|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Double-stranded DNA in exosomes: a novel biomarker in cancer detection显示文摘 | Basant Kumar Thakur Haiying Zhang Annette Becker Irina Matei Yujie Huang Bruno Costa-Silva Yan Zheng Ayuko Hoshino Helene Brazier Jenny Xiang Caitlin Williams Ruth Rodriguez-Barrueco Jose M Silva Weijia Zhang Stephen Hearn Olivier Elemento Navid Paknejad Katia Manova-Todorova Karl Welte Jacqueline Bromberg Hector Peinado David Lyden | 2014 | Cell Research2014，24，6： | 98 |
| 2 | Stable classi?cation with limited sample: transferring a 30-m resolution sample set collected in 2015 to mapping 10-m resolution global land cover in 2017显示文摘As the world strives to reduce the impact of population growth, urbanization, agricultural expansion, and climate change on food security, energy and water shortage, resource over-exploration, biodiversity loss, environmental pollution, and ultimately human health, timely and higher resolution land cover information is urgently needed to achieve the sustainable development goals of the United Nations. | Peng Gong Han Liu Meinan Zhang Congcong Li Jie Wang Huabing Huang Nicholas Clinton Luyan Ji Wenyu Li Yuqi Bai Bin Chen Bing Xu Zhiliang Zhu Cui Yuan Hoi Ping Suen Jing Guo Nan Xu Weijia Li Yuanyuan Zhao Jun Yang Chaoqing Yu Xi Wang Haohuan Fu Le Yu Iryna Dronova Fengming Hui Xiao Cheng Xueli Shi Fengjin Xiao Qiufeng Liu Lianchun Song | 2019 | Science Bulletin2019，64，6： | 166 |
| 3 | Learning from berberine: Treating chronic diseases through multiple targets显示文摘Although advances have been made, chemotherapy for chronic, multifactorial diseases such as cancers, Alzheimer's disease, cardiovascular diseases and diabetes is far from satisfactory. Agents with different mechanisms of action are required. The botanic compound berberine(BBR) has been used as an over-the-counter antibacterial for diarrhea in China for many decades. Recent clinical studies have shown that BBR may be therapeutic in various types of chronic diseases. This review addresses BBR's molecular mechanisms of action and clinical efficacy and safety in patients with type 2 diabetes, hyperlipidemia, heart diseases, cancers and inflammation. One of the advantages of BBR is its multiple-target effects in each of these diseases. The therapeutic efficacy of BBR may reflect a synergistic regulation of these targets, resulting in a comprehensive effect against these various chronic disorders. The safety of BBR may be due to its harmonious distribution into those targets. Although the single-target concept is still the principle for drug discovery and research, this review emphasizes the concept of a multiple target strategy, which may be an important approach toward the successful treatment of multifactorial chronic diseases. | YAO Jing KONG WeiJia JIANG JianDong | 2015 | Science China(Life Sciences)2015，58，9： | 32 |
| 4 | Optimal operation of electricity, natural gas and heat systems considering integrated demand responses and diversified storage devices显示文摘In recent years, the increasing penetration level of renewable generation and combined heat and power(CHP) technology in power systems is leading to significant changes in energy production and consumption patterns. As a result, the integrated planning and optimal operation of a multi-carrier energy(MCE) system have aroused widespread concern for reasonable utilization of multiple energy resources and efficient accommodation of renewable energy sources. In this context, an integrated demand response(IDR) scheme is designed to coordinate the operation of power to gas(P2 G) devices, heat pumps,diversified storage devices and flexible loads within an extended modeling framework of energy hubs. Subsequently, the optimal dispatch of interconnected electricity,natural gas and heat systems is implemented considering the interactions among multiple energy carriers by utilizing the bi-level optimization method. Finally, the proposed method is demonstrated with a 4-bus multi-energy systemand a larger test case comprised of a revised IEEE 118-bus power system and a 20-bus Belgian natural gas system. | Linna NI Weijia LIU Fushuan WEN Yusheng XUE Zhaoyang DONG Yu ZHENG Rui ZHANG | 2018 | Journal of Modern Power Systems and Clean Energy2018，6，3： | 30 |
