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| 1 | Comparing the Diagnostic Criteria for Gestational Diabetes Mellitus of World Health Organization 2013 with 1999 in Chinese Population显示文摘INTRODUCTION Gestational diabetes mellitus (GDM) was earlier defined as 'hyperglycemia first recognized during pregnancy' and has more recently been described by American Diabetes Association (ADA) (2012) as diabetes diagnosed during pregnancy that is not clearly overt diabetes.[1] The hyperglycemia and adverse pregnancy outcomes study (HAPO) demonstrated that the risk of adverse maternal,fetal,and neonatal outcomes continuously increase as a function of maternal glycemia at 24-28 weeks,even within ranges previously considered normal for pregnancy.[2] After reviewing the results of the HAPO study,many international diabetes study groups,including the International Association of Diabetes and Pregnancy Study Groups and ADA have adopted the 75 g oral glucose tolerance test (OGTT) at 24-28 weeks as a screening and diagnostic test and defined new cut-off values for GDM diagnosis.The Ministry of Health of China published the criteria for GDM,that is the same as the ADA criteria on July 1,2011.World Health Organization (WHO) has recommended the 75 g OGTT with different cut-offvalues as a diagnostic test since 1999,changed its recommendation on 2013.In Hongkong and Yunnan province in China,most hospital adopted the WHO 1999 criteria,nevertheless,there is no evidence of multicenter and large sample to show that the GDM population within the same ethnic group diagnosed by the new WHO criteria matches those diagnosed by the old one and consistency between the two criteria has not been reported.Thus,we conducted this study to analyze the two criteria in Chinese pregnant women. | Weiwei Zhu Huixia Yang Yumei Wei Zilian Wang Xuelan Li Hairong Wu Nan Li Meihua Zhang Xinghui Liu Hua Zhang Yunhui Wang Jianmin Niu Yujie Gan Liruo Zhong Yunfeng Wang Anil Kapur | 2015 | Chinese Medical Journal2015，，1： | 42 |
| 2 | Three-dimensional Finite Element Analysis of the Mechanical Properties of Helical Thread Connection显示文摘Conventional analytical and numerical methods for the mechanical properties of helical threads are relied on many assumptions and approximations and thus hardly yield satisfied results. A parameterized 3D finite element model of bolted joints with real helical thread geometry is established and meshed with refined hexahedral elements. The Von Mises plasticity criterion, kinematic hardening rule of materials and interfacial contacts are employed to make it possible for the suggested model be able to approach real assembly conditions. Then, the mechanical properties of bolted joints with different thread pitches, thread numbers and modular ratios are investigated, including the contact pressure distribution at joint interfaces, the axial load distribution and stress concentration in screw threads during the loading and unloading process. Simulation results indicate that the load distribution in screw threads produced by the suggested model agrees well the results from CHEN's photoelastic tests. In addition, an interesting phenomenon is found that tightening the bolt with a large preload first and then adjusting the clamping force by unloading can make the load distribution more uniform and reduce the maximum residual equivalent stress in thread roots by up to 40%. This research provides a simple and practical approach to constructing the 3D finite element model and predicting the mechanical properties of helical thread connection. | YANG Guoqing HONG Jun ZHU Linbo LI Baotong XIONG Meihua WANG Fei | 2013 | Chinese Journal of Mechanical Engineering2013，26，3： | 19 |
| 3 | A Novel Approach to Automatic Security Protocol Analysis Based on Authentication Event Logic显示文摘Since security protocols form the cornerstones of modern secure networked systems, it is important to develop informative, accurate, and deployable approach for finding errors and proving that protocols meet their security requirements. We propose a novel approach to check security properties of cryptographic protocols using authentication event logic. Compared with logic of algorithm knowledge, authentication event logic guarantees that any well-typed protocol is robustly safe under attack while reasoning only about the actions of honest principals in the protocol. It puts no bound on the size of the principal and requires no state space enumeration and it is decidable. The types for protocol data provide some intuitive explanation of how the protocol works. Our approach has led us to the independent rediscovery of flaws in existing protocols and to the design of improved protocols. | XIAO Meihua MA Chenglin DENG Chunyan ZHU Ke | 2015 | Chinese Journal of Electronics2015，24，1： | 10 |
