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| 1 | Liver cancer incidence and mortality in China: Temporal trends and projections to 2030显示文摘Objective: Liver cancer is one of the most common cancers and major cause of cancer deaths in China,which accounts for over 50% of new cases and deaths worldwide.The systematic liver cancer statistics including of projection through 2030 could provide valuable information for prevention and control strategies in China,and experience for other countries.Methods: The burden of liver cancer in China in 2014 was estimated using 339 cancer registries' data selected from Chinese National Cancer Center(NCC).Incident cases of 22 cancer registries were applied for temporal trends from 2000 to 2014.The burden of liver cancer through 2030 was projected using age-period-cohort model.Results: About 364,800 new cases of liver cancer(268,900 males and 95,900 females) occurred in China,and about 318,800 liver cancer deaths(233,500 males and 85,300 females) in 2014.Western regions of China had the highest incidence and mortality rates.Incidence and mortality rates decreased by about 2.3% and 2.6% per year during the period of 2000-2014,respectively,and would decrease by more than 44% between 2014 and 2030 in China.The young generation,particularly for those aged under 40 years,showed a faster down trend.Conclusions: Based on the analysis,incidence and mortality rates of liver cancer are expected to decrease through 2030,but the burden of liver cancer is still serious in China,especially in rural and western areas.Most cases of liver cancer in China can be prevented through vaccination and more prevention efforts should be focused on high risk groups. | Rongshou Zheng Chunfeng Qu Siwei Zhang Hongmei Zeng Kexin Sun Xiuying Gu Changfa Xia Zhixun Yang He Li Wenqiang Wei Wanqing Chen Jie He | 2018 | Chinese Journal of Cancer Research2018，30，6： | 132 |
| 2 | Cancer incidence and mortality in China, 2014显示文摘Background: National Central Cancer Registry of China(NCCRC) updated nationwide cancer statistics using population-based cancer registry data in 2014 collected from all available cancer registries.Methods: In 2017, 449 cancer registries submitted cancer registry data in 2014, among which 339 registries' data met the criteria of quality control and were included in analysis. These cancer registries covered 288,243,347 population, accounting for about 21.07% of the national population in 2014. Numbers of nationwide new cancer cases and deaths were estimated using calculated incidence and mortality rates and corresponding national population stratified by area, sex, age group and cancer type. The world Segi's population was applied for agestandardized rates.Results: A total of 3,804,000 new cancer cases were diagnosed, the crude incidence rate was 278.07/100,000(301.67/100,000 in males, 253.29/100,000 in females) and the age-standardized incidence rate by world standard population(ASIRW) was 186.53/100,000. Calculated age-standardized incidence rate was higher in urban areas than in rural areas(191.6/100,000 vs. 179.2/100,000). South China had the highest cancer incidence rate while Southwest China had the lowest incidence rate. Cancer incidence rate was higher in female for population between20 to 54 years but was higher in male for population younger than 20 years or over 54 years. A total of 2,296,000 cancer deaths were reported, the crude mortality rate was 167.89/100,000(207.24/100,000 in males,126.54/100,000 in females) and the age-standardized mortality rate by world standard population(ASMRW) was106.09/100,000. Calculated age-standardized mortality rate was higher in rural areas than in urban areas(110.3/100,000 vs. 102.5/100,000). East China had the highest cancer mortality rate while North China had the lowest mortality rate. The mortality rate in male was higher than that in female. Common cancer types and major causes of cancer death differed between age group and sex.Conclusions: Heavy cancer burden and its disparities between area, sex and age group pose a major challenge to public health in China. Nationwide cancer registry plays a crucial role in cancer prevention and control. | Wanqing Chen Kexin Sun Rongshou Zheng Hongmei Zeng Siwei Zhang Changfa Xia Zhixun Yang He Li Xiaonong Zou Jie He | 2018 | Chinese Journal of Cancer Research2018，30，1： | 832 |