| 5 | Prevention and treatment of cancer targeting chronic inflammation:research progress,potential agents,clinical studies and mechanisms显示文摘Numerous experimental and clinical studies indicate that chronic inflammation is closely related to the initiation, progression,and spread of cancer, in which proinflammatory cytokines, such as interleukin(IL)-6, IL-1β, and tumor necrosis factor-α(TNF-α), and transcription factors, such as nuclear factor-κB(NF-κB), and signal transducer and activator of transcription 3(STAT3), play pivotal roles. Stimulated by proinflammatory cytokines, NF-κB and STAT3 can modulate the expression of target genes, most of which are oncogenic ones, and promote the survival, proliferation, invasion, and metastasis of cancer cells. Now it is generally accepted that inflammation-related molecules and pathways are useful targets for the prevention and treatment of cancer. In this review, we summarize the relationship between chronic inflammation and cancer and describe some potentially useful agents including aspirin, meformin, statins, and some natural products(green tea catechins, andrographolide,curcumin) for their cancer prevention and treatment activities targeting chronic inflammation. The results of typical clinical studies are included, and the influences of these agents on the proinflammatory cytokines and inflammation-related pathways are discussed. Data from the present review support that agents targeting chronic inflammation may have a broad application prospect for the prevention and treatment of cancer in the future. | Yong Zhang Weijia Kong Jiandong Jiang | 2017 | Science China(Life Sciences)2017，60，6： | 11 |
| 6 | Decolorization on Indigo Dyeing Wastewater by Laccase from Coriolus versicolor显示文摘[Object]The study aimed to discuss the decolorization on indigo dyeing wastewater by laccase from Coriolus versicolor.[Method]Firstly,the effects of temperature,pH,indigo concentration,HBT concentration,laccase dosage on the decolorization of indigo dyeing wastewater by laccase /HBT,and then the synergism of laccase and acid cellulase was analyzed.[Result]Using ABTS as the substrate,the kinetic parameters,K m and V max,were 0.318 mmol/L and 0.035 5 mmol/(L·min) respectively.The decolorization rate of indigo reached 96.5% when the laccase acted on indigo for 40 min with HBT as an introducer at temperature 50 ℃,pH =4.5,indigo concentration 100 mg /L,HBT concentration 0.1% and laccase dosage 100 IU /L.Due to the synergism of laccase and acid cellulase during the bio-finishing of blue jeans,the backstaining degree of blue jeans reduced by 85% when the amount of laccase added was 15 000 IU /kg.Menawhile,the synergism of the laccase and acid cellulase decreased indigo concentration in wastewater by 83.8%.[Conclusion] The laccase from Coriolus versicolor had a good prospect in the bio-finishing of blue jeans and the decolorization of indigo dyeing wastewater. | Enli Gao Weijia Zhong Xiaolan Fu Fushan Chen Zhigang Ye | 2013 | Meteorological and Environmental Research2013，4，1： | 10 |
| 7 | An experimental study on thymus immune tolerance to treat surgical brain injury显示文摘 | Zheng Yongtao Kang Jianmin Liu Baolong Fan Weijia Wu Qiaoli Yan Hua | 2014 | Chinese Medical Journal2014，，4： | 8 |
