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| 1 | RNA-seq analysis of prostate cancer in the Chinese population identifies recurrent gene fusions, cancer-associated long noncoding RNAs and aberrant alternative splicings显示文摘在有前列腺癌症的不同赛跑的病人之中有显著不同;然而,位于这差别下面的机制仍然保持不清楚。这里,我们在场 transcriptome 的一处全面风景用 RNA-seq,越过关于基因熔化的前列腺癌症 transcriptomes 的揭示巨大的差异,长 noncoding RNA (长 ncRNA ) ,其他的拼接和体的变化从中国人口 14 主要前列腺癌症和他们的配对的正常对应物介绍。14 个肿瘤(21.4%) 中的三个在中国病人怀有 TMPRSS2 尔格熔化,和这熔化的低流行进一步在一个另外的肿瘤集合(10/54=18.5%) 被证实。尤其是,二新奇基因熔化, CTAGE5-KHDRBS3 (20/54=37%) 和 USP9Y-TTTY15 (19/54=35.2%) ,在我们的耐心的队经常发生了。介绍的进一步系统的 transcriptional 识别了是在肿瘤表示的差别的众多的长 ncRNAs。在长 ncRNA 和基因的表示之间的关联的分析建议长 ncRNAs 可以在 transcriptional 规定以外有功能。这研究在中国人口产出新卓见进前列腺癌症的致病。 | Shancheng Ren Zhiyu Peng Jian-Hua Mao Yongwei Yu Changjun Yin Xin Gao Zilian Cui Jibin Zhang Kang Yi Weidong Xu Chao Chen Fubo Wang Xinwu Guo Ji Lu Jun Yang Min Wei Zhijian Tian Yinghui Guan Liang Tang Chuanliang Xu Linhui Wang Xu Gao Wei Tian Jian Wang Huanming Yang Jun Wang Yinghao Sun | 2012 | Cell Research2012，22，5： | 66 |
| 2 | Comparing the Diagnostic Criteria for Gestational Diabetes Mellitus of World Health Organization 2013 with 1999 in Chinese Population显示文摘INTRODUCTION Gestational diabetes mellitus (GDM) was earlier defined as 'hyperglycemia first recognized during pregnancy' and has more recently been described by American Diabetes Association (ADA) (2012) as diabetes diagnosed during pregnancy that is not clearly overt diabetes.[1] The hyperglycemia and adverse pregnancy outcomes study (HAPO) demonstrated that the risk of adverse maternal,fetal,and neonatal outcomes continuously increase as a function of maternal glycemia at 24-28 weeks,even within ranges previously considered normal for pregnancy.[2] After reviewing the results of the HAPO study,many international diabetes study groups,including the International Association of Diabetes and Pregnancy Study Groups and ADA have adopted the 75 g oral glucose tolerance test (OGTT) at 24-28 weeks as a screening and diagnostic test and defined new cut-off values for GDM diagnosis.The Ministry of Health of China published the criteria for GDM,that is the same as the ADA criteria on July 1,2011.World Health Organization (WHO) has recommended the 75 g OGTT with different cut-offvalues as a diagnostic test since 1999,changed its recommendation on 2013.In Hongkong and Yunnan province in China,most hospital adopted the WHO 1999 criteria,nevertheless,there is no evidence of multicenter and large sample to show that the GDM population within the same ethnic group diagnosed by the new WHO criteria matches those diagnosed by the old one and consistency between the two criteria has not been reported.Thus,we conducted this study to analyze the two criteria in Chinese pregnant women. | Weiwei Zhu Huixia Yang Yumei Wei Zilian Wang Xuelan Li Hairong Wu Nan Li Meihua Zhang Xinghui Liu Hua Zhang Yunhui Wang Jianmin Niu Yujie Gan Liruo Zhong Yunfeng Wang Anil Kapur | 2015 | Chinese Medical Journal2015，，1： | 42 |
| 3 | Processes of coastal ecosystem carbon sequestration and approaches for increasing carbon sink显示文摘The oceans are the largest carbon pools on Earth, and play the role of a 'buffer' in climate change. Blue carbon, the carbon(mainly organic carbon) captured by marine ecosystems, is one of the important mechanisms of marine carbon storage.Blue carbon was initially recognized only in the form of visible coastal plant carbon sequestration. In fact, microorganisms(phytoplankton, bacteria, archaea, viruses, and protozoa), which did not receive much attention in the past, account for more than 90% of the total marine biomass and are the main contributors to blue carbon. Chinese coastal seas, equivalent to 1/3 of China's total land area, have a huge carbon sink potential needing urgently research and development. In this paper, we focus on the processes and mechanisms of coastal ocean's carbon sequestration and the approaches for increasing that sequestration. We discuss the structures of coastal ecosystems, the processes of carbon cycle, and the mechanisms of carbon sequestration. Using the evolution of coastal ocean's carbon sinks in sedimentary records over geologic times, we also discuss the possible effects of natural processes and anthropogenic activities on marine carbon sinks. Finally, we discuss the prospect of using carbon sequestration engineering for increasing coastal ocean's carbon storage capacity. | ZHANG Yao ZHAO MeiXun CUI Qiu FAN Wei QI JiaGuo CHEN Ying ZHANG YongYu GAO KunShan FAN JingFeng WANG GuangYi YAN ChongLing LU HaoLiang LUO YaWei ZHANG ZiLian ZHENG Qiang XIAO Wei JIAO NianZhi | 2017 | Science China Earth Sciences2017，60，5： | 6 |