| 3 | Breast cancer incidence and mortality in women in China: temporal trends and projections to 2030显示文摘Objective:Breast cancer was the most common cancer and the fifth cause of cancer deaths among women in China in 2015.The evaluation of the long-term incidence and mortality trends and the prediction of the future burden of breast cancer could provide valuable information for developing prevention and control strategies.Methods:The burden of breast cancer in China in 2015 was estimated by using qualified data from 368 cancer registries from the National Central Cancer Registry.Incident cases and deaths in 22 cancer registries were used to assess the time trends from 2000 to 2015.A Bayesian age-period-cohort model was used to project the burden of breast cancer to 2030.Results:Approximately 303,600 new cases of breast cancer(205,100 from urban areas and 98,500 from rural areas)and 70,400 breast cancer deaths(45,100 from urban areas and 24,500 from rural areas)occurred in China in 2015.Urban regions of China had the highest incidence and mortality rates.The most common histological subtype of breast cancer was invasive ductal carcinoma,followed by invasive lobular carcinoma.The age-standardized incidence and mortality rates increased by 3.3%and 1.0%per year during 2000–2015,and were projected to increase by more than 11%until 2030.Changes in risk and demographic factors between 2015 and 2030 in cases are predicted to increase by approximately 13.3%and 22.9%,whereas deaths are predicted to increase by 13.1%and 40.9%,respectively.Conclusions:The incidence and mortality of breast cancer continue to increase in China.There are no signs that this trend will stop by 2030,particularly in rural areas.Effective breast cancer prevention strategies are therefore urgently needed in China. | Shaoyuan Lei Rongshou Zheng Siwei Zhang Ru Chen Shaoming Wang Kexin Sun Hongmei Zeng Wenqiang Wei Jie He | 2021 | Cancer Biology & Medicine2021，18，3： | 53 |
| 4 | Global patterns of breast cancer incidence and mortality:A population-based cancer registry data analysis from 2000 to 2020显示文摘Background:Breast cancer is the most commonly diagnosed cancer and leading cause of cancer death among women worldwide but has patterns and trends which vary in different countries.This study aimed to evaluate the global patterns of breast cancer incidence and mortality and analyze its temporal trends for breast cancer prevention and control.Methods:Breast cancer incidence and mortality data in 2020 were obtained from the GLOBOCAN online database.Continued data from the Cancer Incidence in Five Continents Time Trends,the International Agency for Research on cancer mortality and China National Central Cancer Registry were used to analyze the time trends from 2000 to 2015 through Joinpoint regression,and annual average percent changes of breast cancer incidence and mortality were calculated.Association between Human Development Index and breast cancer incidence and mortality were estimated by linear regression.Results:There were approximately 2.3 million new breast cancer cases and 685,000 breast cancer deaths worldwide in 2020.Its incidence and mortality varied among countries,with the age-standardized incidence ranging from the highest of 112.3 per 100,000 population in Belgium to the lowest of 35.8 per 100,000 population in Iran,and the age-standardized mortality from the highest of 41.0 per 100,000 population in Fiji to the lowest of 6.4 per 100,000 population in South Korea.The peak age of breast cancer in some Asian and African countries were over 10 years earlier than in European or American countries.As for the trends of breast cancer,the age-standardized incidence rates significantly increased in China and South Korea but decreased in the United States of America(USA)during 2000-2012.Meanwhile,the age-standardized mortality rates significantly increased in China and South Korea but decreased in the United Kingdom,the USA,and Australia during 2000 and 2015.Conclusions:The global burden of breast cancer is rising fast and varies greatly among countries.The incidence and mortality rates of breast cancer increased rapidly in China and South Korea but decreased in the USA.Increased health awareness,effective prevention strategies,and improved access to medical treatment are extremely important to curb the snowballing breast cancer burden,especially in the most affected countries. | Shaoyuan Lei Rongshou Zheng Siwei Zhang Shaoming Wang Ru Chen Kexin Sun Hongmei Zeng Jiachen Zhou Wenqiang Wei | 2021 | Cancer Communications2021，41，11： | 55 |