| 8 | Progressive transformation of immortalized esophageal epithelial cells显示文摘AIM: To investigate the progressive transformation of immortal cells of human fetal esophageal epithelium induced by human papillomavirus, and to examine biological criteria of sequential passage of cells, including cellular phenotype, proliferative rate, telomerase, chromosome and tumorigenicity.METHODS: The SHEE cell series consisted of immortalized embryonic esophageal epithelium which was in malignant transformation when cultivated over sixty passages without co-carcinogens. Cells of the 10th, 31st, 60th and 85th passages were present in progressive development after being transfected with HPV. Cells were cultivated in a culture flask and 24-hole cultural plates. Progressive changes of morphology, cell growth, contact-inhibition, and anchoragedependent growth characteristics were examined by phase contrast microscopy. The cell proliferation rate was assayed by flow cytometry. The modal number of chromosomes was analyzed. HPV18E6E7 was detected by Western blot methods and activities of telomerase were analyzed by TRAP.Tumorigenicity of cells was detected with soft agar plates cultivated and with tumor formation in SCID mice.RESULTS: In morphological examination the 10th passage cells were in good differentiation, the 60th and 85th passages cells were in relatively poor differentiation, and the 31st passage cells had two distinct differentiations. The characteristics of the 85th and 60th passage cells were weakened at contact-inhibition and anchorage-dependent growth. Karyotypes of four stages of cells belonged to hyperdiploid or hypotriploid, and bimodal distribution of chromosomes appeared in the 31st and 60th passage cells. All of these characteristics combined with a increasing trend. The activities of telomerase were expressed in the latter three passages. Four fourths of SCID mice in the 85th passage cells and one fourth of SCID mice in the 60th passage cells developed tumors, but the cells in the 10th and 31st passage displayed no tumor formation.CONCLUSION: In continual cultivation of fetal esophageal epithelial cells with transduction of HPV18E6E7, cells from the 10th to the 85th passage were changed gradually from preimmortal, immortal, precancerous to malignantly transformed stages. All of these changes were in a dynamic progressive process. The establishment of a continuous line of esophageal epithelium may provide a in vitro model of carcinogenesis induced by HPV. | Zhong-Ying Shen Li-Yan Xu Min-Hua Chen Jian Shen WeiJia Cai,Department of Tumor Pathology Medical College of Shantou University,Shantou 515031,Guangdong Province,China Yi Zeng,Institute of Virology,Chinese Academy of Preventive Medicine.Beijing 100052,China | 2002 | World Journal of Gastroenterology2002，8，6： | 8 |
| 9 | Up-regulation of breast cancer resistance protein plays a role in HER2-mediated chemoresistance through PI3K/Akt and nuclear factor-kappa B signaling pathways in MCF7 breast cancer cells显示文摘人的表皮的生长因素受体 2 (HER2/neu,也作为 ErbB2 知道) overexpression 在癌症与差的预后和 chemoresistance 被相关。乳癌抵抗蛋白质(BCRP 和 ABCG2 ) 在许多癌症房间是为 multidrug 抵抗(MDR ) 负责的药流出泵。HER2 和 BCRP 在乳癌病人与差的治疗反应被联系,尽管在 HER2 和 BCRP 表示之间的关系不是清楚的。这里,我们证明进 MCF7 乳癌房间(MCF7/HER2 ) 的 HER2 的 transfection 经由 phosphatidylinositol 3-kinase (PI3K ) 导致了 BCRP 的一条起来规定 /Akt 和发信号的原子 factor-kappa B (NF-B ) 。有 PI3K 禁止者 LY294002, IB phosphorylation 禁止者 Bay11-7082,和 IB 的主导的否定异种的 MCF/HER2 房间的治疗禁止了导致 HER2 的 BCRP 倡导者活动。而且,我们发现 HER2 overexpression 导致了 MCF7 房间的一个增加的电阻到多重 antitumor 药象 paclitaxel (Taxol ) 那样, cisplatin (DDP ) , etoposide (VP-16 ) , adriamycin (ADM ) , mitoxantrone (MX ) ,和 5 氟尿嘧啶(5-FU ) 。而且, silencing BCRP 或有选择地的表示禁止 Akt 或 NF-B 的活动部分地至少敏化 MCF7/HER2 房间到这些化疗代理人。一起拿,通过表明小径的 PI3K/AKT/NF-B 的 BCRP 的起来规定在 MCF7 的调停 HER2 的 chemoresistance 起了一个重要作用房间,和 AKT, NF-B,和 BCRP 小径可能为治疗学的干预用作潜在的目标。 | Weijia Zhang Wei Ding Ye Chen Meilin Feng Yongmei Ouyang Yanhui Yu Zhimin He | 2011 | Acta Biochimica et Biophysica Sinica2011，43，8： | 8 |
| 10 | One-step synthesis of Fe-Ni hydroxide nanosheets derived from bimetallic foam for efficient electrocatalytic oxygen evolution and overall water splitting显示文摘The research of superior water oxidation electrodes is essential for the green energy in the form of hydrogen by way of electrolytic water splitting, and still remains challenging. Based upon dealloying foam, Fe-Ni hydroxide nanosheets network structure is designed on the surface of Fe-Ni alloy foam. The ratio of Ni/Fe elements was adjusted to realize the optimal catalytic activities for oxygen evolution reaction(OER) and hydrogen evolution reaction(HER). The obtained electrode of