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| 1 | Grazing effects on herbage nutritive values depend on precipitation and growing season in Inner Mongolian grassland显示文摘Aims Grasslands are widely used for production of livestock,which depend on the nutritive value of herbage species.However,there are still large uncertainties as to how grazing,precipitation and growing season interactively affect herbage nutritive value.Methods Here,based on a grazing experiment with seven grazing intensities in an Inner Mongolian grassland since the year 2005,we analysed nutritive value of four dominant grass species from June to September in both a relatively wetter year(2008)and a drier year(2010).Herbage with high nutritive value is characterized by high concentration of crude protein,high concentration of cellulase digestible organic matter and low concentration of neutral detergent fibre.Important Findings We found that(i)grazing significantly increased the nutritive value of Leymus chinensis,Agropyron michnoi and Cleistogenes squarrosa but had minor effects on the nutritive value of Stipa grandis.(ii)For all species,nutritive values were greater in the wetter year than in the drier year and were greatest in the early growing season(June)and lowest at the end of the growing season(September).Inter-annual and inter-seasonal variations in nutritive value were much greater for L.chinensis and A.michnoi than for C.squarrosa and S.grandis,suggesting higher water use efficiency for the latter two species.(iii)Grazing significantly decreased the drought resistance of three species,but not of S.grandis.(iv)Grazing significantly increased inter-month variation in nutritive value for L.chinensis and A.michnoi but had relatively minor or no effects on that of C.squarrosa and S.grandis.Therefore,grazing effects on species nutritive values showed strong inter-annual and seasonal patterns,and species-specific responses might be related to species traits(i.e.water use efficiency,digestibility).Our results have important implications for ecosystem management of arid and semiarid grasslands under intense grazing and global climatic change. | Haiyan Ren Guodong Han Zhichun Lan Hongwei Wan Philipp Schönbach Martin Gierus Friedhelm Taube | 2016 | Journal of Plant Ecology2016，9，6： | 14 |
| 2 | Cabozantinib in Progressive Medullary Thyroid Cancer显示文摘 | Rossella Elisei Martin J. Schlumberger Stefan P. Müller Patrick Sch?ffski Marcia S. Brose Manisha H. Shah Lisa Licitra Barbara Jarzab Viktor Medvedev Michael C. Kreissl Bruno Niederle Ezra E.W. Cohen Lori J. Wirth Haythem Ali Colin Hessel Yifah Yaron Doug | 2013 | Journal of Clinical Oncology2013，，29： | 3 |
| 3 | Counting and measuring particles sized from soot to pollen显示文摘For number concentration measurements of superfine particles a condensation nucleus counter (CNC) is frequently used. The combination of a new CNC module with a white light aerosol spectrometer and a passive collector makes possible accurate time-resolved determination of particle number within the overall size range of 10 nm to 40 m and at concentrations up to 105 particles/cm3. With the aerosol spectrometer a high time-resolved particle size determination is also possible in the size range of 0.3–40 m up to the same high number concentrations of 105 particles/cm3. | Martin Schmidt Sven Schütz Leander Mlter | 2007 | China Particuology2007，5，5： | 3 |