| 4 | The Differences of Gestational Diabetes Outpatient Management Between China and the United Kingdom:from the Perspective of a First-Year Resident显示文摘Introduction Gestational hyperglycemia is well-known associated with increased risks of fetal malformations,macrosomia,shoulder dystocia,fetal distress,and so on,also it threatens the long-term health of both mothers and their children.1 Gestational diabetes mellitus(GDM)refers to the first onset or detection of impaired glucose tolerance during pregnancy,with the exception of prepregnancy diabetes firstly recognized.Most GDM patients can effectively control blood glucose(BG)and improve pregnancy outcomes through lifestyle interventions2. | Zhuofan Yang Zhuyu Li Haitian Chen Zilian Wang | 2021 | Maternal-Fetal Medicine2021，3，3： | 1 |
| 5 | Two Successful Livebirths from Both Hemiuteruses After Laparoscopic Cervical Cerclage in a Uterus Didelphys Patient with Cervical Insufficiency显示文摘Uterus didelphys occurs in~0.4%of females and is found in~11%-20%of all uterus defects.It is a risk factor for cervical insufficiency,consequently contributing to late miscarriage or preterm birth.Thus far,only two prior cases of uterus didelphys accompanied by cervical insufficiency treated through laparoscopic cervical cerclage have been reported;however,livebirth only occurred in one hemiuterus.Herein,we report a case of uterus didelphys in a patient diagnosed with cervical insufficiency.Following the placement of a modified laparoscopic cervical cerclage,the patient had two successful livebirths through both hemiuteruses,respectively,with longer gestation age(ie,>36 weeks).The aim of this case report was to provide useful information for clinical practitioners to make better decisions on the management of cervical insufficiency in patients with uterus didelphys,and identify obstetric complications that clinicians should pay attention to during pregnancy. | Limei Zhang Xue Zhong Yuqing Chen Tianyu Peng Liyun Yu Jian Cai Shuzhong Yao Zilian Wang | 2022 | Maternal-Fetal Medicine2022，4，2： | 1 |
| 6 | Emergency Cervical Cerclage Following Laparoscopic Abdominal Cerclage with Cervical Dilatation显示文摘To editor:Cervical insufficiency,or cervical incompetence,is characterized by painless cervix dilatation during the second trimester without contractions.1 It is found in 0.1%–1%of all pregnancies and in up to 8.0%of women with recurrent second-trimester miscarriages.2–4 Cervical insufficiency is associated with premature birth,which is a leading cause of neonatal and perinatal mortality and morbidity. | Songqing Deng Yanchun Liang Yajing Wei Jianhong Shang Shuzhong Yao Zilian Wang | 2023 | Maternal-Fetal Medicine2023，5，4： | 0 |
| 7 | Sika Deer Behavior Recognition Based on Machine Vision显示文摘With the increasing intensive and large-scale development of the sika deer breeding industry,it is crucial to assess the health status of the sika deer by monitoring their behaviours.A machine vision-based method for the behaviour recognition of sika deer is proposed in this paper.Google Inception Net(GoogLeNet)is used to optimise the model in this paper.First,the number of layers and size of the model were reduced.Then,the 5×5 convolution was changed to two 3×3 convolutions,which reduced the parameters and increased the nonlinearity of the model.A 5×5 convolution kernel was used to replace the original convolution for extracting coarse-grained features and improving the model’s extraction ability.A multi-scale module was added to the model to enhance the multi-faceted feature extraction capability of the model.Simultaneously,the Squeeze-and-Excitation Networks(SE-Net)module was included to increase the channel’s attention and improve the model’s accuracy.The dataset’s images were rotated to reduce overfitting.For image rotation,the angle wasmultiplied by 30°to obtain the dataset enhanced by rotation operations of 30°,60°,90°,120°and 150°.The experimental results showed that the recognition rate of this model in the behaviour of sika deer was 98.92%.Therefore,the model presented in this paper can be applied to the behaviour recognition of sika deer.The results will play an essential role in promoting animal behaviour recognition technology and animal health monitoring management. | He Gong Mingwang Deng Shijun Li Tianli Hu Yu Sun Ye Mu Zilian Wang Chang Zhang Thobela Louis Tyasi | 2022 | Computers, Materials & Continua2022，，12： | 0 |