Fe-Ni hydroxide nanosheets/Fe-Ni alloy foam-60% Fe(FN LDH/FNF-60, 60 is the percentage of Fe content) possess low overpotential of 261 mV to reach 10 mA/cm^2, small Tafel slope(85.5 mV/dec), and superior long-term stability(remaining 10 mA/cm^2 for over 14 h without attenuation) toward OER in 1.0 mol/L KOH.Moreover, an alkaline water electrolyzer is constructed with the FN LDH/FNF-60 as anode and Ni(OH)_2/Fe-Ni alloy foam-25% Fe(Ni(OH)_2/FNF-25) as cathode, which displays superior electrolytic performance(affording 10 mA/cm^2 at 1.62 V) and lasting durability. | Lili Zeng Linjing Yang Jia Lu Jin Jia Jiayuan Yu Yunqie Deng Mingfei Shao Weijia Zhou | 2018 | Chinese Chemical Letters2018，29，12： | 7 |
| 11 | Enhanced electrocatalytic activity of Co@N-doped carbon nanotubes by ultrasmall defect-rich TiO2 nanoparticles for hydrogen evolution reaction显示文摘尽管有是技术上可能的,切开水产生氢实际上是难实施的,主要因为为氢进化反应的持续、有效的地球丰富的催化剂的缺乏(她的) 。此处,我们报导一持久、高度活跃电气化学她基于充满缺点的 TiO 2 , nanoparticles 在公司做 nanoparticles@N 的碳 nanotubes 上装载了的催化剂(D-TiO 2/Co@NCT) 由静电的旋转和一个随后的锻烧过程综合了。ultrasmall TiO 2 nanoparticles 是在尺寸的 1.5 -2 nm 并且有氧空缺的充满缺点的结构。D-TiO 2/Co@NCT 展览优秀她在酸的电解质的催化活动(0.5 M H 2 那么有 57.5 mV 的一个低发作潜力的 4),( 是的 1 个 mAimmense 潜力由于他们的像三明治的分层的结构的 lithium/ 钠离子电极材料。优化他们的 lithium/sodium-storage 表演,二个问题应该被处理:根本上理解发生在 TMD 电极和发展中的新奇 TMD 的化学反应。在这研究, WSe 2 六角形的 nanoplates 是 sy? | Jiayuan Yu Weijia Zhou Tanli Xiong Aili Wang Shaowei Chen Benli Chu | 2017 | Nano Research2017，10，8： | 7 |
| 12 | Distributed generator-based distribution system service restoration strategy and model-free control methods显示文摘The rapid growth of distributed generator(DG)capacities has introduced additional controllable assets to improve the performance of distribution systems in terms of service restoration.Renewable DGs are of particular interest to utility companies,but the stochastic nature of intermittent renewable DGs could have a negative impact on the electric grid if they are not properly handled.In this study,we investigate distribution system service restoration using DGs as the primary power source,and we develop an effective approach to handle the uncertainty of renewable DGs under extreme conditions.The distribution system service restoration problem can be described as a mixed-integer second-order cone programming model by modifying the radial topology constraints and power flow equations.The uncertainty of renewable DGs will be modeled using a chance-constrained approach.Furthermore,the forecast errors and noises in real-time operation are solved using a novel model-free control algorithm that can automatically track the trajectory of real-time DG output.The proposed service restoration strategy and model-free control algorithm are validated using an IEEE 123-bus test system. | Weijia Liu Yue Chen Fei Ding | 2021 | Global Energy Interconnection2021，4，2： | 7 |
| 13 | Water Splitting:From Electrode to Green Energy System显示文摘Hydrogen(H2)production is a latent feasibility of renewable clean energy.The industrial H2 production is obtained from reforming of natural gas,which consumes a large amount of nonrenewable energy and simultaneously produces greenhouse gas carbon dioxide.Electrochemical water splitting is a promising approach for the H2 production,which is sustainable and pollution-free.Therefore,developing efficient and economic technologies for electrochemical water splitting has been an important goal for researchers around the world.The utilization of green energy systems to reduce overall energy consumption is more important for H2 production.Harvesting and converting energy from the environment by different green energy systems for water splitting can efficiently decrease the external power consumption.A variety of green energy systems for efficient producing H2,such as two-electrode electrolysis of water,water splitting driven by photoelectrode devices,solar cells,thermoelectric devices,triboelectric nanogenerator,pyroelectric device or electrochemical water-gas shift device,have been developed recently.In this review,some notable progress made in the different green energy cells for water splitting is discussed in detail.We hoped this review can guide people to pay more attention to the development of green energy system to generate pollution-free H2 energy,which will realize the whole process of H2 production with low cost,pollution-free and energy sustainability conversion. | Xiao Li Lili Zhao Jiayuan Yu Xiaoyan Liu Xiaoli Zhang Hong Liu Weijia Zhou | 2020 | Nano-Micro Letters2020，12，10： | 6 |