| 5 | Paleogene-Neogene stratigraphic realm and sedimentary sequence of the Qinghai-Tibet Plateau and their response to uplift of the plateau显示文摘Based on the data of 1:250000 geological mapping completed by CGS and the previous literature of the Cenozoic strata, 98 remnant basins and 5 stratigraphic realms with 13 stratigraphic subrealms have been recognized on the Qinghai-Tibet Plateau and its adjacent area. Through the research of the types of remnant basins, tectonic setting, stratigraphic sequence and sedimentary characteristics, contact relationship between the strata, the formation time and evolution history of sediments, we divided the uplift process and sedimentary response of the Qinghai-Tibet Plateau into 3 stages and 8 sub-stages, namely, subduction-collision uplift stage (65-34 Ma) with three sub-stages, intercontinental convergence and compressive uplift stage (34-13 Ma) with three sub-stages, and intercontinental isostatic adjustment uplift stage (since 13 Ma) with two sub-stages. | ZHANG KeXin WANG GuoCan JI JunLiang LUO ManSheng KOU XiaoHu WANG YueMing XU YaDong CHEN FenNing CHEN RuiMing SONG BoWen ZHANG JianYu LIANG YinPing | 2010 | Science China Earth Sciences2010，53，9： | 49 |
| 6 | Cenozoic sedimentary records and geochronological constraints of differential uplift of the Qinghai-Tibet Plateau显示文摘Geological mapping data (1:250000) in the Qinghai-Tibet Plateau and its adjacent regions reveal the sediment sequences, distribution and tectonic evolution of the 92 Tertiary remnant basins. Southern Tibet and the Yecheng area in Xinjiang, located at southern and northwestern margins of the Qinghai-Tibet Plateau, respectively, were parts of the Neo-Tethys remnant sea in the Paleogene. In southern Tibet, both the subabyssal and abyssal sequences occur at the Gyangze, Saga, Guoyala, and Sangmai areas. The deep-water facies successions outcrop in the west, whereas the shallow-water facies sequences in the east, indicating the east to the west retreat of the Neo-Tethys Ocean. The retreat of the Neo-Tethys Ocean in the east was contributed to the earlier tectonic uplift of the eastern Qinghai-Tibet Plateau. The uplift process of the Plateau from the Late Cretaceous to Pliocene is described as follows: During the Late Cretaceous, tectonic uplift of the Qinghai-Tibet Plateau occurred in the northeastern part and the configuration of the Qinghai-Tibet Plateau was characterized by rise in the northeast and depression in the west. In the Paleocene-Eocene interval, the Tengchong-Baingoin and Kuyake-Golmud areas experienced local tectonic uplifting, the West Kunlun uplift zone broadened easterly, the Qilian uplift zone broadened southerly, and the Songpan-Garzê uplift zone shrank easterly. The Oligocene configuration of the Qinghai-Tibet Plateau was characterized by mountain chains rising along its margins and sedimentary basins in the central part because of tectonic uplifts of the Gangdisê and the Himalaya blocks. Meanwhile, the Kunlun-Altyn-Qilian uplift zones have also broadened southerly and northerly. In contrast, the great uplift zones of the Gangdisê, the Himalaya, the Karakorum, and the Kunlun blocks characterize the paleogeographic contours of the Qinghai-Tibet Plateau during the Miocene-Pliocene. Additionally, the thermochronological data on tectonic uplift events in southern Tibet, West Kunlun Mountains, Altyn Tagh, eastern Tibet, and western Sichuan all suggest that the most intense deformation occurred at 13-8 Ma and since 5 Ma, respectively, corresponding to two great uplift periods in Neogene. As a result, turnover of paleogeographic configuration of the Qinghai-Tibet Plateau occurred during the Neogene, experiencing a change from high contours in the east in the pre-Oligocene to high contours in the west at the end-Pliocene. The uplift of the Qinghai-Tibet Plateau during the Cenozoic was episodic, and the uplifts of various blocks within the Plateau were spatially and chronologically different. | ZHANG KeXin WANG GuoCan CAO Kai LIU Chao XIANG ShuYuan HONG HanLie KOU XiaoHu XU YaDong CHEN FenNing MENG YanNing CHEN RuiMing | 2008 | Science China Earth Sciences2008，51，11： | 31 |
| 7 | Precise timing of the Early Paleozoic metamorphism and thrust deformation in the Eastern Kunlun Orogen显示文摘In Dulan County, Qinghai Province NW China, the arc volcanic sequences in the northern side of the Central Fault of the East Kunlun were metamorphosed progressively from upper greenschist facies in the south to epidote-amphibolite facies in the north. High-angle thrust deformation was developed synchronously with the peak metamor-phim and superimposed with later low-angle striking-slip deformation. Zircon U-Pb dating yields a concordant age of (448±4) Ma for the metavolcanics. Syn-kinematic hornblende and muscovite separated from the high-angle thrusting belt give 40Ar-39Ar plateau age of (427±4) Ma and 408 Ma, respectively. These results precisely constrain the timing of the closure of early Paleozoic volcanic basin (Proto-Tethys) over the eastern portion of the East Kunlun Orogen, and the thrust tectonic slice had a cool rate of ca. 9°C/Ma. | CHEN Nengsong SUN Min HE Lei ZHANG Kexin WANG Guocan | 2002 | Chinese Science Bulletin2002，47，13： | 28 |