| 4 | Prognostic value of serum microRNA-122 in hepatocellular carcinoma is dependent on coexisting clinical and laboratory factors显示文摘BACKGROUND There is ongoing search for new noninvasive biomarkers to improve management of patients with hepatocellular carcinoma(HCC).Studies,mostly from the Asian-Pacific region,demonstrated differential expression of liverspecific microRNA-122(miR-122)in tissue as well as in sera of patients with hepatitis B virus-and hepatitis C virus-induced HCC.AIM To evaluate prognostic value of miR-122 in patients with HCC in a European population and determine potential factors related to alteration of miR-122 in sera.METHODS Patients with confirmed HCC(n=91)were included in the study over a two-year period.Patients were characterized according to Child-Pugh score,Barcelona clinic liver cancer(BCLC)staging system,etiology of liver disease,laboratory parameters and overall survival.MiR-122 was measured in sera using TaqMan assay normalized to spiked-in cel-miR-39.RESULTS Serum miR-122 quantity was independent of the Child-Pugh score,the BCLC stage or the underlying etiology.Significant positive correlation was found between miR-122 and alanine aminotransferase(P<0.0001),aspartate aminotransferase(P=0.0001),alpha-fetoprotein(AFP)(P=0.0034)and hemoglobin concentration(P=0.076).Negative correlation was observed between miR-122 level and creatinine concentration(P=0.0028).AFP,Child-Pugh score and BCLC staging system were associated with survival differences.In overall cohort low miR-122 in sera was only associated with a trend for a better overall survival without reaching statistical significance.Subgroup analysis revealed that low miR-122 was significantly associated with better prognosis in patients with advanced cirrhosis(Child-Pugh class B/C),advanced tumor stage(BCLC B/C/D)and normal AFP(<7 ng/mL).CONCLUSION Our results strongly support the value of miR-122 as potential biomarker of liver injury and probably prognosis.Nevertheless,the value of miR-122 in prediction of prognosis of HCC patients was limited to certain patients’subgroups.Since circulating miR-122 may be influenced by impaired renal function,AFP and hemoglobin concentration,those factors need to be considered while interpreting miR-122 level. | Martin Franck Kerstin Schütte Peter Malfertheiner Alexander Link | 2020 | World Journal of Gastroenterology2020，26，1： | 3 |
| 5 | National Forest Inventories capture the multifunctionality of managed forests in Germany显示文摘Background:Forests perform various important ecosystem functions that contribute to ecosystem services.In many parts of the world,forest management has shifted from a focus on timber production to multi-purpose forestry,combining timber production with the supply of other forest ecosystem services.However,it is unclear which forest types provide which ecosystem services and to what extent forests primarily managed for timber already supply multiple ecosystem services.Based on a comprehensive dataset collected across 150 forest plots in three regions differing in management intensity and species composition,we develop models to predict the potential supply of 13 ecosystem services.We use those models to assess the level of multifunctionality of managed forests at the national level using national forest inventory data.Results:Looking at the potential supply of ecosystem services,we found trade-offs(e.g.between both bark beetle control or dung decomposition and both productivity or soil carbon stocks)as well as synergies(e.g.for temperature regulation,carbon storage and culturally interesting plants)across the 53 most dominant forest types in Germany.No single forest type provided all ecosystem services equally.Some ecosystem services showed comparable levels across forest types(e.g.decomposition or richness of saprotrophs),while others varied strongly,depending on forest structural attributes(e.g.phosphorous availability or cover of edible plants)or tree species composition(e.g.potential nitrification activity).Variability in potential supply of ecosystem services was only to a lesser extent driven by environmental conditions.However,the geographic variation in ecosystem function supply across Germany was closely linked with the distribution of main tree species.Conclusions:Our results show that forest multifunctionality is limited to subsets of ecosystem services.The importance of tree species composition highlights that a lack of multifunctionality at the stand level can be compensated by