| 4 | Activity after Site-Directed Mutagenesis of CD59 on Complement-Mediated Cytolysis显示文摘CD59 may inhibit the cytolytic activity of complement by binding to C8/C9 and protect host cell membranes against homologous membrane attack complex (MAC). However,CD59 is widely overexpressed on tumor cells,which has been implicated in tumorigenesis. The active site of CD59 relative to MAC is still confused. As reported the MAC binding site is located in the vicinity of a hydrophobic groove on the membrane distal face of the protein centered around residue W40. Here two site-directed mutagenesis were performed by overlapping extension PCR to delete residue W40 site (Mutant 1,M1) or to change C39W40K41 to W39W40W41 (Mutant 2,M2). Then we constructed mutant CD59 eukaryotic expression system and investigated their biological function on CHO cells compared with wild-type CD59. Stable populations of CHO cells expressing recombinant proteins were screened by immunotechnique. After 30 passages culturing,proteins could be tested. Dye release assays suggest that M1CD59 loses the activity against complement,while M2CD59 increases the anti-complement activity slightly. Results indicate that W40 of human CD59 is important to its activity,and prohibition of this site may be a potential way to increase complement activity and to treat tumors. | Xinhong Zhu Meihua Gao Shurong Ren Qiubo Wang Cunzhi Lin | 2008 | Cellular & Molecular Immunology2008，5，2： | 8 |
| 5 | Trajectory Estimation with Multi-range-rate System Based on Sparse Representation and Spline Model Optimization显示文摘The classic state methods for trajectory estimation in boost phase with multi-range-rate system include method of point-by-point manner and that of spline-model-based manner.Both are deficient in terms of model-approximation accuracy and systematic error determination thus resulting in the estimation errors well beyond the requirements,especially,concerning the maneuvering trajectory.This article proposes a new high-precision estimation approach based on the residual error analysis.The residual error comprises three components,i.e.systematic error,model truncation error and random error.The approach realizes self-adaptive estimation of systematic errors in measurements following the theory of sparse representation of signals to minimize the low-frequency components of residual errors.By taking median-and high-frequency components as indexes,the spline model-approximation is improved by optimizing node sequence of the spline function and the weight selection for data fusion through iteration.Simulation has validated the performances of the proposed method. | Liu Jiying,Zhu Jubo,Xie Meihua Department of Mathematics and Systems Science,National University of Defense Technology,Changsha 410073,China | 2010 | Chinese Journal of Aeronautics2010，23，1： | 5 |
| 6 | AoATG5 plays pleiotropic roles in vegetative growth,cell nucleus development,conidiation,and virulence in the nematode-trapping fungus Arthrobotrys oligospora显示文摘Autophagy is an evolutionarily conserved process in eukaryotes,which is regulated by autophagy-related genes(ATGs).Arthrobotrys oligospora is a representative species of nematode-trapping(NT)fungi that can produce special traps for nematode predation.To elucidate the biological roles of autophagy in NT fungi,we characterized an orthologous Atg protein,AoAtg5,in A.oligospora.We found that AoATG5 deletion causes a significant reduction in vegetative growth and conidiation,and that the transcript levels of several sporulation-related genes were significantly downregulated during sporulation stage.In addition,the cell nuclei were significantly reduced in theΔAoATG5 mutant,and the transcripts of several genes involved in DNA bio-synthesis,repair,and ligation were significantly upregulated.InΔAoATG5 mutants,the autophagic process was significantly impaired,and trap formation and nematocidal activity were significantly decreased.Comparative transcriptome analysis results showed that AoAtg5 is involved in the regulation of multiple cellular processes,such as autophagy,nitrogen metabolism,DNA biosynthesis and repair,and vesicular transport.In summary,our results suggest that AoAtg5 is essential for autophagy and significantly contributes to vegetative growth,cell nucleus development,sporulation,trap formation,and pathogenicity in A.oligospora,thus providing a basis for future studies focusing on related mechanisms of autophagy in NT fungi. | Duanxu Zhou Yingmei Zhu Na Bai Le Yang Meihua Xie Jiangliu Yang Meichen Zhu Ke-Qin Zhang Jinkui Yang | 2022 | Science China(Life Sciences)2022，65，2： | 2 |
