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| 1 | Hypoxia inducible factor-1αaccumulation in steatotic liver preservation:Role of nitric oxide显示文摘AIM:To examine the relevance of hypoxia inducible factor(HIF-1)and nitric oxide(NO)on the preservation of fatty liver against cold ischemia-reperfusion injury(IRI). METHODS:We used an isolated perfused rat liver model and we evaluated HIF-1αin steatotic and non-steatotic livers preserved for 24 h at 4℃in University of Wisconsin and IGL-1 solutions,and then subjected to 2 h of normothermic reperfusion.After normoxic reperfusion,liver enzymes,bile production,bromosulfophthalein clearance,as well as HIF-1αand NO[endothelial NO synthase(eNOS)activity and nitrites/nitrates]were also measured.Other factors associated with the higher susceptibility of steatotic livers to IRI,such as mitochondrial damage and vascular resistance were evaluated. RESULTS:A significant increase in HIF-1αwas found in steatotic and non-steatotic livers preserved in IGL-1 after cold storage.Livers preserved in IGL-1 showed a significant attenuation of liver injury and improvement in liver function parameters.These benefits were enhanced by the addition of trimetazidine(an antiischemic drug),which induces NO and eNOS activation, to IGL-1 solution.In normoxic reperfusion,the presence of NO favors HIF-1αaccumulation,promoting also the activation of other cytoprotective genes,such as hemeoxygenase-1. CONCLUSION:We found evidence for the role of the HIF-1α/NO system in fatty liver preservation,especially when IGL-1 solution is used. | Mohamed Amine Zaouali Ismail Ben Mosbah Eleonora Boncompagni Hassen Ben Abdennebi Maria Teresa Mitjavila Ramon Bartrons Isabel Freitas Antoni Rimola Joan Roselló-Catafau | 2010 | World Journal of Gastroenterology2010，16，28： | 11 |
| 2 | 大气二氧化氮与每日总死亡率、心血管和呼吸系统疾病死亡率的短期关联:398个城市的多中心分析显示文摘目的:采用统一的分析方案,评估全球多个国家/地区的二氧化氮(NO_(2))与总死亡率、心血管和呼吸系统疾病死亡率之间的短期关联。研究设计:采用两阶段的时间序列分析方法、过度离散的广义线性模型和多水平meta分析。研究地点:22个低到高收入国家/地区的398个城市。主要结局指标:1973—2018年逐日总死亡人数(6280万人)、心血管疾病死亡人数(1970万人)和呼吸系统疾病死亡人数(550万人)。结果:平均而言,NO_(2)浓度在滞后1天(前1天)每增加10μg/m^(3),会导致总死亡率、心血管和呼吸系统疾病死亡率分别增加0.46%(95%可信区间0.36%~0.57%)、0.37%(0.22%~0.51%)、0.47%(0.21%~0.72%)。在对共污染物(PM_(10)、PM_(2.5)、臭氧、二氧化硫和一氧化碳)进行调整后,这些关联仍然很稳定。所有3种死因的暴露-反应曲线几乎是线性的,没有明显的阈值。在398个城市中,可归因于高过假定零水平的NO_(2)浓度造成的死亡比例为1.23%(95%可信区间0.96%~1.51%)。结论:这项多中心研究提供了关于NO_(2)短期暴露与总死亡率、心血管和呼吸系统死亡风险之间的独立和线性关联的关键证据,说明通过加强NO_(2)的控制和监管限制标准,可获得人群水平的健康收益。 | 孟夏 刘聪(校) 陈仁杰 郑湃(译) 阚海东(校) Francesco Sera Ana Vicedo-Cabrera Ai Milojevic Maria Guo Yuming Tong Shilu Micheline de Sousa Zanotti Stagliorio Coelh Paulo Hilario Nascimento Saldiva Eric Lavigne Patricia Matus Correa Nicolas Valdes Ortega Samuel Osorio Garcia Jan Kysely Ales Urban Hans Orru Marek Maasikmets Jouni J K Jaakkola Niilo Ryti Veronika Huber Alexandra Schneider Klea Katsouyanni Antonis Analitis Masahiro Hashizume Yasushi Honda Chris Fook Sheng Ng Baltazar Nunes João Paulo Teixeira Iulian Horia Holobaca Simona Fratianni Ho Kim Aurelio Tobias Carmeníniguez Bertil Forsberg ChristoferÅström Martina S Ragettli Yue-Liang Leon Guo Shih-Chun Pan Shanshan Li Michelle L Bell Antonella Zanobetti Joel Schwartz Tangchun Wu Antonio Gasparrini | 2021 | 英国医学杂志中文版2021，24，8： | 7 |
| 3 | Polyethylene glycol rinse solution:An effective way to prevent ischemia-reperfusion injury显示文摘AIM:To test whether a new rinse solution containing polyethylene glycol 35(PEG-35)could prevent ischemia-reperfusion injury(IRI)in liver grafts.METHODS:Sprague-Dawley rat livers were stored in University of Wisconsin preservation solution and then washed with different rinse solutions(Ringer’s lactate solution and a new rinse solution enriched with PEG-35 at either 1 or 5 g/L)before ex vivo perfusion with Krebs-Heinseleit buffer solution.We assessed the following:liver injury(transaminase levels),mitochondrial damage(glutamate dehydrogenase