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| 1 | Mesenchymal stem cell-derived small extracellular vesicles mitigate oxidative stress-induced senescence in endothelial cells via regulation of miR-146a/Src显示文摘Senescent endothelial cells (ECs) could impair the integrity of the blood vessel endothelium, leading to vascular aging and a series of diseases, such as atherosclerosis, diabetes. Preventing or mitigating EC senescence might serve as a promising therapeutic paradigm for these diseases. Recent studies showed that small extracellular vesicles (sEV) have the potential to transfer bioactive molecules into recipient cells and induce phenotypic changes. Since mesenchymal stem cells (MSCs) have long been postulated as an important source cell in regenerative medicine, herein we investigated the role and mechanism of MSC-derived sEV (MSC-sEV) on EC senescence. In vitro results showed that MSC-sEV reduced senescent biomarkers, decreased senescence-associated secretory phenotype (SASP), rescued angiogenesis, migration and other dysfunctions in senescent EC induced by oxidative stress. In the In vivo natural aging and type-2 diabetes mouse wound-healing models (both of which have senescent ECs), MSC-sEV promoted wound closure and new blood vessel formation. Mechanically, miRNA microarray showed that miR-146a was highly expressed in MSC-sEV and also upregulated in EC after MSC-sEV treatment. miR-146a inhibitors abolished the stimulatory effects of MSC-sEV on senescence. Moreover, we found miR-146a could suppress Src phosphorylation and downstream targets VE-cadherin and Caveolin-1. Collectively, our data indicate that MSC-sEV mitigated endothelial cell senescence and stimulate angiogenesis through miR-146a/Src. | Xian Xiao Meiqian Xu Hongliang Yu Liping Wang Xiaoxia Li Janusz Rak Shihua Wang Robert Chunhua Zhao | 2021 | Signal Transduction and Targeted Therapy2021，6，11： | 5 |
| 2 | Degradation of 2,2′,4,4′-tetrabromodiphenyl ether by Pycnoporus sanguineus in the presence of copper ions显示文摘The degradation of 2,2′,4,4′-tetrabromodiphenyl ether(BDE-47) by Pycnoporus sanguineus was investigated in order to explore the impact of the heavy metal Cu2+ on BDE-47 decomposition and the subsequent formation of metabolites, as well as to further elucidate the degradation mechanism of BDE-47. An increase in degradation rate from 18.63% to49.76% in the first four days and its stabilization at(51.26 ± 0.08)% in the following days of BDE-47 incubation were observed. The presence of Cu2+ at 1 and 2 mg/L was found to promote the degradation rate to 56.41% and 60.79%, respectively, whereas higher level of Cu2+(≥ 5 mg/L) inhibited the removal of BDE-47. The similar concentration effects of Cu2+ was also found on contents of fungal protein and amounts of metabolites. Both intracellular and extracellular enzymes played certain roles in BDE-47 transportation with the best degradation rate at 27.90% and 27.67% on the fourth and third day, individually. During the degradation of BDE-47, four types of hydroxylated polybrominated diphenyl ethers(OH-PBDEs), i.e., 6′-OH-BDE-47, 5′-OH-BDE-47, 4′-OH-BDE-17, 2′-OH-BDE-28, and two bromophenols, i.e., 2,4-DBP and 4-BP were detected and considered as degradation products. These metabolites were further removed by P. sanguineus at rates of 22.42%,23.01%, 27.04%, 27.96%, 64.21%, and 40.62%, respectively. | Meiqian Wang Hua Yin Hui Peng Mi Feng Guining Lu Zhi Dang | 2019 | Journal of Environmental Sciences2019，31，9： | 4 |
| 3 | Study on drying and combustion process in grate-CFB incinerator显示文摘The drying and combustion process in the combined grate and circulating fluidized bed(grate-CFB) municipal solid waste(MSW) incinerator was investigated experimentally and mathematically.The drying grate bed was simulated by a muffle furnace,which could be controlled at a constant tempera-ture level.The kind of wastes,thickness of waste layer fed and temperature were chosen as the ad-justable parameters to study their effect on the drying process.The experimental results indicated that the hydrophilic wastes were more difficult to be dried than the hydrophobic wastes.The higher the temperature is the easier the waste is to be dried.The thinner waste layer is favorable to drying the waste.The pyrolysis experiment in the furnace showed that the higher temperature level could reduce the conversion rate of carbon to carbon monoxide.The semi-empirical mathematical model that in-cluded the bed material distribution submodel,volatile matter release submodel,carbon particle combustion submodel and so on was proposed.A 260 t/d grate-CFB incinerator was modeled and the model predicted bulk density agreed with the measured value from industrial field test.The predicted flue gas(e.g.CO2,CO) concentration deviated slightly from the industrial test data.The parameters and variables used in the model were determined by the experiments or practical field test.This model can be used to design the grate-CFB incinerator and guide its operation. | QingHai Li YanGuo Zhang MeiQian Chen AiHong Meng ChangHe Chen | 2009 | Science China(Technological Sciences)2009，52，5： | 3 |