| 7 | Interface Reversible Electric Field Regulated by Amphoteric Charged Protein-Based Coating Toward High-Rate and Robust Zn Anode显示文摘Metallic interface engineering is a promising strategy to stabilize Zn anode via promoting Zn^(2+) uniform deposition.However,strong interactions between the coating and Zn^(2+) and sluggish transport of Zn^(2+) lead to high anodic polarization.Here,we present a bio-inspired silk fibroin(SF)coating with amphoteric charges to construct an interface reversible electric field,which manipulates the transfer kinetics of Zn^(2+) and reduces anodic polarization.The alternating positively and negatively charged surface as a build-in driving force can expedite and homogenize Zn^(2+) flux via the inter-play between the charged coating and adsorbed ions,endowing the Zn-SF anode with low polarization voltage and stable plating/stripping.Experimental analyses with theo-retical calculations suggest that SF can facilitate the desolvation of[Zn(H_(2)O)_(6)]^(2+) and provide nucleation sites for uniform deposition.Consequently,the Zn-SF anode delivers a high-rate performance with low voltage polarization(83 mV at 20 mA cm^(−2)) and excellent stability(1500 h at 1 mA cm^(−2);500 h at 10 mA cm^(−2)),realizing exceptional cumulative capacity of 2.5 Ah cm^(−2).The full cell coupled with Zn_(x)V_(2)O_(5)·nH_(2)O(ZnVO)cathode achieves specific energy of~270.5/150.6 Wh kg^(−1)(at 0.5/10 A g^(−1))with-99.8% Coulombic efficiency and retains~80.3%(at 5.0 A g^(−1))after 3000 cycles. | Meihua Zhu Qing Ran Houhou Huang Yunfei Xie Mengxiao Zhong Geyu Lu Fu-Quan Bai Xing-You Lang Xiaoteng Jia Danming Chao | 2022 | Nano-Micro Letters2022，14，12： | 2 |
| 8 | Preparation and characterization of high water perm-selectivity ZSM-5 membrane without organic template显示文摘 | Zhu Meihua Lu Zhanghui Izumi Kumakiri | 2012 | Journal of Membrane Science2012，，： | 1 |
| 9 | Activating transcription factor 4 mediates a multidrug resistance phenotype of esophageal squamous cell carcinoma cells through transactivation of STAT3 expression显示文摘 | Hongwu Zhu Xiong Chen Bin Chen Bei Chen Jianyong Fan Weibing Song Ziying Xie Dan Jiang Qiuqiong Li Meihua Zhou Dayong Sun Yagang Zhao | 2014 | Cancer Letters2014，，1： | 1 |
| 10 | Growth process and short chain alcohol separation performance of fluoride-containing NaY zeolite membrane显示文摘Growth process of the NaY zeolite membranes was investigated by fluoride-containing precursor synthesis gel.Compared with the fluoride-free precursor synthesis gel,the irregular NaY zeolite crystals were dissolved into amorphous by the fluoride-containing precursor synthesis gel initially,the amorphous contained the Y-type zeolite characteristic bands by the IR characterization.The fine square NaY zeolite crystals arose from the amorphous,which were accumulated and gradually grew into a dense NaY zeolite layer on the support surface after 6.5 h.Because the excessive NaY zeolites were dissolved by the strong alkaline and fluoride-containing precursor synthesis gel,there was plenty of amorphous on NaY zeolites layer for prolonging the crystallization time.The assynthesized NaY zeolite membranes had a good separation performance and repeatability for separation of 10 wt%methanol(MeOH)/methyl methacrylate(MMA) mixture by pervaporation,the flux and separation factor were(1.27 ± 0.07) kg·M^(-2)·h^(-1) and(4900 ± 1500) at 323 K,respectively.Besides,the NaY zeolite membranes were applied to separate the other short chain alcohol from the various alcohol/organic ester and alcohol/organic ether mixtures,the NaY zeolite membranes showed high short chain alcohol perm-selectivity. | Xiaopan Chen Meihua Zhu Sitong Xiang Tian Gui TingWu Yuqin Li NaHu Izumi Kumakiri Xiangshu Chen Hidetoshi Kita | 2021 | Chinese Journal of Chemical Engineering2021，34，1： | 1 |
| 11 | Rapid preparation of acid-stable and high dehydration performance Mordenite membranes显示文摘 | ZHU Meihua XIA Shuilian HUAXuemei | 2014 | Industrial & Engineering Chemistry Research2014，53，19： | 1 |
