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| 1 | Sporadic versus hereditary gastrinomas of the duodenum and pancreas: Distinct clinico-pathological and epidemiological features显示文摘Gastrinomas are defined as gastrin secreting tumors that are associated with Zollinger-Ellison syndrome (ZES). ZES is characterized by elevated fasting gastrin serum levels, positive secretin stimulation test and clinical symptoms such as recurrent peptic ulcer disease, gastroesophageal re?ux disease and occasional diarrhea. Genetically, nonhereditary (sporadic) gastrinomas are distinguished from hereditary gastrinomas, which are associated with multiple endocrine neoplasia type 1 (MEN1) syndrome. In general, duodenal gastrinomas are small and solitary if they are sporadic and multiple as well as hereditary. The sporadic gastrinomas occur in the duodenum or in the pancreas while the hereditary gastrinomas almost all occur in the duodenum. Our series of 77 sporadic duodenal neuroendocrine tumors (NETs) includes 18 patients (23.4%) with gastrinomas and ZES. Of 535 sporadic NETs in the pancreas collected from the NET archives of the departments of pathology in Zürich, Switzerland, and Kiel, Germany, 24 patients (4.5%) suffered from sporadic pancreatic gastrinomas and ZES. These NETs have to be distinguished fromtumors with immunohistochemical positivity for gastrin but without evidence of ZES. An additional 19 patients suffered from MEN1 and ZES. These patients showed exclusively duodenal gastrinomas, but not pancreatic gastrinomas. The prognosis of sporadic and MEN1- associated duodenal gastrinomas is better than that of pancreatic gastrinomas, since they progress slowly to liver metastasis. In summary, sporadic and MEN1- associated gastrinomas in the duodenum and pancreas show different clinico-pathological and genetic features. The incidence of sporadic duodenal gastrin-producing tumors is increasing, possibly due to optimized diagnostic procedures. In contrast, pancreatic MEN1- associated gastrinomas seem to be extremely rare. A considerable subset of tumors with immunohistochemical expression of gastrin but without evidence of ZES should be designated as functionally inactive NETs expressing gastrin, but not as gastrinomas. | Martin Anlauf Nele Garbrecht Tobias Henopp Anja Schmitt Regina Schlenger Andreas Raffel Markus Krausch Oliver Gimm Claus F Eisenberger Wolfram T Knoefel Henning Dralle Paul Komminoth Philipp U Heitz Aurel Perren Günter Klppel | 2006 | World Journal of Gastroenterology2006，12，34： | 7 |
| 2 | Bcl-x_L and Myeloid cell leukaemia-1 contribute to apoptosis resistance of colorectal cancer cells显示文摘AIM: To explore the role of Bcl-xL and Myeloid cell leukaemia (Mcl)-1 for the apoptosis resistance of colorectal carcinoma (CRC) cells towards current treat-ment modalities. METHODS: Bcl-xL and Mcl-1 mRNA and protein ex-pression were analyzed in CRC cell lines as well as human CRC tissue by Western blot,quantitative PCRand immunohistochemistry. Bcl-xL and Mcl-1 protein expression was knocked down or increased in CRC cell lines by applying specific siRNAs or expression plas-mids,respectively. After modulation of protein expres-sion,CRC cells were treated with chemotherapeutic agents,an antagonistic epidermal growth factor recep-tor (EGFR1) antibody,an EGFR1 tyrosine kinase inhibi-tor,or with the death receptor ligand TRAIL. Apoptosis induction and cell viability were analyzed. RESULTS: Here we show that in human CRC tis-sue and various CRC cell lines both Bcl-xL and Mcl-1 are expressed. Bcl-xL expression was higher in CRC tissue than in surrounding non-malignant tissue,both on protein and mRNA level. Mcl-1 mRNA expression was significantly lower in ma-lignant tissues. However,protein expression was slightly higher. Viability rates of CRC cells were significantly decreased after knock down of Bcl-xL expression,and,to a lower extent,after knock down of Mcl-1 expression. Furthermore,cells with reduced Bcl-xL or Mcl-1 expression was more sensitive towards oxaliplatin-and irinotecan-induced apoptosis,and in the case of Bcl-xL also towards 5-FU-induced apoptosis. On the other hand,upregulation of Bcl-xL by transfec-tion of an expression plasmid decreased chemothera-peutic drug-induced apoptosis. EGF treatment clearly induced Bcl-xL and Mcl-1 expression in CRC cells. Apop-tosis induction upon EGFR1 blockage by cetuximab or PD168393 was increased by inhibiting Mcl-1 and Bcl-xL expression. More strikingly,CD95-and TRAIL-induced apoptosis was increased by Bcl-xL knock down. CONCLUSION: Our data suggest that Bcl-xL and,to a lower extent,Mcl-1,are important anti-apoptotic factors in CRC. Specific downregulation of Bcl-xL is a promising approach to sensitize CRC cells towards chemotherapy and targeted therapy. | Henning Schulze-Bergkamen Roland Ehrenberg Lothar Hickmann Binje Vick Toni Urbanik Christoph C Schimanski Martin R Berger Arno Schad Achim Weber Steffen Heeger Peter R Galle Markus Moehler | 2008 | World Journal of Gastroenterology2008，14，24： | 4 |