activity),liver function(bile output and vascular resistance),oxidative stress(malondialdehyde),nitric oxide,liver autophagy(Beclin-1 and LCB3)and cytoskeleton integrity(filament and globular actin fraction);as well as levels of metalloproteinases(MMP2 and MMP9),adenosine monophosphate-activated protein kinase(AMPK),heat shock protein 70(HSP70)and heme oxygenase 1(HO-1).RESULTS:When we used the PEG-35 rinse solution,reduced hepatic injury and improved liver function were noted after reperfusion.The PEG-35 rinse solution prevented oxidative stress,mitochondrial damage,and liver autophagy.Further,it increased the expression of cytoprotective heat shock proteins such as HO-1 and HSP70,activated AMPK,and contributed to the restoration of cytoskeleton integrity after IRI.CONCLUSION:Using the rinse solution containing PEG-35 was effective for decreasing liver graft vulnerability to IRI. | Mohamed Amine Zaouali Mohamed Bejaoui Maria Calvo Emma Folch-Puy Eirini Pantazi Gianfranco Pasut Antoni Rimola Hassen Ben Abdennebi René Adam Joan Roselló-Catafau | 2014 | World Journal of Gastroenterology2014，20，43： | 6 |
| 4 | New genes emerging for colorectal cancer predisposition显示文摘Colorectal cancer(CRC)is one of the most frequent neoplasms and an important cause of mortality in the developed world.This cancer is caused by both genetic and environmental factors although 35%of the variation in CRC susceptibility involves inherited genetic differences.Mendelian syndromes account for about5%of the total burden of CRC,with Lynch syndrome and familial adenomatous polyposis the most common forms.Excluding hereditary forms,there is an important fraction of CRC cases that present familial aggregation for the disease with an unknown germline genetic cause.CRC can be also considered as a complex disease taking into account the common diseasecommom variant hypothesis with a polygenic model of inheritance where the genetic components of common complex diseases correspond mostly to variants of low/moderate effect.So far,30 common,low-penetrance susceptibility variants have been identified for CRC.Recently,new sequencing technologies including exomeand whole-genome sequencing have permitted to add a new approach to facilitate the identification of new genes responsible for human disease predisposition.By using whole-genome sequencing,germline mutations in the POLE and POLD1 genes have been found to be responsible for a new form of CRC genetic predisposition called polymerase proofreading-associated polyposis. | Clara Esteban-Jurado Pilar Garre Maria Vila Juan José Lozano Anna Pristoupilova Sergi Beltrán Anna Abulí Jenifer Muoz Francesc Balaguer Teresa Ocaa Antoni Castells Josep M Piqué Angel Carracedo Clara Ruiz-Ponte Xavier Bessa Montserrat Andreu Luis Bujanda Trinidad Caldés Sergi Castellví-Bel | 2014 | World Journal of Gastroenterology2014，20，8： | 3 |
| 5 | Retention mucocele of distal viable remnant tip of appendix:An unusually rare late surgical complication following incomplete appendectomy显示文摘一个 67 年的老人与周期性的恰好更低的象限的 6 瞬间历史被介绍腹的疼痛。在体格检查上,一个含糊的团在恰好腰部的区域是摸得出的。他的平淡的实验室测试是正常的。Ultrasonography 与内部回响和液体部件在对正确的肾前面的恰好腰部的区域显示出低亚硫酸钠拟声损害。腹的提高对比的计算断层摄影术(CECT ) 显示出明确的低亚硫酸钠对上升冒号 / 盲肠侧面的稠密的膀胱的集体损害,不与冒号 / 盲肠的腔交流。在膀胱的集体损害的完全的开的切除以后,粗野病理学的检查表明阑尾的残余的浮肿的膀胱的膨胀充满了粘蛋白的材料。在组织病理学说的检查上,附录的粘蛋白的包囊腺瘤被证实。我们在远侧的可行阑尾的残余报导粘液囊肿形成的这稀罕不平常的迟了的复杂并发症,它是剩余物列在后面不完全后退阑尾切除术。这不平常的复杂并发症没在文学被描述,我们报导它以便加亮临床、放射学的怀疑的一个高索引为在已经经历了阑尾切除术周期性的腹的疼痛地介绍的一个病人从远侧的可行阑尾的残余产生的粘液囊肿的诊断是必要的事实。 | Maria Antony Johnson Damodaran Jyotibasu Palaniappan Ravichandran Satyanesan Jeswanth Devy Gounder Kannan RajagopalSurendran | 2006 | World Journal of Gastroenterology2006，12，3： | 2 |
| 6 | Performance of compostable baby used diapers in the composting process with the organic fraction of municipal solid waste显示文摘 | Joan Colón Maria Mestre-Montserrat Ignasi Puig-Ventosa Antoni Sánchez | 2013 | Waste Management2013，，5： | 1 |
