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| 1 | Methods of computed tomography screening and management of lung cancer in Tianjin: design of a population-based cohort study显示文摘Objective: European lung cancer screening studies using computed tomography(CT) have shown that a management protocol based on measuring lung nodule volume and volume doubling time(VDT) is more specific for early lung cancer detection than a diameter-based protocol. However, whether this also applies to a Chinese population is unclear. The aim of this study is to compare the diagnostic performance of a volume-based protocol with a diameter-based protocol for lung cancer detection and optimize the nodule management criteria for a Chinese population.Methods: This study has a population-based, prospective cohort design and includes 4000 participants from the Hexi district of Tianjin, China. Participants will undergo low-dose chest CT at baseline and after 1 year. Initially, detected lung nodules will be evaluated for diameter and managed according to a routine diameter-based protocol(Clinical Practice Guideline in Oncology for Lung Cancer Screening, Version 2.2018). Subsequently, lung nodules will be evaluated for volume and management will be simulated according to a volume-based protocol and VDT(a European lung nodule management protocol). Participants will be followed up for 4 years to evaluate lung cancer incidence and mortality. The primary outcome is the diagnostic performance of the European volume-based protocol compared to diameter-based management regarding lung nodules detected using low-dose CT.Results: The diagnostic performance of volume-and diameter-based management for lung nodules in a Chinese population will be estimated and compared.Conclusions: Through the study, we expect to improve the management of lung nodules and early detection of lung cancer in Chinese populations. | Yihui Du Yingru Zhao Grigory Sidorenkov Geertruida H.de Bock Xiaonan Cui Yubei Huang Monique D.Dorrius Mieneke Rook Harry J.M.Groen Marjolein A.Heuvelmans Rozemarijn Vliegenthart Kexin Chen Xueqian Xie Shiyuan Liu Matthijs Oudkerk Zhaoxiang Ye | 2019 | Cancer Biology & Medicine2019，16，1： | 7 |
| 2 | Clinical characteristics and work-up of small to intermediate-sized pulmonary nodules in a Chinese dedicated cancer hospital显示文摘Objectives:To evaluate the characteristics and work-up of small to intermediate-sized pulmonary nodules in a Chinese dedicated cancer hospital.Methods:Patients with pulmonary nodules 4–25 mm in diameter detected via computed tomography(CT)in 2013 were consecutively included.The analysis was restricted to patients with a histological nodule diagnosis or a 2-year follow-up period without nodule growth confirming benign disease.Patient information was collected from hospital records.Results:Among the 314 nodules examined in 299 patients,212(67.5%)nodules in 206(68.9%)patients were malignant.Compared to benign nodules,malignant nodules were larger(18.0 mm vs.12.5 mm,P<0.001),more often partly solid(16.0%vs.4.7%,P<0.001)and more often spiculated(72.2%vs.41.2%,P<0.001),with higher density in contrast-enhanced CT(67.0 HU vs.57.5 HU,P=0.015).Final diagnosis was based on surgery in 232 out of 314(73.9%)nodules,166 of which were identified as malignant[30(18.1%)stage III or IV]and 66 as benign.In 36 nodules(11.5%),diagnosis was confirmed by biopsy and the remainder verified based on stability of nodule size at follow-up imaging(n=46,14.6%).Among 65 nodules subjected to gene(EGFR)mutation analyses,28(43.1%)cases(EGFR19 n=13;EGFR21 n=15)were identified as EGFR mutant and 37(56.9%)as EGFR wild-type.Prior to surgery,the majority of patients[n=194(83.6%)]received a contrast-enhanced CT scan for staging of both malignant[n=140(84.3%)]and benign[n=54(81.8%)]nodules.Usage of positron emission tomography(PET)-CT was relatively uncommon[n=38(16.4%)].Conclusions:CT-derived nodule assessment assists in diagnosis of small to intermediate-sized malignant pulmonary nodules.Currently,contrast-enhanced CT is commonly used as the sole diagnostic confirmation technique for pre-surgical staging,often resulting in surgery for late-stage disease and unnecessary surgery in cases of benign nodules. | Xiaonan Cui Daiwei Han Marjolein AHeuvelmans Yihui Du Yingru Zhao Lei Zhang Harry JMGroen Geertruida Hde Bock Monique DDorrius Matthijs Oudkerk Rozemarijn Vliegenthart Zhaoxiang Ye | 2020 | Cancer Biology & Medicine2020，17，1： | 5 |