| 3 | Hepatitis C virus infection and the brain显示文摘 | Karin Weissenborn Anita B. Tryc Meike Heeren Hans Worthmann Henning Pflugrad Georg Berding Martin Bokemeyer Hans L. Tillmann Annemarie Goldbecker | 2009 | Metabolic Brain Disease2009，，1： | 2 |
| 4 | How Do Regions Diversify over Time? Industry Relatedness and the Development of New Growth Paths in Regions 显示文摘 | Frank Neffke Martin Henning Ran Boschma | 2011 | Economic Geography2011，87，3： | 1 |
| 5 | The Dynamics of Agglomeration Externalities along the Life Cycle of Industries显示文摘 | Frank Neffke Martin Henning Ron Boschma Karl-Johan Lundquist Lars-Olof Olander | 2011 | Regional Studies2011，，1： | 1 |
| 6 | Harald,Experimental demonstration of free-space decoy-state quantum key distribution over 144km显示文摘 | Tobias S M Henning W Martin F | 2007 | Phys Rev Lett2007，98，01： | 1 |
| 7 | Does Prospect Theory Explain the Disposition Effect显示文摘 | Hens Thorsten Martin Vlcek | | 0，，03： | 1 |
| 8 | European consensus for the management of patients with differentiated thyroid carcinoma of the follicular epithelium显示文摘 | Furio P Martin S Henning D | 2006 | Eur J of Endocrinol2006，154，： | 1 |
| 9 | Biomarkers and Mechanisms of FANCD2 Function显示文摘 | Henning Willers Lisa A. Kachnic Chen-Mei Luo Li Li Martin Purschke Kerstin Borgmann Kathryn D. Held Simon N. Powell Lisa Wiesmuller | 2008 | Journal of Biomedicine and Biotechnology2008，，： | 1 |
| 10 | The insulin-like growth factor (IGF) system and its relation to infliximab treatment in adult patients with Crohn’s disease显示文摘 | Martin Eivindson Henning Gr?nb?k Kristin Skogstrand Poul Thorsen Jan Frystyk Allan Flyvbjerg Jens F. Dahlerup | 2007 | Scandinavian Journal of Gastroenterology2007，，4： | 1 |
| 11 | The insulin-like growth factor (IGF)-system in active ulcerative colitis and Crohn’s disease: Relations to disease activity and corticosteroid treatment显示文摘 | Martin Eivindson Henning Gr?nb?k Allan Flyvbjerg Jan Frystyk Erik Zimmermann-Nielsen Jens Frederik Dahlerup | 2006 | Growth Hormone & IGF Research2006，，1： | 1 |
| 12 | Anticoagulation and Survival in Pulmonary Arterial Hypertension: Results From the Comparative, Prospective Registry of Newly Initiated Therapies for Pulmonary Hypertension (COMPERA)显示文摘 | Karen M. Olsson Marion Delcroix H. Ardeschir Ghofrani Henning Tiede Doerte Huscher Rudolf Speich Ekkehard Grünig Gerd Staehler Stephan Rosenkranz Michael Halank Matthias Held Tobias J. Lange Juergen Behr Hans Klose Martin Claussen Ralf Ewert Christian F. | 2014 | Circulation2014，，1： | 1 |
| 13 | Dopexamine Reverses the Vasopressin-Associated Impairment in Tissue Oxygen Supply but Decreases Systemic Blood Pressure in Ovine Endotoxemia显示文摘 | Martin Westphal Andreas Wilhelm Sielenk?mper Hugo Van Aken Henning Dirk Stubbe Fritz Daudel Ralf Schepers Simone Schulte Hans-Georg Bone | 2004 | Anesthesia & Analgesia2004，，3： | 1 |
| 14 | Chlamydia trachomatis-infected macrophages induce apoptosis of activated T cells by secretion of tumor necrosis factor-α in vitro显示文摘 | Michael C. Jendro Frederik Fingerle Tobias Deutsch Andrea Liese Lars K?hler Jens G. Kuipers Elke Raum Michael Martin Henning Zeidler | 2004 | Medical Microbiology and Immunology2004，，1： | 1 |
| 15 | Ischemic Preconditioning for Prevention of Contrast Medium–Induced Nephropathy: Randomized Pilot RenPro Trial (Renal Protection Trial)显示文摘 | Fikret Er Amir M. Nia Henning Dopp Martin Hellmich Kristina M. Dahlem Evren Caglayan Torsten Kubacki Thomas Benzing Erland Erdmann Volker Burst Natig Gassanov | 2012 | Circulation2012，，3： | 1 |
| 16 | Experience with different questionnaires in the management of patients with CP/CPPS: GPSS, IPSS and NIH -CPSI显示文摘 | Henning Schneider Martin Ludwig Wolfgang Weidner | 2003 | World J Urol2003，21，： | 1 |
| 17 | Relative importance of corticosterone and thyroxine in the postnatal development of sucrase and mah- ase in rat small intestine显示文摘 | Martin G R Henning S J | 1982 | Endocrinology1982，111，3： | 1 |
| 18 | Inhibition of NF-κB potentiates amyloid β-mediated neuronal apoptosis显示文摘 | Barbara K Martin U Henning W | 1999 | Proc Natl Acad Sci USA1999，96，： | 1 |
| 19 | Entanglement-based Quantum Communication Over 144 km显示文摘 | TOBIAS S M HENNING W MARTIN F | 2007 | Nature Physics2007，，： | 1 |
| 20 | Producer services:growth and roles in lone-term economic development显示文摘 | Karl-Johan Lundquist Lars-Olof Olander and Martin Svensson Henning | 2008 | The Service Industries Journal2008，，4： | 1 |
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