| 8 | Annual cost of illness of stomach and esophageal cancer patientsin urban and rural areas in China: A multi-center study显示文摘Objective: Stomach and esophageal cancer are imposing huge threats to the health of Chinese people whereas there were few studies on the financial burden of the two cancers.Methods: Costs per hospitalization of all patients with stomach or esophageal cancer discharged between September 2015 and August 2016 in seven cities/counties in China were collected, together with their demographic information and clinical details. Former patients in the same hospitals were sampled to collect information on annual direct non-medical cost, indirect costs and annual number of hospitalization. Annual direct medical cost was obtained by multiplying cost per hospitalization by annual number of hospitalization. Annual cost of illness(ACI)was obtained by adding the average value of annual direct medical cost, direct non-medical cost and indirect cost,stratified by sex, age, clinical stage, therapy and pathologic type in urban and rural areas. Costs per hospitalization were itemized into eight parts to calculate the proportion of each part. All costs were converted to 2016 US dollars(1 USD=6.6423 RMB).Results: Totally 19,986 cases were included, predominately male. Mean ages of stomach cancer and urban patients were lower than that of esophageal cancer and rural patients. ACI of stomach and esophageal cancer patients were $10,449 and $13,029 in urban areas, and $2,927 and $3,504 in rural areas, respectively. Greater ACI was associated with male, non-elderly patients as well as those who were in stage I and underwent surgeries.Western medicine fee took the largest proportion of cost per hospitalization.Conclusions: The ACI of stomach and esophageal cancer was tremendous and varied substantially among the population in China. Preferential policies of medical insurance should be designed to tackle with this burden and further reduce the health care inequalities. | Zhixun Yang Hongmei Zeng Ruyi Xia Qian Liu Kexin Sun Rongshou Zheng Siwei Zhang Changfa Xia He Li Shuzheng Liu Zhiyi Zhang Yuqin Liu Guizhou Guo Guohui Song Yigong Zhu Xianghong Wu Bingbing Song Xianzhen Liao Yanfang Chen Wenqiang Wei Guihua Zhuang Wanqing Chen | 2018 | Chinese Journal of Cancer Research2018，30，4： | 22 |
| 9 | Late Caledonian Ductile Thrusting Deformation in the Central East Kunlun Belt, Qinghai, China and Its Significance: Evidence from Geochronology显示文摘A high-angle ductile thrusting deformation with top-to-the-north movement penetratively developed in the Proterozoic-Early Paleozoic metamorphic rocks along the Central East Kunlun beR. The deformed rocks suffered epidote-amphibolite facies metamorphism. On the basis of our previous study, we present more data in this paper to further support that the ductile thrust deformation occurred in the later Caledonian and more detailed information about the deformation.A zircon U-Pb concordant age of 446±2.2 Ma of a deformed granodiorite in the ductile thrust zone was obtained and can be interpreted as the lower limit of the deformation. A syntectonically crystallized and also strongly deformed hornblende Ar/Ar dating gives an Ar/Ar plateau age of 426.5±3.8 Ma, which represents the deformation age. A strongly orientated muscovite gives an Ar/Ar plateau age of 408±1.6Ma, representing the cooling age after the peak temperature, constraining the upper limit of the ductile thrust deformation. This ductile thrust deformation can be interpreted as the result of the closing of the Central East Kunlun archipelago ocean. To the north, At/At plateau ages of 382.9±0.2 Ma and 386.8±0.8 Ma of muscovite in the deformed Xiaomiao Group represent the uplift cooling ages of deeper rocks after the thrusting movement. The original thrusting foliation has a low angle. A rotation model was put forward to explain the development of the foliation from the original low-angle to present high-angle dipping. | WANG Guocan, CHEN Nengsong, ZHU Yunhai and ZHANG Kexin Faculty of Earth Sciences, China University of Geosciences, Wuhan, Hubei 430074 E-mail: wgcan@cug.edu.cn Ren Xifei, Liu Ruixun and Xie Guanglian | 2003 | Acta Geologica Sinica(English Edition)2003，77，3： | 18 |
