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| 1 | Quantitative and qualitative in vitro analysis of the stem cell potential of hematopoietic cells purified from murine skeletal muscle显示文摘鼠科的骨胳的肌肉包含造血的干细胞,而是这个潜力到目前为止没被学习份量上或品质上试管内。确定造血的干细胞潜力,我们在 long-termculture 开始使用了高度净化的 SP/CD45 (+) 房间房间(LTC-IC ) 试金。从鼠科的肌肉净化的 SP/CD45 (+) 房间人口被发现从肌肉与 1/640 .Single-cell-sorted SP/CD45 (+) 房间的 LTC-IC 频率举办重要干细胞活动在白天 16 点的展出柔韧的 proliferative 活动试管内(380 褶层扩大) ,特别在有 OP-9 层的文化以后,那也支持胚胎的干细胞。放大房间人口与 myeloid 的证据从单个房间 exhibitedmultilineage 区别能力发源,淋巴并且 NK 房间标记。因此,我们的结果证明能被 LTC-IC 试金确定的造血的干细胞第一次也在鼠科的骨胳的肌肉和表演存在,在单个房间的水平,这些房间展出多行的年龄区别能力和主要 proliferative 潜力。 | Celine Haond Frangoise Farace Martine Guillier Yann Lecluse Frederic Mazurier William Vainchenker Ali G Turhan | 2007 | Cell Research2007，17，9： | 4 |
| 2 | Non-Protein-Coding RNAs and their Interacting RNA-Binding Proteins in the Plant Cell Nucleus显示文摘到外部因素的真核细胞的房间的复杂回答被几 transcriptional 和 post-transcriptional 过程管理。他们中的几个发生在原子核并且被连接了到 non-protein-coding RNA 的行动(或 npcRNAs ) ,长、小的 npcRNAs,那最近作为基因表示的主要管理者出现了。规章的 npcRNAs 在原子核行动包括沉默相关的 RNA, intergenic npcRNAs,自然 antisense RNA,和源于在全球抄写和 RNA 处理活动之间的相互影响的另外的异常 RNA (例如 Dicers 和 RNA 依赖的聚合酶) 。通常,产生 npcRNAs 通过和 RNA 有约束力的蛋白质的相互作用施加他们的规章的效果(或 RBP ) 在 ribonucleoprotein 粒子以内(或 RNP ) 。RBP 的一个大组通过小介入 RNA (siRNAs ) 在 silencing 机械被含有,他们的本地化建议几在原子核行动在整个染色体的规模触发 epigenetic 和染色质变化。另外的原子 RBP 与 npcRNAs 交往并且改变他们的本地化。在分裂酵母, RNA 有约束力的 Mei2p 蛋白质,在成熟分裂的玩的枢轴的角色,交往, meiotic npcRNA 在它的原子重新本地化包含了。相关过程在植物被识别了, ENOD40 npcRNA 被显示出到重新本地化从原子核的原子点缀的 RBP 到在 Medicago truncatula 的细胞质。植物 RBP 也通过和特定的 antisense 抄本的相互作用在 FLC 地点在调停 RNA 的染色质 silencing 被含有。在这评论,我们在植物开发和压力回答在原子相关的进程和他们的含意的上下文讨论在 RBP 和 npcRNAs 之间的相互作用。我们建议这些相互作用可以增加调制在原子染色体和环境之间并且,因而的相互作用的规章的层控制植物发展粘性。 | Celine Charon Ana Beatriz Moreno Florian Bardou Martin Crespi | 2010 | Molecular Plant2010，3，4： | 3 |
| 3 | Intellectual property valuation : how to approach the selection of an ap-propriate valuation method 显示文摘 | Celine Lagrost Donald Martin Cyrille Dubois and Sere Quazzotti | 2010 | Journal of Intellectual Capital2010，11，4： | 1 |
| 4 | Intellectual Property Valuation: How to Approach the Selection of an Appropriate Valua- tion Method显示文摘 | Celine Lagrost Donald Martin Cyrilte Dubois and Serge Quazzotti | 2010 | Journal of Intellectual Capital2010，11，4： | 1 |
| 5 | Study of Carbon Dioxide Adsorption on Mesoporotts Aminopropylsilane - Functionalized Silica and Titania Combining Microcalorimetry and in Situ Infrared Spectroscopy 显示文摘 | Kno fel Christina Martin Celine Llewellyn Philip L | 2009 | The Journal of Physical Chemistry C2009，113，21： | 1 |
| 6 | intellectual Property Valuation= How to Approach the Selection of an Appropriate Valuation Method 显示文摘 | Celine Lagrost Donald Martin Cyrille Dubois and Serge Quazzotti | 2010 | Journal of Intellectual Capital2010，，4： | 1 |
| 7 | The PIWI protein Aubergine recruits eIF3 to activate translation in the germ plasm显示文摘Piwi-interacting RNAs(piRNAs)and PIWI proteins are essential in germ cells to repress transposons and regulate mRNAs.In Drosophila,piRNAs bound to the PIWI protein Aubergine(Aub)are transferred maternally to the embryo and regulate maternal mRNA stability through two opposite roles.They target mRNAs by incomplete base pairing,leading to their destabilization in the soma and stabilization in the germ plasm.Here,we report a function of Aub in translation.Aub is required for translational activation of nanos mRNA,a key determinant of the germ plasm.Aub physically interacts with the poly(A)-binding protein(PABP)and the translation initiation factor elF3.Polysome gradient profiling reveals the role of Aub at the initiation step of