| 14 | Radioactive probe-guided parathyroidectomy for secondary hyperparathyroidism显示文摘 | Yuan Fei Yu Weijia Waqas Ahmad Yang Zhixue Cao Hua Li Juncheng Jiang Guoqin | 2014 | Chinese Medical Journal2014，，13： | 6 |
| 15 | Laser Synthesis and Microfabrication of Micro/ Nanostructured Materials Toward Energy Conversion and Storage显示文摘Nanomaterials are known to exhibit a number of interesting physical and chemical properties for various applications,including energy conversion and storage,nanoscale electronics,sensors and actuators,photonics devices and even for biomedical purposes.In the past decade,laser as a synthetic technique and laser as a microfabrication technique facilitated nanomaterial preparation and nanostructure construction,including the laser processing-induced carbon and non-carbon nanomaterials,hierarchical structure construction,patterning,heteroatom doping,sputtering etching,and so on.The laser-induced nanomaterials and nanostructures have extended broad applications in electronic devices,such as light–thermal conversion,batteries,supercapacitors,sensor devices,actuators and electrocatalytic electrodes.Here,the recent developments in the laser synthesis of carbon-based and non-carbon-based nanomaterials are comprehensively summarized.An extensive overview on laser-enabled electronic devices for various applications is depicted.With the rapid progress made in the research on nanomaterial preparation through laser synthesis and laser microfabrication technologies,laser synthesis and microfabrication toward energy conversion and storage will undergo fast development. | Lili Zhao Zhen Liu Duo Chen Fan Liu Zhiyuan Yang Xiao Li Haohai Yu Hong Liu Weijia Zhou | 2021 | Nano-Micro Letters2021，13，3： | 6 |
| 16 | WSe2 2D p-type semiconductor-based electronic devices for information technology:Design,preparation,and applications显示文摘The pioneering exfoliation of monolayer tungsten diselenide has greatly inspired researchers toward semiconducting applications.WSe2 belongs to a family of transition-metal dichalcogenides.Similar to graphene,WSe2 and analogous dichalcogenides have layered structures with weak van der Waals interactions between two adjacent layers.First,the readers are presented with the fundamentals of WSe2,such as types,morphologies,and properties.Here,we report the characterization principles and practices such as microscopy,spectroscopy,and diffraction.Second,the methods for obtaining high-quality WSe2,such as exfoliation,hydrothermal and chemical vapor deposition,are briefly listed.With advantages of light weight,flexibility,and high quantum efficiency,2D materials may have a niche in optoelectronics as building blocks in p-n junctions.Therefore,we introduce a state-of-the-art demonstration of heterostructure devices employing the p-type WSe2 semiconductor.The device architectures include field-effect transistors,photodetectors,gas sensors,and photovoltaic solar cells.Due to its unique electronic,optical,and energy band properties,WSe2 has been increasingly investigated due to the conductivity of the p-type charge carrier upon palladium contact.Eventually,the dynamic research on WSe2 and van der Waals heterostructures is summarized to arouse the passion of the 2D research community. | Qilin Cheng Jinbo Pang Dehui Sun Jingang Wang Shu Zhang Fan Liu Yuke Chen Ruiqi Yang Na Liang Xiheng Lu Yanchen Ji Jian Wang Congcong Zhang Yuanhua Sang Hong Liu Weijia Zhou | 2020 | InfoMat2020，2，4： | 5 |