| 10 | New paleontological evidence on time determination of the east part of the Eastern Kunlun Mélange and its tectonic significance显示文摘New paleontological evidence suggests that the composition of the matrix and slices from the middle and the south of the Eastern Kunlun Mélange Belt is very complex, ranging from Proterozoic to Mesozoic in geological time. A Cambrian acritarch assemblage has been discovered from the middle part of the Eastern Kunlun Mélange, a Neoproterozoic to the early Paleozoic acritarch assemblage has been discovered from the south of the Eastern Kunlun Mé lange, and so has been an Early Permian radiolarian from the A’nyemaqen Mélange in Buqing- shan. In addition, some sporopollen has been obtained from the Mesozoic tectonic slices. The above-mentioned paleontological evidence indicates that the Eastern Kunlun Orogenic Belt experienced two episodes from ocean to continent from the Neoproterozoic to the Early Paleo- zoic and in the Late Paleozoic respectively. In the process of intracontinent development in Mesozoic, because of heavy thrust-nappe, strike-slip sheer and crust shortening, the Mesozoic formation was intercalated in mélange by slices and the Eastern Kunlun Orogenic Belt became more complex. | ZHANG Kexin LIN Qixiang ZHU Yunhai YIN Hongfu LUO Mansheng CHEN Nengsong WANG Guocan | 2004 | Science China Earth Sciences2004，47，10： | 17 |
| 11 | Colorectal cancer burden and trends:Comparison between China and major burden countries in the world显示文摘Objective:To summarize the colorectal cancer(CRC)burden and trend in the world,and compare the difference of CRC burden between other countries and China.Methods:Incidence and mortality data were extracted from the GLOBOCAN2018 and Cancer Incidence in Five Continents.Age-specific incidence trend was conducted by Joinpoint analysis and average annual percent changes were calculated.Results:About 1.85 million new cases and 0.88 million deaths were expected in 2018 worldwide,including 0.52 million(28.20%)new cases and 0.25 million(28.11%)deaths in China.Hungary had the highest age-standardized incidence and mortality rates in the world,while for China,the incidence and mortality rates were only half of that.CRC incidence and mortality were highly correlated with human development index(HDI).Unlike the rapid increase in Republic of Korea and the downward trend in Canada and Australia,the age-standardized incidence rates by world standard population in China and Norway were rising gradually.The age-specific incidence rate in the age group of 50-59 years in China was increasing rapidly,while in Republic of Korea and Canada,the fastest growing age group was 30-39 years.Conclusions:The variations of CRC burden reflect the difference of risk factors,as well as levels of HDI and screening(early detection activities).The burden of CRC in China is high,and the incidence of CRC continues to increase,which may lead to a sustained increase in the burden of CRC in China in the future.Screening should be expanded to control CRC,and focused on young people in China. | Jiachen Zhou Rongshou Zheng Siwei Zhang Hongmei Zeng Shaoming Wang Ru Chen Kexin Sun Minjuan Li Jianhua Gu Guihua Zhuang Wenqiang Wei | 2021 | Chinese Journal of Cancer Research2021，33，1： | 16 |
| 12 | CMIP6和CMIP5模式对中国极端温度的模拟能力的评估显示文摘本文评估了CMIP5和CMIP6模式对中国在1979-2005年期间的极端温度的模拟性能。结果表明:CMIP6模式可以很好地再现年最大日最高气温,年最小日最低气温和霜冻日数的空间分布特征。对于年最大日最高气温,持续暖日日数和暖昼,CMIP6模式间的不确定性相对于CMIP5模式有所降低。并且,CMIP6模式也能表现出观测到的极端温度的趋势。然而,CMIP6模式再现暖昼和冷夜的能力仍然不足,特别是在青藏高原上存在明显的冷偏差或者暖偏差对于某些指数。单个CMIP6或CMIP5模式的模拟能力就不同的指数而有所不同,某些模式的模拟能力较为突出。对于一些来自同一机构不同版本的模式,改进的CMIP6模式与CMIP5模式的模拟结果没有明显差异。多模式中位数平均的模拟效果优于大多数单个模式。 | LUO Neng GUO Yan GAO Zhibo CHEN Kexin CHOU Jieming | 2020 | Atmospheric and Oceanic Science Letters2020，13，6： | 15 |
| 13 | Cancer statistics in Chinese older people,2022:current burden,time trends,and comparisons with the US,Japan,and the Republic of Korea显示文摘Largely due to population ageing,the cancer burden from older people has been rising,which imposed considerable pressure on current Chinese healthcare system.We provide comprehensive information about cancer burden of Chinese older people based on the most recent data from National Central Cancer Registry of China.The logarithmic linear regression was used to project the current cancer burden in 2022,and Joinpoint regression was used for temporal trend analysis from 2000 to 2017.We also estimated cancer statistics of older people in the