| 7 | Heavy metals fractionation before,during and after composting of sewage sludge with natural zeolite显示文摘 | Antonis A Zorpas Vassilis J Inglezakis Maria Loizidou | 2008 | Waste Management2008，28，： | 1 |
| 8 | Physical activity is associated with bone geometry of premenarcheal girls in a dose-dependent manner 显示文摘 | Maria Michalopoulou Antonis Kambas Diamanda Leontsi- ni | 2013 | Metabolism2013，62，12： | 1 |
| 9 | Western and Mediterranean dietary patterns among Balearic Islands’ adolescents: socio-economic and lifestyle determinants显示文摘 | Maria del Mar Bibiloni Elisa Martínez Rosa Llull Antoni Pons Josep A Tur | 2011 | Public Health Nutrition2011，，4： | 1 |
| 10 | Removal of organic mater by coagulation enhanced with adsorption on PAC 显示文摘 | Maria Tomaszewska Sylwia Mozia Antoni W Morawski | 2004 | Desalination2004，161，： | 1 |
| 11 | Sawdust and natural zeolite as a bulking agent for improving quality of a composting product from anaerobically stabilized sewage sludge显示文摘 | Zorpas Antonis A Loizido Maria | 2008 | Bioresource Technology2008，99，16： | 1 |
| 12 | The effect of information literacy on physical education students’ perception of a course management system显示文摘 | Nikolaos Vernadakis Panagiotis Antoniou Maria Giannousi Eleni Zetou Efthimis Kioumourtzoglou | 2011 | Learning Media and Technology2011，，4： | 1 |
| 13 | Insertion of central venous catheters for hemodialysis using angiographic techniques in patients with previous multiple catheterizations显示文摘 | Ioannis Kotsikoris Apollon Zygomalas Theofanis Papas Dimitris Maras Polyvios Pavlidis Maria Andrikopoulou Antonis Tsanis Vasileios Alivizatos Nikolaos Bessias | 2011 | European Journal of Radiology2011，，9： | 1 |
| 14 | Investigation of bone marrow mesenchymal stem cells (BM MSCs) involvement in idiopathic pulmonary fibrosis (IPF)显示文摘 | Katerina M. Antoniou Helen A. Papadaki Giannoula Soufla Maria Christina Kastrinaki Athina Damianaki Helen Koutala Demetrios A. Spandidos Nikolaos M. Siafakas | 2010 | Respiratory Medicine2010，，10： | 1 |
| 15 | An association study between catalase -262C>T gene polymorphism, sodium-lithium countertrasport activity, insulin resistance, blood lipid parameters and their response to atorvastatin, in Greek dyslipidaemic patients and normolipidaemic controls显示文摘 | Maria Kosmidou Apostolos I. Hatzitolios Dimitra Molyva Nikolaos Raikos Christos Savopoulos Niki Daferera Vassileios Kokkas Antonis Goulas | 2009 | Free Radical Research2009，，4： | 1 |
| 16 | Metabotropic Glutamate Receptors in Glial Cells显示文摘 | Simona D'Antoni Antonio Berretta Carmela Maria Bonaccorso | 2008 | Neurochem Res2008，33，： | 1 |
| 17 | Ethanol production in membrane distillation bioreactor显示文摘 | Marek Gryta Antoni Waldemar Morawski and Maria Tomaszewske | 2000 | Catalysis Today2000，56，： | 1 |
| 18 | Randomized phase III clinical trial of a combined treatment with carnitine + celecoxib ± megestrol acetate for patients with cancer-related anorexia/cachexia syndrome显示文摘 | Clelia Madeddu Mariele Dessì Filomena Panzone Roberto Serpe Giorgia Antoni Maria Chiara Cau Lorenza Montaldo Quirico Mela Marco Mura Giorgio Astara Francesca Maria Tanca Antonio Macciò Giovanni Mantovani | 2011 | Clinical Nutrition2011，，2： | 1 |
| 19 | Re- moral of organic matter by coagulation enhanced with adsorption on PAC显示文摘 | Tonmszewska Maria Mozi- Sylwia Morawski Antoni W | 2004 | Desalination2004，161，1： | 1 |
| 20 | Differences between CAFs and their paired NCF from adjacent colonic mucosa reveal functional heterogeneity of CAFs, providing prognostic information显示文摘 | Mireia Berdiel-Acer Rebeca Sanz-Pamplona Alexandre Calon Daniel Cuadras Antoni Berenguer Xavier Sanjuan Maria José Paules Ramon Salazar Victor Moreno Eduard Batlle Alberto Villanueva David G. Molleví | 2014 | Molecular Oncology2014，，： | 1 |
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