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| 1 | SP1 governs primordial folliculogenesis by regulating pregranulosa cell development in mice显示文摘Establishment of the primordial follicle(PF)pool is pivotal for the female reproductive lifespan;however,the mechanism of primordial folliculogenesis is poorly understood.Here,the transcription factor SP1 was shown to be essential for PF formation in mice.Our results showed that SP1 is present in both oocytes and somatic cells during PF formation in the ovary.Knockdown of Sp1 expression,especially in pregranulosa cells,significantly suppressed nest breakdown,oocyte apoptosis,and PF formation,suggesting that SP1 expressed by somatic cells functions in the process of primordial folliculogenesis.We further demonstrated that SP1 governs the recruitment and maintenance of Forkhead box L2-positive(FOXL2^+)pregranulosa cells using an Lgr5-EGFP-IRES-CreER^T2(Lgr5-KI)reporter mouse model and a FOXL2^+ cell-specific knockdown model.At the molecular level,SP1 functioned mainly through manipulation of NOTCH2 expression by binding directly to the promoter of the Notch2 gene.Finally,consistent with the critical role of granulosa cells in follicle survival in vitro,massive loss of oocytes in SP1 knockdown ovaries was evidenced before puberty after the ovaries were tranSP1anted under the renal capsules.Conclusively,our results reveal that SP1 controls the establishment of the ovarian reserve by regulating pregranulosa cell development in the mammalian ovary. | Han Cai Bingying Liu Huarong Wang Guanghong Sun Lizhao Feng Ziqi Chen Jiaqi Zhou Jiawei Zhang Tuo Zhang Meina He Tingting Yang Qirui Guo Zhen Teng Qiliang Xin Bo Zhou Hua Zhang Guoliang Xia Chao Wang | 2020 | Journal of Molecular Cell Biology2020，12，3： | 3 |
| 2 | Quantum:may be a new-found me- ssenger in biological systems显示文摘 | Han Jinxiang Yang Meina | 2011 | Bio Science Trends2011，5，3： | 1 |
| 3 | Quantum: May be a new - found messenger in biological systems 显示文摘 | Jinxiang Han Meina Yang | 2011 | Bioscicnce trends2011，5，3： | 1 |
| 4 | Microarray Analysis Reveals Similarities and Variations in Genetic Programs Controlling Pollination/Fertilization and Stress Responses in Rice (Oryza sativa L.)显示文摘 | Lefu Lan Meina Li Ying Lai Wenying Xu Zhaosheng Kong Kai Ying Bin Han Yongbiao Xue | 2005 | Plant Molecular Biology2005，，1： | 1 |
| 5 | Structure and immunomodulatory activity of Lentinus edodes polysaccharides modified by probiotic fermentation显示文摘Plant-based fermentations provide an untapped source for novel biotechnological applications.In this study,a probiotic named Lactobacillus fermentum 21828 was introduced to ferment Lentinus edodes.Polysaccharides were extracted from fermented and non-fermented L.edodes and purified via DEAE-52 and Sephadex G-100.The components designated F-LEP-2a and NF-LEP-2a were analyzed by FT-IR,HPGPC,HPAEC,SEM,GC-MS and NMR.The results revealed that probiotic fermentation increased the molecular weight from 1.16×10^(4) Da to 1.87×10^(4) Da and altered the proportions of glucose,galactose and mannose,in which glucose increased from 45.94%to 48.16%.Methylation analysis and NMR spectra indicated that F-LEP-2a and NF-LEP-2a had similar linkage patterns.Furthermore,their immunomodulatory activities were evaluated with immunosuppressive mice.NF-LEP and F-LEP improved immune organ indices,immunoglobulin(Ig G and Ig M)and cytokines concentrations;restored the antioxidation capacity of liver;and maintained the balance of gut microbiota.F-LEP displayed better moderating effects on the spleen index,immunoglobulin,cytokines and the diversity of gut microbiota than NF-LEP(200,400 mg/kg).Our study provides an efficient and environment-friendly way for the structural modification of polysaccharides,which helps to enhance their biological activity and promote their wide application in food,medicine and other fields. | Jingjing Liang Meina Zhang Xiaohan Li Yuan Yue Xiaowei Wang Mengzhen Han Tianli Yue Zhouli Wang Zhenpeng Gao | 2024 | Food Science and Human Wellness2024，13，1： | 0 |
| 6 | Immobilized microalgal system:An achievable idea for upgrading current microalgal wastewater treatment显示文摘Efficient wastewater treatment accompanied by sustainable“nutrients/pollutants waste-wastewaterresources/energy nexus”management is acting as a prominent and urgent global issue since severe pollution has occurred increasingly.Diverting wastes from wastewater into the value-added microalgalbiomass stream is a promising goal using biological wastewater treatment technologies.This review proposed an idea of upgrading the current microalgal wastewater treatment by using immobilized microalgal system.Firstly,a systematic analysis of microalgal immobilization technology is displayed through an in-depth discussion on why using immobilized microalgae for wastewater treatment.Subsequently,the main technical approaches employed for microalgal immobilization and pollutant removal mechanisms by immobilized microalgae