managing forests at the landscape level,when stands of complementary forest types are combined.These results imply that multi-purpose forestry should be based on a variety of forest types requiring coordinated planning across larger spatial scales. | Nadja K.Simons María R.Felipe-Lucia Peter Schall Christian Ammer Jürgen Bauhus Nico Blüthgen Steffen Boch François Buscot Markus Fischer Kezia Goldmann Martin M.Gossner Falk Hänsel Kirsten Jung Peter Manning Thomas Nauss Yvonne Oelmann Rodica Pena Andrea Polle Swen C.Renner Michael Schloter Ingo Schöning Ernst-Detlef Schulze Emily F.Solly Elisabeth Sorkau Barbara Stempfhuber Tesfaye Wubet Jörg Müller Sebastian Seibold Wolfgang W.Weisser | 2021 | Forest Ecosystems2021，8，1： | 2 |
| 6 | Differential Modulation of Remifentanil-induced Analgesia and Postinfusion Hyperalgesia by S-Ketamine and Clonidine in Humans显示文摘 | Wolfgang Koppert Reinhard Sittl Karin Scheuber Monika Alsheimer Martin Schmelz Jürgen Schüttler | 2003 | Anesthesiology2003，，1： | 2 |
| 7 | Cytokinin levels and signaling respond to wounding and the perception of herbivore elicitors in Nicotiana attenuata显示文摘Nearly half a century ago insect herbivores were found to induce the formation of green islands by manipulating cytokinin(CK) levels. However, the response of the CK pathway to attack by chewing insect herbivores remains unclear. Here, we characterize the CK pathway of Nicotiana attenuata(Torr. ex S.Wats.) and its response to wounding and perception of herbivore-associated molecular patterns(HAMPs). We identified 44 genes involved in CK biosynthesis, inactivation, degradation, and signaling. Leaf wounding rapidly induced transcriptional changes in multiple genes throughout the pathway, as wel as in the levels of CKs, including isopentenyladenosine and cis-zeatin riboside;perception of HAMPs present in the oral secretions(OS) of the specialist herbivore Manduca sexta amplified these responses.The jasmonate pathway, which triggers many herbivore-induced processes, was not required for these HAMP-triggered changes,but rather suppressed the CK responses. Interestingly CK pathway changes were observed also in systemic leaves in response to wounding and OS application indicating a role of CKs in mediating long distance systemic processes in response to herbivory. Since wounding and grasshopper OS elicited similar Reseaccumulations of CKs in Arabidopsis thaliana L., we propose that CKs are integral components of wounding and HAMP-triggered responses in many plant species. | Martin Sch?fer Ivan D. Meza-Canales Aura Navarro-Quezada Christoph Brütting Radomira Vanková Ian T. Baldwin Stefan Meldau | 2015 | Journal of Integrative Plant Biology2015，57，2： | 2 |
| 8 | S3 Guideline: Sedation for gastrointestinal endoscopy 2008显示文摘 | A. Riphaus T. Wehrmann B. Weber J. Arnold U. Beilenhoff H. Bitter S. von Delius D. Domagk A. Ehlers S. Faiss D. Hartmann W. Heinrichs M.-L. Hermans C. Hofmann S. In der Smitten M. Jung G. K?hler M. Kraus J. Martin A. Meining J. Radke T. R?sch H. Seifert A | 2009 | Endoscopy2009，，09： | 1 |
| 9 | High Proportion of Leukemic Stem Cells at Diagnosis Is Correlated with Unfavorable Prognosis in Childhood Acute Myeloid Leukemia显示文摘 | Kai-Erik Witte J?rg Ahlers Iris Sch?fer Maya André Gunter Kerst Hans-Gerhard Scheel-Walter Carl Philipp Schwarze Matthias Pfeiffer Peter Lang Rupert Handgretinger Martin Ebinger | 2011 | Pediatric Hematology-Oncology2011，，2： | 1 |
| 10 | Extracellular Matrix Metalloproteinase Inducer Regulates Matrix Metalloproteinase Activity in Cardiovascular Cells: Implications in Acute Myocardial Infarction显示文摘 | Roland Schmidt Andreas Bültmann Martin Ungerer Nader Joghetaei ?zgür Bülbül Sven Thieme Triantafyllos Chavakis Bryan P. Toole Meinrad Gawaz Albert Sch?mig Andreas E. May | 2006 | Circulation2006，，6： | 1 |
