|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Tenascin C upregulates interleukin-6 expression in human cardiac myofibroblasts via toll-like receptor 4显示文摘AIM:To investigate the effect of Tenascin C(TNC)on the expression of pro-inflammatory cytokines and matrixmetalloproteinases in human cardiac myofibroblasts(CMF).METHODS:CMF were isolated and cultured from patients undergoing coronary artery bypass grafting.Cultured cells were treated with either TNC(0.1μmol/L,24 h)or a recombinant protein corresponding to different domains of the TNC protein;fibrinogen-like globe(FBG)and fibronectin typeⅢ-like repeats(TNⅢ5-7)(both 1μmol/L,24 h).The expression of the proinflammatory cytokines;interleukin(IL)-6,IL-1β,TNFαand the matrix metalloproteinases;MMPs(MMP1,2,3,9,10,MT1-MMP)was assessed using real time RT-PCR and western blot analysis.RESULTS:TNC increased both IL-6 and MMP3(P<0.01)mR NA levels in cultured human CMF but had no significant effect on the other markers studied.The increase in IL-6 mR NA expression was mirrored by an increase in protein secretion as assessed by enzymelinked immunosorbant assay(P<0.01).Treating CMF with the recombinant protein FBG increased IL-6mR NA and protein(P<0.01)whereas the recombinant protein TNⅢ5-7 had no effect.Neither FBG nor TNⅢ5-7 had any significant effect on MMP3 expression.The expression of toll-like receptor 4(TLR4)in human CMF was confirmed by real time RT-PCR,western blot and immunohistochemistry.Pre-incubation of cells with TLR4neutralising antisera attenuated the effect of both TNC and FBG on IL-6 mR NA and protein expression.CONCLUSION:TNC up-regulates IL-6 expression in human CMF,an effect mediated through the FBG domain of TNC and via the TLR4 receptor. | Azhar Maqbool Emma J Spary Iain W Manfield Michaela Ruhmann Lorena Zuliani-Alvarez Filomena O Gamboa-Esteves Karen E Porter Mark J Drinkhill Kim S Midwood Neil A Turner | 2016 | World Journal of Cardiology2016，8，5： | 4 |
| 2 | Dominic Callaghan, UK to finally implement the WEEE Directive显示文摘 | MARK TURNER | 2007 | Computer law & security report2007，23，： | 1 |
| 3 | Conceptual Integration Networks显示文摘 | Gilles & Mark Turner | 1998 | Cognitive Science1998，，2： | 1 |
| 4 | Conceptual Integration Networks显示文摘 | Mark Turner | 1998 | San Diego:Cognitive Science1998，22，2： | 1 |
| 5 | Phase II study of thalidomide and radiation in children with newly diagnosed brain stem gliomas and glioblastoma multiforme显示文摘 | Christopher D. Turner Susan Chi Karen J. Marcus Tobey MacDonald Roger J. Packer Tina Young Poussaint Sridhar Vajapeyam Nicole Ullrich Liliana C. Goumnerova R. Michael Scott Caitlin Briody Christine Chordas Mary Ann Zimmerman Mark W. Kieran | 2007 | Journal of Neuro - Oncology2007，，1： | 1 |
| 6 | Conceptual Integration Networks显示文摘 | Fauconnier Gilles Mark Turner | 1998 | Cognitive Science1998，，2： | 1 |
| 7 | Effects of a Lactobacillus reuteri BR11 Mutant Deficient in the Cystine-Transport System in a Rat Model of Inflammatory Bowel Disease显示文摘 | Haydn L. Atkins Mark S. Geier Luca D. Prisciandaro Ashok K. Pattanaik Rebecca E. A. Forder Mark S. Turner Gordon S. Howarth | 2012 | Digestive Diseases and Sciences2012，，3： | 1 |
| 8 | Conceptual integration and formal expression显示文摘 | Turner Mark and Gilles Fauconnier | 1995 | Metaphor and Symbolic Activity1995，，10： | 1 |
| 9 | Identification and Characterization of a basic cell surface-located protein from Lactobacillus fermentun BR11显示文摘 | Mark S Turner T Peter H Louisem | 1997 | J Bacteriol1997，179，： | 1 |
| 10 | Conceptual Integration Networks显示文摘 | FAUCONNIER G MARK TURNER | 1998 | Cognitive Science1998，22，2： | 1 |
| 11 | Conceptual integ ration networks显示文摘 | Fauconnier Gilles and Mark Turner | 1998 | Cognitive Science1998，，22： | 1 |
| 12 | Is a single low dose of intratheeal morphine a useful adjunct to patient-controlled analgesia for post- operative pain control following lumbar spine surgery? A prelimi- nary report显示文摘 | Yen D Turner K Mark D | 2015 | Pain Res Manag2015，20，3： | 1 |
| 13 | Physical and psychiatric predictors of late whiplash syndrome显示文摘 | Mark A Turner Pamela J | 2003 | Injury2003，34，6： | 1 |
| 14 | Establishment and operation of a Good Manufacturing Practice‐compliant allogeneic Epstein‐Barr virus ( EBV )‐specific cytotoxic cell bank for the treatment of EBV ‐associated lymphoproliferative disease显示文摘 | Mark A. Vickers Gwen M. Wilkie Nicolas Robinson Nadja Rivera Tanzina Haque Dorothy H. Crawford Jacqueline Barry Neil Fraser David M. Turner Victoria Robertson Phil Dyer Peter Flanagan Helen R. Newlands John Campbell Marc L. Turner | 2014 | Br J Haematol2014，，： | 1 |
| 15 | Predictors of occult nodal metastasis in colon cancer: Results from a prospective multicenter trial显示文摘 | Nabil Wasif Mark B. Faries Sukamal Saha Roderick R. Turner David Wiese Martin D. McCarter Perry Shen Alexander Stojadinovic Anton J. Bilchik | 2010 | Surgery2010，，3： | 1 |
| 16 | A video-based technique for mapping intertidal beach bathymetry 显示文摘 | Stefan G J Aaminkhof Ian L Turner Thomas D T Dronkers Mark Caljouw Leann Nipius | 2003 | Coastal Engineering2003，49，： | 1 |
| 17 | Drooling in Parkinson's disease:a novel speech and language therapy intervention显示文摘 | Marks L Turner K O'Sullivan J | | 0，，： | 1 |
| 18 | Long-Term Fine Particulate Matter Exposure and Mortality From Diabetes in Canada显示文摘 | Robert D. Brook Sabit Cakmak Michelle C. Turner Jeffrey R. Brook Dan L. Crouse Paul A. Peters Aaron van Donkelaar Paul J. Villeneuve Orly Brion Michael Jerrett Randall V. Martin Sanjay Rajagopalan Mark S. Goldberg C. Arden Pope Richard T. Burnett | 2013 | Diabetes Care2013，，10： | 1 |
| 19 | Transgenic switchgrass ( Panicum virgatum L.) biomass is increased by overexpression of switchgrass sucrose synthase ( PvSUS1 )显示文摘 | Charleson R. Poovaiah Mitra Mazarei Stephen R. Decker Geoffrey B. Turner Robert W. Sykes Mark F. Davis C. Neal Stewart | 2015 | Biotechnology Journal2015，，4： | 1 |
| 20 | Conceptual integration net- works 显示文摘 | Fauconnier Gilles Mark Turner | 1998 | Cognitive Science1998，22，2： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员