are summarized.Furthermore,from high-tech technologies to promote large-scale production and application potentials in diverse wastewater and bioreactors to downstream applications lead upgradation closer,the feasibility of upgrading existing microalgal wastewater treatment into immobilized microalgal systems is thoroughly discussed.Eventually,several research directions are proposed toward the future immobilized microalgal system for microalgal wastewater treatment upgrading.Together,it appears that using immobilization for further upgrading the microalgae-based wastewater treatment can be recognized as an achievable alternative to make microalgal wastewater treatment more realistic.The information and perspectives provided in this review also offer a feasible reference for upgrading conventional microalgae-based wastewater treatment. | Meina Han Chaofan Zhang Shih-Hsin Ho | 2023 | Environmental Science and Ecotechnology2023，，2： | 0 |
| 7 | Revealing the role of microalgae-bacteria niche for boosting wastewater treatment and energy reclamation in response to temperature显示文摘Conventional biological treatment usually cannot achieve the same high water quality as advanced treatment when conducted under varied temperatures.Here,satisfactory wastewater treatment efficiency was observed in a microalgae-bacteria consortia(MBC)over a wide temperature range because of the predominance of microalgae.Microalgae contributed more toward wastewater treatment at low temperature because of the unsatisfactory performance of the accompanying bacteria,which experienced cold stress(e.g.,bacterial abundance below 3000 sequences)and executed defensive strategies(e.g.,enrichment of cold-shock proteins).A low abundance of amoA-C and hao indicated that conventional nitrogen removal was replaced through the involvement of microalgae.Diverse heterotrophic bacteria for nitrogen removal were identified at medium and high temperatures,implying this microbial niche treatment contained diverse flexible consortia with temperature variation.Additionally,pathogenic bacteria were eliminated through microalgal photosynthesis.After fitting the neutral community model and calculating the ecological niche,microalgae achieved a maximum niche breadth of 5.21 and the lowest niche overlap of 0.38,while the accompanying bacterial community in the consortia were shaped through deterministic processes.Finally,the maximum energy yield of 87.4 kJ L^(-1)and lipid production of 1.9 g L^(-1)were achieved at medium temperature.Altogether,this study demonstrates that advanced treatment and energy reclamation can be achieved through microalgae-bacteria niche strategies. | Chaofan Zhang Xi Chen Meina Han Xue Li Haixing Chang Nanqi Ren Shih-Hsin Ho | 2023 | Environmental Science and Ecotechnology2023，，2： | 0 |
| 8 | An ethylene-induced NAC transcription factor acts as a multiple abiotic stress responsor in conifer显示文摘The proper response to various abiotic stresses is essential for plants’survival to overcome their sessile nature,especially for perennial trees with very long-life cycles.However,in conifers,the molecular mechanisms that coordinate multiple abiotic stress responses remain elusive.Here,the transcriptome response to various abiotic stresses like salt,cold,drought,heat shock and osmotic were systematically detected in Pinus tabuliformis(P.tabuliformis)seedlings.We found that four transcription factors were commonly induced by all tested stress treatments,while PtNAC3 and PtZFP30 were highly up-regulated and co-expressed.Unexpectedly,the exogenous hormone treatment assays and the content of the endogenous hormone indicates that the upregulation of PtNAC3 and PtZFP30 are mediated by ethylene.Time-course assay showed that the treatment by ethylene immediate precursor,1-aminocyclopropane-1-carboxylic acid(ACC),activated the expression of PtNAC3 and PtZFP30 within 8 hours.We further confirm that the PtNAC3 can directly bind to the PtZFP30 promoter region and form a cascade.Overexpression of PtNAC3 enhanced unified abiotic stress tolerance without growth penalty in transgenic Arabidopsis and promoted reproductive success under abiotic stress by shortening the lifespan,suggesting it has great potential as a biological tool applied to plant breeding for abiotic stress tolerance.This study provides novel insights into the hub nodes of the abiotic stresses response network as well as the environmental adaptation mechanism in conifers,and provides a potential biofortification tool to enhance plant unified abiotic stress tolerance. | Fangxu Han Peiyi Wang Xi Chen Huanhuan Zhao Qianya Zhu Yitong Song Yumeng Nie Yue Li Meina Guo Shihui Niu | 2023 | Horticulture Research2023，10，8： | 0 |
| 9 | Recent progress of traditional Chinese medical science based on theory of biophoton显示文摘 | Xiuxiu WANG Jinzhao HUANG Jinxiang HAN Meina YANG Jingxiang PANG Xiaolei ZHAO | 2014 | Frontiers of Optoelectronics2014，7，1： | 0 |
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