US,Japan and the Republic of Korea for comparisons.It is estimated that 2.79 million cases and 1.94 million deaths occur for Chinese older people,representing 55.8%and 68.2%of cases and deaths in all population in 2022.The overall cancer incidence rate gradually increased among older women,while the mortality rates declined for both sexes.Notably,approximately 10.0%of all cases and 17.7%of all deaths are from people aged over 80 years,and cancer incidence and mortality in this age group showed upward trends for women.Lung cancer and digestive cancers are the leading cancer types for Chinese older people.Compared with other countries,China has lower incidence rates but higher mortality rates for older people.The rapidly growing burden of prostate cancer,breast cancer,colorectal cancer,and declines in esophageal cancer,stomach cancer,and liver cancer among older people indicate the cancer pattern in China is being in a transition stage to that in developed countries.Our findings imply that it should be the national health priority to meet the growing demands for cancer diagnosis,treatment and care services from the older people as the rapid population ageing in next few decades. | Wen Ju Rongshou Zheng Siwei Zhang Hongmei Zeng Kexin Sun Shaoming Wang Ru Chen Li Li Wenqiang Wei Jie He | 2023 | Science China(Life Sciences)2023，66，5： | 15 |
| 14 | Anachronistic facies in the Lower Triassic of South China and their implications to the ecosystems during the recovery time显示文摘The end-Permian mass extinction not only severely distressed the Paleozoic ecosystems but also dramatically changed the sedimentary systems, resulting in a peculiar Early Triassic ecosystem and submarine environment during the recovery time following the mass extinction. The Lower Triassic is characteristic of the wide occurrence of various distinctive sediments and related sedimentary structures, such as flatpebble conglomerates, vermicular limestone, subtidal wrinkle structures, microbialite, carbonate seafloor fans, thin-bedded limestone and zebra limestone-mudstone. These sediments were common in the Precambrian to Early Ordovician marine settings, and then they occurred only in some extreme and unusual environments with the expansion of metazoan faunas. However, the Early Triassic witnessed an 'anachronistic' reappearance of some distinctive sedimentary records in normal shallow marine settings. The study of these anachronistic facies should be of great importance for the understanding of the unique ecosystem and marine environment through the great Paleozoic-Mesozoic transition. The anachronistic facies characterized by vermicular limestone have been documented in many localities in South China and occur at various horizons of the Lower Triassic. Most types of re- ported distinctive sediments over the world have been observed in the Lower Triassic of South China. This provides an excellent opportunity for understanding the Early Triassic environment and its co- evolution with the biotic recovery. Among the anachronistic facies the vermicular limestone is the most characteristic and common distinctive sediments in the Lower Triassic of South China but has received relatively few investigations. Taking it as a case study, we will detail the variation of vermicular limestone and its stratigraphic distribution in the Three Gorges area, Hubei Province. The investigation on the vermicular limestone and other distinctive sediments from the Lower Triassic of South China further indicates that the appearance of anachronistic facies immediately following the mass extinction and the elimination from normal shallow marine facies with the radiation of Mesozoic marine faunas imply the natural response of the sedimentary systems and ecosystems to the great Paleozoic-Mesozoic transitional events and their induced harsh environments. Therefore, the ups and downs of the anachronistic facies may act as a proxy for the evolution of ecosystems independent of fossil analyses. | XiaoMing Zhao (1) (2) JinNan Tong (1) HuaZhou Yao (2) KeXin Zhang (1) Chen Zq (3) | 2008 | Science China Earth Sciences2008，51，11： | 14 |