| 11 | ERCP or EUS for tissue diagnosis of biliary strictures? a prospective comparative study显示文摘 | Thomas R?sch Kim Hofrichter Eckart Frimberger Alexander Meining Peter Born Norbert Weigert Hans-Dieter Allescher Meinhard Classen Marius Barbur Ulrich Schenck Martin Werner | 2004 | Gastrointestinal Endoscopy2004，，3： | 1 |
| 12 | The INTERPHONE study: design, epidemiological methods, and description of the study population显示文摘 | Elisabeth Cardis Lesley Richardson Isabelle Deltour Bruce Armstrong Maria Feychting Christoffer Johansen Monique Kilkenny Patricia McKinney Baruch Modan Siegal Sadetzki Joachim Schüz Anthony Swerdlow Martine Vrijheid Anssi Auvinen Gabriele Berg Maria Blet | 2007 | European Journal of Epidemiology2007，，9： | 1 |
| 13 | Diagnostic Value of Contrast-Enhanced Magnetic Resonance Imaging and Single-Photon Emission Computed Tomography for Detection of Myocardial Necrosis Early After Acute Myocardial Infarction显示文摘 | Tareq Ibrahim Hubertus P. Bülow Thomas Hackl Mira H?rnke Stephan G. Nekolla Martin Breuer Albert Sch?mig Markus Schwaiger | 2007 | Journal of the American College of Cardiology2007，，2： | 1 |
| 14 | Liver transplantation for hilar cholangiocarcinoma—a single-centre experience显示文摘 | Silke Schüle Annelore Altendorf-Hofmann Frank Ute? Falk Rauchfu? Martin Freesmeyer Thomas Kn?sel Yves Dittmar Utz Settmacher | 2013 | Langenbeck’s Archives of Surgery2013，，1： | 1 |
| 15 | Impact of allogeneic haematopoietic stem cell transplantation in patients with abnl(17p) acute myeloid leukaemia显示文摘 | Brigitte Mohr Johannes Schetelig Kerstin Sch?fer‐Eckart Norbert Schmitz Mathias H?nel Wolf R?sler Norbert Frickhofen Hartmut Link Andreas Neubauer Ulrich Schuler Uwe Platzbecker Jan M. Middeke Gerhard Ehninger Martin Bornh?user Markus Schaich Friedrich St | 2013 | Br J Haematol2013，，： | 1 |
| 16 | An automated, 0.5 Hz nano-foil target positioning system for intense laser plasma experiments显示文摘We report on a target system supporting automated positioning of nano-targets with a precision resolution of 4 μm in three dimensions. It relies on a confocal distance sensor and a microscope. The system has been commissioned to position nanometer targets with 1 Hz repetition rate. Integrating our prototype into the table-top ATLAS 300 TW-laser system at the Laboratory for Extreme Photonics in Garching, we demonstrate the operation of a 0.5 Hz laser-driven proton source with a shot-to-shot variation of the maximum energy about 27% for a level of confidence of 0.95. The reason of laser shooting experiments operated at 0.5 Hz rather than 1 Hz is because the synchronization between the nano-foil target positioning system and the laser trigger needs to improve. | Ying Gao Jianhui Bin Daniel Haffa Christian Kreuzer Jens Hartmann Martin Speicher Florian H.Lindner Tobias M.Ostermayr Peter Hilz Thomas F.Rsch Sebastian Lehrack Franz Englbrecht Sebastian Seuferling Max Gilljohann Hao Ding Wenjun Ma Katia Parodi Jorg Schreiber | 2017 | High Power Laser Science and Engineering2017，5，2： | 1 |
| 17 | Protein engineering of cellulases显示文摘 | Martin Schülein | 2000 | Biochimica et Biophysica Acta(BBA)-Protein Structure and Molecular Enzymology2000，1543，2： | 1 |
| 18 | Bioimpedance vector analysis as a measure of muscle function显示文摘 | Kristina Norman Matthias Pirlich Janice Sorensen Pia Christensen Martin Kemps Tatjana Schütz Herbert Lochs Jens Kondrup | 2008 | Clinical Nutrition2008，，1： | 1 |
| 19 | EGFR, HER2 and HER3 dimerization patterns guide targeted inhibition in two histotypes of esophageal cancer显示文摘 | Christiane Daniela Fichter Sylvia Timme Julia Alexandra Braun Verena Gudernatsch Anja Sch?pflin Lioudmilla Bogatyreva Helene Geddert Gerhard Faller David Klimstra Laura Tang Dieter Hauschke Martin Werner Silke Lassmann | 2014 | Int J Cancer2014，，7： | 1 |
| 20 | Wavelet entropy: a new tool for analysis of short duration brain electrical signals显示文摘 | Osvaldo A. Rosso Susana Blanco Juliana Yordanova Vasil Kolev Alejandra Figliola Martin Schürmann Erol Ba?ar | 2001 | Journal of Neuroscience Methods2001，，1： | 1 |
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