| 3 | The DNA-binding factor Ctcf critically controls gene expression in macrophages显示文摘巨噬细胞在免疫和动态平衡起一个重要作用。在经由特定的受体的病原体识别之上,他们很快导致煽动性的回答。这个过程紧在 transcriptional 水平被控制。DNA 有约束力的锌手指蛋白质 CCCTC 有约束力的因素(Ctcf ) 是远程的染色质相互作用的一个关键管理者并且协调在抄写因素和基因表达式进程之间的特定的通讯。在这研究, Ctcf 基因被使用转基因的 Cre-LoxP 系统明确地在 myeloid 房间删除。在 myeloid 房间的 Ctcf 基因的有条件的删除在 vivo 导致了温和显型。显著地展出的 Ctcf 缺乏的老鼠减少了主要 histocompatibility 的表示在肝的建筑群(MHC ) 班 II。Ctcf 缺乏的巨噬细胞表明了正常表面显型和吞噬作用能力。在像使用费的受体(TLR ) 之上刺激,他们生产了支持 inflammatory cytokines IL-12 和 IL-6 的正常层次,但是表明了一个强烈损害的能力生产肿瘤坏死因素(TNF ) 和 IL-10,以及表示 IL-10 家庭成员 IL-19, IL-20 和 IL-24。一起拿,我们的数据表明涉及巨噬细胞功能调整的 Ctcf 的一个角色。 | Tatjana Nikolic Dowty Movita Margaretha EH Lambers Claudia Ribeiro de Almeida] Paula Biesta Kim Kreefft Marjolein JW de Bruijn Ingrid Bergen Niels Galjart Andre Boonstra Rudi Hendriks | 2014 | Cellular & Molecular Immunology2014，11，1： | 2 |
| 4 | Palliative therapy显示文摘 | Marjolein Y.V.Homs Ernst J.Kuipers Peter D.Siersema | 2005 | J Surg Oncol2005，，3： | 2 |
| 5 | Evaluation of current wet sludge disintegration techniques显示文摘 | Marjoleine P. J.Weemaes Willy H.Verstraete | 1999 | J Chem Technol Biotechnol1999，，2： | 2 |
| 6 | Inflammatory Markers and Loss of Muscle Mass (Sarcopenia) and Strength显示文摘 | Laura A. Schaap Saskia M.F. Pluijm Dorly J.H. Deeg Marjolein Visser | 2006 | The American Journal of Medicine2006，，6： | 2 |
| 7 | Glutathione and antioxidant enzymes serve complementary roles in protecting activated hepatic stellate cells against hydrogen peroxide-induced cell death显示文摘 | Sandra Dunning Atta ur Rehman Marjolein H. Tiebosch Rebekka A. Hannivoort Floris W. Haijer Jannes Woudenberg Fiona A.J. van den Heuvel Manon Buist-Homan Klaas Nico Faber Han Moshage | 2013 | BBA - Molecular Basis of Disease2013，，： | 2 |
| 8 | Neurohormonal activation and the chronic heart failure syndrome in adults with congenital heart disease显示文摘 | Marjolein L Michael K Andrew JS | 2002 | Circ J2002，106，1： | 1 |
| 9 | History and factors associated with diabetic foot ulcers in Norwa- y: The Nord-Trendelag Health Study 显示文摘 | Marjolein M Kristian M | 2008 | Scandinavian Journal of Public Health2008，36，： | 1 |
| 10 | The white spot syndrome virus envelope protein VP28 is involved in the irlfection of shrimp显示文摘 | Marielle C W van Hulten Jeroen Witteveldt Marjolein Snippe M Vlak | 2001 | Virology2001，285，： | 1 |
| 11 | The Development of Green Care in Western European Countries显示文摘 | Dorit Karla Haubenhofer Marjolein Elings Jan Hassink Rachel Elizabeth Hine | 2010 | Explore: The Journal of Science and Healing2010，，2： | 1 |
| 12 | Association between insulin-like growth factor-1 and bone mineral density in older women and men:the Framingham heart study显示文摘 | Jean AL Clifford JR Marjolein V | 1998 | J Clin Endocrinol Metab1998，83，12： | 1 |
| 13 | Sarcopenic obesity: definition, cause and consequences显示文摘 | Sari Stenholm Tamara B Harris Taina Rantanen Marjolein Visser Stephen B Kritchevsky Luigi Ferrucci | 2008 | Current Opinion in Clinical Nutrition and Metabolic Care2008，，6： | 1 |
| 14 | Power and dependence perspectives on outsoUrcing decisions显示文摘 | Marjolein C J Caniels Adriaan Roeleveld | 2009 | European Management Journal2009，27，6： | 1 |
| 15 | N-Myc downstream-reg- ulated gene 4 ( NDRG4 ) : A candidate tumor suppressor gene and potential biomarker for colorectal cancer显示文摘 | Veerle M Marjolein H F Lentjes M | 2009 | J Natl Cancer Inst2009，101，13： | 1 |
| 16 | TEB4 is a C4HC3 RING finger--containing ubiquitin ligase of the endoplasmic reticulum显示文摘 | GERCO H MARJOLEIN K SJAAK VV | 2005 | Biochem2005，388，： | 1 |
| 17 | Markers for EGFR pathway activation as predictor of outcome in metastatic colorectal cancer patients treated with or without cetuximab显示文摘 | Jolien Tol Jeroen R. Dijkstra Marjolein Klomp Steven Teerenstra Martin Dommerholt M. Elisa Vink-B?rger Patricia H. van Cleef J. Han van Krieken Cornelis J.A. Punt Iris D. Nagtegaal | 2010 | European Journal of Cancer2010，，11： | 1 |
| 18 | SARS- Coronavirus replication is supported by a reticulovesicular network of modified endoplasmic reticulum 显示文摘 | Kvin Knoops Marjolein Kikkert Sjoerd HE | 2008 | PLoS Biol2008，205，7： | 1 |
| 19 | Coxsackie adenovirus receptor (CAR) regulates integrin function through activation of p44/42 MAPK显示文摘 | Charlotte Farmer Penny E. Morton Marjolein Snippe George Santis Maddy Parsons | 2009 | Experimental Cell Research2009，，： | 1 |
| 20 | Exenatide Reduces Infarct Size and Improves Cardiac Function in a Porcine Model of Ischemia and Reperfusion Injury显示文摘 | Leo Timmers José P.S. Henriques Dominique P.V. de Kleijn J. Hans DeVries Hans Kemperman Paul Steendijk Cees W.J. Verlaan Marjolein Kerver Jan J. Piek Pieter A. Doevendans Gerard Pasterkamp Imo E. Hoefer | 2009 | Journal of the American College of Cardiology2009，，： | 1 |
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