| 15 | U-Pb dating of zircon from the Central Zone of the East Kunlun Orogen and its implications for tectonic evolution显示文摘LA-ICP-MS and SHRIMP U-Pb dating of zircons from orthogneisses and amphibolite from the Central Zone of the Kunlun Orogen is reported in this paper. One orthogneiss sample has metamorphic zircons yielding weighted average 206Pb/238U age of 517.0 +5.0/-6.0 Ma, and the other orthogneiss sample con- tains zircons with inherited magmatic cores giving three population 207Pb/206Pb ages of 955 Ma, 895 Ma and 657 Ma for the magmatic protolith, and metamorphic recrystallized rims with peak 206Pb/238U ages of 559 +12/?17 Ma and 516 ± 13 Ma. The amphibolite yielded three populations of weighted average 206Pb/238U age of 482.0 +10/?8.0 Ma, 516.2 ± 5.8 Ma and 549 ± 10 Ma for the metamorphic zircons. These dating results recorded the tectonothermal events that occurred in the early Paleozoic and the Pre- cambrian time. The records of the Cambrian magmatic-metamorphic event in the Qinling Orogen, the Altyn Tagh belt, north margin of the Qaidam Block and the Kunlun Orogen suggest that continental assembly probably occurred in the early evolutionary history of the Proto-Tethys. | CHEN NengSong SUN Min WANG QinYan ZHANG KeXin WAN YuSheng CHEN HaiHong | 2008 | Science China Earth Sciences2008，51，7： | 13 |
| 16 | Prostate cancer in Asia:A collaborative report显示文摘The incidence of prostate cancer(PCa)within Asian population used to be much lower than in the Western population;however,in recent years the incidence and mortality rate of PCa in some Asian countries have grown rapidly.This collaborative report summarized the latest epidemiology information,risk factors,and racial differences in PCa diagnosis,current status and new trends in surgery management and novel agents for castration-resistant prostate cancer.We believe such information would be helpful in clinical decision making for urologists and oncologists,health-care ministries and medical researchers. | Rui Chen Shancheng Ren 无 Ming Kwong Yiu Ng Chi Fai Wai Sam Cheng Lap Hong Ian Seiji Naito Tadashi Matsuda Elijah Kehinde Ali Kural Jason Yichun Chiu Rainy Umbas Qiang Wei Xiaolei Shi Liqun Zhou Jian Huang Yiran Huang Liping Xie Lulin Ma Changjun Yin Danfeng Xu Kexin Xu Zhangqun Ye Chunxiao Liu Dingwei Ye Xin Gao Qiang Fu Jianquan Hou Jianlin Yuan Dalin He Tiejun Pan Qiang Ding Fengshuo Jin Benkang Shi Gongxian Wang Xiuheng Liu Dongwen Wang Zhoujun Shen Xiangbo Kong Wanhai Xu Yaoliang Deng Haibo Xia Alexa NCohen Xu Gao Chuanliang Xu Yinghao Sun | 2014 | Asian Journal of Urology2014，1，1： | 13 |
| 17 | The epidemiology of colorectal cancer in China显示文摘Objective:Colorectal cancer(CRC)is one of the most common cancers and the major cause of cancer death in China.The aim of this study was to estimate the burden of CRC in China.Materials and methods:Data from the National Cancer Center(NCC)of China was used and stratified by area(urban/rural),sex(male/female)for analyzing the age-speci c incidence and mortality rates.Time trend of colorectal cancer was calculated based on the 22 high-quality cancer registries in China.National new cases and deaths of colorectal cancer were estimated using age-speci c rates multiplied by the corresponding national population in 2014.The Chinese population in 2000 and Segi’s world population were used to calculate age-standardized rates of colorectal cancer in China.Results:Overall,370,400 new colorectal cancer cases and 179,600 deaths were estimated in China in 2014,with about 214,100 new cases in men and 156,300 in women.Meanwhile,104,000 deaths cases of colorectal cancer were men and 75,600 deaths were women,which accounted for 9.74%and 7.82%of all cancer incidence and deaths in China,separately.Relatively higher incidence and mortality was observed in urban areas of China.And the Eastern areas of China showed the highest incidence and mortality.The age-standardized incidence and mortality rate of colorectal cancer has increased by about 1.9%per year for incidence and about 0.9%per year for mortality rate from 2000 to 2014.Conclusion:With gradually higher incidence and mortality rate in the past 15 years,colorectal cancer became a major challenge to China’s public health.E ective control strategies are needed in China. | Rongshou Zheng Hongmei Zeng Siwei Zhang Xiuying Gu Kexin Sun Changfa Xia Zhixun Yang He Li Wanqing Chen | 2018 | Global Health Journal2018，2，3： | 12 |