| 17 | Therapeutic Effects of Selaginella tamariscina on the Model of Acute Gout with Hyperuricemia in Rats Based on Metabolomics Analysis显示文摘 | Weijia Chen Yi Wu Rongbing Bi Shu Liu Zhongying Liu Zhiqiang Liu Fengrui song Yi Shi | 2017 | Chinese Journal of Chemistry2017，35，7： | 5 |
| 18 | Aberrant Resting-State Functional Connectivity in the Default Mode Network in Pediatric Bipolar Disorder Patients with and without Psychotic Symptoms显示文摘Mood disorders/psychosis have been associated with dysfunctions in the default mode network(DMN).However,the relative contributions of DMN regions to state and trait disturbances in pediatric bipolar disorder(PBD)remain unclear.The aim of this study was to investigate the possible mechanisms of PBD through brain imaging and explore the influence of psychotic symptoms on functional alterations in PBD patients.Twenty-nine psychotic and 26 non-psychotic PBD patients,as well as 19 age-and sex-matched healthy controls underwent a restingstate functional MRI scan and the data were analyzed by independent component analysis.The DMN component from the fMRI data was extracted for each participant.Spearman's rank correlation analysis was performed between aberrant connectivity and clinical measurements.The results demonstrated that psychotic PBD was characterized by aberrant DMN connectivity in the anterior cingulate cortex/medial prefrontal cortex,bilateral caudate nucleus,bilateral angular gyri,and left middle temporal gyrus,while non-psychotic PBD was not,suggesting further impairment with the development of psychosis.In summary,we demonstrated unique impairment in DMN functional connectivity in the psychotic PBD group.These specific neuroanatomical abnormalities may shed light on the underlying pathophysiology and presentation of PBD. | Yuan Zhong Chun Wang Weijia Gao Qian Xiao Dali Lu Qing Jiao Linyan Su Guangming Lu | 2019 | Neuroscience Bulletin2019，35，4： | 5 |
| 19 | Near infrared spectral and polarization imaging observation of coronal emission lines during the 2008 total solar eclipse显示文摘During the 2008 total solar eclipse, the coronal emission lines were observed by using optical fibre spectrometric and polarization imaging system in near infrared waveband. The profiles of the coronal emission lines including Fe XIII 10747 , 10798 and He I 10830 were obtained with dispersion of 0.5 /pix. The intensity of Fe XIII 10747 remained unchanged in the two different coronal regions while the intensity of He I 10830 varied considerably in the two coronal locations no matter whether the prominence appeared or not. The coronal polarization images were observed at Fe XI 7892 with a bandpass of 30 in a series of exposure times. | BAO XingMing ZHANG ZhiYong DENG Jian HU KeLiang XUAN WeiJia LIU YangBing ZHANG HongQi DENG YuanYong WANG DongGuang WANG XiaoFan | 2009 | Science China(Physics,Mechanics & Astronomy)2009，52，11： | 5 |
| 20 | Comparative population genetic analyses suggest hybrid origin of Rhododendron pubicostatum,an endangered plant species with extremely small populations endemic to Yunnan,China显示文摘Gene flow between sympatric congeneric plants is thought to be very common and may pose serious threats to endangered species.In the present study,we evaluate the genetic diversity and divergence of three sympatric Rhododendron species in Jiaozi Mountain using newly developed microsatellites through the Illumina MiSeq sequencing approach.Genetic diversity of all three Rhododendron species studied was moderate in comparison to genetic parameters previously reported from species of this genus.Interestingly,genetic structure analysis of the three species identified a possible hybrid origin of the threatened Rh.pubicostatum.This sympatry should be considered a unimodal hybrid zone,since Rh.pubicostatum is predominant here.Unimodal hybrid zones are uncommon in Rhododendron,despite the fact that hybridization frequently occurs in the genus.Issues pertaining to the conservation of Rh.pubicostatum resulting from admixture of genetic material from its parental species are discussed. | Xuemei Zhang Hantao Qin Weijia Xie Yongpeng Ma Weibang Sun | 2020 | Plant Diversity2020，42，4： | 4 |
您所在的机构暂未开通此部分的功能，请联系管理员