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| 1 | Wnt and BMP signaling crosstalk in regulating dental stem cells:Implications in dental tissue engineering显示文摘Tooth is a complex hard tissue organ and consists of multiple cell types that are regulated by important signaling pathways such as Wnt and BMP signaling.Serious injuries and/or loss of tooth or periodontal tissues may significantly impact aesthetic appearance,essential oral functions and the quality of life.Regenerative dentistry holds great promise in treating oral/dental disorders.The past decade has witnessed a rapid expansion of our understanding of the biological features of dental stem cells,along with the signaling mechanisms governing stem cell self-renewal and differentiation.In this review,we first summarize the biological characteristics of seven types of dental stem cells,including dental pulp stem cells,stem cells from apical papilla,stem cells from human exfoliated deciduous teeth,dental follicle precursor cells,periodontal ligament stem cells,alveolar bone-derived mesenchymal stem cells(MSCs),and MSCs from gingiva.We then focus on how these stem cells are regulated by bone morphogenetic protein(BMP)and/or Wnt signaling by examining the interplays between these pathways.Lastly,we analyze the current status of dental tissue engineering strategies that utilize oral/dental stem cells by harnessing the interplays between BMP and Wnt pathways.We also highlight the challenges that must be addressed before the dental stem cells may reach any clinical applications.Thus,we can expect to witness significant progresses to be made in regenerative dentistry in the coming decade. | Fugui Zhang Jinlin Song Hongmei Zhang Enyi Huang Dongzhe Song Viktor Tollemar Jing Wang Jinhua Wang Maryam Mohammed Qiang Wei Jiaming Fan Junyi Liao Yulong Zou Feng Liu Xue Hu Xiangyang Qu Liqun Chen Xinyi Yu Hue H.Luu Michael J.Lee Tong-Chuan He Ping Ji | 2016 | Genes & Diseases2016，3，4： | 16 |
| 2 | NAT2 polymorphism in Omani gastric cancer patients-risk predisposition and clinicopathological associations显示文摘AIM: To study whether N-acetyltransferase 2 (NAT2) genotypes and phenotypes are associated with increased risk factor for gastric cancer in Omani patients and to study the clinico-pathological correlations and the prognostic signifi cance of NAT2.METHODS: Genomic DNA was extracted from peripheral blood of 100 gastric cancer patients and 100 control subjects. NAT2 genotyping was performed using DNA sequencing. The prognostic significance of NAT2 and other clinicopathological features was assessed by univariate and multivariate analyses.RESULTS: We observed no significant association between NAT2 genotypes and phenotypes and gastric cancer risk. The NAT2 phenotype polymorphisms and gastric cancer risk predisposition were not modified by concomitant H pylori infection and smoking. There was no significant association between NAT2 and clinicopathological features, and NAT2 had no independent prognostic signifi cance.CONCLUSION: In the current study, NAT2 genotypes and phenotypes are not associated with gastric cancer risk predisposition. Moreover NAT2 phenotypes had no clinicopathological associations or prognostic signif icance. | Mansour S Al-Moundhri Mohamed Al-Kindi Maryam Al-Nabhani Bassim Al-Bahrani Ikram A Burney Ali Al-Madhani Shyam S Ganguly Misbah Tanira | 2007 | World Journal of Gastroenterology2007，13，19： | 5 |
| 3 | Association of E-cadherin (CDH1) gene polymorphisms and gastric cancer risk显示文摘AIM:To investigate the associations between CDH1 gene polymorphisms and gastric cancer(GC) risk predisposition.METHODS:We analyzed four CDH1 polymorphisms(+54 T>C,-160 C>A,-616 G>C,-3159 T>C) in an Omani population,by extraction of genomic DNA from the peripheral blood of 192 patients with GC and 170 control participants and performed CDH1 genotyping using DNA sequencing.RESULTS:CDH1-160-AA genotype was associated with an increased risk of GC(OR = 3.6,95% CI:1.1-11.8)(P = 0.03).There was no significant association between the other polymorphisms and GC risk.The haplotype analysis of +54 T>C,-160 C>A,-616 G>C,-3159 T>C genotypes revealed that the OR of CCGC and CAGC haplotypes was 1.5(95% CI:0.7-3.5) and 1.5(95% CI:0.2-3.0),but did not reach statistical significance.CONCLUSION:The current study suggests that the-160 AA genotype was associated with an increased risk of GC in Oman. | Mansour S Al-Moundhri Manal Al-Khanbashi Mohammed Al-Kindi Maryam Al-Nabhani Ikram A Burney Abdulaziz Al-Farsi Bassim Al-Bahrani | 2010 | World Journal of Gastroenterology2010，16，27： | 4 |
