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您的检索式：作者名="Maofang Lin"
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| 1 | Bortezomib in combination with dexamethasone and subsequent thalidomide for newly-diagnosed multiple myeloma: A Chinese experience显示文摘 | Weiyan Zheng Guoqing Wei Xiujin Ye Jingsong He Li Li Wenjun Wu Jimin Shi Jie Zhang Weijia Huang Wanzhuo Xie Yi Luo Xingkui Xue Maofang Lin He Huang Zhen Cai | 2009 | Leukemia Research2009，，12： | 1 |
| 2 | Challenges and possible solutions to creating an achievable and effective Post-2020 Global Biodiversity Framework显示文摘Global biodiversity is in crisis as a result of human activity.This biodiversity crisis has been well documented by scientists,recognized by world leaders,politicians,businesses,and citizens.Both the biodiversity and climate crises need to be addressed now.2020 was when this change was supposed to start,with the 15th Conference of Parties(COP15)of the Convention on Biodiversity(CBD)meeting in Kunming,and the 26th Conference of Parties(COP26)of the UN Framework Convention on Climate Change meeting in Glasgow,but both meetings were postponed.COP26 was held a year late(November 2021),while COP15 was split into two,with the first part held in Kunming in October 2021,and the second part scheduled for Montreal in December 2022.This meeting in Montreal-arguably the most important in the CBDs history-must agree on the Post-2020 Global Biodiversity Framework(GBF),to reverse biodiversity loss.Failure to reach agreement in Montreal would ultimately be a failure of us all,with irreversible consequences for life on earth.Yet,with three months before the final deadline only 20%of text and two targets are agreed.This paper reviews the factors hindering progress on the agreement and suggests possible solutions. | Alice Hughes Xiaoli Shen Richard Corlett Lin Li Maofang Luo Stephen Woodley Yuanming Zhang Keping Ma | 2022 | Ecosystem Health and Sustainability2022，8，1： | 1 |
| 3 | 硼替佐米、三氧化二砷对多发性骨髓瘤细胞株KM_3细胞的抑制作用(英文)显示文摘Objective:The aim of our study was to investigate the effect of bortezomib in combination with arsenic trioxide(As2O3) on the proliferation and apoptosis in the human multiple myeloma cell line KM3.Methods:KM3 cells were cultured with different concentrations of bortezomib, As2O3 alone or in combination for different times.Cell proliferation was analyzed by MTT assay, and the IC50 was calculated.Cell morphology was observed under the light microscope(using Wright-Giemsa stain) and electric microscope.Agarose gel electrophoresis was used to evaluate DNA content.Flow cytometry was used to examine Annexin V-FITC/PI stain and mitochondrial transmembrane electric potential(ΔΨm).Results:Bortezomib and As2O3 alone both inhibited KM3 cell proliferation in a time and dose dependent manner, with the IC50 were 0.27, 3.10 μmol/L, respectively;the inhibiting rate on KM3 cells of bortezomib plus As2O3 was significantly higher than bortezomib alone(18.22 ± 1.04)% vs.(13.18 ± 1.29)%, P < 0.05;A series of typical morphological features of apoptosis and a typical DNA ladder were observed in KM3 cell treated with 0.25 μmol/L bortezomib for 48 h, which showed increased Annexin V positivity and decreased ΔΨm.The apoptosis rate induced by bortezomib plus As2O3 was also significantly than that of induced by bortezomib alone.Conclusion:Bortezomib could inhibit the proliferation while induce apoptosis of KM3 cells which may be through decreased ΔΨm.Bortezomib had enhanced inhibitory effect with As2O3 on the growth of KM3 cell(P < 0.05).As2O3 enhances the apoptosis effects of bortezomib on KM3 cell. | Guifang Ouyang Maofang Lin | 2010 | The Chinese-German Journal of Clinical Oncology2010，9，3： | 0 |
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