translation.In the germ plasm,PABP and elF3d assemble in foci that surround Aub-containing germ granules,and Aub acts with elF3d to promote nanos translation.These results identify translational activation as a new mode of mRNA regulation by Aub,highlighting the versatility of PIWI proteins in mRNA regulation. | Anne Ramat Maria-Rosa Garcia-Silva Camille Jahan Rima Nait-Saidi Jeremy Dufourt Celine Garret Aymeric Chartier Julie Cremaschi Vipul Patel Mathilde Decourcelle Amandine Bastide Francois Juge Martine Simonelig | 2020 | Cell Research2020，30，5： | 1 |
| 8 | Safety of conservative management and fertility outcome in women with borderline tumors of the ovary显示文摘 | Jacques Donnez Andy Munschke Martine Berliere Celine Pirard Pascuale Jadoul Mireille Smets Jean Squifflet | 2003 | Fertility and Sterility2003，，： | 1 |
| 9 | Characterization of bacterial and fungal communities in composted biosolids over a 2 year period using denaturing gradient gel electrophoresis 显示文摘 | Novinscak A Nadine JD Celine S Martin F | 2009 | Can J Microbiol2009，55，： | 1 |
| 10 | B-Raf Activation Cooperates with PTEN Loss to Drive c-Myc Expression in Advanced Prostate Cancer显示文摘 | Jingqiang Wang Takashi Kobayashi Nicolas Floc’h Carolyn Waugh Kinkade Alvaro Aytes David Dankort Celine Lefebvre Antonina Mitrofanova Robert D. Cardiff Martin McMahon Andrea Califano Michael M. Shen Cory Abate-Shen | 2012 | Cancer Research2012，，18： | 1 |
| 11 | PPARα regulates the hepatotoxic biomarker alanine aminotransferase (ALT1) gene expression in human hepatocytes显示文摘 | Petra Thulin Ingalill Rafter Kenneth Stockling Celine Tomkiewicz Ensio Norjavaara Martine Aggerbeck Heike Hellmold Ewa Ehrenborg Ulf Andersson Ian Cotgreave Bj?rn Glinghammar | 2008 | Toxicology and Applied Pharmacology2008，，1： | 1 |
| 12 | 人类生命早期暴露组(HELIX):项目理念与设计(续完)显示文摘3.2研究2:室外暴露
传统h基于居住区评估的暴露,如室外空气污染、噪声、建筑环境,可以通过收集时间一空间活动以及(就空气污染而言)个人吸入空气量的信息,改善暴露评估和减小测量误差。例如,可替代吸入率(Kawahara等,2011)的体力活动方面的信息与个人空气污染测量结合来评估吸入剂量。基于暴露评估的新一代地理信息系统(GIS)(Beelen等,2013;Eeflens等,2012)、遥感(Dadvand等,2012)和智能手机技术(deNazelle等,2013)使评估室外暴露和整合个人活动范围及体力活动数据变得更容易。 | Martine Vrijheid Rémy Slama Oliver Robinson Leda Chatzi Muireann Coen Peter van den Hazel Cathrine Thomsen John Wright Toby J.Athersuch Narcis Avellana Xavier Basagana Celine Brochot Luca Bucchini Mariona Bustamante Angel Carracedo Maribel Casas Xavier Estivill Lesley Fairley Diana van Gent Juan R.Gonzalez Berit Granum Regina Grazuleviiene Kristine B.Gutzkow Jordi Julvez Hector C.Keun Manolis Kogevinas Rosemary R.C.McEachan Helle Margrete Meltzer Eduard Sabidó Per E.Schwarze Valérie Siroux Jordi Sunyer Elizabeth J.Want Florence Zeman Mark J.Nieuwenhuijsen 何蓉 操仪 汪源 金泰廙 | 2015 | 环境与职业医学2015，32，2： | 0 |
| 13 | NumericalMethods for Balance Laws with Space Dependent Flux:Application to Radiotherapy Dose Calculation显示文摘The present work is concerned with the derivation of numerical methods to approximate the radiation dose in external beam radiotherapy.To address this issue,we consider a moment approximation of radiative transfer,closed by an entropy minimization principle.The model under consideration is governed by a system of hyperbolic equations in conservation form supplemented by source terms.The main difficulty coming from the numerical approximation of this system is an explicit space dependence in the flux function.Indeed,this dependence will be seen to be stiff and specific numerical strategiesmust be derived in order to obtain the needed accuracy.A first approach is developed considering the 1D case,where a judicious change of variables allows to eliminate the space dependence in the flux function.This is not possible in multi-D.We therefore reinterpret the 1D scheme as a scheme on two meshes,and generalize this to 2D by alternating transformations between separate meshes.We call this procedure projection method.Several numerical experiments,coming from medical physics,illustrate the potential applicability of the developed method. | Christophe Berthon Martin Frank Celine Sarazin Rodolphe Turpault | 2011 | Communications in Computational Physics2011，10，10： | 0 |