| 4 | Foxp3 inter- acts with nuclear factor of activated T cells and NF-kappa B to repress cytokine gene expression and effector functions of T helper ceils 显示文摘 | Estelle Bettelli Maryam Dastrange and Mohamed Oukka | 2005 | Proc Natl Acad Sci U S A2005，102，14： | 1 |
| 5 | Oxidation of aromatic amines to quinones by iodic acid under microwave irradiation in the presence of montmorillonite K10 and silica gel显示文摘 | Mohammed M Hashemi Maryam Akhbari | 2003 | Monatshefte für Chemie2003，134，： | 1 |
| 6 | In Vivo Evaluation of Ethanolic Extract of Zingiber officinale Rhizomes for Its Protective Effect against Liver Cirrhosis显示文摘 | Daleya Abdulaziz Bardi Mohammed Farouq Halabi Nor Azizan Abdullah Elham Rouhollahi Maryam Hajrezaie Mahmood Ameen Abdulla Ibrahim Banat | 2013 | BioMed Research International2013，，： | 1 |
| 7 | Repeated immobilization stress increases total cytosoli glucocorticiodreceptor in rat liver显示文摘 | Maryam A-1Mohaisen Arturo Cardounel Mohammed Kal-imi | 2000 | Steriod2000，65，： | 1 |
| 8 | Effect of seawater and warm environment on glass/ epoxy and glass/polyurethane composites 显示文摘 | Abdel-Hamid I Mourad Beckry Mohamed Maryam E Grami | 2010 | Appl Compos Mater2010，17，： | 1 |
| 9 | Molecular pathogenesis and therapeutic strategies of human osteosarcoma显示文摘Osteosarcoma(OS)is a devastating illness with rapid rates of dissemination and a poor overall prognosis,despite aggressive standard-of-care surgical techniques and combination chemotherapy regimens.Identifying the molecular mechanisms involved in disease pathogenesis and progression may offer insight into new therapeutic targets.Defects in mesenchymal stem cell differentiation,abnormal expression of oncogenes and tumor suppressors,and dysregulation within various important signaling pathways have all been implicated in development of various disease phenotypes.As such,a variety of basic science and translational studies have shown promise in identifying novel markers and modulators of these disease-specific aberrancies.Born out of these and similar investigations,a variety of emerging therapies are now undergoing various phases of OS clinical testing.They broadly include angiogenesis inhibitors,drugs that act on the bone microenvironment,receptor tyrosine kinase inhibitors,immune system modulators,and other radio-or chemo-sensitizing agents.As new forms of drug delivery are being developed simultaneously,the possibility of targeting tumors locally while minimizing systemic toxicityis is seemingly more achievable now than ever.In this review,we not only summarize our current understanding of OS disease processes,but also shed light on the multitude of potential therapeutic strategies the scientific community can use to make long-term improvements in patient prognosis. | Sahitya K Denduluri Zhongliang Wang Zhengjian Yan Jing Wang Qiang Wei Maryam K Mohammed Rex C Haydon Hue H Luu Tong-Chuan He | 2016 | The Journal of Biomedical Research2016，30，1： | 1 |
| 10 | Surfen and oxalyl surfen decrease tau hyperphosphorylation and mitigate neuron deficits in vivo in a zebrafish model of tauopathy显示文摘Background:Tauopathies comprise a family of neurodegenerative disorders including Alzheimer’s disease for which there is an urgent and unmet need for disease-modifying treatments.Tauopathies are characterized by pathological tau hyperphosphorylation,which has been shown to correlate tightly with disease progression and memory loss in patients suffering from Alzheimer’s disease.We recently demonstrated an essential requirement for 3-O-sulfated heparan sulfate in pathological tau hyperphosphorylation in zebrafish,a prominent model organism for human drug discovery.Here,we investigated whether in vivo treatment