| 18 | Dynamic Changes in the Wetland Landscape Pattern of the Yellow River Delta from 1976 to 2016 Based on Satellite Data显示文摘The Yellow River Delta wetland is the youngest wetland ecosystem in China's warm temperate zone. To better understand how its landscape pattern has changed over time and the underlying factors responsible, this study analyzed the dynamic changes of wetlands using five Landsat series of images, namely MSS(Mulri Spectral Scanner), TM(Thematic Mapper), and OLI(Operational Land Imager) sensors in 1976, 1986, 1996, 2006, and 2016. Object-oriented classification and the combination of spatial and spectral features and both the Normalized Difference Vegetation Index(NDVI) and Normalized Difference Water Index(NDWI), as well as brightness characteristic indices, were used to classify the images in eCognition software. Landscape pattern changes in the Yellow River Delta over the past 40 years were then delineated using transition matrix and landscape index methods. Results show that: 1) from1976 to 2016, the total area of wetlands in the study area decreased from 2594.76 to 2491.79 km^2, while that of natural wetlands decreased by 954.03 km^2 whereas human-made wetlands increased by 851.06 km^2. 2) The transformation of natural wetlands was extensive: 31.34% of those covered by Suaeda heteropteras were transformed into reservoirs and ponds, and 24.71% with Phragmites australis coverage were transformed into dry farmland. Some human-made wetlands were transformed into non-wetlands types: 1.55% of reservoirs and ponds became construction land, and likewise 21.27% were transformed into dry farmland. 3) From 1976 to 2016, as the intensity of human activities increased, the number of landscape types in the study area continuously increased. Patches were scattered and more fragmented. The whole landscape became more complex. In short, over the past 40 years, the wetlands of the Yellow River Delta have been degraded, with the area of natural wetlands substantially reduced. Human activities were the dominant forces driving these changes in the Yellow River Delta. | CONG Pifu CHEN Kexin QU Limei HAN Jianbo | 2019 | Chinese Geographical Science2019，29，3： | 12 |
| 19 | Interpretation of breast cancer screening guideline for Chinese women显示文摘Breast cancer is the most common malignant tumor in Chinese women.Early screening is the best way to improve the rates of early diagnosis and survival of breast cancer patients.The peak onset age for breast cancer in Chinese women is considerably younger than those in European and American women.It is imperative to develop breast cancer screening guideline that is suitable for Chinese women.By summarizing the current evidence on breast cancer screening in Chinese women,and referring to the latest guidelines and consensus on breast cancer screening in Europe,the United States,and East Asia,the China Anti-Cancer Association and National Clinical Research Center for Cancer(Tianjin Medical University Cancer Institute and Hospital)have formulated population-based guideline for breast cancer screening in Chinese women.The guideline provides recommendations on breast cancer screening for Chinese women at average or high risk of breast cancer according to the following three aspects:age of screening,screening methods,and screening interval.This article provides more detailed information to support the recommendations in this guideline and to provide more direction for current breast cancer screening practices in China. | Yubei Huang Zhongsheng Tong Kexin Chen Ying Wang Peifang Liu Lin Gu Juntian Liu Jinpu Yu Fengju Song Wenhua Zhao Yehui Shi Hui Li Huaiyuan Xiao Xishan Hao | 2019 | Cancer Biology & Medicine2019，16，4： | 10 |
| 20 | ^(40)Ar-^(39)Ar and U-Pb ages of metadiorite from the East Kunlun Orogenic Belt: Evidence for Early-Paleozoic magmatic zone and excess argon in amphibole minerals显示文摘Single-grain zircon U-Pb and amphibole 40Ar-39Ar dating have been conducted on a deformed and metamorphosed diorite in the East Kunlun Orogenic Belt, which intruded into the middle Proterozoic Kuhai Group exposed in the south of Xiangride region, Dulan County, NW Qinghai Province. The zircon gives a concordant U-Pb age of (446.5±9.1) Ma. The amphibole yields Ar plateau age of (488.0±1.2) Ma and an isochronal age of (488.9±5.6) Ma. Age results of both stepwise released Ar and conventional K-Ar analysis are remarkably higher than that of zircon U-Pb, suggesting that the amphibole contains excess argon and the amphibole plateau age cannot be taken as the timing of metamorphism or deformation. The zircon age is interpreted to be crystallization age of the diorite pluton, which suggests that an Early-Paleozoic magmatic zone indeed existed in the East Kunlun Orogenic Belt stretching along the region south to the Golmud, Normuhong and Xiangride. | CHEN Nengsong, SUN Min, ZHANG Kexin & ZHU YunhaiFaculty of Earth Sciences, China University of Geosciences, Wuhan 430074, China Department of Earth Sciences, The University of Hong Kong, Hong Kong SAR, China | 2001 | Chinese Science Bulletin2001，46，4： | 10 |
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