| 12 | The distribution and availability of phosphorus fractions in restored cut slopes soil aggregates:a case study of subalpine road,Southwest China显示文摘The distribution and availability of phosphorus(P)fractions in restored cut slope soil aggregates,along altitude gradients,were analyzed.Samples were collected at 3009,3347,3654 and 3980 m of altitude.We examined soil aggregates total phosphorus(TP),available phosphorus(AP)and phosphorus activation coefficient(PAC),and discovered that there was no significant difference in TP levels between all four altitudes samples(p>0.05).However,there was a significant difference in AP at 3009,3347 and 3980 m of altitude(p<0.05).At the altitudes of 3009,3347 and 3654 m,the AP accumulation in small size aggregates was more advantageous.Overall,PAC dropped steadily as soil aggregates sizes increased,as shown:PAC(3654 m)>PAC(3347 m)>PAC(3009 m)>PAC(3980 m).In all particle size soil aggregates,the distribution of the P fractions was as follows:total inorganic phosphorus(TPi)>total organic phosphorus(TPo)>residual phosphorus(R-P),at 3009,3347 and 3654 m,but a different registry was observed at 3980 m of altitude:TPo>TPi>R-P.Through correlation and multiple stepwise regression analysis,it was concluded that active NaHCO_(3)-Pi was the main AP source.It was also suggested that more attention should be given to the ratio of small particle size aggregates to increase soil AP storage.In order to improve the activation capacity and supply of soil P,along with promotion of the healthy development of soil ecosystem on slope land,it was suggest that inorganic P fertilizer and P activator could be added to soil at both low(3009 m)and high altitudes(3980 m). | Mengke Zhu Bocong Huang Shenghao Ai Zongyang Liu Xiaoyan Ai Meihua Sheng Yingwei Ai | 2023 | Frontiers of Environmental Science & Engineering2023，17，4： | 1 |
| 13 | Dehydration of acetic acid and esterification product by acid-stable ZSM-5 membrane显示文摘 | ZHU Meihua KUMAKIRI Izumi TANAKA Kazuhiro | 2013 | Microporous and Mesoporous Materials2013，181，： | 1 |
| 14 | Enterprise information cost management显示文摘 | Zhu Meihua | | 0，，09： | 1 |
| 15 | Itraconazole and Nail Scraping in the Treatment of Onychomycosis( A open trial of175 cases)显示文摘Objective Itraconazole pulse therapy is at lest as efficient as itraconazole continuous treatment for onychomyocsis, but the long term oral antimycotic therapy has potential hepatotoxicity.Methods\ 40% urea paste was thickly applied to each affected nail which was dressed by three cloth adhesive tapes. The urea paste was changed every day or every other day for 5 to 7 days. The sick softened nails were scraped off thoroughly with razer blade. After sick nails were removed, all patients received 200 mg of itraconazole twice a day for seven consecutive days. Results\ Fingernail onychomycosis were cured in 93% (130/140), markedly improved in 6.4% (9/140). Toenail onychomycosis were cured in 82% (29/35), markedly improved in 17.1(6/35). And in a 18 month follow up period, 16(10 2%) of 147 patients had relapses. Conclusion\ The treatment of onychomycosis with oral itraconazole plus nail scraping is as effective as that of itraconazole pulse therapy but has less side effect and lower cost.\; | Zhu Wenyuan(朱文元) Fan Weixin(范卫新) Zhou Baoquan(周宝泉) Zhang Meihua(张美华) Department of Dermatology, the First Affiliated Hospital, Nanjing Medical University,Nanjing 210029, P.R.China | 2000 | Journal of Nanjing Medical University2000，14，1： | 0 |
| 16 | Effects of ion-exchange on the pervaporation performance and microstructure of NaY zeolite membrane显示文摘Pervaporation performance of NaY zeolite membranes is improved by ion-exchange with di-valent nitrate salt.Different nitrate salts,including Co(NO_(3))_(2),Mg(NO_(3))_(2),Zn(NO_(3))_(2),Ca(NO_(3))_(2),Cu(NO_(3))_(2),KNO_(3),and AgNO_(3),have great effects on the channel structure and water affinity of the NaY zeolite membrane.When the concentration of nitrate salt,ion-exchange temperature and time are 0.1 mol·L^(-1),50℃and 2 h,the ion-exchange degree order of NaY zeolites is Ag^(+)>K^(+)>Ca^(2+)>Zn^(2+)>>Co^(2+)>Mg^(2+).Especially,Ag^(+)and K^(+)cation exchange degree of NaY zeolites are achieved to 96.54% and 82.77% in this work.BET surface,total pore capacity,pore size distribution and water contact angle of the ion-exchanged NaY zeolites are all disordered by mono-and di-valent cations.Di-valent nitrate salt is favor for increasing the dehydration performance of NaY zeolite membranes by ion-exchange.When the ion-exchange solution is Zn(NO_(3))_(2),the total flux variation and separation factor variation of the NaY membrane(M-5)are -45% and 230% for separation of 10%(mass)H_(2)O/EtOH mixture by pervaporation,and the ion-exchanged membranes showed good reproducibility. | Meihua Zhu Xingguo An Tian Gui Ting Wu Yuqin Li Xiangshu Chen | 2023 | Chinese Journal of Chemical Engineering2023，59，7： | 0 |
