrointestinal Surgery2022，14，5： | 2 |
| 4 | Analyzing Unidentified Locked-Joint Failures in Kinematically Redundant Manipulators 显示文摘 | Manish G Maciejewski A A Balakrishnan V | 2005 | Journal of Robotic System2005，22，1： | 1 |
| 5 | Surface chemical modification of silica aerogels using various alkyl/alkoxyl chlorosilanes显示文摘 | VENKATESWARA R A MANISH M | 2003 | Appl Surf Sci2003，206，： | 1 |
| 6 | Molecular Synthesis of Polymer-Trapped Silica and Titania Nanoclustres显示文摘 | Manish N Jeanine A Ayusman S | 1991 | Chemistry of Materials1991，3，1： | 1 |
| 7 | Hydrophobic properties of TMOS/TMES-based silica aerogels显示文摘 | VENKATESWARA R A MANISH M | 2002 | Mater Res Bull2002，37，： | 1 |
| 8 | Hydrophobic properties of TMOS/ TMES based silica areogels 显示文摘 | RAO A V MANISH S K | 2002 | Materials Research Bulletin2002，37，： | 1 |
| 9 | Increased 99m-Tc-sestamibi accumulation in normal liver and drag-resistant tumor after the administration of the glyocoprotein inhibitor XR9576 显示文摘 | Manish A Jame A Frank M | 2003 | Clin Can Res2003，19，： | 1 |
| 10 | In vivo video rate optical coherence tomography显示文摘 | ANDREW M R MANISH D K SIAVASH Y et a l | 1998 | Optics Express1998，3，6： | 1 |
| 11 | Surface chemical modification of silica aerogels using various alkyl-alkoxy/chlorosilanes显示文摘 | VENKATESWARA A KULKARNI Manish M AMALNERKAR D P | 2003 | Appl Surf Sci2003，206，： | 1 |
| 12 | A method for judicious fusion of inconsistent multiple sensor data显示文摘 | Manish Kumar Devendra P Garg Randy A Zachery | 2007 | IEEE Sensors Journal2007，，5： | 1 |
| 13 | Hydrophobic properties of TMOS/TMES-based silica aerogels显示文摘 | Rao A V Kulkarni Manish M | 2002 | Materials Research Bulletin2002，37，： | 1 |
| 14 | Creep behavior in near-nanostructured Al 5083 alloy显示文摘 | MANISH C H I ROY FARGHALLI A Mohamed | 2005 | Materials Science and Engineering A2005，41，： | 1 |
| 15 | Transport of Liquids Using Superhydrophobic Aerogels显示文摘 | Venkateswara A Rao Manish M Kulkarni Sharad D Bhagat | 2005 | Journal of Colloid and Interface Science2005，285，： | 1 |
| 16 | Superhydrophobic Silica Aerogels Based on Methyltrimethoxysilane Precursor显示文摘 | Venkateswara A Rao Manish M Kulkarni Amalnerkar D P | 2003 | Journal of Non-Crystalline Solids2003，330，： | 1 |
| 17 | Mechanisms of sliding wear of metals and alloys at elevated temperatures显示文摘 | Pauschitz A Manish Roy Franek F | 2008 | Tribology International2008，41，7： | 1 |
| 18 | Minimally invasive versus open transforaminal lumbar interbody fusion for degenerative spondylolisthesis grades 1-2:patient-reported clinical outcomes and cost-utility analysis显示文摘 | Wale A R Manish S | 2014 | The Ochsner Journal2014，14，1： | 1 |
| 19 | Intraventricular gan- glioglioma with bleed: a rare case report显示文摘 | Bhat D I Mahadevan A Manish R | 2010 | Neurol India2010，58，3： | 1 |
| 20 | Influence of price perception and shopping motives on Indian con- sumers' attitude towards retailer promotions in malls 显示文摘 | ARPITA K DHIREN A MANISH K | 2014 | Asia Pacific Journal of Marketing and Logistics2014，26，2： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员