with surfen or its derivatives oxalyl surfen and hemisurfen,small molecules with heparan sulfate antagonist properties,could mitigate tau hyperphosphorylation and neuronal deficits in a zebrafish model of tauopathies.Results:In vivo treatment of Tg[HuC::hTau^(P301L);DsRed]embryos for 2 days with surfen or oxalyl surfen significantly reduced the accumulation of the pThr181 tau phospho-epitope measured by ELISA by 30%and 51%,respectively.Western blot analysis also showed a significant decrease of pThr181 and pSer396/pSer404 in embryos treated with surfen or oxalyl surfen.Immunohistochemical analysis further confirmed that treatment with surfen or oxalyl surfen significantly decreased the AT8 tau epitope in spinal motoneurons.In addition,in vivo treatment of Tg[HuC::hTau^(P301L);DsRed]embryos with surfen or oxalyl surfen significantly rescued spinal motoneuron axon-branching defects and,as a likely consequence,the impaired stereotypical touch-evoked escape response.Importantly,treatment with hemisurfen,a surfen derivative devoid of heparan sulfate antagonist activity,does not affect tau hyperphosphorylation,nor neuronal or behavioural deficits in Tg[HuC::hTau^(P301L);DsRed]embryos.Conclusion:Our findings demonstrate for the first time that surfen,a well-tolerated molecule in clinical settings,and its derivative,oxalyl surfen,could mitigate or delay neuronal defects in tauopathies,including Alzheimer’s disease. | Seyedeh Maryam Alavi Naini Constantin Yanicostas Rahma Hassan-Abdi Sébastien Blondeel Mohamed Bennis Ryan J.Weiss Yitzhak Tor Jeffrey D.Esko Nadia Soussi-Yanicostas | 2018 | Translational Neurodegeneration2018，7，1： | 1 |
| 11 | An investigation into a carbon burnout kinetic model for oxy–coal combustion显示文摘 | Maryam Gharebaghi Robin M. Irons Mohamed Pourkashanian Alan Williams | 2011 | Fuel Processing Technology2011，，： | 1 |
| 12 | Brain Insulin Dysregulation: Implication for Neurological and Neuropsychiatric Disorders显示文摘 | Rasoul Ghasemi Leila Dargahi Ali Haeri Maryam Moosavi Zahurin Mohamed Abolhassan Ahmadiani | 2013 | Molecular Neurobiology2013，，3： | 1 |
| 13 | Brain Insulin Dysregulation: Implication for Neurological and Neuropsychiatric Disorders显示文摘 | Rasoul Ghasemi Leila Dargahi Ali Haeri Maryam Moosavi Zahurin Mohamed Abolhassan Ahmadiani | 2013 | Molecular Neurobiology2013，，3： | 1 |
| 14 | A novel one- pot synthesis of tetrasubstituted imidazoles under solvent-free conditions and microwave irradiation显示文摘 | SAEED B MOHAMMED M H MARYAM A | 2003 | Tetrahedron Letters2003，44，8： | 1 |
| 15 | Foxp3 interacts with nuclear factor of activated T cells and NF-κB to repress cytokine gene expression and effector functions of T helper cells显示文摘 | Estelle B Maryam D Mohamed O | 2005 | Proc Natl Acad Sci USA2005，102，14： | 1 |
| 16 | Sex Determination Using Mandibular Canine among Northeastern Nigerian Population显示文摘Establishing a person’s identity is important for both legal and humanitarian purposes.Sex determination is a key characteristic used in the identification of a deceased individual.The aim of this study was to determine sex by using mandibular canines among individuals in the Northeastern Nigerian population.Two hundred and eight individuals(102 men and 106 women)participated in this study.The mesiodistal widths of the mandibular canines and intercanine distances were measured using a vernier caliper and a divider.Step‑wise logistic regression analyses were used to determine sex based on mandibular parameters.Male participants had significantly higher mandibular mesiodistal width than female participants.Similarly,the canine index was significantly higher in male participants than in female participants.The mesiodistal width of the left mandibular canine exhibited the highest sexual dimorphism(9.78%)and was the best characteristic for use in determining sex,with an accuracy of 75%.Among the Northwestern Nigerian population,sex can be most accurately determined using the mesiodistal width of the left mandibular canine. | Saleh Nuhu Babagana Mohammed Dalori Lawan Hassan Adamu Isyaku Ibrahim Maryam Nasir Aliyu | 2019 | Journal of Forensic Science and Medicine2019，5，3： | 0 |