| 14 | Qualitative and quantitative analysis of Arnebiae Radix and Dictamni Cortex and efficacy study of herbal extracts on allergic contact dermatitis using 3D human reconstructed epidermis显示文摘Objective:To evaluate the quality of Arnebiae Radix(AR)and Dictamni Cortex(DC)and study the efficacy of herbal extracts of these two herbs on the treatment of allergic contact dermatitis(ACD).Methods:Qualitative and quantitative analysis of effective components was performed using High Performance Thin Layer Chromatography(HPTLC),High Performance Liquid Chromatography(HPLC),and HPLC-Quadrupole Time of Flight-Mass Spectrometry(HPLC-QTOF-MS).In vitro allergic ACD 3D model was established by incubating 3D reconstructed human epidermis(RHE)with skin sensitizer,potassium dichromate.A total of 65 gene expression that were associated with ACD,which included 24 antioxidant responsive element(ARE)and 41 SENS-IS genes were quantified by q RT-PCR.More than or equal to 10 ARE genes and 18 SENN-IS genes were induced by 1.3-fold,demonstrating the successful establishment of in vitro ACD model.Oil extracts of AR and DC were applied on the in vitro ACD model to study the efficacy.Results:Batch 3 of AR and batch 2 of DC showed presence of all active ingredients with the highest concentrations.Active ingredients of the herbs were extracted using a special oil and formulated into herbal oil extracts.The herbal oil extracts were able to down regulate the induced genes in the in-vitro ACD skin model,bringing the tissue back to homeostatic status.Conclusion:The oil extracts showed the potent efficacy of using AR and DC in ACD treatment.The combination study will be done to optimize the formulation ratio which will be developed into a topical cream. | Huan Li Esther Lim Gladys Ang Zhi-qing Lim Martin Hui Cai Jo-anne Loh Celine Ng Peijia Seetoh Edmund Tian Lay Beng Goh | 2021 | Chinese Herbal Medicines2021，13，4： | 0 |
| 15 | 人类生命早期暴露组(HELIX):项目理念与设计(待续)显示文摘[背景]人类在生命早期的发育期间可能特别容易受到环境暴露的影响。有关这一主题的人体研究一般集中在单一暴露与健康效应之间的关系。而'暴露组'的概念涵盖了从受孕开始的的全部暴露,完善了基因组。[目的]人类生命早期暴露组(HELIX)项目是一个新的合作研究项目,目的是为了采用新的暴露评估和生物标志分析方法来描述生命早期多种环境因素的暴露,并将这些与生物标志组学和儿童健康结局相关联,从而刻画'生命早期暴露组'。本文描述了该项目的总体设计。[方法]HELIX将利用欧洲现有的6个出生队列研究来估计产前、产后暴露的一系列化学和物理暴露。建立全部队列中总共32 000对母亲和儿童的暴露模型,并在一个包含1 200对母亲和儿童的子队列中测量生物标志。嵌套重复采样的定组研究(n=150)将收集生物标志的变化数据,利用智能手机来评估流动性和体力活动,并监测个体暴露。采用组学技术确定与暴露相关的分子学特征(代谢组、蛋白质组、转录组和表观基因组)。对于多次暴露,采用统计方法估计胎儿和儿童的成长、肥胖、神经发育和呼吸系统结局中的暴露-效应关系。项目还将进行一项健康效应评估测试,以评价组合暴露的风险和收益。[结论]HELIX是描述欧洲人群生命早期暴露组并解开它与组学标志物和儿童健康之间关联的首次尝试之一。作为对暴露组学这一概念的验证,该项目向生命过程中暴露组迈出了重要的第一步。 | Martine Vrijheid Rémy Slama Oliver Robinson Leda Chatzi Muireann Coen Peter van den Hazel Cathrine Thomsen John Wright Toby J.Athersuch Narcis Avellana Xavier Basagana Celine Brochot Luca Bucchini Mariona Bustamante Angel Carracedo Maribel Casas Xavier Estivill Lesley Fairley Diana van Gent Juan R.Gonzalez Berit Granum Regina Grazuleviiene Kristine B.Gutzkow Jordi Julvez Hector C.Keun Manolis Kogevinas Rosemary R.C.McEachan Helle Margrete Meltzer Eduard Sabidó PerE.Schwarze Valérie Siroux Jordi Sunyer Elizabeth J.Want Florence Zeman Mark J.Nieuwenhuijsen 何蓉 操仪 汪源 金泰廙 | 2015 | 环境与职业医学2015，32，1： | 0 |
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