| 8 | Flexible Strain Sensor Based on 3D Electrospun Carbonized Sponge显示文摘Flexible strain sensor has attracted much attention because of its potential application in human motion detection.In this work,the prepared strain sensor was obtained by encapsulating electrospun carbonized sponge(CS)with room temperature vulcanized silicone rubber(RTVS).In this paper,the formation mechanism of conductive sponge was studied.Based on the combination of carbonized sponge and RTVS,the strain sensing mechanism and piezoresistive properties are discussed.After research and testing,the CS/RTVS flexible strain sensor has excellent fast response speed and stability,and the maximum strain coefficient of the sensor is 136.27.In this study,the self-developed CS/RTVS sensor was used to monitor the movements of the wrist joint,arm elbow joint and fingers in real time.Research experiments show that CS/RTVS flexible strain sensor has good application prospects in the field of human motion monitoring. | He Gong Zilian Wang Zhiqiang Cheng Lin Chen Haohong Pan Daming Zhang Tianli Hu Thobela Louis Tyasi | 2022 | Computers, Materials & Continua2022，，12： | 0 |
| 9 | Interobserver Agreement and Reliability of Intrapartum Nonreassuring Cardiotocography and Prediction of Neonatal Acidemia显示文摘Objective:To evaluate the agreement and reliability of intrapartum nonreasurring cardiotocography(CTG)interpretation and prediction of neonatal acidemia by obstetricians working in different centers.Methods:A retrospective cohort study involving two tertiary hospitals(The First Affiliated Hospital of Sun Yat-sen University and Perking University Third Hospital)was conducted between 30th September 2018 and 1st April 2019.Six obstetricians from two hospitals with three levels of experience(junior,medium,and senior)reviewed 100 nonreassuring fetal heart rate(FHR)tracings from 1 hour before the onset of abnormalities until delivery.Each reviewer determined the FHR pattern,the baseline,variability,and presence of acceleration,deceleration,sinusoidal pattern,and predicted whether neonatal acidemia and abnormal umbilical arterial pH<7.1 would occur.Inter-observer agreement was assessed using the proportions of agreement(Pa)and the proportion of specific agreement(Pa for each category).Reliability was evaluated with the kappa statistic(k-Light’s kappa for n raters)and Gwet’s AC1 statistic.Results:Good inter-observer agreement was found in evaluation of most variables(Pa>0.5),with the exception of early deceleration(Pa=0.39,95%confidence interval(CI):0.36,0.43).Reliability was also good among most variables(AC1>0.40),except for acceleration,early deceleration,and prediction of neonatal acidemia(AC1=0.17,0.10,and 0.25,respectively).There were no statistically significant differences among the three groups,except in the identification of accelerations(Pa=0.89,95%CI:0.83,0.95;Pa=0.50,95%CI:0.41,0.60,and Pa=0.35,95%CI:0.25,0.43 in junior,medium and senior groups,respectively)and the prediction of neonatal acidemia(Pa=0.52,0.52,and 0.62 in junior,medium and senior groups,respectively),where agreement was highest and lowest in the junior-level group,respectively.The accuracy and sensitivity of the prediction for umbilical artery pH<7.1 were similar among the three groups,but the specificity was higher in the senior groups(93.68%vs.92.53%vs.98.85%in junior,medium and senior groups,P=0.015).Conclusion:Although we found a good inter-observer agreement in the evaluation of the most basic CTG features and FHR category statistically,it was insufficient to meet the clinical requirements for'no objection'interpretation for FHR tracings.Further specialized training is needed for standardized interpretation of intrapartum FHR tracings. | Zhuyu Li Yan Wang Jian Cai Peizhen Zhao Hanqing Chen Haiyan Liu Lixia Shen Lian Chen Shufang Li Yangyu Zhao Zilian Wang | 2022 | Maternal-Fetal Medicine2022，4，2： | 0 |
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