| 17 | Modeling and Verification of Aircraft Takeoff Through Novel Quantum Nets显示文摘The formal modeling and verification of aircraft takeoff is a challenge because it is a complex safety-critical operation.The task of aircraft takeoff is distributed amongst various computer-based controllers,however,with the growing malicious threats a secure communication between aircraft and controllers becomes highly important.This research serves as a starting point for integration of BB84 quantum protocol with petri nets for secure modeling and verification of takeoff procedure.The integrated model combines the BB84 quantum cryptographic protocol with powerful verification tool support offered by petri nets.To model certain important properties of BB84,a new variant of petri nets coined as Quantum Nets are proposed by defining their mathematical foundations and overall system dynamics,furthermore,some important system properties are also abstractly defined.The proposed QuantumNets are then applied for modeling of aircraft takeoff process by defining three quantum nets:namely aircraft,runway controller and gate controller.For authentication between quantum nets,the use of external places and transitions is demonstrated to describe the encryptiondecryption process of qubits stream.Finally,the developed takeoff quantum network is verified through simulation offered by colored petri-net(CPN)Tools.Moreover,reachability tree(RT)analysis is also performed to have greater confidence in feasibility and correctness of the proposed aircraft takeoff model through the Quantum Nets. | Maryam Jamal Nazir Ahmad Zafar Atta-ur-Rahman Dhiaa Musleh Mohammed A.Gollapalli Sghaier Chabani | 2022 | Computers, Materials & Continua2022，，8： | 0 |
| 18 | Diagnosis of Clinical Cases of Infectious Bursal Disease Using a Modified Rapid Taq Man-MGB Real-Time RT-PCR Assay显示文摘Infectious bursal disease(IBD)is an important contagious viral infection of immune system of poultry.This infection possesses a permanent threat to the profitability of poultry industry worldwide.The aim of this work was to modify the Taq Man-MGB real-time reverse transcription-polymerase chain reaction(rRT-PCR)in one step involving two fluorogenic Taq Man labeled probe and using this protocol for detection of infectious bursal disease virus(IBDV)collected from suspected cases distributed in different regions of the country during the period 2013-2016.The intralaboratory validation of modified method was realized for specificity,linearity,repeatability,sensitivity and reproducibility.It allowed reducing the test running time by six folds.This method was applied on 102 pools of bursa of fabricius(BF)samples collected from affected broiler farms suspected to be infected by IBDV.Birds showing macroscopic lesions including muscle petechial hemorrhages,hypertrophy and hemorrhage of BF,were subjected to molecular analysis using modified protocol“Taq Man-MGB rRT-PCR”.The validation satisfied all criteria and the assay developed could be a useful tool for a very rapid diagnosis of IBDV and permit to detect and to discriminate in one-step very virulent(vv)from non-vv(classic and variant)IBDV strains.Out of 84 IBDV positive samples,a prevalence of 39%for vv strains and 61%for classical strains was noted.These results indicate that despite the vaccination against IBDV,the vv form of this pathologie continues to cause serious problems for Moroccan broiler chickens.The obtained results indicate the successfully detection of IBDV and differentiated all vvIBDV strains from non-vvIBDV strains;Avian infectious agent RNA viruses tested are negative,demonstrating great specificity of the assay.The results obtained indicate that this method is suitable as a routine laboratory test for the rapid detection and differentiation of IBDV strains in samples of avian origin. | Maryame Cheggag Khalil Zro Ghizlane Sebbar Naoufal Rahmatallah Mohamed Mouahid Mohammed EL Houadfi Faouzi Kichou | 2018 | Journal of Agricultural Science and Technology(A)2018，8，4： | 0 |