| 17 | Design,synthesis and biological evaluation of pyridyl substituted benzoxazepinones as potent and selective inhibitors of aldosterone synthase显示文摘Exorbitant aldosterone is closely associated with various severe diseases,including congestive heart failure and chronic kidney disease.As aldosterone synthase is the pivotal enzyme in aldosterone biosynthesis,its inhibition constitutes a promising treatment for these diseases.Via a structure-based approach,a series of pyridyl substituted 3,4-dihydrobenzo[f][1,4]oxazepin-5(2 H)-ones were designed as inhibitors of aldosterone synthase.Six compounds(5 j,5 l,5 m 5 w,5 x and 5 y)distinguished themselves with potent inhibition(IC50<100 nmol/L)and high selectivity over homogenous 11β-hydroxylase.As the most promising compound,5 x exhibited an IC_(50) of 12 nmol/L and an excellent selectivity factor(SF)of157,which are both superior to those of the re ference fadrazole(IC_(50)=21 nmol/L,SF=7).Importantly,5 x showed no inhibition against steroidogenic CYP17,CYP19 and a panel of hepatic CYP enzymes indicating an outstanding sa fety profile.As it manifested satis factory pharmacokinetic pro perties in rats,compound5 x was considered as a drug candidate for further development. | Haichao Zhu Meihua Liu Haiyan Li Ting Guan Qi Zhang Yang Chen Yingxiang Liu Rolf RHartmann Lina Yin Qingzhong Hu | 2021 | Chinese Chemical Letters2021，32，7： | 0 |
| 18 | BEAUTIFUL STREETS, BEAUTIFUL LIVES显示文摘Beijing's top10'most beautiful streets and alleys'in 2020 were recently officially announced,highlighting the revitalisation of the city's historic byways.Ten streets and alleys,including Changxiang Toutiao in Dongcheng District,Wenhua Hutong in Xicheng District and Luhe Middle School North Street in Tongzhou District,have become the new standard bearers of Bejing's rebirth,standing out as shining examples of community collaboration and joint governance. | Zhu Jiangting Qu Bowei(Photos) Xu Meihua(Photos) Zhou Shijie(Photos) | 2021 | Beijing2021，，2： | 0 |
| 19 | Optimal procurement strategy of fresh produce retailer under stochastic product qualification and market demand显示文摘Consider an optimal procurement strategy for fresh produce,which is a type of perishable product.Due to the different quality provided by each manufacturer,the fresh produce qualification rates are dissimilar.Simultaneously,consumers demand is influenced by the freshness and price of products,as a result,the demand in the market is not fixed.In this scenario,how a particular retailer should develop an optimal procurement strategy will be a core issue in supply chain management.In order to address the above questions,the Bayesian approach is adopted to explore retailer optimal procurement strategies with uncertainty about product supply and market demand.Finally,simulation data are used to analyse the results of the proposed model and expected non-random model to illustrate the validity and feasibility of the proposed model. | Zhouyang Liang Hongwei Liu Meihua Zuo Hui Zhu Yonghua Zuo | 2021 | Journal of Control and Decision2021，8，2： | 0 |
| 20 | Role of neutrophil extracellular traps in inflammatory evolution in severe acute pancreatitis显示文摘Severe acute pancreatitis(SAP)is a life-threatening acute abdominal disease with two peaks of death:the first in the early stage,characterized by systemic inflammatory response-associated organ failure;and the second in the late stage,characterized by infectious complications.Neutrophils are the main immune cells participating in the whole process of SAP.In addition to the traditional recognition of neutrophils as the origination of chemokine and cytokine cascades or phagocytosis and degranulation of pathogens,neutrophil extracellular traps(NETs)also play an important roles in inflammatory reactions.We reviewed the role of NETs in the occurrence and development of SAP and its fatal complications,including multiple organs injury,infected pancreatic necrosis,and thrombosis.This review provides novel insights into the involvement of NETs throughout the entire process of SAP,showing that targeting NETs might be a promising strategy in SAP treatment.However,precision therapeutic options targeting NETs in different situations require further investigation. | Hongxin Kang Yue Yang Lv Zhu Xianlin Zhao Juan Li Wenfu Tang Meihua Wan | 2022 | Chinese Medical Journal2022，135，23： | 0 |
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