| 4 | Isother- mal Kinetics Based on two-Periods Scheme for Co-Drying of Biomass and Lignite 显示文摘 | Liu Huanming Chen Meiqian Han Zilong | 2013 | Thermochimica Acta2013，573，： | 1 |
| 5 | Thermodynamic-analy- sis-based energy consumption minimization for natural gas liquefac- tion显示文摘 | Wang Meiqian Zhang Jian Xu Qiang | 2011 | Industrial & Engineering Chemistry Research2011，50，12： | 1 |
| 6 | Butyrate Regulates the Expression of Pathogen - Triggered IL - 8 in Intestinal Epithelia 显示文摘 | Weng Meiqian Walker W allan Sanderson Ianr | 2007 | Pediatric Res2007，62，5： | 1 |
| 7 | Numerical study of the optimum counter-flow mode of air jets in a large utility furnace显示文摘 | HE BOSHU CHEN MEIQIAN YU QIUMEI | 2004 | Computers and fluids2004，33，： | 1 |
| 8 | Adiponectin deo creases pulmonary arterial remodeling in murine models of pulmonary hypertension显示文摘 | Meiqian Weng Michael J Raher Patricio Leyton | 2011 | Am J Respir Cell Mol Bio12011，45，： | 1 |
| 9 | Numerical study of the optimum counter-flow mode of air jets in a large utility furnace显示文摘 | HE Boshu CHEN Meiqian YU Qiumei LIU Shumin FAN Lijuan SUN Shouguang XU Jinyuan PAN Wei-Ping | | 0，，： | 1 |
| 10 | Temperature impact on SO 2 removal efficiency by ammonia gas scrubbing显示文摘 | Boshu He Xianyu Zheng Yan Wen Huiling Tong Meiqian Chen Changhe Chen | 2002 | Energy Conversion and Management2002，，13： | 1 |
| 11 | A highly-efficient concentrated perovskite solar cell-thermoelectric generator tandem system显示文摘Concentrated photovoltaic(CPV)has been identified as an effective method to further enhance the efficiency of photovoltaic cells.Previous studies on CPV mainly focused on III-V multi-junction cells.Nevertheless,Ⅲ-ⅤCPV technology is mainly used in niche applications due to its high cost.Here,we use metal-halide perovskite solar cell(PSC)to demonstrate a concentrated photovoltaic-thermoelectric tandem device.The thermoelectric generator(TEG)is utilized to reduce the effect of heat generation under concentrated solar irradiance.Our tandem system achieved a peak power conversion efficiency(PCE)of 25.0%at a solar concentration of 3 suns.This efficiency exceeded that of the single PSC by~4.7%.Our work proves that by controlling the heat flow in concentrated PSC-TEG tandem system,the redundant heat produced by upper PSC can be effectively reused.This tandem structure provides a promising approach to improve the efficiency and stability of PSC under low-concentrated solar irradiation. | Yangying Zhou Yanan Chen Qi Zhang Yu Zhou Meiqian Tai Kunihito Koumoto Hong Lin | 2021 | Journal of Energy Chemistry2021，30，8： | 0 |
| 12 | Real-time Synchrophasor Data Compression Technique with Phasor Interpolation and Extrapolation显示文摘To completely eliminate the time delays caused by phasor data compressions for real-time synchrophasor applications,a real-time synchrophasor data compression(RSDC)is proposed in this paper.The two-way rotation characteristic and elliptical trajectory of dynamic synchrophasors are introduced first to enhance the compressions along with a fast solving method for elliptical trajectory fitting equations.The RSDC for phasor data compression and reconstruction is then proposed by combining the interpolation and extrapolation compressions.The proposed RSDC is verified by both the actual phasor measurement data recorded in a two-phase short-circuit incident and a subsynchronous oscillation incident,and the synthetic dynamic synchrophasors.It is also compared with two previous real-time phasor data compression techniques,i.e.,phasor swing door trending(PSDT)and exception and swing door trending(SDT)data compression(ESDC).The verification results demonstrate that RSDC can achieve significantly higher compression ratios for offline applications with the interpolation and the zero-delay phasor data compression with the extrapolation for real-time applications simultaneously. | Fang Zhang Meiqian Liu Zixuan Zhang Jinghan He Wenzhong Gao | 2023 | Journal of Modern Power Systems and Clean Energy2023，11，3： | 0 |
| 13 | Correction to:Mesenchymal stem cell-derived small extracellular vesicles mitigate oxidative stress-induced senescence in endothelial cells via regulation of miR-146a/Src显示文摘In the process of collating the raw data,the authors noticed several inadvertent mistakes occurred in Fig.1b,Fig.2d,f,l,and Supplementary Fig.1b that need to be corrected after online publication of the article1.The correct data are provided as follows.The key findings of the article are not affected by these corrections.The original article has been corrected. | Xian Xiao Meiqian Xu Hongliang Yu Liping Wang Xiaoxia Li Janusz Rak Shihua Wang Robert Chunhua Zhao | 2022 | Signal Transduction and Targeted Therapy2022，7，8： | 0 |
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