| 19 | Analysing user daylight preferences in heritage buildings using virtual reality显示文摘Technology has always been creating effective ways to support human decisions.Immersive virtual reality(IVR)has emerged to engage users in a simulated world,and this has gained the interest of a wide variety of users in the heritage industry.A historical case study built in the early 19th century is considered for an adaptive reuse exhibition.The palace is located in Cairo,Egypt,and named after Prince Omar Tosson.The current palace state incorporates a smashed top-lit zone,which is being studied and analyzed for daylighting adequacy.Three simulated distinct optimum skylight configurations are suggested for the redesign where the selection should not be based solely on simulation data,but should consider real-user preferences.Most daylight design criteria are previously based on simulation data that do not necessarily indicate the users'preferences.But utilizing user interactive tools such as IVR to test daylight redesign options,a whole new dimension is provided.In this study,the VR users’survey data is statistically analyzed using Statistical Package for Social Sciences(SPSS),where results revealed that the assessment attributes succeeded in reflecting the users'preferences;which,motivated designers to consider potential users’daylight preferences in reused spaces.The paper highlights the most significant emotional attributes that provide cost-effective and reliable information concerned with the performance of daylight in IVR before design implementation.This study compares and analyzes the effect of three skylight designs(Cases A,B&C)on the users'perception before design implementation using(IVR)post-survey.Forty-eight participants have contributed to the study,providing their feedback on six attributes namely:Pleasant,Contrasting,Brightness,Uniform Distribution,Visual Comfort,and Satisfaction.Those attributes are evaluated for the three cases in space using five scale rating values to reveal that the'Pleasant'attribute is most reliable in the study to reflect the users'preferences for design Case B. | Mohamed Marzouk Maryam ElSharkawy Ayman Mahmoud | 2022 | Building Simulation2022，15，9： | 0 |
| 20 | A Novel Metadata Based Multi-Label Document Classification Technique显示文摘From the beginning,the process of research and its publication is an ever-growing phenomenon and with the emergence of web technologies,its growth rate is overwhelming.On a rough estimate,more than thirty thousand research journals have been issuing around four million papers annually on average.Search engines,indexing services,and digital libraries have been searching for such publications over the web.Nevertheless,getting the most relevant articles against the user requests is yet a fantasy.It is mainly because the articles are not appropriately indexed based on the hierarchies of granular subject classification.To overcome this issue,researchers are striving to investigate new techniques for the classification of the research articles especially,when the complete article text is not available(a case of nonopen access articles).The proposed study aims to investigate the multilabel classification over the available metadata in the best possible way and to assess,“to what extent metadata-based features can perform in contrast to content-based approaches.”In this regard,novel techniques for investigating multilabel classification have been proposed,developed,and evaluated on metadata such as the Title and Keywords of the articles.The proposed technique has been assessed for two diverse datasets,namely,from the Journal of universal computer science(J.UCS)and the benchmark dataset comprises of the articles published by the Association for computing machinery(ACM).The proposed technique yields encouraging results in contrast to the state-ofthe-art techniques in the literature. | Naseer Ahmed Sajid Munir Ahmad Atta-ur Rahman Gohar Zaman Mohammed Salih Ahmed Nehad Ibrahim Mohammed Imran BAhmed Gomathi Krishnasamy Reem Alzaher Mariam Alkharraa Dania AlKhulaifi Maryam AlQahtani Asiya A.Salam Linah Saraireh Mohammed Gollapalli Rashad Ahmed | 2023 | Computer Systems Science & Engineering2023，46，8： | 0 |
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